Review
Public, Environmental & Occupational Health
Veronica N. E. Malange, Gitte Hedermann, Ulrik Lausten-Thomsen, Steen Hoffmann, Marianne Voldstedlund, Anna J. M. Aabakke, Anna K. K. Eltvedt, Jorgen S. Jensen, Morten Breindahl, Lone Krebs, Michael Christiansen, Paula L. L. Hedley
Summary: In the past decade, there have been numerous infectious disease outbreaks worldwide, which have had significant effects on perinatal health, including increased risk of preterm delivery and the delivery of low birth weight or small for gestational age babies. Severe perinatal outcomes, such as perinatal and infant death, have also been observed in relation to various infectious diseases. It is important to monitor perinatal health and collect systematic data to understand the implications of these diseases for pregnant women and their unborn infants.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Annalisa Chianese, Carla Zannella, Alessandra Monti, Nunzianna Doti, Giuseppina Sanna, Aldo Manzin, Anna De Filippis, Massimiliano Galdiero
Summary: Pandemic and epidemic outbreaks of respiratory viruses pose significant challenges to public health. This study identifies a potent antimicrobial peptide with broad-spectrum antiviral activity against several respiratory viruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pediatrics
Seth A. Hoffman, Yvonne A. Maldonado
Summary: This review article explores the global health challenge posed by emerging and re-emerging pediatric viral diseases, highlighting the complex dynamics contributing to this challenge. It emphasizes the urgent need for prevention, preparedness, and response efforts, particularly in resource-limited communities disproportionately affected by climate change. Adopting a One Health/Planetary Health approach can enhance equity and resilience in global communities.
PEDIATRIC RESEARCH
(2023)
Review
Microbiology
Dario Correa, Iara Bastos de Andrade, Vinicius Alves, Glauber R. de S. Araujo, Susana Frases
Summary: This review explores emerging and re-emerging yeast infections in the current clinical context. The rapid and accurate diagnosis and treatment of systemic mycoses caused by yeasts are a significant clinical challenge, particularly in the context of COVID-19.
Review
Microbiology
Lizdany Florez-Alvarez, Edmarcia Elisa de Souza, Viviane Fongaro Botosso, Danielle Bruna Leal de Oliveira, Paulo Lee Ho, Carlos Pelleschi Taborda, Giuseppe Palmisano, Margareth Lara Capurro, Joao Renato Rebello Pinho, Helena Lage Ferreira, Paola Minoprio, Eurico Arruda, Luis Carlos de Souza Ferreira, Carsten Wrenger, Edison Luiz Durigon
Summary: This article discusses the pathogenesis and treatment options for viral hemorrhagic fevers caused by hemorrhagic fever viruses (HFVs), as well as the potential for these viruses to cause global emergencies and factors favoring their spread beyond their original niches.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Syed A. A. Rizvi, George P. Einstein, Orien L. Tulp, Frantz Sainvil, Rolando Branly
Summary: Infectious diseases pose a threat to global human health, and overcoming them requires constant efforts and research. However, microbial adaptation and mutation lead to antibiotic and antiviral resistance. Treating infections faces challenges, necessitating multidisciplinary collaboration to develop more effective and versatile therapies. Natural medicine has proven effective, but the full potential of natural resources remains untapped, warranting continuous research and analysis.
Review
Agriculture, Dairy & Animal Science
Hien Van Doan, Mehdi Soltani, Alexandra Leitao, Shafigh Shafiei, Sepideh Asadi, Alan J. Lymbery, Einar Ringo
Summary: Streptococcosis is a significant bacterial disease in aquaculture with potential economic losses. Medicinal herbs and plant extracts have shown promise in controlling and treating the disease, with essential oils being more effective than extracts. However, there is a lack of research on dosage optimization, toxicity, and bioavailability of these compounds in fish organs, making it difficult to validate their clinical efficacy. Further investigations are needed to address these gaps.
Review
Biochemistry & Molecular Biology
Weiqian E. Lee, Elijah Genetzakis, Gemma A. Figtree
Summary: Although recognized cardiovascular risk factors play a role in the development of coronary artery disease (CAD) and heart attack, the susceptibility of humans to this process is different from other animals. Mitochondrial dysfunction, particularly in the endothelial cells, has been found to be strongly associated with CAD. In this review, we explore the potential opportunities in analyzing mitochondrial function using patient-derived cells, such as endothelial colony-forming cells cultured from venous blood. We discuss how this analysis may serve as a biomarker for diagnosis and risk management, and how patient-derived cell models can aid in the development of novel therapies for humans.
Review
Public, Environmental & Occupational Health
Vincent Kipkorir, Arkadeep Dhali, Bahadar Srichawla, Simhachalam Kutikuppala, Madeleine Cox, Dennis Ochieng, Fiona Nyaanga, Mihnea Alexandru Gaman
Summary: This scoping review provides an extensive overview of our current understanding of monkeypox disease. Further research is needed to better understand its risk factors, genetics, and natural history, in order for public health strategists to develop prevention strategies and management decisions.
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Sanjana Vig, Maria Helena Fernandes
Summary: This article reviews the cellular communication and the role of exosomes in the process of bone tissue remodeling. Exosomes, nanometer-sized extracellular vesicles, mediate information transfer between cells and have potential applications in maintaining bone homeostasis and repairing bone defects. The article explains the interactions between exosomes and different types of bone cells, as well as tumor cells, and explores the potential use of exosomes in bone repair and related biomaterials.
Review
Immunology
Balaji Balakrishnan, Uday Prakash Kulkarni, Aswin Anand Pai, Raveen Stephen Stallon Illangeswaran, Ezhilpavai Mohanan, Vikram Mathews, Biju George, Poonkuzhali Balasubramanian
Summary: Hematopoietic cell transplantation (HCT) is an effective treatment for hematological diseases, but early complications such as GVHD and SOS limit its success. Research has focused on discovering blood-based biomarkers to diagnose and predict complications and therapy response. However, these biomarkers are not yet used in routine clinical practice. This review summarizes the biomarkers for early complications post-HCT, ongoing trials, and challenges in using them.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tomas L. White, Neha Deshpande, Varun Kumar, Alex G. Gauthier, Ula V. Jurkunas
Summary: Fuchs endothelial corneal dystrophy is an age-related disease that causes vision loss due to the progressive loss of corneal endothelial cells. The study has shown a causal relationship between senescence and endothelial-mesenchymal transition, with UVA light inducing EMT and senescence in CEnCs. Inhibiting ATR signaling and preventing G2/M arrest attenuated EMT, while selectively eliminating senescent cells using dasatinib and quercetin cocktail reduced UVA-induced fibrosis, suggesting a potential new therapeutic intervention for FECD.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Immunology
Yifan Lu, Yu Sun, Keman Xu, Fatma Saaoud, Ying Shao, Charles Drummer, Sheng Wu, Wenhui Hu, Jun Yu, Satya P. Kunapuli, John R. Bethea, Roberto I. Vazquez-Padron, Jianxin Sun, Xiaohua Jiang, Hong Wang, Xiaofeng Yang
Summary: By analyzing the transcriptomes of six types of secretomic genes in the aorta and vascular cells, we found that various diseases and virus infections can modulate the secretomes in the aorta. These secretomes are related to immune and vascular cell differentiations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaobing Zheng, Zujie Gao, Yunfan Pan, Shuguang Zhang, Ruiqing Chen
Summary: This study investigates the effects of ultrasound on endothelial cell cytoskeleton, and finds that ultrasound can lead to significant changes in cytoskeletal structure, including rupture, blebbing, and apoptosis. Moreover, a temporal threshold for cell injury under different ultrasound intensities is established, providing guidance for selecting a safe threshold for clinical ultrasound applications.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Microbiology
Alangar Ishwara Bhat, Ramasamy Selvarajan, Velusamy Balasubramanian
Summary: New and emerging plant diseases caused by viruses, such as badnaviruses, result in significant crop losses and infect a wide range of economically important crops. These viruses spread through vegetative propagating materials and insects, and their emergence is influenced by favorable environmental conditions. The integration of viral genome into the host chromosome and the development of new strains through recombination contribute to disease formation. Management strategies for badnaviruses have been explored using conventional and precision breeding techniques. The number of known badnavirus species has increased from 32 to 68 in six years, highlighting the importance of understanding and managing these emerging diseases.
