Biological pathways to adaptability - interactions between genome, epigenome, nervous system and environment for adaptive behavior

A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme

(2011) Luke H. Chao et al.   CELL

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

(2011) Junjie U. Guo et al.   CELL

Chromatin higher-order structures and gene regulation

(2011) Guohong Li et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Loss of activated CaMKII at the synapse underlies Alzheimer’s disease memory loss

(2011) Philip T. T. Ly et al.   JOURNAL OF NEUROCHEMISTRY

Dysregulated phosphorylation of Ca2+/calmodulin-dependent protein kinase II-α in the hippocampus of subjects with mild cognitive impairment and Alzheimer’s disease

(2011) Lindsay C. Reese et al.   JOURNAL OF NEUROCHEMISTRY

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

APOBEC3G: a double agent in defense

(2011) Harold C. Smith   TRENDS IN BIOCHEMICAL SCIENCES

Functions and Regulation of RNA Editing by ADAR Deaminases

(2010) Kazuko Nishikura   Annual Review of Biochemistry

Dysbindin and Schizophrenia: It's Dopamine and Glutamate All Over Again

(2010) Francesco Papaleo et al.   BIOLOGICAL PSYCHIATRY

Upregulation of Dicer and MicroRNA Expression in the Dorsolateral Prefrontal Cortex Brodmann Area 46 in Schizophrenia

(2010) Danielle M. Santarelli et al.   BIOLOGICAL PSYCHIATRY

Characterizing Light-Regulated Retinal MicroRNAs Reveals Rapid Turnover as a Common Property of Neuronal MicroRNAs

(2010) Jacek Krol et al.   CELL

LINE-1 Activity in Facultative Heterochromatin Formation during X Chromosome Inactivation

(2010) Jennifer C. Chow et al.   CELL

The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc

(2010) Paul L. Greer et al.   CELL

Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines

(2010) Baris Bingol et al.   CELL

Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses

(2010) Tim F. Oberlander et al.   Epigenetics

Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer

(2010) M. R. H. Estecio et al.   GENOME RESEARCH

High-throughput sequencing reveals extensive variation in human-specific L1 content in individual human genomes

(2010) A. D. Ewing et al.   GENOME RESEARCH

Epigenetics and gene expression

(2010) E R Gibney et al.   HEREDITY

Epigenomic plasticity within populations: its evolutionary significance and potential

(2010) L J Johnson et al.   HEREDITY

cAMP-response Element-binding Protein (CREB) Controls MSK1-mediated Phosphorylation of Histone H3 at the c-fosPromoterin Vitro

(2010) Miho Shimada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons

(2010) John Meitzen et al.   JOURNAL OF NEUROCHEMISTRY

Membrane-Associated Glucocorticoid Activity Is Necessary for Modulation of Long-Term Memory via Chromatin Modification

(2010) B. Roozendaal et al.   JOURNAL OF NEUROSCIENCE

Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency

(2010) Christian Popp et al.   NATURE

L1 retrotransposition in neurons is modulated by MeCP2

(2010) Alysson R. Muotri et al.   NATURE

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

(2010) Jun Gao et al.   NATURE

Widespread transcription at neuronal activity-regulated enhancers

(2010) Tae-Kyung Kim et al.   NATURE

Optogenetics

(2010) Karl Deisseroth   NATURE METHODS

Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons

(2010) Jian Feng et al.   NATURE NEUROSCIENCE

Active DNA demethylation: many roads lead to Rome

(2010) Susan C. Wu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic control of neural precursor cell fate during development

(2010) Yusuke Hirabayashi et al.   NATURE REVIEWS NEUROSCIENCE

Age-related changes in Arc transcription and DNA methylation within the hippocampus

(2010) M.R. Penner et al.   NEUROBIOLOGY OF AGING

RNA editing changes the lesion specificity for the DNA repair enzyme NEIL1

(2010) J. Yeo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection

(2010) N. Volakakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diverse functions for DNA and RNA editing in the immune system

(2010) Claire E. Hamilton et al.   RNA Biology

MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders

(2010) Albert H. Kim et al.   SCHIZOPHRENIA RESEARCH

Fast signals and slow marks: the dynamics of histone modifications

(2010) Teresa K. Barth et al.   TRENDS IN BIOCHEMICAL SCIENCES

Crosstalk between genetic and epigenetic information through cytosine deamination

(2010) Richard Chahwan et al.   TRENDS IN GENETICS

CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models

(2010) Eva Benito et al.   TRENDS IN NEUROSCIENCES

LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes?

(2010) Tatjana Singer et al.   TRENDS IN NEUROSCIENCES

Epigenetic Regulation of a Murine Retrotransposon by a Dual Histone Modification Mark

(2010) Reinhard Brunmeir et al.   PLoS Genetics

X inactivation and the complexities of silencing a sex chromosome

(2009) Jennifer Chow et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of spine and synapse formation by activity-dependent intracellular signaling pathways

(2009) Takeo Saneyoshi et al.   CURRENT OPINION IN NEUROBIOLOGY

Mef2-mediated transcription of the miR379–410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels

(2009) Roberto Fiore et al.   EMBO JOURNAL

Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis

(2009) Anna C Need et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Context-specific modulation of cocaine-induced locomotor sensitization and ERK and CREB phosphorylation in the rat nucleus accumbens

(2009) Marcelo T. Marin et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

L1 retrotransposition occurs mainly in embryogenesis and creates somatic mosaicism

(2009) H. Kano et al.   GENES & DEVELOPMENT

Large-scale mRNA sequencing determines global regulation of RNA editing during brain development

(2009) H. Wahlstedt et al.   GENOME RESEARCH

Environmental influence on L1 retrotransposons in the adult hippocampus

(2009) Alysson R. Muotri et al.   HIPPOCAMPUS

Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia

(2009) Peixiong Yuan et al.   JOURNAL OF AFFECTIVE DISORDERS

Ca2+/Calmodulin-dependent Protein Kinase IV-mediated LIM Kinase Activation Is Critical for Calcium Signal-induced Neurite Outgrowth

(2009) Miyohiko Takemura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Amyloid Impairs AMPA Receptor Trafficking and Function by Reducing Ca2+/Calmodulin-dependent Protein Kinase II Synaptic Distribution

(2009) Zhenglin Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CREB-dependent Nur77 induction following depolarization in PC12 cells and neurons is modulated by MEF2 transcription factors

(2009) Brian Yee Hong Lam et al.   JOURNAL OF NEUROCHEMISTRY

Altered Sensitivity to Rewarding and Aversive Drugs in Mice with Inducible Disruption of cAMP Response Element-Binding Protein Function within the Nucleus Accumbens

(2009) J. A. DiNieri et al.   JOURNAL OF NEUROSCIENCE

Energetics, epigenetics, mitochondrial genetics

(2009) Douglas C. Wallace et al.   MITOCHONDRION

Dysbindin-1 genotype effects on emotional working memory

(2009) C Wolf et al.   MOLECULAR PSYCHIATRY

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

(2009) Patrick O McGowan et al.   NATURE NEUROSCIENCE

Dynamic DNA methylation programs persistent adverse effects of early-life stress

(2009) Chris Murgatroyd et al.   NATURE NEUROSCIENCE

CREB regulation of nucleus accumbens excitability mediates social isolation–induced behavioral deficits

(2009) Deanna L Wallace et al.   NATURE NEUROSCIENCE

The impact of retrotransposons on human genome evolution

(2009) Richard Cordaux et al.   NATURE REVIEWS GENETICS

Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal

(2009) Myriam Hemberger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Heterosynaptic Molecular Dynamics: Locally Induced Propagating Synaptic Accumulation of CaM Kinase II

(2009) Jacqueline Rose et al.   NEURON

Characterization of Small RNAs in Aplysia Reveals a Role for miR-124 in Constraining Synaptic Plasticity through CREB

(2009) Priyamvada Rajasethupathy et al.   NEURON

Control of Cognition and Adaptive Behavior by the GLP/G9a Epigenetic Suppressor Complex

(2009) Anne Schaefer et al.   NEURON

Alterations in AMPA receptor phosphorylation in the rat striatum following acute and repeated cocaine administration

(2009) S.M. Kim et al.   NEUROSCIENCE

Alternative-Splicing in the Exon-10 Region of GABAA Receptor β2 Subunit Gene: Relationships between Novel Isoforms and Psychotic Disorders

(2009) Cunyou Zhao et al.   PLoS One

Reversal of long-term dendritic spine alterations in Alzheimer disease models

(2009) D. L. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed

(2009) Simone R. Alt et al.   PSYCHONEUROENDOCRINOLOGY

On the Origin and Spread of an Adaptive Allele in Deer Mice

(2009) C. R. Linnen et al.   SCIENCE

Neuronal Activity-Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis

(2009) D. K. Ma et al.   SCIENCE

Genome-Wide Identification of Human RNA Editing Sites by Parallel DNA Capturing and Sequencing

(2009) J. B. Li et al.   SCIENCE

The RNA infrastructure: dark matter of the eukaryotic cell?

(2009) Lesley J. Collins et al.   TRENDS IN GENETICS

Small RNAs and the control of transposons and viruses in Drosophila

(2009) Ronald P. van Rij et al.   TRENDS IN MICROBIOLOGY

Alterations of the microRNA network cause neurodegenerative disease

(2009) Sébastien S. Hébert et al.   TRENDS IN NEUROSCIENCES

Lineage-Specific Biology Revealed by a Finished Genome Assembly of the Mouse

(2009) Deanna M. Church et al.   PLOS BIOLOGY

HIV Evolution in Early Infection: Selection Pressures, Patterns of Insertion and Deletion, and the Impact of APOBEC

(2009) Natasha Wood et al.   PLoS Pathogens

The Arc of synaptic memory

(2009) Clive R. Bramham et al.   EXPERIMENTAL BRAIN RESEARCH

Communication Between the Synapse and the Nucleus in Neuronal Development, Plasticity, and Disease

(2008) Sonia Cohen et al.   Annual Review of Cell and Developmental Biology

Positive Selection in the Human Genome: From Genome Scans to Biological Significance

(2008) Joanna L. Kelley et al.   Annual Review of Genomics and Human Genetics

Signaling Mechanisms Linking Neuronal Activity to Gene Expression and Plasticity of the Nervous System

(2008) Steven W. Flavell et al.   Annual Review of Neuroscience

Regulation of gene expression in the nervous system

(2008) Lezanne Ooi et al.   BIOCHEMICAL JOURNAL

Experience-Dependent Epigenetic Modifications in the Central Nervous System

(2008) J. David Sweatt   BIOLOGICAL PSYCHIATRY

Quantifying the heritability of task-related brain activation and performance during the N-back working memory task: A twin fMRI study

(2008) Gabriëlla A.M. Blokland et al.   BIOLOGICAL PSYCHOLOGY

Non-coding RNAs in imprinted gene clusters

(2008) Hélène Royo et al.   BIOLOGY OF THE CELL

Habitat Complexity, Brain, and Behavior

(2008) Caroly A. Shumway   BRAIN BEHAVIOR AND EVOLUTION

Distinct Role of Long 3′ UTR BDNF mRNA in Spine Morphology and Synaptic Plasticity in Hippocampal Neurons

(2008) Juan Ji An et al.   CELL

CaMKII Activation State Underlies Synaptic Labile Phase of LTP and Short-Term Memory Formation

(2008) Huimin Wang et al.   CURRENT BIOLOGY

Cyclic Adenosine 3′,5′-Monophosphate Responsive Element Binding Protein Phosphorylation Is Required But Not Sufficient for Activation of Corticotropin-Releasing Hormone Transcription

(2008) Ying Liu et al.   ENDOCRINOLOGY

Epigenetic mechanisms and the transgenerational effects of maternal care

(2008) Frances A. Champagne   FRONTIERS IN NEUROENDOCRINOLOGY

Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism

(2008) Susan E. Swanberg et al.   HUMAN MOLECULAR GENETICS

Epigenetic Regulation of bdnf Gene Transcription in the Consolidation of Fear Memory

(2008) F. D. Lubin et al.   JOURNAL OF NEUROSCIENCE

Effector Immediate-Early Gene Arc in the Amygdala Plays a Critical Role in Alcoholism

(2008) S. C. Pandey et al.   JOURNAL OF NEUROSCIENCE

Depression-prone mice with reduced glucocorticoid receptor expression display an altered stress-dependent regulation of brain-derived neurotrophic factor and activity-regulated cytoskeleton-associated protein

(2008) R. Molteni et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia

(2008) S G Potkin et al.   MOLECULAR PSYCHIATRY

Failure of neuronal homeostasis results in common neuropsychiatric phenotypes

(2008) Melissa B. Ramocki et al.   NATURE

Activity-dependent regulation of inhibitory synapse development by Npas4

(2008) Yingxi Lin et al.   NATURE

Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription

(2008) Xiangting Wang et al.   NATURE

Evolutionary expansion and anatomical specialization of synapse proteome complexity

(2008) Richard D Emes et al.   NATURE NEUROSCIENCE

Activity-Dependent Synaptogenesis: Regulation by a CaM-Kinase Kinase/CaM-Kinase I/βPIX Signaling Complex

(2008) Takeo Saneyoshi et al.   NEURON

Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity

(2008) Gary A. Wayman et al.   NEURON

Decoding the Epigenetic Language of Neuronal Plasticity

(2008) Emiliana Borrelli et al.   NEURON

From Synapse to Nucleus: Calcium-Dependent Gene Transcription in the Control of Synapse Development and Function

(2008) Paul L. Greer et al.   NEURON

Rapid Translation of Arc/Arg3.1 Selectively Mediates mGluR-Dependent LTD through Persistent Increases in AMPAR Endocytosis Rate

(2008) Maggie W. Waung et al.   NEURON

A Biological Function for the Neuronal Activity-Dependent Component of Bdnf Transcription in the Development of Cortical Inhibition

(2008) Elizabeth J. Hong et al.   NEURON

MicroRNA regulation and the variability of human cortical gene expression

(2008) Rui Zhang et al.   NUCLEIC ACIDS RESEARCH

Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping

(2008) Christoph Bock et al.   NUCLEIC ACIDS RESEARCH

An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP

(2008) Gary A. Wayman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function

(2008) A. C. Barbosa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons

(2008) T. Kawashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Epigenetic Role for Maternally Inherited piRNAs in Transposon Silencing

(2008) J. Brennecke et al.   SCIENCE

Convergent CaMK and RacGEF signals control dendritic structure and function

(2008) Peter Penzes et al.   TRENDS IN CELL BIOLOGY

The functional impact of structural variation in humans

(2008) Matthew E. Hurles et al.   TRENDS IN GENETICS

RNA editing, DNA recoding and the evolution of human cognition

(2008) John S. Mattick et al.   TRENDS IN NEUROSCIENCES

The immediate early gene Arc is associated with behavioral resilience to stress exposure in an animal model of posttraumatic stress disorder

(2007) Nitsan Kozlovsky et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Common variants underlying cognitive ability: further evidence for association between the SNAP-25 gene and cognition using a family-based study in two independent Dutch cohorts

(2007) M. F. Gosso et al.   GENES BRAIN AND BEHAVIOR

Aerobic metabolism underlies complexity and capacity

(2007) Lauren G. Koch et al.   JOURNAL OF PHYSIOLOGY-LONDON

Networks of neurons, networks of genes: An integrated view of memory consolidation

(2007) Teiko Miyashita et al.   NEUROBIOLOGY OF LEARNING AND MEMORY