☆ 4.5 Article

Replication protein A: directing traffic at the intersection of replication and repair

FRONTIERS IN BIOSCIENCE-LANDMARK (2010)

期刊

FRONTIERS IN BIOSCIENCE-LANDMARK

卷 15, 期 -, 页码 883-900

出版社

FRONTIERS IN BIOSCIENCE INC

DOI: 10.2741/3652

关键词

RPA; phosphorylation; DNA replication; DNA repair; DNA Damage Response; Checkpoint Activation; Review

类别

Biochemistry & Molecular Biology Cell Biology

资金

American Cancer Society [ACS RSG-06163-01-GMC, ACS RSG-10-031-01-CCG]

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Reagent

摘要

Since the initial discovery of replication protein A (RPA) as a DNA replication factor, much progress has been made on elucidating critical roles for RPA in other DNA metabolic pathways. RPA has been shown to be required for DNA replication, DNA repair, DNA recombination, and the DNA damage response pathway with roles in checkpoint activation. This review summarizes the current understanding of RPA structure, phosphorylation and protein-protein interactions in mediating these DNA metabolic processes.

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