Anticancer activities of a benzimidazole compound through sirtuin inhibition in colorectal cancer

Sirtuin 2 mutations in human cancers impair its function in genome maintenance

(2017) PamelaSara E. Head et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma

(2017) Xiaoyun Dai et al.   Oncotarget

Sirtuin Inhibitors: An Overview from Medicinal Chemistry Perspective

(2016) Yeong Keng Yoon et al.   Anti-Cancer Agents in Medicinal Chemistry

Abstract 4619: Sirt2 protein is required for activation of mTOR signaling in colorectal cancer cells

(2016) Qingding Wang et al.   CANCER RESEARCH

Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage

(2016) Ansar Karimian et al.   DNA REPAIR

Global patterns and trends in colorectal cancer incidence and mortality

(2016) Melina Arnold et al.   GUT

Clinical Cancer Advances 2016: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology

(2016) Don S. Dizon et al.   JOURNAL OF CLINICAL ONCOLOGY

Hybrid imidazole (benzimidazole)/pyridine (quinoline) derivatives and evaluation of their anticancer and antimycobacterial activity

(2016) Dorina Mantu et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Sirtuins and Cancer: Role in the Epithelial-Mesenchymal Transition

(2016) Raffaele Palmirotta et al.   Oxidative Medicine and Cellular Longevity

Sirtuin functions and modulation: from chemistry to the clinic

(2016) Vincenzo Carafa et al.   Clinical Epigenetics

TRAF2 is a biologically important necroptosis suppressor

(2015) S L Petersen et al.   CELL DEATH AND DIFFERENTIATION

SIRT1 inhibition in pancreatic cancer models: Contrasting effects in vitro and in vivo

(2015) Chern Ein Oon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sirtuin inhibitors, EX527 and AGK2, suppress cell migration by inhibiting HSF1 protein stability

(2015) HYUN-WOO KIM et al.   ONCOLOGY REPORTS

Correction: Discovery of a potent and highly fluorescent sirtuin inhibitor

(2015) Y. K. Yoon et al.   MedChemComm

A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulates DR5 in breast cancer cells

(2015) B Chu et al.   Cell Death & Disease

Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma

(2015) Chong Hao et al.   BMC CANCER

Nitric Oxide Down-Regulates Topoisomerase I and Induces Camptothecin Resistance in Human Breast MCF-7 Tumor Cells

(2015) Nilesh K. Sharma et al.   PLoS One

Anticancer Agents Targeted to Sirtuins

(2014) Tomohiro Kozako et al.   MOLECULES

Biological approach of anticancer activity of new benzimidazole derivatives

(2014) Katarzyna Błaszczak-Świątkiewicz et al.   Pharmacological Reports

Antitumor Effects of a Sirtuin Inhibitor, Tenovin-6, against Gastric Cancer Cells via Death Receptor 5 Up-Regulation

(2014) Sachiko Hirai et al.   PLoS One

High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients

(2014) Xiaojing Chen et al.   Scientific Reports

MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells

(2013) Lihua Zhang et al.   BMC CANCER

High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma

(2013) Albrecht Stenzinger et al.   BMC CANCER

Primary anti-proliferative activity evaluation of 1-(quinolizidin-1’-yl)methyl- and 1-( $$\omega $$ -tert-amino)alkyl-substituted 2-phenyl-, 2-benzyl- and 2-[(benzotriazol-1/2-yl)methyl]benzimidazoles on human cancer cell lines

(2013) Michele Tonelli et al.   MOLECULAR DIVERSITY

Sirtuins in stress response: guardians of the genome

(2013) L Bosch-Presegué et al.   ONCOGENE

GADD45 Proteins: Central Players in Tumorigenesis

(2012) R. E. Tamura et al.   CURRENT MOLECULAR MEDICINE

Antitumor effects of novel compound, guttiferone K, on colon cancer by p21Waf1/Cip1-mediated G0/G1cell cycle arrest and apoptosis

(2012) Winnie Lai Ting Kan et al.   INTERNATIONAL JOURNAL OF CANCER

1-Benzyl-2-Phenylbenzimidazole (BPB), a Benzimidazole Derivative, Induces Cell Apoptosis in Human Chondrosarcoma through Intrinsic and Extrinsic Pathways

(2012) Ju-Fang Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells

(2012) JING WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Synthesis and biological activity of splitomicin analogs targeted at human NAD+-dependent histone deacetylases (sirtuins)

(2011) Marcus Freitag et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Sirtuin 1 Is Upregulated in a Subset of Hepatocellular Carcinomas where It Is Essential for Telomere Maintenance and Tumor Cell Growth

(2011) J. Chen et al.   CANCER RESEARCH

PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration

(2011) Ganta Chaitanya et al.   Cell Communication and Signaling

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2

(2010) Barrie Peck et al.   MOLECULAR CANCER THERAPEUTICS

p21 does not protect cancer cells from apoptosis induced by nongenotoxic p53 activation

(2010) M Xia et al.   ONCOGENE

Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model

(2009) Ines J Marques et al.   BMC CANCER

SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer

(2009) Katsuhiko Nosho et al.   MODERN PATHOLOGY

Bcl-2 family proteins and cancer

(2008) K W Yip et al.   ONCOGENE

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect

(2008) E Lara et al.   ONCOGENE