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Cell Biology
James A. Oo, Katalin Palfi, Timothy Warwick, Ilka Wittig, Cristian Prieto-Garcia, Vigor Matkovic, Ines Tomaskovic, Frederike Boos, Judit Izquierdo Ponce, Tom Teichmann, Kirill Petriukov, Shaza Haydar, Lars Maegdefessel, Zhiyuan Wu, Minh Duc Pham, Jaya Krishnan, Andrew H. Baker, Stefan Guenther, Helle D. Ulrich, Ivan Dikic, Matthias S. Leisegang, Ralf P. Brandes
Summary: PCAT19 acts as a dynamic guardian of the endothelial genome, facilitating rapid switching from quiescence to proliferation in response to injury.
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Biochemistry & Molecular Biology
Stuart A. MacNeill
Summary: RPA is a crucial DNA binding factor in eukaryotic cells, with six OB folds and a wH domain. The similarity in structure of archaeal RPA proteins to eukaryotic RPA1 confirms their evolutionary relationship.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
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Genetics & Heredity
Yong-jie Xu, Sankhadip Bhadra, Alaa Taha A. M. Mahdi, Kamal Dev, Ilknur Yurtsever, Toru Nakamura
Summary: The study carried out an extensive genetic screen of RPA in fission yeast, identifying two mutants with partial defects in checkpoint signaling primarily at the replication fork. Additionally, several mutants with defects in other functions such as DNA repair or telomere maintenance were uncovered, providing a valuable tool for further dissecting the multiple functions of this protein.
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Biochemistry & Molecular Biology
Stefan Schuetz, Christian Bergsdorf, Benedikt Goretzki, Andreas Lingel, Martin Renatus, Alvar D. Gossert, Wolfgang Jahnke
Summary: This study utilizes Nuclear Magnetic Resonance (NMR) spectroscopy and Surface Plasmon Resonance (SPR) to investigate the interactions between the proteins MYC and MAX, and their roles in regulating cellular processes.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
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Biochemistry & Molecular Biology
Kenna Ruis, Oanh Huynh, Katrina Montales, Nina A. Barr, W. Matthew Michael
Summary: TOPBP1 is an important activator of ATR kinase that contains nine BRCT domains and an AAD domain, playing a role in ATR activation through protein-protein interactions. The delineation of TOPBP1 Junior, composed of BRCT0-2, AAD, and BRCT7 & 8, provides insight into the mechanism of ATR activation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Review
Immunology
Shuang Tang, Jie Li, Yung-Fu Chang, Wencheng Lin
Summary: Avian leukosis virus (ALV) causes various diseases, including tumor formation and decreased fertility. In addition, ALV induces immunosuppression, increasing susceptibility to other microbial infections and the risk of vaccine failure against other diseases. Evidence shows an interaction between ALV and the host.
FRONTIERS IN IMMUNOLOGY
(2022)
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Multidisciplinary Sciences
Zu Ye, Shengfeng Xu, Yin Shi, Albino Bacolla, Aleem Syed, Davide Moiani, Chi-Lin Tsai, Qiang Shen, Guang Peng, Paul G. Leonard, Darin E. Jones, Bin Wang, John A. Tainer, Zamal Ahmed
Summary: In this study, GRB2 was found to play a crucial role in DNA double-strand break repair by forming a complex with MRE11 to promote efficient homology-directed repair initiation and releasing MRE11 through ubiquitination. Depletion of RBBP6 leads to prolonged HDR defects, highlighting GRB2's importance in the repair process.
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Biochemistry & Molecular Biology
Yiling Jiang, Kuijie Tong, Roubin Yao, Yuanze Zhou, Hanwen Lin, Liubing Du, Yunyun Jin, Liu Cao, Jingquan Tan, Xing-Ding Zhang, Deyin Guo, Ji-An Pan, Xiaoxue Peng
Summary: The study identified multiple protein-protein interactions in SARS-CoV-2 viral proteins, with Nsp1 displaying the most interacting partners among all viral proteins. Specific interactions such as Nsp3.1/N, Nsp3.2/Nsp12, and Nsp10/Nsp14 were found to be bidirectional. Additionally, Nsp3.1 was shown to inhibit viral replication by interacting with N through its N-terminus.
CELL AND BIOSCIENCE
(2021)
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Virology
Satyamurthy Kundharapu, Tirumala Kumar Chowdary
Summary: Dengue virus replication relies on interactions between NS proteins, with the NS4b-NS3 interaction enhancing helicase activity. The N-terminal region of NS4b interacts with NS3, wrapping around the C-terminal subdomain of the helicase and influencing its activity.
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Multidisciplinary Sciences
Tomohiko Hara, Hidenori Nakaoka, Tomoicihiro Miyoshi, Fuyuki Ishikawa
Summary: Genomic DNA is frequently damaged by genotoxic stresses, and it is essential for organisms to possess mechanisms for repairing the damaged genome. The CST complex, initially identified as a protein complex involved in telomere maintenance, is also involved in the repair of diverse types of DNA damage induced by oxidizing agents.
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Biochemistry & Molecular Biology
B. Lev, M. Chennath, C. G. Cranfield, F. Cornelius, T. W. Allen, R. J. Clarke
Summary: The aim of this study is to identify the location of the interaction that stabilizes the E2 state of the Na+,K+-ATPase enzyme. Molecular dynamics simulations showed that the predicted salt bridge between Lys32 and Glu233 does not exist, but there are strong interactions with anionic lipid head groups. Experimental measurements and electron microscopic images suggest that this interaction is through electrostatic attraction between the N-terminus of the Na+,K+-ATPase α-subunit and negatively-charged lipid head groups of the neighboring cytoplasmic membrane surface.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
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Physiology
Yadan Zhang, Camille Rabesahala de Meritens, Astrid Beckmann, F. Anthony Lai, Spyros Zissimopoulos
Summary: This study demonstrates that pathogenic mutations in the Ryanodine receptor (RyR) decrease N-terminus domain (NTD) tetramerization, and introducing positively-charged residues can normalize the tetramerization. These findings suggest that disruption of NTD-NTD inter-subunit interactions is an underlying mechanism in RyR1 and RyR2 pathophysiology, and stabilizing this critical structure-function parameter offers therapeutic potential.
FRONTIERS IN PHYSIOLOGY
(2022)
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Materials Science, Textiles
Ivy Gan, W. S. Chow
Summary: In this study, cellulose nanocrystals were isolated from sugarcane bagasse using three different concentrations of phosphoric acid and analyzed using various techniques. The results showed that the morphology and crystallinity index of the PCNC were influenced by the concentration of phosphoric acid, providing important information for selecting the appropriate PCNC for different applications.
JOURNAL OF NATURAL FIBERS
(2021)
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Chemistry, Physical
Majid Monajjemi, Fatemeh Mollaamin, Narges Najaflou, Hossein Sakhaeinia
Summary: This study investigates the (pi-pi) interactions between (n)-Annulene solvents and graphene sheets using electronic structure methods, and finds that these interactions play a crucial role in the exfoliation process.
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A
(2022)
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Virology
Ju-Yeon Yoon, Eseul Baek, Mira Kim, Peter Palukaitis
Summary: In this study, it was found that the expression of transcription factor SHE1 was induced by tobacco mosaic virus (TMV) infection. Over-expression of SHE1 inhibited TMV accumulation. The study also revealed that SHE1 and the virus replication inhibitor (IVR) were associated with a common signaling pathway and interacted with each other.
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Pathology
Alamelu G. Bharadwaj, Joy L. Kovar, Eileen Loughman, Christian Elowsky, Gregory G. Oakley, Melanie A. Simpson
AMERICAN JOURNAL OF PATHOLOGY
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Biochemistry & Molecular Biology
Xiaoyi Deng, Aishwarya Prakash, Kajari Dhar, Gilson S. Baia, Carol Kolar, Greg G. Oakley, Gloria E. O. Borgstahl
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Biochemistry & Molecular Biology
Jason G. Glanzer, Shengqin Liu, Gregory G. Oakley
BIOORGANIC & MEDICINAL CHEMISTRY
(2011)
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Oncology
Alamelu G. Bharadwaj, Nathaniel P. Goodrich, Caitlin O. McAtee, Katie Haferbier, Gregory G. Oakley, James K. Wahl, Melanie A. Simpson
EXPERIMENTAL CELL RESEARCH
(2011)
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Biochemistry & Molecular Biology
Greg G. Oakley, Steve M. Patrick
FRONTIERS IN BIOSCIENCE-LANDMARK
(2010)
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Otorhinolaryngology
Karoline C. Manthey, Jason G. Glanzer, Diana D. Dimitrova, Greg G. Oakley
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2010)
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Gastroenterology & Hepatology
Namal P. M. Liyanage, Karoline C. Manthey, Rohana P. Dassanayake, Charles A. Kuszynski, Gregory G. Oakley, Gerald E. Duhamel
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Biochemistry & Molecular Biology
Xiujuan Zhu, Ferhat Ozturk, ChangChih Liu, Gregory G. Oakley, Ali Nawshad
JOURNAL OF CELLULAR BIOCHEMISTRY
(2012)
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Oncology
Ling Wang, Adam J. Mosel, Gregory G. Oakley, Aimin Peng
MOLECULAR CANCER THERAPEUTICS
(2012)
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Biochemistry & Molecular Biology
Jason G. Glanzer, Katie A. Carnes, Patricia Soto, Shengqin Liu, Lawrence J. Parkhurst, Gregory G. Oakley
NUCLEIC ACIDS RESEARCH
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Biochemistry & Molecular Biology
Shengqin Liu, Stephen O. Opiyo, Karoline Manthey, Jason G. Glanzer, Amanda K. Ashley, Courtney Amerin, Kyle Troksa, Meena Shrivastav, Jac A. Nickoloff, Greg G. Oakley
NUCLEIC ACIDS RESEARCH
(2012)
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Cell Biology
Karoline C. Manthey, Stephen Opiyo, Jason G. Glanzer, Diana Dimitrova, James Elliott, Gregory G. Oakley
JOURNAL OF CELL SCIENCE
(2007)
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Genetics & Heredity
S Cruet-Hennequart, S Coyne, MT Glynn, GG Oakley, MP Carty
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Biochemistry & Molecular Biology
JE Nuss, SM Patrick, GG Oakley, GM Alter, JG Robison, K Dixon, JJ Turchi