Article
Cell Biology
Gabrielle Schanne, Martha Zoumpoulaki, Geraldine Gazzah, Amandine Vincent, Hugues Preud'homme, Ryszard Lobinski, Sylvie Demignot, Philippe Seksik, Nicolas Delsuc, Clotilde Policar
Summary: Oxidative stress is important in the pathogenesis of inflammatory bowel diseases (IBDs). Superoxide dismutase (SOD) defenses are weakened in IBD patients. A Mn(II) complex SOD mimic (Mn1) based on an open-chain diaminoethane ligand has antioxidant and anti-inflammatory effects. Metal exchanges occur between the manganese center and metal ions in the biological environment. New Mn(II) complexes with cyclohexyl and/or propyl groups show improved SOD activity and kinetic inertness in metal ion exchange processes. They provide anti-inflammatory and antioxidant effects in cells at lower doses than Mn1.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Katarina Valachova, Peter Rapta, Nuno M. M. Moura, Ines Batinic-Haberle, Ladislav Soltes
Summary: The study investigated ways to enhance the degradation of hyaluronic acid into low-molecular fragments to boost the immune system's ability to combat tumor growth. Results showed that certain Mn(III) porphyrins, through redox cycling with ascorbate, could produce reactive oxygen species essential for hyaluronan degradation, providing further insights into the anticancer potential of these compounds in high oxidative stress environments within tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Clotilde Policar, Jean Bouvet, Helene C. Bertrand, Nicolas Delsuc
Summary: Superoxide dismutases (SODs) are metalloproteins that protect cells from oxidative stress by controlling the concentration of superoxide. Recent studies have shown that some SOD mimics designed to react with superoxide could indirectly enhance cellular antioxidant defenses. Understanding the bioactivity of these SOD mimics requires information on their cell-penetration, speciation, and subcellular location.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2022)
Review
Chemistry, Inorganic & Nuclear
Oishi Mallick Ganguly, Shuvojit Moulik
Summary: Manganese (Mn) is a bio-metal that plays a crucial role in various bodily functions, including tissue formation, metabolism, calcium absorption, and brain function. It also acts as an antioxidant and has been investigated as a potential treatment for cancer and infectious diseases. Recent studies have shown that synthetic Mn-complexes have antibacterial and antifungal properties. In addition, their interactions and nuclease activities with DNA are being explored for their therapeutic applications.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Micaela Richezzi, Sharon Signorella, Claudia Palopoli, Nora Pellegri, Christelle Hureau, Sandra R. Signorella
Summary: The flexibility of the ligand plays a crucial role in tuning the reactivity of Mn SOD mimics, and immobilization techniques can enhance the stability and activity of the catalyst.
Article
Chemistry, Physical
Mohamed M. Ibrahim, Maged A. El-Kemary, Sami A. Al-Harbi, Hamed M. Al-Saidi, Shehab A. Sallam, Abd El-Motaleb M. Ramadan
Summary: The interaction of 2-picolylamine with Mn(II), Fe(III) and Co(II) chlorides in an ethanolic solution forms two types of metal chelates. Structural analysis reveals the molecular structure of these metal chelates, and ligand substitution studies suggest their catalytic activity as SOD mimics. The ability of these metal chelates to scavenge superoxide anions was confirmed through kinetic studies and thermodynamic considerations.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Clinical Neurology
Waleed M. Renno, Ludmil Benov, Khalid M. Khan
JOURNAL OF NEUROSURGERY-SPINE
(2017)
Article
Biochemistry & Molecular Biology
Sara Moghnie, Artak Tovmasyan, James Craik, Ines Batinic-Haberle, Ludmil Benov
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2017)
Article
Oncology
Khazna Alenezi, Artak Tovmasyan, Ines Batinic-Haberle, Ludmil T. Benov
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2017)
Article
Biochemistry & Molecular Biology
Artak Tovmasyan, Jacqueline C. Bueno-Janice, Melba C. Jaramillo, Romulo S. Sampaio, Julio S. Reboucas, Natalia Kyui, Ludmil Benov, Brian Deng, Ting-Ting Huang, Margaret E. Tome, Ivan Spasojevic, Ines Batinic-Haberle
ANTIOXIDANTS & REDOX SIGNALING
(2018)
Article
Biochemistry & Molecular Biology
Sebastian Carballal, Valeria Valez, Damian Alvarez-Paggi, Artak Tovmasyan, Ines Batinic-Haberle, Gerardo Ferrer-Sueta, Daniel H. Murgida, Rafael Radi
FREE RADICAL BIOLOGY AND MEDICINE
(2018)
Article
Multidisciplinary Sciences
Malak Charara, Artak Tovmasyan, Ines Batinic-Haberle, James Craik, Ludmil Benov
Article
Microbiology
Rawan Al-Mutairi, Artak Tovmasyan, Ines Batinic-Haberle, Ludmil Benov
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Multidisciplinary Sciences
Ludmil Benov
Article
Biochemistry & Molecular Biology
Artak Tovmasyan, Ines Batinic-Haberle, Ludmil Benov
Review
Cell Biology
Ines Batinic-Haberle, Artak Tovmasyan, Zhiqing Huang, Weina Duan, Li Du, Sharareh Siamakpour-Reihani, Zhipeng Cao, Huaxin Sheng, Ivan Spasojevic, Angeles Alvarez Secord
Summary: MnPs were initially developed as SOD mimics but later found to react with various reactive species and modify protein activities through oxidation, affecting both normal and cancer cells. Lead Mn porphyrins have been tested in various injury and cancer models, with some progressing to clinical trials for glioma, head and neck cancer, anal cancer, and other conditions.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
Luksana Chaiswing, Chontida Yarana, William St Clair, Artak Tovmasyan, Ines Batinic-Haberle, Ivan Spasojevic, Daret St Clair
Summary: This study used a redox-active MnP compound to investigate the redox status of ovarian cancer cells. The results showed that chemotherapy-resistant cells were under higher oxidative stress and had increased glycolysis activity and mitochondrial respiration. Altering the redox state could effectively inhibit the growth and metabolic activity of these cells.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Pharmacology & Pharmacy
Tigran Margaryan, Mackenna Elliott, Nader Sanai, Artak Tovmasyan
Summary: A sensitive and rapid LC-MS/MS method was developed for quantifying LY3214996, abemaciclib, and their metabolites in human samples. The method was successfully applied in a clinical trial.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Katherine L. Houlihan, Petros P. Keoseyan, Amber N. Juba, Tigran Margaryan, Max E. Voss, Alexander M. Babaoghli, Justin M. Norris, Greg J. Adrian, Artak Tovmasyan, Lori M. Buhlman
Summary: Loss-of-function parkin mutations lead to oxidative stress and degeneration of dopaminergic neurons. In this study, the researchers found that the absence of parkin in fruit flies resulted in sustained increase of mitochondrial hydrogen peroxide levels in vulnerable neurons, as well as dysregulation of glutathione redox equilibrium. Supplementation of folic acid improved these abnormalities but did not mitigate whole-brain oxidative stress.
Article
Biochemistry & Molecular Biology
Milini Thomas, Ludmil Benov
BIOLOGICAL TRACE ELEMENT RESEARCH
(2018)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
