Bacterial Type IV secretion systems: versatile virulence machines

In search of Brucella abortus type IV secretion substrates: screening and identification of four proteins translocated into host cells through VirB system

(2011) María Inés Marchesini et al.   CELLULAR MICROBIOLOGY

Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2

(2011) Marie de Barsy et al.   CELLULAR MICROBIOLOGY

Protein Kinase LegK2 Is a Type IV Secretion System Effector Involved in Endoplasmic Reticulum Recruitment and Intracellular Replication of Legionella pneumophila

(2011) Eva Hervet et al.   INFECTION AND IMMUNITY

An Agrobacterium VirB10 Mutation Conferring a Type IV Secretion System Gating Defect

(2011) L. M. Banta et al.   JOURNAL OF BACTERIOLOGY

The Coxiella burnetii Cryptic Plasmid Is Enriched in Genes Encoding Type IV Secretion System Substrates

(2011) D. E. Voth et al.   JOURNAL OF BACTERIOLOGY

Legionella pneumophila SidD is a deAMPylase that modifies Rab1

(2011) Yunhao Tan et al.   NATURE

Modulation of Rab GTPase function by a protein phosphocholine transferase

(2011) Shaeri Mukherjee et al.   NATURE

Identification of Anaplasma marginale Type IV Secretion System Effector Proteins

(2011) Svetlana Lockwood et al.   PLoS One

Fic domain-catalyzed adenylylation: Insight provided by the structural analysis of the type IV secretion system effector BepA

(2011) Dinesh V. Palanivelu et al.   PROTEIN SCIENCE

Dot/Icm Type IVB Secretion System Requirements for Coxiella burnetii Growth in Human Macrophages

(2011) P. A. Beare et al.   mBio

The Coxiella burnetii Dot/Icm System Delivers a Unique Repertoire of Type IV Effectors into Host Cells and Is Required for Intracellular Replication

(2011) Kimberly L. Carey et al.   PLoS Pathogens

Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune Response to Virulent Legionella pneumophila

(2011) Mary F. Fontana et al.   PLoS Pathogens

Modulation of Host Cell Function byLegionella pneumophilaType IV Effectors

(2010) Andree Hubber et al.   Annual Review of Cell and Developmental Biology

The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication

(2010) M. Lomma et al.   CELLULAR MICROBIOLOGY

LnaB: a Legionella pneumophila activator of NF-κB

(2010) Vicki P. Losick et al.   CELLULAR MICROBIOLOGY

Combined action of the type IV secretion effector proteins BepC and BepF promotes invasome formation of Bartonella henselae on endothelial and epithelial cells

(2010) Matthias C. Truttmann et al.   CELLULAR MICROBIOLOGY

Microreview: Type IV secretion in the obligatory intracellular bacterium Anaplasma phagocytophilum

(2010) Yasuko Rikihisa et al.   CELLULAR MICROBIOLOGY

Microreview: Type IV secretion systems: versatility and diversity in function

(2010) Karin Wallden et al.   CELLULAR MICROBIOLOGY

The E Block motif is associated with Legionella pneumophila translocated substrates

(2010) Li Huang et al.   CELLULAR MICROBIOLOGY

Anaplasma phagocytophilum and Ehrlichia chaffeensis type IV secretion and Ank proteins

(2010) Yasuko Rikihisa et al.   CURRENT OPINION IN MICROBIOLOGY

High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA

(2010) Stefan Schoebel et al.   EMBO REPORTS

AnIn VivoHigh-Throughput Screening Approach Targeting the Type IV Secretion System Component VirB8 Identified Inhibitors ofBrucella abortus2308 Proliferation

(2010) Athanasios Paschos et al.   INFECTION AND IMMUNITY

Indispensable Role for the Eukaryotic-Like Ankyrin Domains of the Ankyrin B Effector of Legionella pneumophila within Macrophages and Amoebae

(2010) C. T. D. Price et al.   INFECTION AND IMMUNITY

Anaplasma marginale Type IV Secretion System Proteins VirB2, VirB7, VirB11, and VirD4 Are Immunogenic Components of a Protective Bacterial Membrane Vaccine

(2010) E. L. Sutten et al.   INFECTION AND IMMUNITY

E3 Ubiquitin Ligase Activity and Targeting of BAT3 by Multiple Legionella pneumophila Translocated Substrates

(2010) A. W. Ensminger et al.   INFECTION AND IMMUNITY

Evidence for VirB4-Mediated Dislocation of Membrane-Integrated VirB2 Pilin during Biogenesis of the Agrobacterium VirB/VirD4 Type IV Secretion System

(2010) J. E. Kerr et al.   JOURNAL OF BACTERIOLOGY

Agrobacterium tumefaciens Type IV Secretion Protein VirB3 Is an Inner Membrane Protein and Requires VirB4, VirB7, and VirB8 for Stabilization

(2010) P. Mossey et al.   JOURNAL OF BACTERIOLOGY

Biochemical Dissection of the ATPase TraB, the VirB4 Homologue of the Escherichia coli pKM101 Conjugation Machinery

(2010) E. Durand et al.   JOURNAL OF BACTERIOLOGY

Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector ofLegionella pneumophila

(2010) Christopher T.D. Price et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anaplasma phagocytophilum APH_0032 is expressed late during infection and localizes to the pathogen-occupied vacuolar membrane

(2010) Bernice Huang et al.   MICROBIAL PATHOGENESIS

Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein

(2010) A. Luhrmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large-scale identification and translocation of type IV secretion substrates by Coxiella burnetii

(2010) C. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Host Vacuolar H+-ATPase Activity by a Legionella pneumophila Effector

(2010) Li Xu et al.   PLoS Pathogens

Anaplasma phagocytophilum Ats-1 Is Imported into Host Cell Mitochondria and Interferes with Apoptosis Induction

(2010) Hua Niu et al.   PLoS Pathogens

Crystal Structure of Legionella DotD: Insights into the Relationship between Type IVB and Type II/III Secretion Systems

(2010) Noboru Nakano et al.   PLoS Pathogens

Legionella Metaeffector Exploits Host Proteasome to Temporally Regulate Cognate Effector

(2010) Tomoko Kubori et al.   PLoS Pathogens

Temporal resolution of two-tracked NF-κB activation byLegionella pneumophila

(2009) Sina Bartfeld et al.   CELLULAR MICROBIOLOGY

Distinct activities ofBartonella henselaetype IV secretion effector proteins modulate capillary-like sprout formation

(2009) F. Scheidegger et al.   CELLULAR MICROBIOLOGY

A translocated protein ofBartonella henselaeinterferes with endocytic uptake of individual bacteria and triggers uptake of large bacterial aggregates via the invasome

(2009) Thomas A. Rhomberg et al.   CELLULAR MICROBIOLOGY

Targeting eEF1A by aLegionella pneumophilaeffector leads to inhibition of protein synthesis and induction of host stress response

(2009) Xihui Shen et al.   CELLULAR MICROBIOLOGY

Silencing of Host Cell CYBB Gene Expression by the Nuclear Effector AnkA of the Intracellular Pathogen Anaplasma phagocytophilum

(2009) J. C. Garcia-Garcia et al.   INFECTION AND IMMUNITY

The Coxiella burnetii Ankyrin Repeat Domain-Containing Protein Family Is Heterogeneous, with C-Terminal Truncations That Influence Dot/Icm-Mediated Secretion

(2009) D. E. Voth et al.   JOURNAL OF BACTERIOLOGY

Region of Elongation Factor 1A1 Involved in Substrate Recognition byLegionella pneumophilaGlucosyltransferase Lgt1

(2009) Yury Belyi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biological Diversity of Prokaryotic Type IV Secretion Systems

(2009) C. E. Alvarez-Martinez et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Structure of the outer membrane complex of a type IV secretion system

(2009) Vidya Chandran et al.   NATURE

An Anomalous Type IV Secretion System in Rickettsia Is Evolutionarily Conserved

(2009) Joseph J. Gillespie et al.   PLoS One

A Legionella type IV effector activates the NF- B pathway by phosphorylating the I B family of inhibitors

(2009) J. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a Type IV Secretion System Core Complex

(2009) R. Fronzes et al.   SCIENCE

Genome-Scale Identification of Legionella pneumophila Effectors Using a Machine Learning Approach

(2009) David Burstein et al.   PLoS Pathogens

Molecular Mimicry by an F-Box Effector of Legionella pneumophila Hijacks a Conserved Polyubiquitination Machinery within Macrophages and Protozoa

(2009) Christopher T. Price et al.   PLoS Pathogens

Chemical Genetics Reveals Bacterial and Host Cell Functions Critical for Type IV Effector Translocation by Legionella pneumophila

(2009) Xavier Charpentier et al.   PLoS Pathogens

TheLegionella pneumophilaphosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuole

(2008) Curdin Ragaz et al.   CELLULAR MICROBIOLOGY

Large-scale identification ofLegionella pneumophilaDot/Icm substrates that modulate host cell vesicle trafficking pathways

(2008) Matthew Heidtman et al.   CELLULAR MICROBIOLOGY

Candidate Antigens for Q Fever Serodiagnosis Revealed by Immunoscreening of a Coxiella burnetii Protein Microarray

(2008) P. A. Beare et al.   Clinical and Vaccine Immunology

Role for the Ankyrin eukaryotic-like genes of Legionella pneumophila in parasitism of protozoan hosts and human macrophages

(2008) Fabien Habyarimana et al.   ENVIRONMENTAL MICROBIOLOGY

Lgt: a Family of Cytotoxic Glucosyltransferases Produced by Legionella pneumophila

(2008) Y. Belyi et al.   JOURNAL OF BACTERIOLOGY

Rab1 Guanine Nucleotide Exchange Factor SidM Is a Major Phosphatidylinositol 4-Phosphate-binding Effector Protein ofLegionella pneumophila

(2008) Eva Brombacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An intracellular wave of cytochrome c propagates and precedes Bax redistribution during apoptosis

(2008) L. Lartigue et al.   JOURNAL OF CELL SCIENCE

Emerging Pathogens: Challenges and Successes of Molecular Diagnostics

(2008) Jianli Dong et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions

(2008) Tomoko Kubori et al.   MOLECULAR MICROBIOLOGY

Identification of VceA and VceC, two members of the VjbR regulon that are translocated into macrophages by theBrucellatype IV secretion system

(2008) Maarten F. de Jong et al.   MOLECULAR MICROBIOLOGY

AgrobacteriumVirB10 domain requirements for type IV secretion and T pilus biogenesis

(2008) Simon J. Jakubowski et al.   MOLECULAR MICROBIOLOGY

Emerging and re-emerging rickettsioses: endothelial cell infection and early disease events

(2008) David H. Walker et al.   NATURE REVIEWS MICROBIOLOGY

An in vivo gene deletion system for determining temporal requirement of bacterial virulence factors

(2008) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ankyrin Repeat Proteins Comprise a Diverse Family of Bacterial Type IV Effectors

(2008) X. Pan et al.   SCIENCE

VirB2 and VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems?

(2008) Steffen Backert et al.   TRENDS IN MICROBIOLOGY

Legionella Eukaryotic-Like Type IV Substrates Interfere with Organelle Trafficking

(2008) Karim Suwwan de Felipe et al.   PLoS Pathogens