Article
Genetics & Heredity
Julien Ablain, Amira Al Mahi, Harriet Rothschild, Meera Prasad, Sophie Aires, Song Yang, Maxim E. Dokukin, Shuyun Xu, Michelle Dang, Igor Sokolov, Christine G. Lian, Leonard Zon
Summary: The study reveals that the loss of NECTIN1 gene plays a major role in melanoma dissemination by stimulating cell migration and spreading. The absence of adherens junctions in NECTIN1-deficient tumors indicates the association between NECTIN1 loss and low IGF1 levels in melanoma. This genetic control of microenvironmental signals provides insights into the understanding of melanoma metastasis.
Article
Cell Biology
Ye Lei, Hong-Fen Shen, Qi-Wen Li, Sheng Yang, Hong-Ting Xie, Xu-Feng Li, Mei -Ling Chen, Jia-Wei Xia, Sheng-Chun Wang, Guan-Qi Dai, Ying Zhou, Ying-Chun Li, Shi-Hao Huang, Dan-Hua He, Zhi-Hao Zhou, Jin-Ge Cong, Xiao-Lin Lin, Tao-Yan Lin, Ai -Bing Wu, Dong Xiao, Sheng-Jun Xiao, Xin-Ke Zhang, Jun-Shuang Jia
Summary: Bmi-1 is overexpressed in various cancer types, including nasopharyngeal carcinoma (NPC). High Bmi-1 levels were observed in NPC cell lines and specimens, especially in advanced cases. Depletion of Bmi-1 suppressed cell proliferation, induced cell cycle arrest, reduced cell stemness, and inhibited cell migration and invasion in NPC cells. Hairy gene homolog (HRY) upregulated Bmi-1 by binding to its promoter, promoting NPC cell stemness. Silencing Bmi-1 suppressed NPC progression.
Article
Biochemistry & Molecular Biology
Teekaraman Dhanaraj, Manju Mohan, Jagadeesan Arunakaran
Summary: Research has shown that quercetin inhibits the survival and proliferation of human metastatic ovarian cancer cells by inactivating PI3K/Akt, Ras/Raf pathways, and EGFR expression. It also alters N-cadherin expression, decreases gelatinase secretion and MMP-2/-9 gene expression, and inhibits migration and adhesion of the cancer cells. These findings suggest that quercetin could be a valuable therapeutic drug for the treatment and prevention of metastatic ovarian cancer.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Oncology
Julia M. DeRogatis, Karla M. Viramontes, Emily N. Neubert, Monique L. Henriquez, Christian F. Guerrero-Juarez, Roberto Tinoco
Summary: Therapeutically targeting PSGL-1 can reinvigorate antitumor immunity by enhancing effector T-cell responses and reducing regulatory T cells, thus delaying tumor growth in a melanoma mouse model.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Cell Biology
Hope E. Burks, Jenny L. Pokorny, Jennifer L. Koetsier, Quinn R. Roth-Carter, Christopher R. Arnette, Pedram Gerami, John T. Seykora, Jodi L. Johnson, Ziyou Ren, Kathleen J. Green
Summary: Melanoma cells hijack keratinocyte signaling to downregulate Dsg1 expression, leading to increased migration and epidermal spread. Paracrine signaling via CXCL1/CXCR2 and regulation of Slug and Grhl1 are involved in this intercellular communication.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Cell Biology
Bo He, Li Guo, Youwen Hu, Hongyan Huang, Lijun Wan, Kedong Xu, Fenfen Wang, Zhili Wen
Summary: Hepatocellular carcinoma (HCC) is a common cancer with poor prognosis due to difficulties in early detection and lack of effective treatment strategies. This study investigated the role of Desmocollin-2 (DSC2) in HCC and found that DSC2 is a tumor suppressor gene with low expression in liver cancer. Overexpression of DSC2 inhibited the proliferation, migration, and invasion abilities of HCC cells and promoted apoptosis through the ERK/c-MYC signaling pathway.
Article
Biochemistry & Molecular Biology
Guang-Liang Chen, Rui Li, Xiao-Xiang Chen, Juan Wang, Shan Cao, Rui Song, Ming-Chun Zhao, Li-Ming Li, Nicole Hannemmann, Georg Schett, Cheng Qian, Aline Bozec
Summary: Metastatic melanoma is a challenging disease, and understanding the molecular mechanisms behind its metastasis is crucial. The downregulation of AP-1 transcription factor member Fra-2 in melanoma cells is associated with a more aggressive phenotype both in vitro and in vivo. Further research revealed that the Fra-2-Fam212b axis plays a key role in promoting melanoma metastasis by affecting cell migration, invasion, cell cycle transition, and tissue angiogenesis.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Biochemistry & Molecular Biology
Samar Sayedyahossein, Kenneth Huang, Zhigang Li, Christopher Zhang, Alexandra M. Kozlov, Danielle Johnston, Daniel Nouri-Nejad, Lina Dagnino, Dean H. Betts, David B. Sacks, Silvia Penuela
Summary: The study revealed a direct interaction between PANX1 and beta-catenin to modulate growth and metabolism in melanoma cells, providing mechanistic insight into melanoma progression. This interaction may be a new component of the Wnt signaling pathway in various contexts.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Cell & Tissue Engineering
Fiona R. Passanha, Madeleine L. Divinagracia, Vanessa L. S. LaPointe
Summary: Cadherin-11 regulates the activity of RTKs in hMSCs, affecting the activation of the MAPK pathway and cell proliferation.
Article
Dermatology
Ana F. A. Moraes, Tatiana C. M. P. Blumetti, Clovis Pinto, Eduardo Bertolli, Gisele Rezze, Ashfaq A. Marghoob, Juliana C. T. Braga
Summary: This study compared the dermatoscopic characteristics of nevi and melanomas with peripheral globules. The findings showed that nevi with peripheral globules located on the lower extremities, displaying a disorganized pattern, and showing features such as blotches, atypical dots and globules, or atypical vessels were more likely to be melanomas.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Cell Biology
Maria Victoria Castro, Gaston Alexis Barbero, Maria Belen Villanueva, Luca Grumolato, Jeremie Nsengimana, Julia Newton-Bishop, Edith Illescas, Maria Josefina Quezada, Pablo Lopez-Bergami
Summary: Contrary to previous findings, the study reveals that ROR2 acts as a tumor suppressor in melanoma by inhibiting cell-cycle progression and melanoma cell proliferation. This effect is mediated through inhibition of Akt phosphorylation and subsequent regulation of key cell-cycle regulators, leading to reduced tumor growth both in vitro and in vivo. The expression of ROR2 is associated with favorable clinical outcomes in melanoma patients, indicating its potential as a prognostic marker.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Rony Shreberk-Hassidim, Stephen M. Ostrowski, David E. Fisher
Summary: One approach to combat malignant melanoma is through early detection by screening melanocytic nevi clinically and dermoscopically. However, the relationship between nevi, which are benign melanocytic proliferations, and melanoma remains unclear. While most melanomas are believed to develop de novo, an increased number of nevi is a strong risk factor for developing melanoma. Various factors, such as pigmentation, genetics, and sun exposure, influence nevus formation and progression to melanoma. This review discusses the clinical, histological, molecular, and genetic factors involved in nevus formation and evolution into melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Marc A. Vittoria, Nathan Kingston, Kristyna Kotynkova, Eric Xia, Rui Hong, Lee Huang, Shayna McDonald, Andrew Tilston-Lunel, Revati Darp, Joshua D. Campbell, Deborah Lang, Xiaowei Xu, Craig J. Ceol, Xaralabos Varelas, Neil J. Ganem
Summary: Activating mutations of BRAF alone are not enough to drive melanoma formation. Activation of the Hippo signaling pathway by oncogenic BRAF acts as an additional safeguard to limit the growth of BRAF-dependent melanocytes and melanoma formation. The Hippo pathway enforces the stable arrest of nevus melanocytes and serves as a critical barrier to melanoma development.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Sha Song, Ji Zhang, Qi Su, Weimin Zhang, Yunxin Jiang, Gao Fan, Chen'ao Qian, Bingzong Li, Wenzhuo Zhuang
Summary: The study revealed differential expression of ITGA6 between multiple myeloma and secondary plasma cell leukemia patients, with low ITGA6 expression associated with increased myeloma cell invasion and significant impact on patient prognosis.
BRITISH JOURNAL OF CANCER
(2021)
Article
Cell Biology
Vanessa Schimek, Katharina Strasser, Andrea Beer, Samantha Goeber, Natalie Walterskirchen, Christine Brostjan, Catharina Mueller, Thomas Bachleitner-Hofmann, Michael Bergmann, Helmut Dolznig, Rudolf Oehler
Summary: Sporadic apoptosis of tumour cells in colorectal cancer is associated with poor patient prognosis. Apoptotic cancer cells release chemotactic factors that attract neutrophils, inducing changes in neutrophil phenotype and lifespan and promoting interaction with macrophages in the tumor microenvironment, potentially contributing to an immunologically unfavorable environment.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Kaitlyn M. Tsuruda, Solveig Hofvind, Lars A. Akslen, Solveig R. Hoff, Marit B. Veierodg
Article
Clinical Neurology
Umber Dube, Laura Ibanez, John P. Budde, Bruno A. Benitez, Albert A. Davis, Oscar Harari, Mark M. Iles, Matthew H. Law, Kevin M. Brown, Michelle Agee, Babak Alipanahi, Adam Auton, Robert K. Bell, Katarzyna Bryc, Sarah L. Elson, Pierre Fontanillas, Nicholas A. Furlotte, David A. Hinds, Karen E. Huber, Aaron Kleinman, Nadia K. Litterman, Jennifer C. McCreight, Matthew H. McIntyre, Joanna L. Mountain, Elizabeth S. Noblin, Carrie A. M. Northover, Steven J. Pitts, J. Fah Sathirapongsasuti, Olga V. Sazonova, Janie F. Shelton, Suyash Shringarpure, Chao Tian, Joyce Y. Tung, Vladimir Vacic, Catherine H. Wilson, M. H. Law, M. H. Law, D. T. Bishop, J. E. Lee, M. Brossard, N. G. Martin, E. K. Moses, F. Song, J. H. Barrett, R. Kumar, D. F. Easton, P. D. Pharoah, A. J. Swerdlow, K. P. Kypreou, J. C. Taylor, M. Harland, J. Randerson-Moor, L. A. Akslen, P. A. Andresen, M. F. Avril, E. Azizi, G. B. Scarra, K. M. Brown, T. Debniak, D. L. Duffy, D. E. Elder, S. Fang, E. Friedman, P. Galan, P. Ghiorzo, E. M. Gillanders, A. M. Goldstein, N. A. Gruis, J. Hansson, P. Helsing, M. Hocevar, V. Hoiom, C. Ingvar, P. A. Kanetsky, W. V. Chen, M. T. Landi, J. Lang, G. M. Lathrop, J. Lubinski, R. M. Mackie, G. J. Mann, A. Molven, G. W. Montgomery, S. Novakovic, H. Olsson, S. Puig, J. A. Puig-Butille, W. Wu, A. A. Qureshi, G. L. Radford-Smith, N. Van der Stoep, R. Van Doorn, D. C. Whiteman, J. E. Craig, E. Schadendorf, L. A. Simms, K. P. Burdon, D. R. Nyholt, K. A. Pooley, N. Orr, A. J. Stratigos, A. E. Cust, S. V. Ward, N. K. Hayward, J. Han, H. J. Schulze, A. M. Dunning, J. A. Bishop, F. Demenais, C. I. Amos, S. MacGregor, M. M. Iles, Carlos Cruchaga
ACTA NEUROPATHOLOGICA
(2020)
Article
Oncology
Maria L. Lotsberg, Katarzyna Wnuk-Lipinska, Stephane Terry, Tuan Zea Tan, Ning Lu, Laura Trachsel-Moncho, Gro V. Rosland, Muntequa I. Siraji, Monica Hellesoy, Austin Rayford, Kirstine Jacobsen, Henrik J. Ditzel, Olav K. Vintermyr, Trever G. Bivona, John Minna, Rolf A. Brekken, Bruce Baguley, David Micklem, Lars A. Akslen, Gro Gausdal, Anne Simonsen, Jean Paul Thiery, Salem Chouaib, James B. Lorens, Agnete Svendsen Tenfjord Engelsen
JOURNAL OF THORACIC ONCOLOGY
(2020)
Article
Multidisciplinary Sciences
Cecilie Askeland, Elisabeth Wik, Kenneth Finne, Even Birkeland, Jarle B. Arnes, Karin Collett, Goril Knutsvik, Kristi Kruger, Benedicte Davidsen, Turid Aas, Geir Egil Eide, Ingunn M. Stefansson, William D. Foulkes, Lars A. Akslen
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Trygve Lofterod, Hanne Frydenberg, Vidar Flote, Anne Elise Eggen, Anne McTiernan, Elin S. Mortensen, Lars A. Akslen, Jon B. Reitan, Tom Wilsgaard, Inger Thune
BREAST CANCER RESEARCH AND TREATMENT
(2020)
Article
Genetics & Heredity
Maria Teresa Landi, D. Timothy Bishop, Stuart MacGregor, Mitchell J. Machiela, Alexander J. Stratigos, Paola Ghiorzo, Myriam Brossard, Donato Calista, Jiyeon Choi, Maria Concetta Fargnoli, Tongwu Zhang, Monica Rodolfo, Adam J. Trower, Chiara Menin, Jacobo Martinez, Andreas Hadjisavvas, Lei Song, Irene Stefanaki, Richard Scolyer, Rose Yang, Alisa M. Goldstein, Miriam Potrony, Katerina P. Kypreou, Lorenza Pastorino, Paola Queirolo, Cristina Pellegrini, Laura Cattaneo, Matthew Zawistowski, Pol Gimenez-Xavier, Arantxa Rodriguez, Lisa Elefanti, Siranoush Manoukian, Licia Rivoltini, Blair H. Smith, Maria A. Loizidou, Laura Del Regno, Daniela Massi, Mario Mandala, Kiarash Khosrotehrani, Lars A. Akslen, Christopher Amos, Per A. Andresen, Marie-Francoise Avril, Esther Azizi, H. Peter Soyer, Veronique Bataille, Bruna Dalmasso, Lisa M. Bowdler, Kathryn P. Burdon, Wei Chen, Veryan Codd, Jamie E. Craig, Tadeusz Debniak, Mario Falchi, Shenying Fang, Eitan Friedman, Sarah Simi, Pilar Galan, Zaida Garcia-Casado, Elizabeth M. Gillanders, Scott Gordon, Adele Green, Nelleke A. Gruis, Johan Hansson, Mark Harland, Jessica Harris, Per Helsing, Anjali Henders, Marko Hocevar, Veronica Hoiom, David Hunter, Christian Ingvar, Rajiv Kumar, Julie Lang, G. Mark Lathrop, Jeffrey E. Lee, Xin Li, Jan Lubinski, Rona M. Mackie, Maryrose Malt, Josep Malvehy, Kerrie McAloney, Hamida Mohamdi, Anders Molven, Eric K. Moses, Rachel E. Neale, Srdjan Novakovic, Dale R. Nyholt, Hakan Olsson, Nicholas Orr, Lars G. Fritsche, Joan Anton Puig-Butille, Abrar A. Qureshi, Graham L. Radford-Smith, Juliette Randerson-Moor, Celia Requena, Casey Rowe, Nilesh J. Samani, Marianna Sanna, Dirk Schadendorf, Hans-Joachim Schulze, Lisa A. Simms, Mark Smithers, Fengju Song, Anthony J. Swerdlow, Nienke van der Stoep, Nicole A. Kukutsch, Alessia Visconti, Leanne Wallace, Sarah Ward, Lawrie Wheeler, Richard A. Sturm, Amy Hutchinson, Kristine Jones, Michael Malasky, Aurelie Vogt, Weiyin Zhou, Karen A. Pooley, David E. Elder, Jiali Han, Belynda Hicks, Nicholas K. Hayward, Peter A. Kanetsky, Chad Brummett, Grant W. Montgomery, Catherine M. Olsen, Caroline Hayward, Alison M. Dunning, Nicholas G. Martin, Evangelos Evangelou, Graham J. Mann, Georgina Long, Paul D. P. Pharoah, Douglas F. Easton, Jennifer H. Barrett, Anne E. Cust, Goncalo Abecasis, David L. Duffy, David C. Whiteman, Helen Gogas, Arcangela De Nicolo, Margaret A. Tucker, Julia A. Newton-Bishop, Ketty Peris, Stephen J. Chanock, Florence Demenais, Kevin M. Brown, Susana Puig, Eduardo Nagore, Jianxin Shi, Mark M. Iles, Matthew H. Law
Article
Medicine, General & Internal
Katrin Kleinmanns, Katharina Bischof, Shamundeeswari Anandan, Mihaela Popa, Lars A. Akslen, Vibeke Fosse, Ida Tveit Karlsen, Bjorn T. Gjertsen, Line Bjorge, Emmet McCormack
Article
Oncology
Liv Cecilie Vestrheim Thomsen, Katrin Kleinmanns, Shamundeeswari Anandan, Stein-Erik Gullaksen, Tamim Abdelaal, Grete Alrek Iversen, Lars Andreas Akslen, Emmet Mccormack, Line Bjorge
Summary: This study utilized mass cytometry to analyze the tumor microenvironment of high-grade serous ovarian cancer, revealing high interpatient heterogeneity and identifying new marker combinations through merging datasets.
Meeting Abstract
Pathology
Lufei Sui, Suming Wang, Noah Sorrelle, Anna Blois, Yuqing Zhang, Arturas Ziemys, Ole Johan Halvorsen, Diane Bielenberg, Lars Akslen, Rolf Brekken, Randolph Watnick
AMERICAN JOURNAL OF PATHOLOGY
(2020)
Article
Multidisciplinary Sciences
Agnete S. T. Engelsen, Katarzyna Wnuk-Lipinska, Sebastien Bougnaud, Fanny A. Pelissier Vatter, Crina Tiron, Rene Villadsen, Masaru Miyano, Maria L. Lotsberg, Noelly Madeleine, Pouda Panahandeh, Sushil Dhakal, Tuan Zea Tan, Stacey D'mello Peters, Sturla Grondal, Sura M. Aziz, Silje Nord, Lars Herfindal, Martha R. Stampfer, Therese Sorlie, Rolf A. Brekken, Oddbjorn Straume, Nils Halberg, Gro Gausdal, Jean Paul Thiery, Lars A. Akslen, Ole W. Petersen, Mark A. LaBarge, James B. Lorens
Meeting Abstract
Oncology
Liv Cecilie Vestrheim Thomsen, Alfred Honore, Lars Anders Reisaeter, Bjarte Almas, Kristina Forde, Einar Kleboe Kristoffersen, Guro Kristin Melve, Martin Biermann, Svein Inge Helle, Waqas Azeem, Ole Johan Halvorsen, Lars Akslen, Duke Bahn, Klaus Pantel, Sabine Riethdorf, Haakon Ragde, Bjorn T. Gjertsen, Anne Margrete Oyan, Karl-Henning Kalland, Christian Beisland
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Meeting Abstract
Oncology
Carina Strell, Dick Folkvaljon, Erik Holmberg, Per Karlsson, Jonas Bergh, Troy Bremer, Lars A. Akslen, Fredrik Warnberg, Arne Ostman
Article
Economics
Mikyung Kelly Seo, Oddbjorn Straume, Lars A. Akslen, John Cairns
PHARMACOECONOMICS-OPEN
(2020)
Article
Pathology
Hilde Ytre-Hauge Smeland, Cecilie Askeland, Elisabeth Wik, Goril Knutsvik, Anders Molven, Reidunn J. Edelmann, Rolf K. Reed, David J. Warren, Donald Gullberg, Linda Stuhr, Lars A. Akslen
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2020)
Article
Oncology
Lars A. R. Reisaeter, Ole J. Halvorsen, Christian Beisland, Alfred Honore, Karsten Gravdal, Are Losnegard, Jan Monssen, Lars A. Akslen, Martin Biermann
RADIOLOGY-IMAGING CANCER
(2020)
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.