Article
Materials Science, Multidisciplinary
Qingzhi An, Fabian Paulus, David Becker-Koch, Changsoon Cho, Qing Sun, Andreas Weu, Sapir Bitton, Nir Tessler, Yana Vaynzof
Summary: Studies find that recombination at grain boundaries is diffusion limited and inversely proportional to the grain area to the power of 3/2. The prevalence of small grains, which act as recombination hot spots, dictates the photovoltaic performance of perovskite solar cells.
Article
Multidisciplinary Sciences
Jingqi Dai, Aurore Sanchez, Celine Adam, Lepakshi Ranjha, Giordano Reginato, Pierre Chervy, Carine Tellier-Lebegue, Jessica Andreani, Raphael Guerois, Virginie Ropars, Marie-Helene Le Du, Laurent Maloisel, Emmanuelle Martini, Pierre Legrand, Aurelien Thureau, Petr Cejka, Valerie Borde, Jean-Baptiste Charbonnier
Summary: The study characterized the crystal structure of Saccharomyces cerevisiae MutL gamma and identified its specificity in mismatch repair and meiotic recombination. The research also revealed clear divergent features between MutL homologs and identified, at the molecular level, their specialization towards MMR or meiotic recombination functions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Genetics & Heredity
Zhiyuan Chen, Mohamed Nadhir Djekidel, Yi Zhang
Summary: In mouse preimplantation embryos, H2AK119ub1 and H3K27me3 have distinct genome-wide dynamics. Loss of H2AK119ub1 results in premature activation of developmental genes, while loss of H3K27me3 does not.
Article
Cell Biology
Hyunjin Yoo, Hyeonwoo La, Chanhyeok Park, Seonho Yoo, Hyeonji Lee, Hyuk Song, Jeong Tae Do, Youngsok Choi, Kwonho Hong
Summary: Dot1l is a key transcription factor involved in the development and function of lymphatic endothelial cells (LECs) and blood endothelial cells (BECs). Dot1l depletion and overexpression affect cell adhesion, immune response, and angiogenesis-related biological processes. Dot1l regulates specific tissue development and ion transportation through the modulation of gene expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Criminology & Penology
Brian P. Schaefer, Thomas Hughes, W. Cameron Stelzig
Summary: This study conducted a department-wide hot spots patrol experiment in Louisville, Kentucky, and found that the intervention did not have a significant impact on three outcomes related to crime. However, the location of hot spots did impact crime-related calls for service. The study discusses the importance and limitations of hot spots policing in suburban locations and the challenges of department-wide interventions.
Article
Chemistry, Multidisciplinary
Dezhao Huang, Qiangsheng Sun, Zeyu Liu, Shen Xu, Ronggui Yang, Yanan Yue
Summary: The authors developed a tip-enhanced Raman thermometry approach to study thermal transport at nanoscale hotspots and predicted the phonon mean free path through a combination of experiments and simulations.
Article
Chemistry, Multidisciplinary
Thomas Vasileiadis, Adnane Noual, Yuchen Wang, Bartlomiej Graczykowski, Bahram Djafari-Rouhani, Shu Yang, George Fytas
Summary: This study investigates the effect of plasmonic coupling on optomechanics using Brillouin light spectroscopy in a nanocomposite system of gold nanorods and polyvinyl alcohol. The intensity of inelastically scattered light on thermal phonons is found to be strongly influenced by the wavelength of the probing light, revealing different vibrational modes for resonant and off-resonant light.
Article
Multidisciplinary Sciences
David Weisburd, Cody W. Telep, Heather Vovak, Taryn Zastrow, Anthony A. Braga, Brandon Turchan
Summary: This study found that training police in procedural justice can improve their behavior in the field and lead to fewer arrests. Residents in areas with trained police were less likely to perceive harassment or unnecessary force from the police. Additionally, there was a significant decrease in crime incidents in areas with trained police.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Medicinal
Callum J. Dickson, Viktor Hornak, Jose S. Duca
Summary: RBFE calculations are resurging in computer-aided drug design for small molecules, showing promising performance for predicting drug discovery programs targeting lipid-exposed sites. By using a microkinetic model, RBFE can calculate the free energy of membrane partitioning and binding at extra-helical sites, guiding drug discovery programs toward optimizing intrinsic activity at the target.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2021)
Article
Ergonomics
M. Al Hamami, T. C. Matisziw
Summary: Vehicular accidents can happen anywhere and at any time, but research suggests that spatial and temporal dependencies among accidents likely exist. Analyzing the morphological characteristics of accident hot spots and tracking their dynamics is crucial for mitigation and prevention efforts. A GIS-based framework can be utilized to facilitate the analysis of hot spot morphology over time and detect informative spatial and temporal patterns.
ACCIDENT ANALYSIS AND PREVENTION
(2021)
Article
Multidisciplinary Sciences
Jiarui Wang, W. E. Moerner, Lucy Shapiro
Summary: In asymmetric cell division of Caulobacter crescentus, a regulatory protein adapts distinct functions at opposing cell poles through asymmetrically distributed c-di-GMP, revealing how second messengers can influence protein behavior for asymmetry facilitation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Jiarui Wang, W. E. Moerner, Lucy Shapiro
Summary: Asymmetric cell division in Caulobacter crescentus leads to the production of daughter cells with distinct characteristics due to the presence of different oligomeric states of a regulatory protein at the opposing cell poles. This regulatory protein interacts with molecular machines at each pole to mediate specific functions, ultimately regulating the physical behavior of the cells. The second messenger c-di-GMP provides spatiotemporal cues that allow for the asymmetry in protein behavior, facilitating the differentiation of daughter cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Genetics & Heredity
Guoqing Liu, Shuangjian Song, Qiguo Zhang, Biyu Dong, Yu Sun, Guojun Liu, Xiujuan Zhao
Summary: Characterization and identification of recombination hotspots in yeast were conducted based on public high-resolution Spo11-oligo-seq data, revealing that hotspots could be characterized by both DNA-based features and remarkable features associated with DNA physical properties and shape. SVM classifier performed the best in discriminating hotspots from coldspots with an accuracy of around 92%, highlighting the importance of both DNA-based features and epigenetic marks in hotspot identification.
FRONTIERS IN GENETICS
(2021)
Article
Environmental Sciences
Tyler L. Anthony, Whendee L. Silver
Summary: Although drained agricultural peatlands only occupy 1% of agricultural land, they are responsible for about one third of global cropland greenhouse gas emissions. Recent studies have shown that greenhouse gas fluxes from these peatlands vary greatly over time. The relationship between these fluctuations and the locations of emissions is poorly understood but may provide insights into the patterns and drivers of high greenhouse gas emissions from agricultural peatland soils.
Article
Biochemistry & Molecular Biology
Sanghyun Sung, Eunkyeong Kim, Hiroyuki Niida, Chuna Kim, Junho Lee
Summary: Telomere length must be maintained in actively dividing cells to avoid cellular arrest or death. In the absence of telomerase activity, activation of alternative lengthening of telomeres (ALT) allows the maintenance of telomeric length and prolongs the cellular lifespan. Our study investigated the characteristics and fates of two types of ALT survivors, type I and type II, through multi-omics approaches. The gene expression signatures of type I and type II ALT cell lines were chromatin remodeling and DNA repair, respectively. Type I ALT cells accumulated more mutations and demonstrated persistent telomere instability compared to type II cells. These findings shed light on the plasticity of crisis-suffering cells and cancers.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Boubou Diagouraga, Julie A. J. Clement, Laurent Duret, Jan Kadlec, Bernard de Massy, Frederic Baudat
Article
Cell Biology
Liisa Kauppi, Marco Barchi, Julian Lange, Frederic Baudat, Maria Jasin, Scott Keeney
GENES & DEVELOPMENT
(2013)
Article
Genetics & Heredity
Aliya Ishmukhametova, Jian-Min Chen, Rafaelle Bernard, Bernard de Massy, Frederic Baudat, Amandine Boyer, Deborah Mechin, Delphine Thorel, Brigitte Chabrol, Marie-Claire Vincent, Philippe Khau Van Kien, Mireille Claustres, Sylvie Tuffery-Giraud
News Item
Medicine, Research & Experimental
Frederic Baudat, Jerome Buard, Corinne Grey, Bernard de Massy
M S-MEDECINE SCIENCES
(2010)
News Item
Medicine, Research & Experimental
Frederic Baudat, Jerome Buard, Corinne Grey, Bernard de Massy
M S-MEDECINE SCIENCES
(2011)
Article
Genetics & Heredity
April Reynolds, Huanyu Qiao, Ye Yang, Jefferson K. Chen, Neil Jackson, Kajal Biswas, J. Kim Holloway, Frederic Baudat, Bernard de Massy, Jeremy Wang, Christer Hoog, Paula E. Cohen, Neil Hunter
Article
Genetics & Heredity
Francesca Cole, Frederic Baudat, Corinne Grey, Scott Keeney, Bernard de Massy, Maria Jasin
Review
Genetics & Heredity
Frederic Baudat, Yukiko Imai, Bernard de Massy
NATURE REVIEWS GENETICS
(2013)
Article
Multidisciplinary Sciences
Liisa Kauppi, Marco Barchi, Frederic Baudat, Peter J. Romanienko, Scott Keeney, Maria Jasin
Article
Cell Biology
Hong Wu, Nikolas Mathioudakis, Boubou Diagouraga, Aiping Dong, Ludmila Dombrovski, Frederic Baudat, Stephen Cusack, Bernard de Massy, Jan Kadlec
Article
Biochemistry & Molecular Biology
Corinne Grey, Pauline Barthes, Gaeelle Chauveau-Le Friec, Francina Langa, Frederic Baudat, Bernard de Massy
Article
Genetics & Heredity
Petr Flachs, Ondrej Mihola, Petr Simecek, Sona Gregorova, John C. Schimenti, Yasuhisa Matsui, Frederic Baudat, Bernard de Massy, Jaroslav Pialek, Jiri Forejt, Zdenek Trachtulec
Article
Biochemistry & Molecular Biology
Frederic Baudat, Bernard de Massy, Frederic Veyrunes
Article
Biology
Yukiko Imai, Mathilde Biot, Julie A. J. Clement, Mariko Teragaki, Serge Urbach, Thomas Robert, Frederic Baudat, Corinne Grey, Bernard de Massy
Article
Biochemistry & Molecular Biology
Yukiko Imai, Frederic Baudat, Miguel Taillepierre, Marcello Stanzione, Attila Toth, Bernard de Massy