Review
Endocrinology & Metabolism
Antonio Bianchi, Sabrina Chiloiro, Antonella Giampietro, Simona Gaudino, Rosalinda Calandrelli, Ciro Mazzarella, Carmelo Caldarella, Mario Rigante, Marco Gessi, Liverana Lauretti, Laura De Marinis, Alessandro Olivi, Alfredo Pontecorvi, Francesco Doglietto
Summary: Growth hormone-secreting adenomas exhibit a wide range of behaviors and outcomes, from mild disease to aggressive neoplasms. Treatment for patients who do not respond to surgery or first-generation somatostatin receptor ligands may involve multiple surgical, medical, and radiation treatments. Currently, there are no markers that can predict the prognosis or aggressiveness of acromegaly. A multidisciplinary approach is necessary to tailor treatment for difficult/aggressive cases, including radiation therapy, chemotherapy, and emerging treatments.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Min Zhao, Kai Li, Hongchuan Niu, Yuanli Zhao, Changyu Lu
Summary: This study used case data analysis to examine changes in hormone levels before and after surgery in patients with pituitary adenoma and investigated the influence of various factors on endocrine function. The findings show that surgical intervention effectively improves endocrine disorders in these patients, with preoperative management of hormone levels facilitating postoperative remission. Multiple surgeries and an extended interval between hormone retesting and surgery can affect postoperative cortisol secretion function.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Gudmundur Johannsson, Oskar Ragnarsson
Summary: GH deficiency is common in patients with hypothalamic-pituitary disorders, and its replacement therapy can improve symptoms and quality of life while maintaining a good safety profile.
JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Yutong Xing, Fan Xuan, Kaixi Wang, Huifeng Zhang
Summary: Aging is a biological process that leads to a progressive decline in physiological function due to interaction between the environment and the body. It can result in dysfunction of vital organ systems and the onset of age-related diseases that significantly impact quality of life. The endocrine system plays a role in coordinating cellular interactions, metabolism, growth, and aging through hormones and related functional factors. This paper explores the mechanisms of growth hormone, thyroid hormone, and estrogen in the aging process, offering insights into endocrine mechanisms associated with aging.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Ana-Maria Gheorghe, Alexandra-Ioana Trandafir, Mihaela Stanciu, Florina Ligia Popa, Claudiu Nistor, Mara Carsote
Summary: This article provides new insights into the challenges of pituitary apoplexy during pregnancy and the postpartum period. The study includes a review of 35 original studies and highlights the importance of prompt recognition of headache as the main clinical feature. Most patients receive conservative management with corticosteroid substitution and dopamine agonists. Surgical intervention is reserved for cases with neuro-ophthalmological deterioration. This study is clinically significant for obstetricians and neurologists.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Jiun-Lin Yan, Mao-Yu Chen, Yao-Liang Chen, Chi-Cheng Chuang, Peng-Wei Hsu, Kuo-Chen Wei, Chen-Nen Chang
Summary: This study evaluated the outcomes of the endoscopic transsphenoidal approach as the primary treatment for somatotroph adenomas and investigated patients with suboptimal surgical results. Factors such as tumor size, preoperative GH level, and residual tumors were found to be associated with surgical failure. Octreotide showed good outcomes for treating DGSA patients, while SRS/EXRT generated good results for patients receiving secondary treatments when remission could not be reached after 6 months of TSA operation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Clinical Neurology
Zihao Zhou, Sheng Zhang, Fangqi Hu
Summary: Craniopharyngioma is an intracranial congenital epithelial tumor with main symptoms including high intracranial pressure, visual field defect, endocrine dysfunction, and hypothalamic dysfunction. Surgical treatment is the preferred method, but postoperative endocrine disorders affect the quality of life, with research focusing on improving endocrine dysfunction.
FRONTIERS IN NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
Deepali Gupta, Anna M. Patterson, Sherri Osborne-Lawrence, Angie L. Bookout, Salil Varshney, Kripa Shankar, Omprakash Singh, Nathan P. Metzger, Corine P. Richard, Steven C. Wyler, Joel K. Elmquist, Jeffrey M. Zigman
Summary: The study investigated the role of acyl-ghrelin on GH secretion and metabolic actions by selectively deleting GHSR from somatotrophs. Results suggest that the direct engagement of GHSR-expressing somatotrophs is essential for acyl-ghrelin to stimulate GH secretion and influence its metabolic actions.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Joanna Smyczynska, Natalia Pawelak, Maciej Hilczer, Andrzej Lewinski
Summary: Growth hormone deficiency is a common component of combined pituitary hormone deficiency, often with unknown genetic causes, leading to severe symptoms depending on the deficient hormone type. MRI findings show abnormalities in anterior pituitary development, and delayed diagnosis and treatment can be life-threatening.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Amit Akirov, Hiba Masri-Iraqi, Idit Dotan, Ilan Shimon
Summary: The diagnosis, management, and treatment of acromegaly heavily rely on the levels of serum IGF-1, basal GH, and nadir GH following OGTT. However, these hormone concentrations can be influenced by various factors, leading to discordant levels that may require additional monitoring and data. New standards for GH and IGF-1 provide more accurate tools, but limitations should be considered along with clinical history and imaging studies when evaluating patients with acromegaly.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Junpei Sanada, Fuminori Tatsumi, Shinji Kamei, Yoshiro Fushimi, Masashi Shimoda, Kenji Kohara, Shuhei Nakanishi, Kohei Kaku, Tomoatsu Mune, Hideaki Kaneto
Summary: Pituitary adenoma producing both growth hormone (GH) and thyroid-stimulating hormone (TSH) is rare but possible. This case study presented a 27-year-old woman with symptoms of acromegaly and simultaneous production of both GH and TSH by the pituitary adenoma. Treatment included pituitary tumor resection, cyber knife therapy, somatostatin analog, GH receptor antagonist, and anti-thyroid drug thiamazole.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Joan Gil, Mireia Jorda, Berta Soldevila, Manel Puig-Domingo
Summary: Epithelial-mesenchymal transition is a dynamic process that plays essential roles in both physiological and pathological processes, particularly in the growth and invasion of pituitary tumors. Studies have shown the association of EMT with resistance to somatostatin receptor ligands in the treatment of acromegaly.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Chenxing Ji, Wen Xu, Hong Ding, Zhengyuan Chen, Chengzhang Shi, Jie Han, Liang Yu, Nidan Qiao, Yichao Zhang, Xiaoyun Cao, Xiang Zhou, Haixia Cheng, Huijin Feng, Cheng Luo, Zhiyu Li, Bing Zhou, Zhao Ye, Yao Zhao
Summary: Our study found that the expression of p300 is elevated in GHPA tissues compared to normal pituitary tissues. Knockdown of p300 inhibits cell proliferation and clone formation. Treatment with A-485 can suppress cell growth and inhibit GH secretion both in vitro and in vivo. Mechanistic studies showed that A-485 can downregulate the expression or activity of several oncogenes involved in the Pttg1, c-Myc, cAMP, and PI3K/AKT/mTOR signaling pathways, which play crucial roles in PA tumorigenesis and progression.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Clinical Neurology
Charles Ashton, Suhn K. Rhie, John D. Carmichael, Gabriel Zada
Summary: Profiling of human pituitary adenoma DNA methylome identified KCNAB2 as differentially methylated between NFPAs and GH-secreting PAs. Modulation of Kcnab2 expression in GH3 cells affected GH secretion, and quinidine administration reduced GH secretion in a dose-dependent manner. These findings suggest potential new therapeutic targets for acromegaly.
JOURNAL OF NEUROSURGERY
(2021)
Article
Endocrinology & Metabolism
Caitlin E. Stallings, Jyoti Kapali, Brian W. Evans, Stacey R. McGee, Buffy S. Ellsworth
Summary: Understanding the molecular mechanisms underlying pituitary organogenesis and function is crucial for improving therapeutics and diagnosing hypopituitarism. This study reveals FOXO transcription factors as important regulators of pituitary gland function, affecting somatotrope function and the expression of somatotrope differentiation factors.
Article
Endocrinology & Metabolism
Xiaomeng Li, Charles Brighton Ndandala, Qi Zhou, Chunyan Huang, Guangli Li, Huapu Chen
Summary: This study investigated the role of estrogen receptors (ERs) in vitellogenesis (Vtgs) regulation in pompano fish. The findings suggest that E2 may regulate the expression of different subtypes of vtg through ERs, displaying a compensatory expression effect on the regulation of ers and vtgs. This provides a theoretical basis for further research on reproductive endocrinology in pompano fish.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Norio Kansaku, Takeshi Ohkubo
Summary: Endocrine changes during bird reproduction, particularly the relationship between prolactin and incubation behavior, were investigated. The study monitored the physiological status and incubation behavior of Silkie hens over 1-2 years. The results showed that most mature hens exhibited incubation behavior multiple times, and there was a noticeable increase in nest occupancy 7-10 days before incubation onset. Protein analysis revealed that secreted prolactin during the reproductive cycle contains various isoforms, suggesting post-translational modifications like glycosylation and phosphorylation.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Minghui Li, Lina Sun, Linyan Zhou, Deshou Wang
Summary: This article summarizes the importance of the Nile tilapia as an excellent animal model for studying reproductive endocrinology in fish, with a focus on the crucial role of estrogen in female development.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Breanna N. Harris, Carolyn M. Bauer, James A. Carr, Caitlin R. Gabor, Jennifer L. Grindstaff, Caleigh Guoynes, Jennifer J. Heppner, Cris C. Ledon-Rettig, Patricia C. Lopes, Sharon E. Lynn, Carla B. Madelaire, Lorin A. Neuman-Lee, Maria G. Palacios, Paul Soto, Jennifer Terry
Summary: The COVID-19 pandemic had a significant impact on academics, particularly on those with minoritized identities or who were early career, caregivers, or had intersecting identities. The pandemic altered the impact factors of academia, including scholarly products, and affected the way individuals could respond. It is predicted that the pandemic will have long-term impacts on the population dynamics, composition, and landscape of the academic ecosystem. The number of journal submissions decreased, especially among women authors, and the pandemic heavily impacted women authors from Asia and the Middle East.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)