Article
Environmental Sciences
Nathalie Leroux, Mahboubeh Hosseinzadeh, Alberto Katsumiti, Cinta Porte, Miren P. Cajaraville
Summary: The production and usage of plastics have significantly increased in the past decades, leading to insufficient waste management and the accumulation of plastic particles in the environment. This study focuses on the impact of polystyrene nanoparticles on the lipid composition of mussel hemocytes, showing that exposure to these particles leads to membrane reorganization and oxidation of highly unsaturated lipids. The findings suggest potential effects on the immune function of hemocytes, although further investigation is needed.
ENVIRONMENTAL RESEARCH
(2022)
Article
Engineering, Environmental
Ning Sun, Jinhu Wang, Huijian Shi, Xiangxiang Li, Shuqi Guo, Yaoyue Wang, Shaoyang Hu, Rutao Liu, Canzhu Gao
Summary: Through combined experimental and simulation studies, it was found that polystyrene nanoplastics (PS NPs) and benzo[a]pyrene (BaP) exhibit synergistic toxicity in inducing oxidative stress. The cellular reactive oxygen species (ROS) levels were higher under co-exposure of PS NPs and BaP compared to individual exposure. Furthermore, BaP and PS NPs inhibited the decomposition of H2O2 by affecting the structure of the enzyme CAT, exacerbating oxidative stress. This study provides a new perspective and approach for understanding the toxicity of combined pollutants.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Yang Liu, Guanghui Xu, Yong Yu
Summary: This study investigated the influence of microplastics and nanoplastics with different sizes and concentrations on the accumulation of organic pollutants in earthworms. The results showed that microplastics facilitated the accumulation of pollutants by damaging the integrity of earthworm intestine, while nanoplastics inhibited the bacteria responsible for pollutant degradation in earthworms.
Review
Environmental Sciences
Jianli Yin, Ye Ju, Honghao Qian, Jia Wang, Xiaohan Miao, Ying Zhu, Liting Zhou, Lin Ye
Summary: This paper summarizes the adverse effects and mechanisms of microplastics on the liver and provides a valuable reference for understanding the liver toxicity caused by microplastics, highlighting the studies that have been published to date.
Article
Environmental Sciences
J. M. Goncalves, M. Benedetti, G. d'Errico, F. Regoli, M. J. Bebianno
Summary: Concerns about plastic pollution and toxicity towards animals and people are increasing. Polystyrene (PS), a commonly used plastic polymer, ends up in the marine environment through illegal dumping, improper waste management, and lack of treatment. Nanoplastics (<1000 nm) have gained interest due to their small size that allows them to cross cellular boundaries and cause toxic effects. This study examined the cellular viability and acute toxicity of PS nano-plastics (PS-NPs) on Mytilus galloprovincialis haemocytes and Aliivibrio fischeri bacteria, as well as the neurotoxic effects and uptake of PS-NPs in mussel tissues. The results showed decreased cellular viability and significant neurotoxic effects, with PS-NPs being ingested primarily through the gills and then translocated throughout the mussel's body. The ingestion of PS-NPs compromised digestive gland function and reproductive success. The study provides a synthetic assessment of cellular hazard from PS-NPs based on weighted criteria and previous data on cellular biomarkers.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Siwar Abouda, Omayma Missawi, Tiziana Cappello, Iteb Boughattas, Giuseppe De Marco, Maria Maisano, Mohamed Banni
Summary: Marine ecosystems are currently facing severe threats from multiple stressors, including microplastics and polycyclic aromatic hydrocarbons. This study assessed the toxicity of environmental relevant concentrations of microplastics and benzo[a]pyrene, and found that they can accumulate in marine organisms and cause cytotoxicity, genotoxicity, and oxidative stress effects.
ENVIRONMENTAL POLLUTION
(2022)
Article
Marine & Freshwater Biology
Ying Wang, Mingxing Zhang, Guanghui Ding, Huahong Shi, Yi Cong, Zhaochuan Li, Juying Wang
Summary: The presence of microplastics (MPs) significantly reduced the accumulation of benzo[a]pyrene (B[a]P) in the soft tissues of Mytilus galloprovincialis. The adverse impacts of digestive tubule thinning and increased reactive oxygen species (ROS) levels were alleviated when the mussels were exposed to both MPs and B[a]P. The co-presence of MPs also down-regulated the mRNA expression of NF-Kappa B in gills compared to B[a]P alone.
AQUATIC TOXICOLOGY
(2023)
Article
Engineering, Environmental
Liu Cao, Ximin Zeng, Jun Lin
Summary: Micro- and nano-plastics are pollutants that have negative impacts on the environment and are difficult to analyze. This study successfully developed plastic-specific antibodies for the first time, laying the foundation for innovative antibody-based immunoassays for future risk assessment and management of micro- and nano-plastics.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Environmental Sciences
Rebecca von Hellfeld, Maria Zarzuelo, Benat Zaldibar, Miren P. Cajaraville, Amaia Orbea
Summary: This study assessed the impact of polystyrene (PS) microplastics on filter feeders and found that the accumulation and depuration time of microplastics are size-dependent. Microplastics can act as carriers for metallic and organic pollutants.
Article
Environmental Sciences
Wenwen Gong, Wei Zhang, Mengyun Jiang, Shasha Li, Gang Liang, Qingwei Bu, Li Xu, Hong Zhu, Anxiang Lu
Summary: The study found that different plant species had varying responses to exposure to nano-PS and micro-PS, with Italian lettuce being the most sensitive crop. Root growth of Italian lettuce and corn was significantly inhibited by polystyrene exposure, while radish and wheat were hardly affected. Antioxidant enzymatic activities, lipid peroxidation, and biomarker indexes confirmed that the toxic effects of nanoplastics on crops are likely due to oxidative stress.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Nutrition & Dietetics
Javad Bazeli, Zarrin Banikazemi, Michael R. R. Hamblin, Reza Sharafati Chaleshtori
Summary: Nanoplastics (NPs) and microplastics (MPs) made of polystyrene (PS) can be toxic to humans, especially when ingested. They can cause various adverse effects, but limited information is available on how probiotics may protect against PS toxicity. However, studies suggest that probiotics can overcome the toxicity of polystyrene nanoplastics and microplastics in humans, although more research is needed before clinical recommendations can be made.
FRONTIERS IN NUTRITION
(2023)
Review
Environmental Sciences
Ming Zhang, Liheng Xu
Summary: Micro- and nanoplastics are emerging pollutants that can be transported worldwide due to their unique properties and affinity towards organic contaminants. The interaction between these plastics and organic pollutants poses potential health risks and requires further field studies and comprehensive understanding.
CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2022)
Review
Environmental Sciences
Catarina Serrao, Luis Fernando Marques-Santos
Summary: Plastic pollution poses a threat to the marine environment, particularly microplastics and nanoplastics (MNPs), which can interact with various organisms. This study critically reviewed the ecotoxicological studies on plastic particles and brine shrimp, identifying methodological issues and effects caused by MNPs. The review highlights the importance and limitations of the research, and suggests future directions. Analysis of various parameters revealed gaps in standardization of physicochemical parameters, biology of the animals, and culture conditions. Results indicate that MNPs can harm microcrustaceans through particle ingestion and accumulation, leading to reduced survival/mobility of brine shrimp. The review suggests brine shrimp as suitable organisms for investigating the risks of MNP exposure, but emphasizes the need for protocol standardization.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Zhen Lu, Sihan Wu, Zeyu Xiao, Jun Song, Huifeng Wu, Xiao Peng
Summary: In this study, the miRNA responses of digestive glands in mussels treated with PS-NPs were analyzed. The results showed significant differential expression of miRNAs, indicating that PS-NPs disturb various biological processes. Additionally, histopathological analysis revealed severe disruptions in metabolic capability in digestive glands under PS-NPs stress.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Alessio Alesci, Davide Di Paola, Angelo Fumia, Sebastian Marino, Claudio D'Iglio, Sergio Famulari, Marco Albano, Nunziacarla Spano, Eugenia Rita Lauriano
Summary: This study investigates the effects of thiacloprid and B[a]P pollution on the internal defense system of mussels, specifically focusing on the hemocytes in the mantle and gills. The researchers found that exposure to these pollutants leads to increased oxidative stress and explored the potential synergistic effects between the two. The findings contribute to our understanding of the defense mechanisms in bivalves and provide valuable insights for the development of new technologies and strategies for water pollution management.
Article
Environmental Sciences
Nerea Duroudier, Alberto Katsumiti, Mathilde Mikolaczyk, Jorg Schafer, Eider Bilbao, Miren P. Cajaraville
Summary: This study investigated the cell and tissue level responses in mussels Mytilus galloprovincialis dietarily exposed to PVP/PEI coated 5 nm Ag NPs, showing significant accumulation and adverse effects in both autumn and spring. The results indicate that ingestion of Ag NPs through the food web can lead to toxic effects in aquatic organisms, with potential implications for ecosystem health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Pediatrics
Alba Fernandez-Pena, Alberto Katsumiti, Amaya De Basagoiti, Mikel Castano, Goizane Ros, Saioa Sautua, Monike De Miguel, Ainara Campino
Summary: This study reviewed the compatibility data of drug combinations commonly used in nine Spanish neonatal intensive care units and analyzed the agreement among three databases. While the three databases demonstrated strong concordance, important discrepancies were found for some drug combinations, indicating a need for further research to enhance the safety of intravenous administration.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Ruth Prieto-Montero, Alejandro Prieto-Castaneda, Alberto Katsumiti, Miren P. Cajaraville, Antonia R. Agarrabeitia, Maria J. Ortiz, Virginia Martinez-Martinez
Summary: BODIPY-based commercial and novel photosensitizers were successfully linked onto mesoporous silica nanoparticles, further functionalized with PEG and folic acid, enhancing the biocompatibility of the photosensitizers. Different functional groups of MSNs allowed for various options of PS-PEG-FA decoration on the external surface.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Ignacio Martinez-Alvarez, Karyn Le Menach, Marie-Helene Devier, Iranzu Barbarin, Radmila Tomovska, Miren P. Cajaraville, Helene Budzinski, Amaia Orbea
Summary: The study found that graphene oxide has the capacity to adsorb PAHs and induce sublethal effects in zebrafish, including embryonic malformations and alterations in some biochemical parameters.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Applied
Ruth Prieto-Montero, Alejandro Prieto-Castaneda, Alberto Katsumiti, Rebeca Sola-Llano, Antonia R. Agarrabeitia, Miren P. Cajaraville, Maria J. Ortiz, Virginia Martinez-Martinez
Summary: Three different molecular designs based on BODIPY dye have been proposed as photosensitizers for photodynamic therapy, showing a good balance between singlet oxygen generation and fluorescence for potential applications. In vitro experiments in HeLa cells were conducted to elucidate the best potential candidate for PDT.
Article
Environmental Sciences
Rebecca von Hellfeld, Maria Zarzuelo, Benat Zaldibar, Miren P. Cajaraville, Amaia Orbea
Summary: This study assessed the impact of polystyrene (PS) microplastics on filter feeders and found that the accumulation and depuration time of microplastics are size-dependent. Microplastics can act as carriers for metallic and organic pollutants.
Article
Chemistry, Multidisciplinary
Ignacio Martinez-Alvarez, Karyn Le Menach, Marie-Helene Devier, Miren P. Cajaraville, Helene Budzinski, Amaia Orbea
Summary: This study aimed to assess the bioavailability and toxicity of polystyrene nanoparticles (NPs) and microplastics (MPs) in aquatic organisms. The findings showed that NPs were capable of entering and spreading within brine shrimp and zebrafish embryos, while MPs were ingested only by brine shrimps. Both NPs and MPs acted as vectors for benzo(a)pyrene, a persistent organic pollutant, in brine shrimp and zebrafish embryos.
Article
Environmental Sciences
Nathalie Leroux, Mahboubeh Hosseinzadeh, Alberto Katsumiti, Cinta Porte, Miren P. Cajaraville
Summary: The production and usage of plastics have significantly increased in the past decades, leading to insufficient waste management and the accumulation of plastic particles in the environment. This study focuses on the impact of polystyrene nanoparticles on the lipid composition of mussel hemocytes, showing that exposure to these particles leads to membrane reorganization and oxidation of highly unsaturated lipids. The findings suggest potential effects on the immune function of hemocytes, although further investigation is needed.
ENVIRONMENTAL RESEARCH
(2022)
Meeting Abstract
Toxicology
N. Ruijter, H. Braakhuis, J. Cabellos, A. Katsumiti, F. R. Cassee
TOXICOLOGY LETTERS
(2022)
Meeting Abstract
Toxicology
H. Braakhuis, J. Cabellos, M. Auffan, R. Ayerbe, M. Boyles, A. Candalija, M. Carriere, J. Catalan, R. Cross, J. Hanlon, A. Katsumiti, E. Lahive, A. Masion, P. McLean, E. Morel, S. Rashid, I. Rodriguez-Llopis, N. Ruijter, F. Simeone, L. Soeteman-Hernandez, R. Vanhauten, S. Vazquez-Campos
TOXICOLOGY LETTERS
(2022)
Review
Chemistry, Multidisciplinary
Nienke Ruijter, Lya G. Soeteman-Hernandez, Marie Carriere, Matthew Boyles, Polly McLean, Julia Catalan, Alberto Katsumiti, Joan Cabellos, Camilla Delpivo, Araceli Sanchez Jimenez, Ana Candalija, Isabel Rodriguez-Llopis, Socorro Vazquez-Campos, Flemming R. Cassee, Hedwig Braakhuis
Summary: The Safe-by-Design (SbD) concept aims to enhance the development of safer materials/products by reducing hazards and exposures through timely interventions. This review evaluates commonly used in vitro assays for their suitability in SbD hazard testing of nanomaterials (NMs). It also discusses the effects of various factors on predictivity and the compatibility of assays with advanced materials and NMs released during the lifecycle.
Article
Environmental Sciences
Maria Paula Carrillo, Marina Sevilla, Marta Casado, Benjamin Pin, Victor Matamoros, Maria Vila-Costa, Carlos Barata
Summary: Wastewater Treatment Plant (WWTP) effluents are significant sources of antibiotics, antibiotic resistance genes (ARGs), and resistant bacteria, posing threats to aquatic biota and human health. This study explores the impact of the antibiotic doxycycline on the microbiome of Daphnia magna in lab water and treated wastewater media. The results indicate that doxycycline and the media significantly influence the composition of the Daphnia-associated microbiome, with notable changes in Enterococcus spp. Furthermore, doxycycline reduces the presence of Limnohabitans sp. and impairs Daphnia reproduction in lab water, while treated wastewater increases microbiome diversity, richness, and promotes fecundity. The study also detects various ARG genes, including qnrS1, sul1, and blaTEM, with a higher abundance in treated wastewater compared to lab water.
ENVIRONMENTAL POLLUTION
(2023)