Article
Plant Sciences
Ming-You Dong, Ling Lei, Xian-Wei Fan, You-Zhi Li
Summary: This study investigated the variations in CCT protein-encoding gene number across plant species and different maize inbred lines, providing insights into structural variations, copy number variations, expression patterns under stresses and light cycles, and associations with maize quantitative trait loci (QTLs). The data revealed chromosome collinearity, stress responsiveness, and potential functions in perceiving dark-light transitions among ZmCCTs, with no germplasm specificity observed in structural variations and CNVs.
Review
Medicine, Research & Experimental
Yi Qin, Zhong-hua Chen, Jun-Jie Wu, Zhen-Yu Zhang, Zheng-Dong Yuan, Dan-Yang Guo, Meng-Nan Chen, Xia Li, Feng-Lai Yuan
Summary: The circadian clock plays a crucial role in regulating bone metabolism, including bone loss. Clock-related genes control signaling pathways and transcription factors in osteoblasts and osteoclasts, while also regulating osteocytes and endothelial cells. Furthermore, the regulation of circadian clock genes by novel modulators presents a potential strategy for preventing and treating bone diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biology
Suil Kim, Douglas G. McMahon
Summary: This study reveals that light input to the SCN can change the waveform of molecular clockworks, marking clock advances and delays at simulated dawn and dusk. The changes in waveform seem to be greatest in the ventrolateral SCN, while the effects on period are greatest in the dorsomedial SCN, suggesting spatiotemporally distinct responses within the SCN neural network.
Article
Biochemistry & Molecular Biology
Maria Savino, Claudio Carmine Guida, Maria Nardella, Emanuele Murgo, Bartolomeo Augello, Giuseppe Merla, Salvatore De Cosmo, Antonio Fernando Savino, Roberto Tarquini, Francesco Cei, Filippo Aucella, Gianluigi Mazzoccoli
Summary: This article investigates the relationship between heme biosynthesis disorders and altered expression of circadian genes, finding that changes in circadian gene expression may be associated with the symptoms and signs of porphyria patients.
Article
Environmental Sciences
Yu Zhang, Yong Li, Yilin Yuan, Jun Wang, Shiyu Zhang, Run Zhu, Yan Wang, Yinbao Wu, Xindi Liao, Jiandui Mi
Summary: Light plays a crucial role in regulating the central biological clock system. Intermittent photoperiods enhance the circadian rhythms of gut microbes and the expression of clock genes in the hypothalamus, liver, and cecal wall. This regulation is mediated through the melatonin pathway and the production of short-chain fatty acids.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Biochemistry & Molecular Biology
Tingting Li, Shihua Zhang, Yuxuan Yang, Lingli Zhang, Yu Yuan, Jun Zou
Summary: This paper reviews the progress of research on the co-regulation of bone metabolism by circadian clock genes and microRNAs, aiming to provide new ideas for the prevention and treatment of bone metabolic diseases such as osteoporosis.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Microbiology
Zala Zuzek, Lucija Raspor Dall'Olio, Katka Pohar, Alojz Ihan, Miha Moskon, Damjana Rozman, Ursa Kovac, Marjanca Starcic Erjavec
Summary: Research has shown that dysbiosis of gut microbiota can affect the circadian clock of mammalian hosts, highlighting the importance of genetic background of E. coli in influencing the host's circadian clock genes.
Review
Biochemistry & Molecular Biology
Ana Beatriz Aguiar Sanford, Leidivan Sousa da Cunha, Caio Bezerra Machado, Flavia Melo Cunha de Pinho Pessoa, Abigail Nayara dos Santos Silva, Rodrigo Monteiro Ribeiro, Fabiano Cordeiro Moreira, Manoel Odorico de Moraes Filho, Maria Elisabete Amaral de Moraes, Lucas Eduardo Botelho de Souza, Andre Salim Khayat, Caroline Aquino Moreira-Nunes
Summary: The circadian clock is a system that regulates physiological processes and responds to the external environment, while its disruption can lead to various diseases. Leukemia is a malignancy of the blood and bone marrow caused by alterations in cellular regulatory processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Corine Faehn, Michael Reichelt, Axel Mithofer, Timo Hytonen, Jorgen Molmann, Laura Jaakola
Summary: This study compares the expression of clock genes in four woodland strawberry (Fragaria vesca L.) accessions from different populations under Arctic and mid-latitude photoperiod conditions. The results show that circadian rhythms in Fragaria vesca are driven by both the experienced photoperiod and genetic factors, while phytohormone levels are primarily determined by specific accessions' genetic factors rather than the experienced photoperiod.
Article
Biochemistry & Molecular Biology
Ryota Nakazato, Yuki Matsuda, Faryal Ijaz, Koji Ikegami
Summary: Clock genes regulate the length of primary cilia through circadian dynamics, which affects fibroblast migration. The length of primary cilia exhibits circadian oscillation and controls the migration of fibroblasts.
Review
Immunology
Kun Xiang, Zhiwei Xu, Yu-Qian Hu, Yi-Sheng He, Guo-Cui Wu, Tian-Yu Li, Xue-Rong Wang, Li-Hong Ding, Qin Zhang, Sha-Sha Tao, Dong-Qing Ye, Hai-Feng Pan, De-Guang Wang
Summary: Circadian rhythm plays a crucial role in immune system function, with disruptions to clock genes increasing the risk of autoimmune diseases. Research on synthetic ligands of circadian clock genes may help reduce the susceptibility and severity of autoimmune diseases.
AUTOIMMUNITY REVIEWS
(2021)
Article
Microbiology
Amy R. Ellison, David Wilcockson, Jo Cable
Summary: The study reveals daily rhythms in fish skin immune expression and microbiomes, modulated by photoperiod and parasitic lice infection. Disruption of circadian rhythms could be detrimental to fish health by affecting immune and microbiota activity. Understanding these dynamics and relationships provides a foundation for investigating the use of chronotherapies in aquaculture and sheds light on the role of microbiomes in circadian health of vertebrates.
Article
Medicine, Research & Experimental
Takashi Iwamoto, Kazumasa Torimoto, Daisuke Gotoh, Sayuri Onishi, Shunta Hori, Yousuke Morizawa, Yasushi Nakai, Makito Miyake, Kiyohide Fujimoto
Summary: This study aims to investigate the circadian expression changes of bladder clock genes in Dahl salt-sensitive rats following high salt intake. The results showed that high salt intake led to lower mRNA levels and reduced amplitude of circadian expression changes in bladder clock genes. However, reducing salt intake partially restored these rhythms.
Article
Biochemistry & Molecular Biology
Xiaomeng Liu, Niuben Cao, Xinchan Liu, Yu Deng, Yu Xin, Ruobing Fu, Xirui Xin, Yubo Hou, Weixian Yu
Summary: Circadian rhythms play a crucial role in regulating the body's homeostasis, and circadian rhythm disorders can have detrimental effects on metabolic and immune functions. However, the relationship between circadian rhythm disorders and periodontitis has not been well studied. This research aimed to investigate the role of the circadian rhythm control gene BMAL1 in periodontitis. The results showed that downregulation of BMAL1 in circadian rhythm disorder-induced periodontitis led to significant alveolar bone resorption, increased osteoclast differentiation, upregulation of the inflammatory signaling molecule NF-kappa B, elevated apoptosis and oxidative stress levels in periodontal tissues. This study suggests that BMAL1 is a key regulator in periodontitis exacerbated by circadian rhythm disorders, highlighting a potential avenue for periodontitis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Takashi Kitahashi, Daisuke Kurokawa, Shouzo Ogiso, Nobuo Suzuki, Hironori Ando
Summary: The study found that there were no significant diurnal or circadian changes in melanopsin gene mRNA levels in the brain of juvenile grass puffer, but a significant diurnal rhythm was observed in the mRNA levels of opn4xa in the eyes, while opn4xb showed both diurnal and circadian changes. Continuous exposure to light during the subjective night significantly increased the mRNA levels of opn4xa in the eyes at ZT24.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Review
Plant Sciences
Radka Slovak, Takehiko Ogura, Santosh B. Satbhai, Daniela Ristova, Wolfgang Busch
Review
Plant Sciences
Santosh B. Satbhai, Daniela Ristova, Wolfgang Busch
JOURNAL OF EXPERIMENTAL BOTANY
(2015)
Article
Multidisciplinary Sciences
Santosh B. Satbhai, Claudia Setzer, Florentina Freynschlag, Radka Slovak, Envel Kerdaffrec, Wolfgang Busch
NATURE COMMUNICATIONS
(2017)
Article
Genetics & Heredity
Nadia Bouain, Santosh B. Satbhai, Arthur Korte, Chorpet Saenchai, Guilhem Desbrosses, Pierre Berthomieu, Wolfgang Busch, Hatem Rouached
Article
Multidisciplinary Sciences
Elwira Smakowska-Luzan, G. Adam Mott, Katarzyna Parys, Martin Stegmann, Timothy C. Howton, Mehdi Layeghifard, Jana Neuhold, Anita Lehner, Jixiang Kong, Karin Gruenwald, Natascha Weinberger, Santosh B. Satbhai, Dominik Mayer, Wolfgang Busch, Mathias Madalinski, Peggy Stolt-Bergner, Nicholas J. Provart, M. Shahid Mukhtar, Cyril Zipfel, Darrell Desveaux, David S. Guttman, Youssef Belkhadir
Correction
Multidisciplinary Sciences
Elwira Smakowska-Luzan, G. Adam Mott, Katarzyna Parys, Martin Stegmann, Timothy C. Howton, Mehdi Layeghifard, Jana Neuhold, Anita Lehner, Jixiang Kong, Karin Grunwald, Natascha Weinberger, Santosh B. Satbhai, Dominik Mayer, Wolfgang Busch, Mathias Madalinski, Peggy Stolt-Bergner, Nicholas J. Provart, M. Shahid Mukhtar, Cyril Zipfel, Darrell Desveaux, David S. Guttman, Youssef Belkhadir
Article
Genetics & Heredity
Monica Meijon, Santosh B. Satbhai, Takashi Tsuchimatsu, Wolfgang Busch
Article
Biochemistry & Molecular Biology
Takehiko Ogura, Christian Goeschl, Daniele Filiault, Madalina Mirea, Radka Slovak, Bonnie Wolhrab, Santosh B. Satbhai, Wolfgang Busch
Article
Genetics & Heredity
Nadia Bouain, Arthur Korte, Santosh B. Satbhai, Hye-In Nam, Seung Y. Rhee, Wolfgang Busch, Hatem Rouached
Article
Plant Sciences
Prince Saini, Shivani Bhatia, Monika Mahajan, Anshul Kaushik, Sangram Keshari Sahu, Asis Kumar, Santosh B. Satbhai, Manoj Kumar Patel, Shweta Saxena, Om Prakash Chaurasia, Maneesh Lingwan, Shyam Kumar Masakapalli, Ram Kishor Yadav
Article
Plant Sciences
Alejandro Alonso-Diaz, Santosh B. Satbhai, Roger de Pedro-Jove, Hannah M. Berry, Christian Goschl, Cristiana T. Argueso, Ondrej Novak, Wolfgang Busch, Marc Valls, Nuria S. Coll
Summary: This study investigated the genetic determinants of root immunity against the soil-borne pathogen Ralstonia solanacearum in Arabidopsis, highlighting the role of cytokinin signaling in early defense responses. The researchers used a high-throughput in vitro infection system to identify allelic variation in genes related to cytokinin metabolism, providing insights into the mechanisms underlying root defenses against the devastating bacterial wilt disease.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Multidisciplinary Sciences
Matthieu Pierre Platre, Santosh B. Satbhai, Lukas Brent, Matias F. Gleason, Min Cao, Magali Grison, Marie Glavier, Ling Zhang, Christophe Gaillochet, Christian Goeschl, Marco Giovannetti, Balaji Enugutti, Julie Neveu, Marcel von Reth, Ruben Alcazar, Jane E. Parker, Gregory Vert, Emmanuelle Bayer, Wolfgang Busch
Summary: Iron plays a critical role in host-pathogen interactions, and the link between iron homeostasis and immune pathways is well established in plants. However, the mechanisms of iron sensing and integration with immune response pathways remain unknown. This study identifies a receptor kinase, SRF3, which coordinates root growth, iron homeostasis, and immune response pathways in plants through the regulation of callose synthases. SRF3 responds to low iron levels and bacterial elicitation, and is proposed to be part of nutritional immune responses involved in sensing external iron levels.
NATURE COMMUNICATIONS
(2022)
Review
Plant Sciences
Deep Shikha, Pooja Jakhar, Santosh B. Satbhai
Summary: JA serves as a phytohormone that regulates various physiological and biochemical processes in plants, including responses to biotic and abiotic stresses as well as growth and development under nutrient deficiency conditions. Research has shown that JA plays a crucial role in plant resilience against environmental changes.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Plant Sciences
Samriti Mankotia, Dhriti Singh, Kumari Monika, Muskan Kalra, Himani Meena, Varsha Meena, Ram Kishor Yadav, Ajay Kumar Pandey, Santosh B. Satbhai
Summary: Iron is essential for plants and animals, and its limitation significantly affects crop yield and human nutrition. Plants have adapted strategies to regulate iron uptake and homeostasis, as well as modify root system architecture to survive under low iron conditions. Understanding the molecular mechanism of root growth responses has implications for plant breeding.
Meeting Abstract
Biochemistry & Molecular Biology
S. Satbhai, W. Busch