Article
Pharmacology & Pharmacy
Bhupesh Vaidya, Kritika Dhamija, Priyanka Guru, Shyam Sunder Sharma
Summary: Parkinson's disease is less prevalent in women compared to men, but this difference tends to diminish with age. Various genetic, hormonal, and molecular factors contribute to the differences in the pathogenesis of Parkinson's disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Geriatrics & Gerontology
Firoz Akhter, Alicia Persaud, Younis Zaokari, Zhen Zhao, Donghui Zhu
Summary: Vascular dementia (VaD) is a type of dementia caused by reduced blood flow to the brain, accounting for 20% of all dementia cases. There are subtle differences in the presentation of VaD between males and females, but they are often overlooked.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jerome Lamontagne-Proulx, Katherine Coulombe, Marc Morissette, Marie Rieux, Frederic Calon, Therese Di Paolo, Denis Soulet
Summary: The mutation and overexpression of alpha-synuclein protein is associated with Parkinson's disease. The prevalence of PD is higher in men than in women, suggesting the involvement of female hormones in slowing PD progression. In mice, male individuals are more vulnerable to toxins and exhibit more severe toxicity from alpha-synuclein protein than females.
Article
Neurosciences
Tianyu Gao, Xiaochun Han, Dan Bang, Shihui Han
Summary: Believing, as a fundamental mental process, influences other cognitive/affective processes and behavior. This study found that individuals from different cultural backgrounds engage in distinct neurocognitive mechanisms during believing judgments, indicating the cultural dependence of the believing process.
Review
Biochemistry & Molecular Biology
Donghui Zhu, Axel Montagne, Zhen Zhao
Summary: AD is a neurodegenerative disease, with studies showing gender differences in risk and progression. The higher risk and progression of AD in women are largely attributed to distinct biological mechanisms, such as deviations in brain structure and biomarkers, psychosocial stress responses, genetic background, and more.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Karen Reue, Carrie B. Wiese
Summary: Sex is a key risk factor for many types of cardiovascular disease. Both biological sex and gender influence differences between men and women in disease susceptibility and pathology. Experimental mouse models have revealed the influence of sex chromosome complement and gonad type on cardiovascular risk factors and disease development.
CIRCULATION RESEARCH
(2022)
Review
Psychology, Multidisciplinary
Caroline Blais, Karina J. Linnell, Serge Caparos, Amanda Estephan
Summary: Researchers have found that individuals with different cultural backgrounds use different types of visual information in face processing, but the mechanisms underlying these differences remain unclear. They have integrated these group differences into a visual categorization model in the field of psychophysics and discussed potential face-specific or non-specific mechanisms.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Peripheral Vascular Disease
Ryo Nakamaru, Koichi Yamamoto, Hiroshi Akasaka, Hiromi Rakugi, Isao Kurihara, Takashi Yoneda, Takamasa Ichijo, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Tetsuya Yamada, Hiroki Kobayashi, Kouichi Tamura, Yoshihiro Ogawa, Junji Kawashima, Nobuya Inagaki, Megumi Fujita, Kenji Oki, Kohei Kamemura, Akiyo Tanabe, Mitsuhide Naruse
Summary: The study found that female patients with bilateral primary aldosteronism have worse renal outcomes compared to male patients after receiving mineralocorticoid receptor antagonist treatment. Despite similar systolic blood pressure levels between the sexes, women experienced a greater decline in estimated glomerular filtration rate, especially during the late phase of 6 to 60 months post-treatment initiation.
Article
Multidisciplinary Sciences
Thomas Baumgartner, Emmanuel Guizar Rosales, Daria Knoch
Summary: This study used fMRI to explore the neural mechanisms underlying interindividual differences in intergenerational sustainable behavior. The results showed that neural communication within and between the mentalizing and cognitive control networks is related to these differences. The findings suggest that the engagement of perspectivetaking and self-control processes are important factors contributing to interindividual differences in intergenerational sustainable behavior.
SCIENTIFIC REPORTS
(2023)
Review
Behavioral Sciences
Amy J. Wegener, Gretchen N. Neigh
Summary: Animal models are commonly used to study the development of mood disorders, particularly by inducing behaviors consistent with anxiety and depression through stress paradigms. Understanding gender differences following stress is crucial for enhancing predictive validity of models and identifying therapeutic targets.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Joshua R. Smith, Randal J. Thomas, Amanda R. Bonikowske, Shane M. Hammer, Thomas P. Olson
Summary: This article reviews the sex differences in outpatient phase II cardiac rehabilitation (CR) programming, including CR participation rates, core components, and barriers to participation. Strategies to mitigate these disparities are discussed, along with areas for future research.
CIRCULATION RESEARCH
(2022)
Review
Physiology
Autumn N. Harris, I. David Weiner
Summary: Sexual dimorphic variations in renal ammonia metabolism and structure suggest a significant impact of gender on acid-base balance. Testosterone plays a key role in regulating these differences, particularly through androgen receptor activation in the proximal tubule. Further research is needed to understand the mechanisms and implications of sex differences in renal function for optimal patient care.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Review
Cell Biology
Chao Hu, Yufeng Zhao, Xuanchuan Wang, Tongyu Zhu
Summary: Intratumoral fibrosis in renal cell carcinoma is a complex histological manifestation involving interactions between cancer cells and fibrotic stroma. The underlying mechanisms are not completely understood, but promising targets for future studies have been identified through exploring shared mechanisms between RCC tumorigenesis and renal fibrogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Anesthesiology
Ann M. Gregus, Ian S. Levine, Kelly A. Eddinger, Tony L. Yaksh, Matthew W. Buczynski
Summary: The text discusses the physiological consequences of pain, management of chronic pain, and the development of nonopioid interventions. It emphasizes the role of the immune system in pain hypersensitivity and the importance of gender differences in chronic pain.
Review
Immunology
Zena Wehbe, Safaa Hisham Hammoud, Hadi M. Yassine, Manal Fardoun, Ahmed F. El-Yazbi, Ali H. Eid
Summary: Globally, over two million people have died from the recent SARS-CoV-2 pandemic, with males showing higher severity. Gender differences in host mechanisms of SARS-CoV-2 infection may contribute to the more severe disease prognosis in male COVID-19 patients, with disparities in comorbidities, ACE2 receptor, RAS, viral replication molecules, immune response, and behavioral factors playing a role.
FRONTIERS IN IMMUNOLOGY
(2021)