Article
Biochemistry & Molecular Biology
Anna Todeva-Radneva, Sevdalina Kandilarova, Rositsa Paunova, Drozdstoy Stoyanov, Tina Zdravkova, Ronald Sladky
Summary: This study aimed to explore possible differences in whole-brain functional connectivity in patients with major depressive disorder (MDD), bipolar disorder (BD), and healthy controls (HC). The results showed increased connectivity in certain brain regions in the BD group compared to the HC group, while the MDD group showed enhanced connectivity in different regions. These findings suggest that these connectivity patterns may serve as potential diagnostic biomarkers for MDD and BD.
Article
Anesthesiology
Hung-Yu Liu, Kun-Hsien Chou, Pei-Lin Lee, Yen-Feng Wang, Shih-Pin Chen, Kuan-Lin Lai, Ching-Po Lin, Shuu-Jiun Wang, Wei-Ta Chen
Summary: This study used magnetic resonance imaging to investigate the neural structures and networks associated with widespread pain in fibromyalgia patients. The findings revealed that as the number of pain areas increased, the volume of the right anterior insular cortex decreased. Additionally, there was an increasing number of neural substrates in subcortical regions that showed structural covariance with the right anterior insular cortex. Conversely, the strength of structural covariance between the right anterior insular cortex and other brain regions, such as the precuneus, frontal cortex, anterior and posterior cingulate, and lingual gyri, decreased.
Article
Neuroimaging
Tianyi Zhang, Qingze Zeng, Kaicheng Li, Xiaocao Liu, Yanv Fu, Tiantian Qiu, Peiyu Huang, Xiao Luo, Zhirong Liu, Guoping Peng
Summary: Smoking is a modifiable risk factor for Alzheimer's disease, and the insula plays a crucial role in both smoking and cognition. However, the effects of smoking on insula-related networks in cognitively normal controls (CN) and mild cognitive impairment (MCI) patients are still unknown.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Neurosciences
Pierre-Eric Lutz, Daniel Almeida, Dominique Filliol, Fabrice Jollant, Brigitte L. Kieffer, Gustavo Turecki
Summary: Research indicates that depression is associated with increased MOR activity, partially explained by a specific increase in expression of the inhibitory alpha G-protein subunit GNAI2. This enhanced endogenous opioidergic tone may help buffer negative affective states in depressed individuals.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Cedric Gollion, Fleur Lerebours, Federico Nemmi, Germain Arribarat, Fabrice Bonneville, Vincent Larrue, Patrice Peran
Summary: This study found a functional connectivity between the insula subregions and vermis VI in patients with migraine with aura during the resting state. This connectivity may reflect the cardiovascular features of migraine with aura.
JOURNAL OF HEADACHE AND PAIN
(2022)
Review
Anatomy & Morphology
Meng Zhang, Yunwen Peng
Summary: Two large-scale meta-analyses of brain imaging studies were conducted to explore the brain regions involved in emotional and behavioral regulation. The results showed that the dorsal anterior cingulate cortex, bilateral anterior insula, and right inferior parietal lobule played crucial roles in both regulation domains. The coactivation patterns and functional characteristics of these regions were also analyzed and confirmed their involvement in self-regulation.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Psychology, Biological
Andrea Caria, Alessandro Grecucci
Summary: Research has shown that learned control of metabolic activity in specific brain regions can help regulate emotions. Neurofeedback-based regulation of fMRI activity in emotion-related areas has been found to modify emotional behavior and neural activity in both healthy individuals and those with emotional disorders. However, there is still limited understanding of the neural mechanisms underlying self-regulation of the emotional brain and its relationship with other emotion regulation strategies.
Article
Clinical Neurology
Sun-Young Kim, Kyung Hwa Lee, Hayoung Lee, Jeong Eun Jeon, Mi Hyun Lee, Jooyoung Lee, Seong-Min Oh, Yu Jin Lee, Seog Ju Kim
Summary: The study examined the effects of anterior insula (AI) activation on the associations between stress, sleep disturbance, and depression. Results showed that higher levels of AI activation were associated with greater sleep disturbance under high stress, and with more severe depression symptoms alongside sleep disturbance. AI activation may play a crucial role in the etiology of insomnia and stress-related disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Rui Wang, Fan Mo, Yuhao Shen, Yu Song, Huanhuan Cai, Jiajia Zhu
Summary: The insula plays diverse functional roles due to its strong connectivity with various cortical and subcortical areas. This study identified three primary patterns of functional connectivity gradients of the insula to different cerebral systems, providing insights into the role of the insula in brain disorders.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Raymond P. Viviano, Jessica S. Damoiseaux
Summary: This study found that individuals with greater subjective cognitive decline showed a larger decrease in connectivity between components of the default mode network and an increase in connectivity between salience and default mode network components. These changes in functional connectivity were observed in the absence of changes in cognitive performance.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Yangyang Wang, Xuhong Yang, Lifei Xiao, Wenchao Li, Xianhao Huo, Chaofan Wang, Mei Li, Tao Sun
Summary: Sleep deprivation is a significant cause of cognitive impairment. This study investigated the relationship between functional connectivity of anterior insular subregions and cognitive impairment following total sleep deprivation. The results suggest that altered functional connectivity in these subregions may serve as a neuroimaging biomarker for cognitive impairment after sleep deprivation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neuroimaging
Fabien Almairac, Jeremy Deverdun, Jerome Cochereau, Arthur Coget, Anne-Laure Lemaitre, Sylvie Moritz-Gasser, Hugues Duffau, Guillaume Herbet
Summary: In patients with glioma, infiltration of the insular cortex leads to significant increase in functional connectivity in the contralesional hemisphere, especially in cortical areas involved in visual and sensorimotor networks. This functional redistribution is not observed in control regions unaffected by the tumor.
NEUROIMAGE-CLINICAL
(2021)
Article
Psychology, Biological
Milena Radoman, Stephanie M. Gorka
Summary: Individuals with high intolerance of uncertainty (IU) display maladaptive responses to uncertain outcomes and IU is a risk factor for psychiatric disorders. This study examined the relationship between IU and anterior insula (AIC) using fMRI. IU was correlated with increased functional connectivity between the AIC and dorsal anterior cingulate cortex (dACC) and right dorsolateral prefrontal cortex (dlPFC) in the U-threat model. These findings suggest that salience and central executive control networks may underlie IU expression.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2023)
Article
Neurosciences
Carlos Silva, Blake S. Porter, Kristin L. Hillman
Summary: Animals must continually assess effort and physiological states during tasks, with the ACC and anterior insular cortex implicated in cost-benefit decision-making. Contrary to predictions, stimulation of Cg1 did not increase persistence in the task, while stimulation of the anterior insula had little effect on effortful behavior.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biology
Hussein Ghareh, Isis Alonso-Lozares, Dustin Schetters, Rae J. Herman, Tim S. Heistek, Yvar Van Mourik, Philip Jean-Richard-dit-Bressel, Gerald Zernig, Huibert D. Mansvelder, Taco J. De Vries, Nathan J. Marchant
Summary: This study shows the critical role of environmental contexts in promoting nicotine relapse and the importance of aIC activity in context-induced relapse.
Article
Neurosciences
Tianyu Gao, Yuqing Zhou, Wenxin Li, Daniela M. Pfabigan, Shihui Han
SOCIAL NEUROSCIENCE
(2020)
Article
Psychology, Biological
Yuqing Zhou, Tianyu Gao, Ting Zhang, Wenxin Li, Taoyu Wu, Xiaochun Han, Shihui Han
NATURE HUMAN BEHAVIOUR
(2020)
Review
Behavioral Sciences
Cecilia Heyes, Dan Bang, Nicholas Shea, Christopher D. Frith, Stephen M. Fleming
TRENDS IN COGNITIVE SCIENCES
(2020)
Article
Biology
Dan Bang, Sara Ershadmanesh, Hamed Nili, Stephen M. Fleming
Article
Neurosciences
Dan Bang, Kenneth T. Kishida, Terry Lohrenz, Jason P. White, Adrian W. Laxton, Stephen B. Tatter, Stephen M. Fleming, P. Read Montagu
Article
Psychology, Biological
Xiaochun Han, Shuai Zhou, Nardine Fahoum, Taoyu Wu, Tianyu Gao, Simone Shamay-Tsoory, Michele J. Gelfand, Xinhuai Wu, Shihui Han
Summary: The study reveals decreased avoidance of harming outgroup civilians when conflict escalates, and this phenomenon is predicted by inhibition of the left middle frontal activity.
NATURE HUMAN BEHAVIOUR
(2021)
Article
Neurosciences
Tianyu Gao, Shihui Han
Summary: This study reveals the neurocognitive mechanisms underlying the learning and representations of symbols related to life and death. The results demonstrate that people have a positive response bias towards life symbols and a negative response bias towards death symbols. Brain imaging results show that different brain regions monitor and respond to these biases. Additionally, life and death symbols have different effects on brain oscillations.
Article
Biochemistry & Molecular Biology
Ali Mahmoodi, Hamed Nili, Dan Bang, Carsten Mehring, Bahador Bahrami
Summary: This study reveals that informational conformity and normative conformity have distinct behavioral and neural markers. The neural activity associated with informational conformity tracks both human and computer interactions, while the neural activity associated with normative conformity only tracks human interactions.
Article
Psychology, Social
Xiaoyue Fan, Tianyu Gao, Siyang Luo, Michele J. Gelfand, Shihui Han
Summary: This study provides evidence that religious afterlife beliefs decrease behavioral avoidance of symbols of mortality. Christians, Muslims, Hindus, and Buddhists exhibit lower levels of avoidance compared to nonbelievers.
PERSONALITY AND SOCIAL PSYCHOLOGY BULLETIN
(2023)
Article
Multidisciplinary Sciences
Dan Bang, Rani Moran, Nathaniel D. Daw, Stephen M. Fleming
Summary: Computing confidence in one's own and others' decisions is critical for social success. Little is known about how people form confidence estimates about others. In this study, participants placed bets on perceptual decisions made by themselves or other players with different abilities. The results showed that participants computed confidence in another player's decisions by considering the player's ability and the decision difficulty, and this computation involved an interaction between brain systems implicated in decision-making and theory of mind.
NATURE COMMUNICATIONS
(2022)
Article
Psychology, Experimental
Elisa van der Plas, Shiqi Zhang, Keer Dong, Dan Bang, Jian Li, Nicholas D. Wright, Stephen M. Fleming
Summary: By studying populations from two different cultural backgrounds in China and the UK, the researchers found differences in metacognitive performance, suggesting that metacognitive capacity may be shaped by sociocultural interactions.
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-GENERAL
(2022)
Article
Neurosciences
Ali Mahmoodi, Hamed Nili, Caroline Harbison, Sorcha Hamilton, Nadescha Trudel, Dan Bang, Matthew F. S. Rushworth
Summary: People's ability to focus on relevant traits in social judgement is supported by distinct neural representations in the dorsomedial prefrontal cortex (dmPFC) and anterior insula (AI). Disrupting the AI alters the impact of relevant information, while disrupting the dmPFC affects the impact of irrelevant information. This neural circuit is separate from the one supporting integration across different features.
Article
Neurosciences
Yuqing Zhou, Wenxin Li, Tianyu Gao, Xinyue Pan, Shihui Han
Summary: This study investigates the relationship between cultural traits and outgroup aggression behavior by collecting self-construal scores, EEG signals in response to different race faces, and decisions on punishing racial outgroup individuals. The findings reveal that interdependent self-construal can be explained by two subcomponents, esteem for group and relational interdependence, which have opposite relationships with the decisions to punish racial outgroup targets. These relationships are mediated by neural representations of perceived race.
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.