Review
Agronomy
Qinyue Lu, Weicheng Zong, Mingyixing Zhang, Zhi Chen, Zhangping Yang
Summary: Beta-oxidation is an important metabolic process that breaks down fatty acids for energy production. Peroxisomal beta-oxidation plays a crucial role in the oxidative metabolism of very long-chain fatty acids and its importance in disease treatment should not be overlooked.
Article
Cell Biology
Carlo W. T. van Roermund, Lodewijk IJlst, Nicole Linka, Ronald J. A. Wanders, Hans R. Waterham
Summary: Peroxisomes are essential organelles involved in various metabolic processes, including fatty acid beta-oxidation. Different proteins, including Ant1p, Pxa1p/Pxa2p, and Aac2p, are found to be involved in the peroxisomal uptake of ATP in yeast.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Environmental Sciences
Marta Cunha, Patricia Louro, Monica Silva, Amadeu M. V. M. Soares, Eduarda Pereira, Rosa Freitas
Summary: This study evaluated the toxicity of two rare earth elements (La and Gd) on the mussel species Mytilus galloprovincialis. The results showed that short-term exposure to these elements can have deleterious effects on the mussels, but the organisms were able to recover their biochemical status after a recovery period.
ENVIRONMENTAL POLLUTION
(2022)
Article
Cell Biology
Amr Kataya, Nitija Gautam, Muhammad Jamshed, Douglas G. Muench, Marcus A. Samuel, Jay J. Thelen, Greg B. Moorhead
Summary: This study identified protein kinases in peroxisomes and investigated their functions and regulation. The findings provide new insights into the regulation of peroxisome functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Plant Sciences
Ting Zhang, Ya-Nan Li, Xue Li, Wangliu Gu, Emily Kolojane Moeketsi, Ruiwen Zhou, Xiaobo Zheng, Zhengguang Zhang, Haifeng Zhang
Summary: The study identified MoPCS60 as a key peroxisomal-CoA synthetase involved in fatty acid beta-oxidation and pathogenicity in rice blast fungi. MoPCS60 was highly expressed during the conidial and early infectious stages and was induced under oleate treatment.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Mounia Tahri-Joutey, Pierre Andreoletti, Sailesh Surapureddi, Boubker Nasser, Mustapha Cherkaoui-Malki, Norbert Latruffe
Summary: This article discusses the shared ability of mitochondria and peroxisomes in degrading fatty acid chains, the hepatomegaly effect caused by clofibrate, the identification of peroxisome proliferators and their impact on the peroxisomal fatty acid beta-oxidation pathway, and the modulation of PPAR alpha function by dietary micronutrients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Ruipan Zheng, Yurong Wang
Summary: Growing evidence suggests a strong association between decreased lipid catabolism and the development of cancer. In this study, we found that SLC9A5 exhibited significantly higher expression in CRC tumor tissues compared to adjacent paratumor tissues. Knockdown of SLC9A5 resulted in suppressed cell proliferation, migration, and invasion, and further bioinformatics analysis revealed its involvement in the peroxisomal fatty acid oxidation pathway (FAO). The findings suggest that SLC9A5 could serve as a promising therapeutic target for inhibiting the progression of colorectal cancer.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Cell Biology
Yannick Das, Danielle Swinkels, Sai Kocherlakota, Stefan Vinckier, Frederic M. Vaz, Eric Wever, Antoine H. C. van Kampen, Bokkyoo Jun, Khanh V. Do, Lieve Moons, Nicolas G. Bazan, Paul P. Van Veldhoven, Myriam Baes
Summary: Mice with inactivation of MFP2 exhibit decreased retinal function and shortened photoreceptor segments at 3 weeks of age, along with changes in gene expression and reduced DHA content. This highlights the essential role of intact peroxisomal beta-oxidation in maintaining retinal integrity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Food Science & Technology
Ane del Rio-Lavin, Jan Weber, Joachim Molkentin, Elisa Jimenez, Iraide Artetxe-Arrate, Miguel Angel Pardo
Summary: Determining the geographic origin of farmed mussels is important for regulators and fishing industries to prevent fraud and ensure food safety. This study used stable isotope ratio analysis and trace element fingerprinting to trace the origin of mussels harvested from different regions. The results showed significant differences in the chemical signatures of mussels from different locations, and a classification method correctly assigned 97% of individuals to their harvest location. This method has potential applications in seafood traceability and food safety.
Article
Biochemistry & Molecular Biology
Katerina Cizkova, Tereza Foltynkova, Jiri Hanyk, Zbynek Kamencak, Zdenek Tauber
Summary: The study found that PPAR alpha plays an important role in the differentiation of intestinal cells, but the differentiation of intestinal epithelium may be independent of PPAR alpha.
Article
Biotechnology & Applied Microbiology
R. J. M. Lubbers, A. Dilokpimol, J. Visser, R. P. de Vries
Summary: Aromatic compounds derived from renewable sources such as plant biomass are of interest for various industries. The fungus Aspergillus niger can release valuable compounds like ferulic acid and p-coumaric acid from plant biomass. Genes involved in the degradation of hydroxycinnamic acids have been identified through whole-genome transcriptomic analysis in A. niger, providing insights into metabolic pathways and potential applications in the degradation of aromatic compounds.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jie Yang, Xiao Yang, Yi-fei Zhang, Jia-ning Tian, Shi-cheng Fan, Yue Gao, Hui-lin Li, Cheng-hui Cai, Min Huang, Hui-chang Bi
Summary: In this study, it was found that activation of PPARa leads to hepatomegaly in mice, with hepatocyte hypertrophy around the central vein area and hepatocyte proliferation around the portal vein area. The study also revealed that the upregulation of PPARa targets is higher in the central vein area compared to the portal vein area, while the upregulation of proliferation-related proteins mainly occurs in the portal vein area. These findings provide new insights into the understanding of PPARa activation-induced liver enlargement and regeneration.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Environmental Sciences
Sergey V. Kapranov, Nadezhda V. Karavantseva, Nikolay I. Bobko, Vitaliy I. Ryabushko, Larisa L. Kapranova
Summary: The study reveals the impact of sex and sexual maturation on element accumulation in mussels, including accumulation patterns during reproductive stages and a new phenomenon of element circulation in gonads. Differences in element accumulation are mainly attributed to element uptake pathways and sexual differentiation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Yiyi Ma, Minglu Wang, Shuaishuai Guo, Tong Li, Xiaodong Liu, Limei Zhao
Summary: Valproic acid (VPA) is widely used in the treatment of epilepsy, but its potential hepatotoxicity is a major concern. This study aimed to investigate the biomarkers and mechanisms of VPA-induced liver injury in epileptic children. Metabolomic analysis revealed that VPA disrupts fatty acid beta-oxidation (beta-FAO) and leads to the accumulation of serum long-chain acylcarnitines (LCACs). Additionally, the study found that fenofibrate (Feno) can improve beta-FAO and protect against VPA-induced hepatotoxicity by activating PPAR alpha.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Joanna Skinner, Payal Arora, Nicole McMath, Meera Penumetcha
Summary: This study found that oxidized lipids are present in commonly consumed foods and some of them contain ligands of PPAR gamma. The oxidative levels of some foods decreased after three months, with French fries showing the highest PPAR gamma binding affinity among the tested foods.
Article
Environmental Sciences
Nerea Duroudier, Alberto Katsumiti, Mathilde Mikolaczyk, Jorg Schafer, Eider Bilbao, Miren P. Cajaraville
Summary: This study investigated the cell and tissue level responses in mussels Mytilus galloprovincialis dietarily exposed to PVP/PEI coated 5 nm Ag NPs, showing significant accumulation and adverse effects in both autumn and spring. The results indicate that ingestion of Ag NPs through the food web can lead to toxic effects in aquatic organisms, with potential implications for ecosystem health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Ruth Prieto-Montero, Alejandro Prieto-Castaneda, Alberto Katsumiti, Miren P. Cajaraville, Antonia R. Agarrabeitia, Maria J. Ortiz, Virginia Martinez-Martinez
Summary: BODIPY-based commercial and novel photosensitizers were successfully linked onto mesoporous silica nanoparticles, further functionalized with PEG and folic acid, enhancing the biocompatibility of the photosensitizers. Different functional groups of MSNs allowed for various options of PS-PEG-FA decoration on the external surface.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Christian Galasso, Xabier Lekube, Ibon Cancio, Antonio Dell'Anno, Christophe Brunet, Clementina Sansone, Michael Tangherlini
Summary: This study isolated four marine fungal taxa with high tolerance to e-waste from contaminated sediments, showing their potential for bioleaching and bioaccumulation of metals present in electronic waste. Among these fungi, platinum was highly concentrated within their biomass, indicating their promising role in the recovery of precious metals.
WASTE AND BIOMASS VALORIZATION
(2022)
Article
Chemistry, Applied
Ruth Prieto-Montero, Alejandro Prieto-Castaneda, Alberto Katsumiti, Rebeca Sola-Llano, Antonia R. Agarrabeitia, Miren P. Cajaraville, Maria J. Ortiz, Virginia Martinez-Martinez
Summary: Three different molecular designs based on BODIPY dye have been proposed as photosensitizers for photodynamic therapy, showing a good balance between singlet oxygen generation and fluorescence for potential applications. In vitro experiments in HeLa cells were conducted to elucidate the best potential candidate for PDT.
Article
Multidisciplinary Sciences
Amber Hartman Scholz, Jens Freitag, Christopher H. C. Lyal, Rodrigo Sara, Martha Lucia Cepeda, Ibon Cancio, Scarlett Sett, Andrew Lee Hufton, Yemisrach Abebaw, Kailash Bansal, Halima Benbouza, Hamadi Iddi Boga, Sylvain Brisse, Michael W. Bruford, Hayley Clissold, Guy Cochrane, Jonathan A. Coddington, Anne-Caroline Deletoille, Felipe Garcia-Cardona, Michelle Hamer, Raquel Hurtado-Ortiz, Douglas W. Miano, David Nicholson, Guilherme Oliveira, Carlos Ospina Bravo, Fabian Rohden, Ole Seberg, Gernot Segelbacher, Yogesh Shouche, Alejandra Sierra, Ilene Karsch-Mizrachi, Jessica da Silva, Desiree M. Hautea, Manuela da Silva, Mutsuaki Suzuki, Kassahun Tesfaye, Christian Keambou Tiambo, Krystal A. Tolley, Rajeev Varshney, Maria Mercedes Zambrano, Joerg Overmann
Summary: Open access to sequence data is crucial for biology and biodiversity research, but it has caused tension under the United Nations Convention on Biological Diversity (CBD). Finding a practical solution to ensure international benefit-sharing without jeopardising open sharing is a major challenge for the CBD and other UN negotiations.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Alberto Katsumiti, Maria Paula Losada-Carrillo, Marta Barros, Miren P. Cajaraville
Summary: In this study, it was found that polystyrene nanoparticles and microplastics can act as carriers for transferring benzo(a)pyrene to mussel hemocytes, potentially posing risks to aquatic organisms. The presence of BaP reduced particle aggregation and both plastics and BaP showed cytotoxic effects on hemocytes.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Amber Hartman Scholz, Matthias Lange, Pia Habekost, Paul Oldham, Ibon Cancio, Guy Cochrane, Jens Freitag
Summary: Research shows that the relationship between provision and use of digital sequence information (DSI) is more complex than believed, calling for policymakers to pay attention to the high level of DSI usage in low- and middle-income countries and preserve open access to this critical common good.
Article
Environmental Sciences
Rebecca von Hellfeld, Maria Zarzuelo, Benat Zaldibar, Miren P. Cajaraville, Amaia Orbea
Summary: This study assessed the impact of polystyrene (PS) microplastics on filter feeders and found that the accumulation and depuration time of microplastics are size-dependent. Microplastics can act as carriers for metallic and organic pollutants.
Article
Chemistry, Multidisciplinary
Ignacio Martinez-Alvarez, Karyn Le Menach, Marie-Helene Devier, Miren P. Cajaraville, Helene Budzinski, Amaia Orbea
Summary: This study aimed to assess the bioavailability and toxicity of polystyrene nanoparticles (NPs) and microplastics (MPs) in aquatic organisms. The findings showed that NPs were capable of entering and spreading within brine shrimp and zebrafish embryos, while MPs were ingested only by brine shrimps. Both NPs and MPs acted as vectors for benzo(a)pyrene, a persistent organic pollutant, in brine shrimp and zebrafish embryos.
Article
Environmental Sciences
Nathalie Leroux, Mahboubeh Hosseinzadeh, Alberto Katsumiti, Cinta Porte, Miren P. Cajaraville
Summary: The production and usage of plastics have significantly increased in the past decades, leading to insufficient waste management and the accumulation of plastic particles in the environment. This study focuses on the impact of polystyrene nanoparticles on the lipid composition of mussel hemocytes, showing that exposure to these particles leads to membrane reorganization and oxidation of highly unsaturated lipids. The findings suggest potential effects on the immune function of hemocytes, although further investigation is needed.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Anthony Nzioka, Ainara Valencia, Aitor Atxaerandio-Landa, Oihane Diaz de Cerio, Mohammad Amzad Hossain, Maria Korta, Maren Ortiz-Zarragoitia, Ibon Cancio
Summary: This study investigated genes related to apoptosis and autophagy during follicular atresia in European hake. The results showed different implications of apoptotic and autophagic processes during oocyte development. The analyzed genes could serve as biomarkers for early detection of follicular atresia and evaluation of fecundity in fish stocks.
MARINE ENVIRONMENTAL RESEARCH
(2023)
Article
Engineering, Environmental
Nagore Gonzalez-Soto, Nagore Blasco, Mireia Irazola, Eider Bilbao, Lucia Guilhermino, Miren P. Cajaraville
Summary: Graphene oxide (GO) is gaining attention for its unique properties and increasing use in consumer products. There is a concern that GO will end up in oceans and potentially affect marine organisms. This study evaluated the hazards of GO and benzo(a)pyrene (BaP) in marine mussels after exposure, finding that GO acts as a carrier for BaP but may also offer some protection against BaP accumulation.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Joyanta Bir, Iratxe Rojo-Bartolome, Xabier Lekube, Oihane Diaz de Cerio, Maren Ortiz-Zarragoitia, Ibon Cancio
Summary: The highly transcribed 5S rRNA in fish oocytes can be used as a marker for oocytes in intersex testes of fish exposed to xenoestrogens. This study analyzed the tRNA expression levels in different teleost species' gonads and found that tRNAs and 5S rRNA were significantly higher in ovaries compared to testes. The tRNA/5.8S rRNA ratio can differentiate ovaries from testes and identify intersex testes.
MARINE ENVIRONMENTAL RESEARCH
(2023)
Editorial Material
Health Policy & Services
Rudolf Wittner, Petr Holub, Cecilia Mascia, Francesca Frexia, Heimo Mueller, Markus Plass, Clare Allocca, Fay Betsou, Tony Burdett, Ibon Cancio, Adriane Chapman, Martin Chapman, Melanie Courtot, Vasa Curcin, Johann Eder, Mark Elliot, Katrina Exter, Carole Goble, Martin Golebiewski, Bron Kisler, Andreas Kremer, Simone Leo, Sheng Lin-Gibson, Anna Marsano, Marco Mattavelli, Josh Moore, Hiroki Nakae, Isabelle Perseil, Ayat Salman, James Sluka, Stian Soiland-Reyes, Caterina Strambio-De-Castillia, Michael Sussman, Jason R. Swedlow, Kurt Zatloukal, Jörg Geiger
Summary: Open and practical exchange, dissemination, and reuse of specimens and data have become essential for life sciences research. The quality of the data and findings rely on the quality of samples, experimental methods, and data analysis, which necessitate comprehensive and precise documentation. Current information on sample and data provenance is often sparse or incomplete, and lacks a uniform framework for interoperability. Additionally, the collection and sharing of specimens require consideration of benefit sharing and regulatory compliance. This publication presents a standardization effort to provide trustworthy documentation of data lineage and specimens, and invites experts to contribute.
LEARNING HEALTH SYSTEMS
(2023)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.