Article
Oncology
Tianlan Xi, Ruiyu Wang, Damao Pi, Jing Ouyang, Jiadan Yang
Summary: In this study, leonurine (LE) was found to inhibit myocardial fibrosis (MF) by regulating the expression of miR-29a-3p and p53. LE effectively inhibited collagen synthesis and myofibroblast generation, and promoted apoptosis in cardiac fibroblasts (CFs) stimulated by angiotensin II (Ang II).
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Ryan M. Burke, Ronald A. Dirkx, Pearl Quijada, Janet K. Lighthouse, Amy Mohan, Meghann O'Brien, Wojciech Wojciechowski, Collynn F. Woeller, Richard P. Phipps, Jeffrey D. Alexis, John M. Ashton, Eric M. Small
Summary: Salinomycin as an antifibrotic agent demonstrates potent anti-fibrotic activity in cardiac fibroblasts, prevents cardiac fibrosis and functional decline in mouse models of ischemic and nonischemic heart disease, and inhibits cardiac fibroblast activation by targeting p38/MAPK and Rho signaling. Moreover, salinomycin promotes cardiomyocyte survival and improves coronary vessel density, showing promise for the treatment of heart failure patients.
CIRCULATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Xiao-Han Tang, Jessica Gambardella, Stanislovas Jankauskas, Xujun Wang, Gaetano Santulli, Lorraine J. Gudas, Roberto Levi
Summary: AC261066 attenuates post-MI cardiac dysfunction and maladaptive remodeling by modulating a set of genes involved in oxidant/antioxidant balance. This suggests that RAR beta(2) could be a potential pharmacological target for the treatment of HF, as MI is a major cause of this condition.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Article
Cardiac & Cardiovascular Systems
Moritz Schnelle, Iain Sawyer, Narayana Anilkumar, Belal A. Mohamed, Daniel A. Richards, Karl Toischer, Min Zhang, Norman Catibog, Greta Sawyer, Heloise Mongue-Din, Katrin Schroeder, Gerd Hasenfuss, Ajay M. Shah
Summary: The study found that Nox4 plays a significant role in cardiac remodeling induced by volume overload, involving the activation of Akt and downstream targets S6 and 4E-BP1.
CARDIOVASCULAR RESEARCH
(2021)
Article
Chemistry, Medicinal
Xingxing Chen, Xue Xia, Tiancheng Dong, Zhiwei Lin, Leilei Du, Hao Zhou
Summary: The study investigated the potential impact of TMZ on cardiac fibrosis by inhibiting NOX2-mediated EndMT. Results showed that TMZ treatment mitigated cardiac fibrosis and improved left ventricular dysfunction by suppressing NOX activity and EndMT. The study suggests that TMZ may play a role in preventing ISO-induced cardiac fibrosis through the NOX2/NF-Kappa B/Snail pathway.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Nicholas W. Chavkin, Soichi Sano, Ying Wang, Kosei Oshima, Hayato Ogawa, Keita Horitani, Miho Sano, Susan MacLauchlan, Anders Nelson, Karishma Setia, Tanvi Vippa, Yosuke Watanabe, Jeffrey J. Saucerman, Karen K. Hirschi, Noyan Gokce, Kenneth Walsh
Summary: The study showed that Ror1/2 play a crucial role in the differentiation of cardiac myofibroblasts and in the adaptive remodeling of the heart in response to pressure overload. These findings provide new insights into cardiac fibrosis research and potential therapeutic strategies.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Seong Ji Woo, Youngmi Kim, Harry Jung, Jae Jun Lee, Ji Young Hong
Summary: In this study, we found that miR-148a may protect against tuberculous pleural fibrosis by inhibiting the expression of NOX4 and POLDIP2, and reducing fibrogenesis and epithelial mesenchymal transition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Eder Anderson Rodrigues, Aline Regina Ruiz Lima, Mariana Janini Gomes, Lidiane Moreira Souza, Thierres Hernani Dias Pontes, Luana Urbano Pagan, Gilson Masahiro Murata, Felipe Cesar Damatto, Igor Carvalho Depra, Amanda Bergamo Goncalves Castro Rego, David Rafael Abreu Reyes, Leonardo Antonio Mamede Zornoff, Katashi Okoshi, Marina Politi Okoshi
Summary: Exercise plays an important role in preventing and treating cardiac remodeling and heart failure caused by myocardial infarction. This study investigated the effects of resistance exercise on structural, functional, and molecular alterations in infarcted rats. The results showed that resistance exercise improved maximum load-carrying capacity, reduced myocardial oxidative stress, and preserved myocardial metabolism, without changing cardiac structure or left ventricular function in infarcted rats.
Article
Cardiac & Cardiovascular Systems
Wan-Tseng Hsu, Ya-Hsuan Tseng, Hsiang-Yiang Jui, Chen-Chin Kuo, Kenneth K. Wu, Chii-Ming Lee
Summary: The study showed that exogenous 5-MTP administration can reduce infarct area and myocardial apoptosis, alleviate systolic dysfunction and left ventricular dilatation, and decrease myocardial fibrosis, thus protecting the heart from oxidative stress.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Medicine, Research & Experimental
Jinchao Song, Jiankui Du, Xing Tan, Yang Li, Qing Yu, Wen Liu, Xiaoyan Zhu, Binhai Cong
Summary: Tissue kallikrein-related peptidase8 (KLK8) has been found to aggravate cardiac remodeling in response to acute myocardial ischemia-reperfusion (IR) injury. KLK8 overexpression enhances cardiac dysfunction, fibrosis, and hypertrophy after IR injury, possibly mediated by the epidermal growth factor receptor (EGFR) signaling in cardiac fibroblasts (CFs). This study highlights the importance of KLK8 in cardiac remodeling after myocardial infarction.
Article
Pharmacology & Pharmacy
Trenton E. Banks, Maheshinie Rajapaksha, Li-Hui Zhang, Feng Bai, Ning-Ping Wang, Zhi-Qing Zhao
Summary: This study found that stabilizing GLP-1 levels can reduce Ang II-induced cardiac fibrosis and high blood pressure by inhibiting NOX4 expression and preserving mitochondrial integrity.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Min Zhang, Min Zhang, Ting Zhou, Meilin Liu, Ni Xia, Muyang Gu, Tingting Tang, Shaofang Nie, Zhengfeng Zhu, Bingjie Lv, Jiao Jiao, Xiangping Yang, Xiang Cheng
Summary: ACKR4 plays a critical role in cardiac remodeling post-myocardial infarction by regulating IL-6 production in cardiac fibroblasts and endothelial cell functions to inhibit cardiac fibrosis. Targeting ACKR4 may offer a novel therapeutic strategy for ameliorating cardiac remodeling.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Cardiac & Cardiovascular Systems
Maya Learmonth, Alexa Corker, Shaoni Dasgupta, Kristine Y. DeLeon-Pennell
Summary: This review focuses on the regulation of cardiac fibrosis by lymphocyte subsets, particularly CD4(+) and CD8(+) T cells, and their effects on fibroblasts and cardiac remodeling. It also highlights the need for further exploration of the interactions between T cells and fibroblasts for understanding and treating cardiac fibrosis and heart failure.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Rongheng Liao, Bo Xie, Jun Cui, Zhen Qi, Song Xue, Yongyi Wang
Summary: The study identified the crucial role of E2F1 in TGF-beta 1-induced HCFs differentiation, involving the targeting of the CCNE2 gene. Therefore, E2F1 and its downstream target gene CCNE2 may serve as potential therapeutic targets for cardiac fibrosis.
Article
Pharmacology & Pharmacy
Meifang Wu, Yanguang Guo, Ying Wu, Kaizu Xu, Liming Lin
Summary: Sacubitril/valsartan has a significant improvement on cardiac function and fibrosis in rats after experimental myocardial infarction, by inhibiting collagen synthesis in myocardial fibroblasts through the suppression of the TGF/Smads signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Guo-Hua Zhu, Lu Liu, Xi-Xi Huang, Da-Jin Li, Yi-Zhun Zhu, Xin Lu, Mei-Rong Du
Summary: This article reviews the impact of novel coronavirus infection on pregnancy, elucidates the mechanisms by which immune-related changes may lead to fetal loss, and discusses the role of SARS-CoV-2 in the female reproductive system and existing evidence of infection in pregnant women.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Zhongxiao Lin, Jishuo Chang, Xinzhi Li, Jianglin Wang, Xiaodan Wu, Xiaoyan Liu, YiZhun Zhu, Xi-Yong Yu
Summary: In this study, epigenetic modifications including DNA methylation play a crucial role in the development of cardiovascular diseases, particularly heart failure. Through analysis of DNA methylation and gene expression levels in failing hearts of rats surviving myocardial infarction, a large number of differentially methylated genes and transcriptome-altered genes were identified, potentially serving as important regulators in heart failure.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2022)
Article
Biochemistry & Molecular Biology
Yun-Yun Li, Yi-Kong Lin, Yue Li, Xin-Hua Liu, Da-Jin Li, Xiao-Lin Wang, Li Wang, Yi-Zhun Zhu, Min Yu, Mei-rong Du
Summary: This study found that Tregs were increased in the peritoneal fluid of EMS patients, accompanied by overactivation of estrogen-ER alpha. SCM-198 could reverse the expansion of Tregs induced by estrogen-ER alpha and reduce their invasion and viability effects on eESCs. In vivo experiments confirmed that SCM-198 significantly retarded the growth of ectopic lesions.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Qiuyan Zhang, Zhuqing Shen, Yaqi Shen, Muye Ma, Hao Jue, Yizhun Zhu, Wei Guo
Summary: Hydrogen sulfide (H2S) plays a role in oxidative stress induced hypoxia by regulating CBS expression through miR-203. miR-203 can protect cells from injury by regulating lipid peroxidation, cell apoptosis, and mitochondrial membrane potential. Overexpression of miR-203 may exacerbate cell injury, while inhibition of miR-203 can provide protection against cell injury induced by oxidative stress.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jian-mei Gao, Xun Zhang, Guo-tao Shu, Na-na Chen, Jian-yong Zhang, Fan Xu, Fei Li, Yuan-gui Liu, Yu Wei, Yu-qi He, Jing-shan Shi, Qi-hai Gong
Summary: This study demonstrates that trilobatin (TLB) has neuroprotective effects in experimental models of Alzheimer's disease (AD) by inhibiting inflammation and restoring redox balance.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Pharmacology & Pharmacy
Congjian Ma, Yanjun Deng, Ran Xiao, Fan Xu, Mobai Li, Qihai Gong, Jianmei Gao
Summary: The study found that Phlorizin (PHZ) has positive effects on fatigue, as it can alleviate fatigue and improve exercise endurance. PHZ achieves these effects by reducing reactive oxygen species, enhancing antioxidant enzyme activity, and regulating apoptosis-related factors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jianmei Gao, Congjian Ma, Dianya Xia, Nana Chen, Jianyong Zhang, Fan Xu, Fei Li, Yuqi He, Qihai Gong
Summary: This study demonstrates that ICS II preconditioning provides neuroprotection against ischaemic stroke by enhancing Nrf2 activity, which alleviates brain injury and promotes long-term recovery.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Weiwei Rong, Jiejia Li, Dingyi Pan, Qinbei Zhou, Yexuan Zhang, Qianxing Lu, Liyun Wang, Andong Wang, Yizhun Zhu, Qing Zhu
Summary: In this study, metabolomics approach was used to investigate the protective effects of leonurine on myocardial ischemia. The results showed that leonurine regulates the metabolism of glycine, serine and threonine, purine, fatty acids, and amino acids in the liver and heart, leading to reduced myocardial injury during myocardial ischemia.
Article
Biochemistry & Molecular Biology
Haiyan Xi, Chenye Wang, Qixiu Li, Qing Ye, Yizhun Zhu, Yicheng Mao
Summary: This study aims to investigate the pro-angiogenic ability of S-Propargyl-cysteine (SPRC) and its potential mechanisms in peripheral nerve repair. The effects of SPRC on peripheral nerve repair were examined using animal models and in vitro cell experiments. SPRC was found to accelerate the recovery of injured nerves and promote angiogenesis. It activated the expression of SIRT1 and regulated Notch signaling, resulting in enhanced angiogenesis. This study provides evidence that SPRC could be an effective medical therapy for peripheral nerve injury through microvascular reconstruction.
Article
Nutrition & Dietetics
Meng Liu, Yuhui Wang, Guoqiang Guan, Xi Lu, Yizhun Zhu, Xiaoqun Duan
Summary: This study explores the impact of a complex dietary fiber supplement called Ancientino on ulcerative colitis. The results show that Ancientino alleviates colitis by reducing inflammatory response, suppressing oxidative stress, and repairing intestinal barrier function, indicating its potential as an effective therapeutic resource for ulcerative colitis.
Review
Biochemistry & Molecular Biology
Menglin Zhu, Qian Ding, Zhongxiao Lin, Rong Fu, Fuyuan Zhang, Zhaoyi Li, Mei Zhang, Yizhun Zhu
Summary: Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes joint damage and disability, greatly impacting patients' quality of life. Although a complete cure is not currently possible, measures to relieve symptoms and reduce pain are used. RA can be induced by environmental factors, genes, and gender. Common treatments include non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, and glucocorticoids. Some biological agents have been used but often have side effects. Therefore, the search for new mechanisms and targets for treating RA is crucial.
Review
Biochemistry & Molecular Biology
Asrar Alsaeedi, Simon Welham, Peter Rose, Yi-Zhun Zhu
Summary: Mammalian cells and tissues have the ability to produce hydrogen sulfide gas (H2S) through cysteine metabolism. H2S plays roles in cell signaling cascades essential in many biochemical and physiological processes in various organs and systems of mammals. Reduced levels of H2S are observed in several pathophysiological conditions, and it has been discovered that certain commonly prescribed drugs can affect the enzymes responsible for H2S production. Therefore, this review summarizes the studies on key drugs and their impact on H2S production in mammals.
Article
Biochemistry & Molecular Biology
Xiaoyu Wu, Jiajia Wei, Yang Yi, Guotao Shu, Zhixu He, Qihai Gong, Jianmei Gao
Summary: Cerebral ischemia/reperfusion (CIR) leads to neuronal damage through neuroinflammation and oxidative stress. The ROS/NLRP3/pyroptosis axis plays a crucial role in CIR pathogenesis. Epimedium (EP), containing active ingredients, has shown potential pharmacological activities. In this study, EP was found to protect against CIR by reducing oxidative stress and neuroinflammation through inhibition of the ROS/NLRP3/pyroptosis axis. The main compounds of EP directly interacted with NLRP3 as a potential therapeutic target for cerebral protection.
Article
Pharmacology & Pharmacy
Yeli Li, Linying Feng, Dianyou Xie, Yunmei Luo, Mu Lin, Jianmei Gao, Yuandong Zhang, Zhixu He, Yi Zhun Zhu, Qihai Gong
Summary: This study demonstrated that post-treatment with icariside II can alleviate myocardial infarction (MI) by promoting mitochondrial fusion, suppressing mitochondrial fission, and reducing oxidative stress. These effects were achieved by activating the Nrf2/SIRT3 signaling pathway. These findings suggest that icariside II may be a potential therapeutic option for MI.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mu Guo, Xiangbin Yu, Yi Zhun Zhu, Yue Yu
Summary: This review summarizes the main pharmacological effects and mechanisms of imidazothiazole derivatives, which have biological effects such as antitumor, anti-infection, anti-inflammatory, and antioxidant effects. The contents summarized herein aim to advance the research and rational development of imidazothiazole-based drugs in the future.
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)