Article
Chemistry, Multidisciplinary
Sukhendu Dey, Puspita Ballav, Palas Samanta, Arghya Mandal, Atanu Patra, Subhas Das, Arnab Kumar Mondal, Apurba Ratan Ghosh
Summary: The study found that Anabas testudineus exposed to naphthalene suffered significant impacts on blood pathophysiology, with decreases in red blood cells, Hb, and platelet levels, as well as enhanced levels in other blood parameters. Additionally, exposure to naphthalene led to changes in serum biochemical parameters, indicating more harmful effects under long-term exposure.
Article
Cell Biology
Jing Wang, Zhiyong Zhuo, Xiao Ma, Yunjie Liu, Jing Xu, Changjiu He, Yao Fu, Feng Wang, Pengyun Ji, Lu Zhang, Guoshi Liu
Summary: The study found that melatonin protects against nuclear inhibition caused by hypoxanthine and restores oocyte meiosis via MT1 by reducing the intracellular concentration of cAMP.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Reproductive Biology
Min Zhang, Jingcheng Zhang, Debao Wang, Zhengqing Liu, Kangning Xing, Yongsheng Wang, Mei Jiao, Yong Wang, Binqiang Shi, Hexu Zhang, Yong Zhang
Summary: In vitro maturation is an important technique in assisted reproductive technology, but its efficiency is currently low due to suboptimal in vitro culture process and low oocyte quality. This study identified a potential maternal regulator, C-X-C motif chemokine ligand 12, which improved oocyte developmental potential by enhancing protein synthesis and reorganizing cellular structures. Activation of SH2 domain-containing tyrosine phosphatase 2 and the mitogen-activated protein kinase signaling pathway mediated these effects. These findings provide an in vitro maturation system that mimics the maternal environment and produces high-quality oocytes.
BIOLOGY OF REPRODUCTION
(2023)
Article
Medicine, Research & Experimental
Weijie Wang, Jing Guo, Juanzi Shi, Qun Li, Biaobang Chen, Zhiqi Pan, Ronggui Qu, Jing Fu, Rong Shi, Xia Xue, Jian Mu, Zhihua Zhang, Tianyu Wu, Wenjing Wang, Lin Zhao, Qiaoli Li, Lin He, Xiaoxi Sun, Qing Sang, Ge Lin, Lei Wang
Summary: PABPC1L gene variants are responsible for female infertility characterized by oocyte maturation arrest. These variants result in truncated proteins, reduced abundance, altered localization, and decreased mRNA translational activation. PABPC1L plays an important role in human oocyte maturation and could be a potential candidate gene for infertility causes.
EMBO MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Anumegha Gupta, Surendra Kumar Trigun
Summary: This study describes the effects of Cilostamide on oocytes at different meiotic stages, showing that Cilostamide treatment promotes meiotic arrest by increasing cAMP and cGMP levels and modulating related regulatory factors.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Agriculture, Dairy & Animal Science
Daniela-Alejandra Medina-Chavez, Irene Sanchez-Ajofrin, Patricia Peris-Frau, Carolina Maside, Vidal Montoro, Rocio Fernandez-Santos, Jose Julian Garde, Ana Josefa Soler
Summary: In vitro maturation of oocytes has the potential to generate a large number of embryos for research and assisted reproduction technologies, but the developmental ability of these oocytes is lower than those matured in vivo. This study found that pre-treating oocytes with cAMP modulating agents improved DNA damage repair mechanism and increased developmental competence. The use of forskolin and IBMX before in vitro maturation could be a promising approach to enhance the quality of in vitro matured oocytes.
Article
Biochemistry & Molecular Biology
Radek Prochazka, Alexandra Bartkova, Lucie Nemcova, Matej Murin, Ahmed Gad, Katerina Marcollova, Veronika Kinterova, Andrea Lucas-Hahn, Jozef Laurincik
Summary: Culturing porcine oocytes in a medium containing FGF2, LIF and IGF1 (FLI) significantly enhances their developmental potential. Analyzing the time course of MAPK3/1 and AKT activation, as well as gene expression controlled by these kinases, suggests that both MAPK3/1 and AKT play crucial roles in improving oocyte quality in FLI medium.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Patrycja Straczynska, Krzysztof Papis, Emilia Morawiec, Michal Czerwinski, Zdzislaw Gajewski, Anita Olejek, Anna Bednarska-Czerwinska
Summary: In vitro fertilization (IVF) is an effective method for treating infertility. In vitro maturation (IVM) of oocytes can be an alternative to ovarian hyperstimulation. The development of the embryo depends on the maturity of the oocyte. The microenvironment of the ovarian follicle and maternal signals play a role in the growth and maturation of the oocyte.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Reproductive Biology
M. A. S. Novaes, L. F. Lima, N. A. R. Sa, A. C. A. Ferreira, V. M. Paes, J. F. Souza, B. G. Alves, N. V. Gramosa, C. A. A. Torres, B. Pukazhenthi, E. L. Gastal, J. R. Figueiredo
Summary: The study evaluated the effects of ultra-diluted arnica montana and ethanol on bovine oocyte maturation and in vitro embryo production, showing that the impact of arnica montana on IVEP varies with culture conditions, while ethanol consistently improves IVEP regardless of heat stress exposure.
Article
Cell Biology
Natalie Gindi, Hadas Grossman, Hadas Bar-Joseph, Irit Miller, Luba Nemerovsky, Ron Hadas, Nava Nevo, Dalia Galiani, Nava Dekel, Ruth Shalgi
Summary: The study revealed that Fyn/SFKs play a role in maintaining the stability of pre-transcribed mRNAs in oocytes at the GV stage, while Fyn, SFKs, and AGO2 are involved in promoting the degradation of maternal mRNAs during in-vivo oocyte maturation.
Article
Cell Biology
Gilad Karavani, Peera Wasserzug-Pash, Talya Mordechai-Daniel, Dvora Bauman, Michael Klutstein, Tal Imbar
Summary: The study evaluated in vitro maturation (IVM) outcomes in 133 chemotherapy naive patients aged 1-35 years. The results showed a gradual increase in IVM rates from 1 to 24 years, with a peak in the 18-24 years group and a decrease in the 25-35 years group. Significantly lower success rates were observed in patients under 6 years old and over 30 years old compared to the 18-24 years group.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Minghua Cao, Karol Nawalaniec, Amrendra K. Ajay, Yueming Luo, Romana Moench, Yanfei Jin, Sheng Xiao, Li-Li Hsiao, Ana Maria Waaga-Gasser
Summary: This study explores the role of PDE4 in ccRCC and its potential as a therapeutic target. The results demonstrate that PDE4 inhibition reduces cell proliferation and increases intracellular cAMP expression. PDE4D depletion and/or inhibition attenuates the MAPK/ERK signaling pathway and enhances the effectiveness of the TKI sorafenib in inhibiting cell survival.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Debapriya Bhattacharya, Shrabanti Sarkar, Panchanan Nath
Summary: This study demonstrates that CFVg1 induces oocyte maturation in Clarias batrachus by regulating the levels of intracellular cAMP and the PI3K/Akt pathway.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Neurosciences
Sunny Zhihong Jiang, Sean Sweat, Sam P. Dahlke, Kathleen Loane, Gunner Drossel, Wenqin Xu, Hugo A. Tejeda, Charles R. Gerfen, Lee E. Eiden
Summary: The study reveals the crucial role of NCS-Rapgef2 signaling to ERK in dopamine D1 receptor-expressing neurons of the NAc in cocaine-induced locomotor sensitization and conditioned place preference, while showing no impact in corticolimbic areas. Ablation of cocaine-dependent ERK activation by eliminating NCS-Rapgef2 suggests a new cAMP-dependent signaling pathway for cocaine-induced behavioral adaptations independent of PKA/CREB signaling.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Berta Serra-Navarro, Rebeca Fernandez-Ruiz, Ainhoa Garcia-Alaman, Marta Pradas-Juni, Eduardo Fernandez-Rebollo, Yaiza Esteban, Joan Mir-Coll, Julia Mathieu, Stephane Dalle, Max Hahn, Ulf Ahlgren, Lee S. Weinstein, Josep Vidal, Ramon Gomis, Rosa Gasa
Summary: This study reveals the essential role of Gs protein in early postnatal beta-cell growth and maturation, partly mediated through its crosstalk with insulin signaling pathways. The findings suggest a close connection between these two pathways in postnatal beta cells, potentially implicating the use of cAMP-raising agents for promoting beta-cell regeneration and maturation in diabetes.
MOLECULAR METABOLISM
(2021)
Article
Cell Biology
Debabrata Das, Poulomi Nath, Soumojit Pal, Sudip Hajra, Pritha Ghosh, Sudipta Maitra
Article
Endocrinology & Metabolism
Poulomi Nath, Sudipta Maitra
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2019)
Article
Environmental Sciences
Soumojit Pal, Poulomi Nath, Subhasri Biswas, Urmi Mukherjee, Sudipta Maitra
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2019)
Article
Cell Biology
Poulomi Nath, Urmi Mukherjee, Subhasri Biswas, Soumojit Pal, Sriparna Das, Soumyajyoti Ghosh, Anwesha Samanta, Sudipta Maitra
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2019)
Article
Environmental Sciences
Urmi Mukherjee, Anwesha Samanta, Subhasri Biswas, Sriparna Das, Soumyajyoti Ghosh, Dipak Kumar Mandal, Sudipta Maitra
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)
Article
Environmental Sciences
Subhasri Biswas, Soumyajyoti Ghosh, Anwesha Samanta, Sriparna Das, Urmi Mukherjee, Sudipta Maitra
ENVIRONMENTAL POLLUTION
(2020)
Article
Biochemistry & Molecular Biology
Subhasri Biswas, Sudipta Maitra
Summary: This passage discusses the importance of steroids and insulin-like growth factors in folliculogenesis and reproductive fitness in vertebrate ovaries, as well as the significant impact of intrafollicular redox balance on ovarian follicle function.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Urmi Mukherjee, Anwesha Samanta, Subhasri Biswas, Soumyajyoti Ghosh, Sambuddha Banerjee, Sudipta Maitra
Summary: The study investigates the impact of Nonylphenol (NP) on liver health and finds that NP exposure can lead to chronic liver injury through oxidative stress, metabolic disruption, and immune modulation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Physical
Shampa Kundu, Subhasri Biswas, Soumyajyoti Ghosh, Indrajit Karmakar, Goutam Brahmachari, Sudipta Maitra, Prithidipa Sahoo
Summary: In this study, we have developed an easily accessible probe named DPC, which shows excellent selectivity towards ATP. Through fluorescence imaging, we have successfully detected high concentrations of ATP in intracellular compartments. Furthermore, we have achieved ATP fluorescence imaging at distinct sites in live zebrafish embryos and estimated the endogenous ATP level.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Chemistry, Applied
Swarup Kumar Tarai, Angana Pan, Sriparna Das, Rituparna Bhaduri, Saikat Mandal, Sudipta Maitra, Sankar Chandra Moi
Summary: The bioactivity and cytotoxicity of four platinum complexes were investigated to discover more active and less toxic anticancer lead molecules. The interaction of the complexes with DNA and BSA was evaluated using various methods, and their pharmacokinetic and pharmacodynamic importance was determined. Molecular docking was performed to assess the interaction mode and binding strength of the complexes with DNA and BSA. In vitro cell experiments revealed their anticancer activity and cytotoxicity.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Cell Biology
Subhasri Biswas, Soumyajyoti Ghosh, Sudipta Maitra
Summary: Optimal mitochondrial functioning is crucial for oocyte competence and maturation, while dysfunction can impair fertility. The role of IGF system in ovarian follicles has been studied, but its effect on oocyte energy metabolism is not well understood. This study using zebrafish investigated the importance of IGF1 in modulating oocyte mitochondrial bioenergetics. Increased expression of lhcgr and igf1 in fullgrown oocytes was accompanied by elevated ATP levels and mitochondrial polarization. In vitro, hCG stimulation increased igf1 expression and ATP levels, indicating a positive influence of gonadotropin on oocyte bioenergetics. Recombinant IGF1 administration enhanced mitochondrial function, while IGF1R immunodepletion or PI3K inhibition abrogated NRF-1 immunoreactivity, respiratory chain subunit expression, Delta Psi(M), and ATP content.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Environmental Sciences
Urmi Mukherjee, Sriparna Das, Soumyajyoti Ghosh, Sudipta Maitra
Summary: This study examines the impact of BPA on reproductive toxicity in female Labeo bata. The results show that BPA exposure leads to follicular atresia and impaired ovarian function, associated with oxidative stress and activation of apoptotic markers.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Chemistry, Organic
Shrabani Saha, Sujoy Das, Sriparna Das, Anwesha Samanta, Sudipta Maitra, Prithidipa Sahoo
ORGANIC & BIOMOLECULAR CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Sujay Mahata, Subhajit Mukherjee, Swarup Kumar Tarai, Angana Pan, Ishani Mitra, Soumojit Pal, Sudipta Maitra, Sankar Ch. Moi
NEW JOURNAL OF CHEMISTRY
(2019)
Article
Chemistry, Organic
Sujoy Das, Urmi Mukherjee, Soumojit Pal, Sudipta Maitra, Prithidipa Sahoo
ORGANIC & BIOMOLECULAR CHEMISTRY
(2019)
Article
Endocrinology & Metabolism
Xiaomeng Li, Charles Brighton Ndandala, Qi Zhou, Chunyan Huang, Guangli Li, Huapu Chen
Summary: This study investigated the role of estrogen receptors (ERs) in vitellogenesis (Vtgs) regulation in pompano fish. The findings suggest that E2 may regulate the expression of different subtypes of vtg through ERs, displaying a compensatory expression effect on the regulation of ers and vtgs. This provides a theoretical basis for further research on reproductive endocrinology in pompano fish.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Norio Kansaku, Takeshi Ohkubo
Summary: Endocrine changes during bird reproduction, particularly the relationship between prolactin and incubation behavior, were investigated. The study monitored the physiological status and incubation behavior of Silkie hens over 1-2 years. The results showed that most mature hens exhibited incubation behavior multiple times, and there was a noticeable increase in nest occupancy 7-10 days before incubation onset. Protein analysis revealed that secreted prolactin during the reproductive cycle contains various isoforms, suggesting post-translational modifications like glycosylation and phosphorylation.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Minghui Li, Lina Sun, Linyan Zhou, Deshou Wang
Summary: This article summarizes the importance of the Nile tilapia as an excellent animal model for studying reproductive endocrinology in fish, with a focus on the crucial role of estrogen in female development.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Breanna N. Harris, Carolyn M. Bauer, James A. Carr, Caitlin R. Gabor, Jennifer L. Grindstaff, Caleigh Guoynes, Jennifer J. Heppner, Cris C. Ledon-Rettig, Patricia C. Lopes, Sharon E. Lynn, Carla B. Madelaire, Lorin A. Neuman-Lee, Maria G. Palacios, Paul Soto, Jennifer Terry
Summary: The COVID-19 pandemic had a significant impact on academics, particularly on those with minoritized identities or who were early career, caregivers, or had intersecting identities. The pandemic altered the impact factors of academia, including scholarly products, and affected the way individuals could respond. It is predicted that the pandemic will have long-term impacts on the population dynamics, composition, and landscape of the academic ecosystem. The number of journal submissions decreased, especially among women authors, and the pandemic heavily impacted women authors from Asia and the Middle East.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)