Protein export systems ofMycobacterium tuberculosis: novel targets for drug development?

Discovery and Characterization of Inhibitors of Pseudomonas aeruginosa Type III Secretion

(2010) D. Aiello et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The first low μM SecA inhibitors

(2010) Weixuan Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mycobacterium tuberculosis MycP1 Protease Plays a Dual Role in Regulation of ESX-1 Secretion and Virulence

(2010) Yamini M. Ohol et al.   Cell Host & Microbe

Antivirulence drugs to target bacterial secretion systems

(2010) Christian Baron   CURRENT OPINION IN MICROBIOLOGY

SecA: a tale of two protomers

(2010) Marios Frantzeskos Sardis et al.   MOLECULAR MICROBIOLOGY

Mycobacterial outer membranes: in search of proteins

(2010) Michael Niederweis et al.   TRENDS IN MICROBIOLOGY

Proteolytic processing of Escherichia coli twin-arginine signal peptides by LepB

(2009) Iris Lüke et al.   ARCHIVES OF MICROBIOLOGY

Synthesis and biological evaluation of penem inhibitors of bacterial signal peptidase

(2009) David A. Harris et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection

(2009) J. Muse Davis et al.   CELL

Molecular Dissection of the secA2 Locus of Group B Streptococcus Reveals that Glycosylation of the Srr1 LPXTG Protein Is Required for Full Virulence

(2009) M.-Y. Mistou et al.   JOURNAL OF BACTERIOLOGY

Characterization of a Mycobacterium tuberculosis ESX-3 Conditional Mutant: Essentiality and Rescue by Iron and Zinc

(2009) A. Serafini et al.   JOURNAL OF BACTERIOLOGY

The Lateral Gate of SecYEG Opens during Protein Translocation

(2009) David J. F. du Plessis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Accessory SecA2 System of Mycobacteria Requires ATP Binding and the Canonical SecA1

(2009) Nathan W. Rigel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of LAP, a SecA2-dependent secretory protein, is induced under anaerobic environment

(2009) Kristin M. Burkholder et al.   MICROBES AND INFECTION

ESX-1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteria

(2009) Patricia A. DiGiuseppe Champion et al.   MOLECULAR MICROBIOLOGY

PPE and PE_PGRS proteins ofMycobacterium marinumare transported via the type VII secretion system ESX-5

(2009) Abdallah M. Abdallah et al.   MOLECULAR MICROBIOLOGY

Reducing the Activity and Secretion of Microbial Antioxidants Enhances the Immunogenicity of BCG

(2009) Shanmugalakshmi Sadagopal et al.   PLoS One

Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition

(2009) M. S. Siegrist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Antibiotics and a Proto-Oncogene Homolog on Destruction of Protein Translocator SecY

(2009) J. van Stelten et al.   SCIENCE

Systematic Genetic Nomenclature for Type VII Secretion Systems

(2009) Wilbert Bitter et al.   PLoS Pathogens

Corynebacterium glutamicum possesses two secA homologous genes that are essential for viability

(2008) Michael Caspers et al.   ARCHIVES OF MICROBIOLOGY

Discovery of the first SecA inhibitors using structure-based virtual screening

(2008) Minyong Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antivirulence as a new antibacterial approach for chemotherapy

(2008) Sonia Escaich   CURRENT OPINION IN CHEMICAL BIOLOGY

Evidence for Pore Formation in Host Cell Membranes by ESX-1-Secreted ESAT-6 and Its Role in Mycobacterium marinum Escape from the Vacuole

(2008) J. Smith et al.   INFECTION AND IMMUNITY

Characterization of the Accessory Sec System of Staphylococcus aureus

(2008) I. R. Siboo et al.   JOURNAL OF BACTERIOLOGY

Identification of Functional Tat Signal Sequences in Mycobacterium tuberculosis Proteins

(2008) J. A. McDonough et al.   JOURNAL OF BACTERIOLOGY

ATPase Activity of Mycobacterium tuberculosis SecA1 and SecA2 Proteins and Its Importance for SecA2 Function in Macrophages

(2008) J. M. Hou et al.   JOURNAL OF BACTERIOLOGY

Direct Visualization of the Outer Membrane of Mycobacteria and Corynebacteria in Their Native State

(2008) B. Zuber et al.   JOURNAL OF BACTERIOLOGY

Genetic Toggling of Alkaline Phosphatase Folding Reveals Signal Peptides for All Major Modes of Transport across the Inner Membrane of Bacteria

(2008) Matthew Marrichi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Rv3868, an Essential Hypothetical Protein of the ESX-1 Secretion System inMycobacterium tuberculosis

(2008) Amit Luthra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antisense-Guided Isolation and Structure Elucidation of Pannomycin, a Substitutedcis-Decalin fromGeomyces pannorum

(2008) Craig A. Parish et al.   JOURNAL OF NATURAL PRODUCTS

LspA inactivation in Mycobacterium tuberculosis results in attenuation without affecting phagosome maturation arrest

(2008) S. K. Rampini et al.   MICROBIOLOGY-SGM

Novel mechanism of outer membrane targeting of proteins in Gram-negative bacteria

(2008) Yann Ferrandez et al.   MOLECULAR MICROBIOLOGY

A new twist on an old pathway – accessory secretion systems

(2008) Nathan W. Rigel et al.   MOLECULAR MICROBIOLOGY

Secreted transcription factor controls Mycobacterium tuberculosis virulence

(2008) Sridharan Raghavan et al.   NATURE

Disclosure of the mycobacterial outer membrane: Cryo-electron tomography and vitreous sections reveal the lipid bilayer structure

(2008) C. Hoffmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The importance of the twin-arginine translocation pathway for bacterial virulence

(2008) Emmy De Buck et al.   TRENDS IN MICROBIOLOGY

Sec- and Tat-mediated protein secretion across the bacterial cytoplasmic membrane—Distinct translocases and mechanisms

(2007) Paolo Natale et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES