Article
Biochemistry & Molecular Biology
David G. Ashbrook, Danny Arends, Pjotr Prins, Megan K. Mulligan, Suheeta Roy, Evan G. Williams, Cathleen M. Lutz, Alicia Valenzuela, Casey J. Bohl, Jesse F. Ingels, Melinda S. McCarty, Arthur G. Centeno, Reinmar Hager, Johan Auwerx, Lu Lu, Robert W. Williams
Summary: The expansion of the BXD family of mice to 140 fully isogenic strains has created a uniquely powerful model for precision medicine, with the ability to map heritable traits with high power and precision. The BXD family, which segregates for 6 million common DNA variants, is an effective platform for testing causal modeling and predictive validation in experimental precision medicine.
Article
Multidisciplinary Sciences
Price E. Dickson, Guy Mittleman
Summary: Working memory and pattern separation are fundamental cognitive abilities that can greatly impact quality of life when impaired. This study used the TUNL assay to assess these abilities in mice and found that pattern separation was influenced by mouse strain, while working memory was not. The distance between choice-phase stimuli also had differing effects on TUNL performance.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Sangwon Jang, Inah Park, Mijung Choi, Jihoon Kim, Seungeun Yeo, Sung-Oh Huh, Ji-Woong Choi, Cheil Moon, Han Kyoung Choe, Youngshik Choe, Kyungjin Kim
Summary: The circadian regulation of 5-HT levels, controlled by the nuclear receptor REV-ERBα, plays a significant role in social interaction behaviors. The genetic ablation of REV-ERBα in DR 5-HTergic neurons leads to impaired social preference, which is associated with elevated neuron activity and 5-HT levels at dusk. Furthermore, inhibiting the DR to NAc 5-HTergic circuit restores the impairment of social preference in these mice.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Anjali Bhat, Haritz Irizar, Johan Hilge Thygesen, Karoline Kuchenbaecker, Oliver Pain, Rick A. Adams, Eirini Zartaloudi, Jasmine Harju-Seppanen, Isabelle Austin-Zimmerman, Baihan Wang, Rebecca Muir, Ann Summerfelt, Xiaoming Michael Du, Heather Bruce, Patricio O'Donnell, Deepak P. Srivastava, Karl Friston, L. Elliot Hong, Mei-Hua Hall, Elvira Bramon
Summary: A study identified two genes associated with MMN, which are overexpressed in the frontal cortex during prenatal development but significantly downregulated in adulthood. MMN was found to be a considerably superior psychosis endophenotype compared to three other candidate endophenotypes.
Article
Neurosciences
Jessica A. Baker, Jacob T. Brettin, Megan K. Mulligan, Kristin M. Hamre
Summary: Genetics and sex play important roles in the differential cell death pathways after alcohol exposure during development in fetal alcohol spectrum disorders (FASD). In a mouse study, ethanol-induced gene expression changes were found to be influenced by genetic background and sex, suggesting potential long-term consequences.
Review
Biochemistry & Molecular Biology
Chisomo Zimphango, Farah C. Alimagham, Keri L. H. Carpenter, Peter J. Hutchinson, Tanya Hutter
Summary: Cerebral microdialysis technique provides useful information on brain metabolites for clinical decision making and medical treatment, but the limitations of hourly result retrieval exist. Recent focus has been on developing biosensing techniques for continuous online monitoring. Further research and future perspectives are still worth attention.
Article
Ophthalmology
Adam P. Faranda, Mahbubul H. Shihan, Yan Wang, Melinda K. Duncan
Summary: Aging affects the transcriptome of lens cells, leading to changes in differentiation markers and transcription factors expression. Aged lens cells upregulate genes controlling immune response and stress response, and exhibit changes in mitochondrial gene expression related to mitochondrial stress. Additionally, age does not profoundly impact the response of lens epithelial cells to injury.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Celeste M. Sheftel, Lihe Liu, Sena L. Field, Samantha R. Weaver, Chad M. Vezina, Francisco Penagaricano, Laura L. Hernandez
Summary: Serotonin is a key regulator of mammary gland homeostasis during lactation, and this study found that selective serotonin reuptake inhibitors (SSRIs) alter gene expression in the mammary gland, affecting milk synthesis and mammary gland function. Folic acid supplementation also has an impact on the mammary gland transcriptome, but it does not reverse the effects caused by SSRI treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Tingzhi Deng, Jingjing Li, Jian Liu, Fuyi Xu, Xiaoya Liu, Jia Mi, Jonas Bergquist, Helen Wang, Chunhua Yang, Lu Lu, Xicheng Song, Cuifang Yao, Geng Tian, Qing Yin Zheng
Summary: This study investigated the potential underlying mechanism of age-related hearing loss (ARHL) and cognitive dysfunction using a system genetics approach. Analysis of the transcriptome data in aged BXD mice strains identified 1,435 hearing-related genes in the hippocampus, with the impaired glutamatergic synapse pathway implicated in ARHL. Further research showed that the expression level of glutamine synthetase is a crucial regulator in the glutamatergic synapse pathway and associated with learning and memory behavior.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Ophthalmology
Meghashri Saravanan, Rong Xu, Olivia Roby, Yekai Wang, Siyan Zhu, Amy Lu, Jianhai Du
Summary: This study investigates the influence of sex on metabolism in the retina, RPE, lens, and brain under fed and fasted conditions. Sex differences in metabolites were observed in different tissues, with the lens and retina showing the most tissue-specific changes. The female RPE and brain were more sensitive to fasting, with decreased metabolites in amino acid metabolism, tricarboxylic acid cycles, and glycolysis. The plasma had the fewest sex-different metabolites, with limited overlap with tissue changes.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Endocrinology & Metabolism
Theodosia Vallianatou, Weifeng Lin, Nicholas B. Bechet, Mario S. P. Correia, Nagesh C. Shanbhag, Iben Lundgaard, Daniel Globisch
Summary: Sleep serves as a universal core function allowing for restorative biological processes. Metabolic analysis of four mouse brain regions revealed region-specific circadian variations, with metabolites linked to oxidative stress showing alterations during sleep. This provides molecular evidence of significant metabolic shifts in brain energy metabolism, including the discovery of brain metabolites not previously associated with circadian functions.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christopher Pham Pacia, Jinyun Yuan, Yimei Yue, Eric C. Leuthardt, Tammie L. S. Benzinger, Arash Nazeri, Hong Chen
Summary: This study evaluated the feasibility and safety of focused ultrasound-mediated liquid biopsy (sonobiopsy) in detecting brain-derived protein biomarkers in tau protein-related diseases. Sonobiopsy released phosphorylated tau species and neurofilament light chain into the blood circulation, potentially facilitating diagnosis of neurodegenerative disorders.
Article
Multidisciplinary Sciences
Benatti Cristina, Rivi Veronica, Alboni Silvia, Grilli Andrea, Castellano Sara, Pani Luca, Brunello Nicoletta, Blom M. C. Johanna, Bicciato Silvio, Tascedda Fabio
Summary: Dysregulation of the kynurenine pathway is involved in various human diseases and disorders. Lymnaea stagnalis (LS), an invertebrate model, is a valuable tool for studying the complexity of this pathway. The researchers characterized the kynurenine pathway in LS, confirming the sequence conservation of key enzymes and identifying several compounds in the LS hemolymph.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Hyunjin Yoo, Hyeonwoo La, Chanhyeok Park, Seonho Yoo, Hyeonji Lee, Hyuk Song, Jeong Tae Do, Youngsok Choi, Kwonho Hong
Summary: Dot1l is a key transcription factor involved in the development and function of lymphatic endothelial cells (LECs) and blood endothelial cells (BECs). Dot1l depletion and overexpression affect cell adhesion, immune response, and angiogenesis-related biological processes. Dot1l regulates specific tissue development and ion transportation through the modulation of gene expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jean-David Morel, Lucie Sauzeat, Ludger J. E. Goeminne, Pooja Jha, Evan Williams, Riekelt H. Houtkooper, Ruedi Aebersold, Johan Auwerx, Vincent Balter
Summary: The metallome is often overlooked in mammals, but it plays a crucial role in cell functioning. In this study, the authors analyze the metallome and copper and zinc isotope compositions in aging mice and identify organ-specific, age-dependent, and isotopically-typified networks of interactions that are associated with clinical and molecular traits. The findings shed light on the importance of the metallome as an overlooked omic layer and provide insights into potential manipulation of cellular processes.
NATURE COMMUNICATIONS
(2022)
Review
Behavioral Sciences
D. G. Ashbrook, M. K. Mulligan, R. W. Williams
GENES BRAIN AND BEHAVIOR
(2018)
Article
Cell Biology
Pedro M. Quiros, Miguel A. Prado, Nicola Zamboni, Davide D'Amico, Robert W. Williams, Daniel Finley, Steven P. Gygi, Johan Auwerx
JOURNAL OF CELL BIOLOGY
(2017)
Article
Neurosciences
Sudarat Nimitvilai, Joachim D. Uys, John J. Woodward, Patrick K. Randall, Lauren E. Ball, Robert W. Williams, Byron C. Jones, Lu Lu, Kathleen A. Grant, Patrick J. Mulholland
JOURNAL OF NEUROSCIENCE
(2017)
Review
Biochemistry & Molecular Biology
Michael Hook, Suheeta Roy, Evan G. Williams, Maroun Bou Sleiman, Khyobeni Mozhui, James F. Nelson, Lu Lu, Johan Auwerx, Robert W. Williams
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2018)
Review
Behavioral Sciences
Neri Kafkafi, Joseph Agassi, Elissa J. Chesler, John C. Crabbe, Wim E. Crusio, David Eilam, Robert Gerlai, Ilan Goiani, Alex Gomez-Marin, Ruth Heller, Fuad Iraqi, Iman Jaljuli, Natasha A. Karp, Hugh Morgan, George Nicholson, Donald W. Pfaff, S. Helene Richter, Philip B. Stark, Oliver Stiedl, Victoria Stodden, Lisa M. Tarantino, Valter Tucci, William Valdar, Robert W. Williams, Hanno Wurbel, Yoav Benjamini
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2018)
Article
Multidisciplinary Sciences
Saet-Byel Jung, Min Jeong Choi, Dongryeol Ryu, Hyon-Seung Yi, Seong Eun Lee, Joon Young Chang, Hyo Kyun Chung, Yong Kyung Kim, Seul Gi Kang, Ju Hee Lee, Koon Soon Kim, Hyun Jin Kim, Cuk-Seong Kim, Chul-Ho Lee, Robert W. Williams, Hail Kim, Heung Kyu Lee, Johan Auwerx, Minho Shong
NATURE COMMUNICATIONS
(2018)
Article
Pharmacology & Pharmacy
Cheryl Reed, Harue Baba, Zhen Zhu, Jason Erk, John R. Mootz, Nicholas M. Varra, Robert W. Williams, Tamara J. Phillips
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Hao Li, Xu Wang, Daria Rukina, Qingyao Huang, Tao Lin, Vincenzo Sorrentino, Hongbo Zhang, Maroun Bou Sleiman, Danny Arends, Aaron McDaid, Peiling Luan, Naveed Ziari, Laura A. Velazquez-Villegas, Karim Gariani, Zoltan Kutalik, Kristina Schoonjans, Richard A. Radcliffe, Pjotr Prins, Stephan Morgenthaler, Robert W. Williams, Johan Auwerx
Article
Neurosciences
Kristin R. Anderson, Julie A. Harris, Lydia Ng, Pjotr Prins, Sara Memar, Bengt Ljungquist, Daniel Furth, Robert W. Williams, Giorgio A. Ascoli, Dani Dumitriu
Summary: The neuroscience field is undergoing an open science revolution, with a focus on digital connectivity and reproducibility. Various free resources and platforms have emerged, paving the way for data sharing, analysis, and reuse.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Genetics & Heredity
Mustafa H. Gunturkun, Efraim Flashner, Tengfei Wang, Megan K. Mulligan, Robert W. Williams, Pjotr Prins, Hao Chen
Summary: GeneCup is a literature mining web service that aids in integrating omics study results with existing literature by retrieving sentences containing user-provided gene symbols and keywords from PubMed abstracts. The sentences where the gene symbols and keywords co-occur are presented to the user through an interactive graphical interface or as tables.
G3-GENES GENOMES GENETICS
(2022)
Article
Neurosciences
Nian Wang, Robert J. Anderson, David G. Ashbrook, Vivek Gopalakrishnan, Youngser Park, Carey E. Priebe, Yi Qi, Rick Laoprasert, Joshua T. Vogelstein, Robert W. Williams, G. Allan Johnson
Article
Neurosciences
Sarah E. Heuer, Sarah M. Neuner, Niran Hadad, Kristen M. S. O'Connell, Robert W. Williams, Vivek M. Philip, Chris Gaiteri, Catherine C. Kaczorowski
Article
Substance Abuse
Marcelo F. Lopez, Michael F. Miles, Robert W. Williams, Howard C. Becker
Article
Substance Abuse
Andrew D. van der Vaart, Jennifer T. Wolstenholme, Maren L. Smith, Guy M. Harris, Marcelo E. Lopez, Aaron R. Wolen, Howard C. Becker, Robert W. Williams, Michael F. Miles
Article
Substance Abuse
Megan K. Mulligan, Khyobeni Mozhui, Ashutosh K. Pandey, Maren L. Smith, Suzhen Gong, Jesse Ingels, Michael F. Miles, Marcelo F. Lopez, Lu Lu, Robert W. Williams