Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs

Preclinical Differences of Intravascular AAV9 Delivery to Neurons and Glia: A Comparative Study of Adult Mice and Nonhuman Primates

(2011) Steven J Gray et al.   MOLECULAR THERAPY

Stem cell technology for the study and treatment of motor neuron diseases

(2011) J Simon Lunn et al.   Regenerative Medicine

Antisense Oligonucleotides Delivered to the Mouse CNS Ameliorate Symptoms of Severe Spinal Muscular Atrophy

(2011) M. A. Passini et al.   Science Translational Medicine

Viral vector-mediated gene transfer for CNS disease

(2010) Brooke R Snyder et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Intravenous scAAV9 delivery of a codon-optimized SMN1 sequence rescues SMA mice

(2010) Elisa Dominguez et al.   HUMAN MOLECULAR GENETICS

CNS-targeted gene therapy improves survival and motor function in a mouse model of spinal muscular atrophy

(2010) Marco A. Passini et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential Adeno-Associated Virus Mediated Gene Transfer to Sensory Neurons following Intrathecal Delivery by Direct Lumbar Puncture

(2010) Lucy Vulchanova et al.   Molecular Pain

MicroRNA-regulated, Systemically Delivered rAAV9: A Step Closer to CNS-restricted Transgene Expression

(2010) Jun Xie et al.   MOLECULAR THERAPY

Systemic Delivery of scAAV9 Expressing SMN Prolongs Survival in a Model of Spinal Muscular Atrophy

(2010) C. F. Valori et al.   Science Translational Medicine

Cervical Multilevel Intraspinal Stem Cell Therapy

(2010) Bethwel Raore et al.   SPINE

Preclinical Safety Validation of a Stabilized Viral Vector Direct Injection Approach to the Cervical Spinal Cord

(2009) Thais Federici et al.   CTS-Clinical and Translational Science

Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6

(2009) C Towne et al.   GENE THERAPY

Global diffuse distribution in the brain and efficient gene delivery to the dorsal root ganglia by intrathecal injection of adeno-associated viral vector serotype 1

(2009) Naotaka Iwamoto et al.   JOURNAL OF GENE MEDICINE

Monitoring of acute axonal injury in the swine spinal cord with EAE by diffusion tensor imaging

(2009) Song Feng et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Recombinant Adeno-Associated Virus Serotype 6 (rAAV2/6)-Mediated Gene Transfer to Nociceptive Neurons through Different Routes of Delivery

(2009) Chris Towne et al.   Molecular Pain

AAV9: a potential blood-brain barrier buster

(2009) Fredric P Manfredsson et al.   MOLECULAR THERAPY

Intravenous Administration of Self-complementary AAV9 Enables Transgene Delivery to Adult Motor Neurons

(2009) Sandra Duque et al.   MOLECULAR THERAPY

Directed Evolution of a Novel Adeno-associated Virus (AAV) Vector That Crosses the Seizure-compromised Blood–Brain Barrier (BBB)

(2009) Steven J Gray et al.   MOLECULAR THERAPY

CERVICAL SPINAL CORD THERAPEUTICS DELIVERY

(2009) Jonathan Riley et al.   NEUROSURGERY

Robotic Approaches to the Posterior Spine

(2009) Karthikeyan Ponnusamy et al.   SPINE

Efficient Retrograde Neuronal Transduction Utilizing Self-complementary AAV1

(2008) Edmund R Hollis II et al.   MOLECULAR THERAPY

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

(2008) Kevin D Foust et al.   NATURE BIOTECHNOLOGY

Intraspinal cord delivery of IGF-I mediated by adeno-associated virus 2 is neuroprotective in a rat model of familial ALS

(2008) Colin K. Franz et al.   NEUROBIOLOGY OF DISEASE

Results from a phase I safety trial of hAADC gene therapy for Parkinson disease

(2008) J. L. Eberling et al.   NEUROLOGY

Sensory neuron targeting by self-complementary AAV8 via lumbar puncture for chronic pain

(2008) B. Storek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neonatal Intraperitoneal or Intravenous Injections of Recombinant Adeno-Associated Virus Type 8 Transduce Dorsal Root Ganglia and Lower Motor Neurons

(2007) Kevin D. Foust et al.   HUMAN GENE THERAPY