Antibacterial Activity of Synthetic Cationic Iron Porphyrins

Fe Porphyrin-Based SOD Mimic and Redox-Active Compound, (OH)FeTnHex-2-PyP4+, in a Rodent Ischemic Stroke (MCAO) Model: Efficacy and Pharmacokinetics as Compared to Its Mn Analogue, (H2O)MnTnHex-2-PyP5+

(2020) Litao Li et al.   Antioxidants

Thiol regulation by Mn porphyrins, commonly known as SOD mimics

(2019) Ines Batinic-Haberle et al.   Redox Biology

First in Human Clinical Trial of a Metalloporphyrin Dual Radioprotectant and Radiosensitizer, BMX-001, in Newly Diagnosed High-Grade Glioma Undergoing Concurrent Chemoradiation

(2019) K.B. Peters et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Effect of growth media on the MTT colorimetric assay in bacteria

(2019) Ludmil Benov   PLoS One

25 years of development of Mn porphyrins — from mimics of superoxide dismutase enzymes to thiol signaling to clinical trials: The story of our life in the USA

(2019) Ines Batinic-Haberle et al.   JOURNAL OF PORPHYRINS AND PHTHALOCYANINES

Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate

(2018) Artak Tovmasyan et al.   ANTIOXIDANTS & REDOX SIGNALING

ACTR-28. PHASE 1 DOSE ESCALATION TRIAL OF THE SAFETY OF BMX-001 CONCURRENT WITH RADIATION THERAPY AND TEMOZOLOMIDE IN NEWLY DIAGNOSED PATIENTS WITH HIGH-GRADE GLIOMAS

(2018) Katherine Peters et al.   NEURO-ONCOLOGY

Photoantimicrobials—are we afraid of the light?

(2017) Mark Wainwright et al.   LANCET INFECTIOUS DISEASES

Cationic amphiphilic Zn-porphyrin with high antifungal photodynamic potency

(2017) Sara Moghnie et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Optimizing Zn porphyrin-based photosensitizers for efficient antibacterial photodynamic therapy

(2017) Khazna Alenezi et al.   Photodiagnosis and Photodynamic Therapy

Important cellular targets for antimicrobial photodynamic therapy

(2016) Mariam M. Awad et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Antimicrobial photodynamic inactivation: a bright new technique to kill resistant microbes

(2016) Michael R Hamblin   CURRENT OPINION IN MICROBIOLOGY

A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics

(2015) Artak Tovmasyan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Amphiphilic cationic Zn-porphyrins with high photodynamic antimicrobial activity

(2015) Milini Thomas et al.   Future Microbiology

Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450

(2015) John A. McIntosh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Simple Biological Systems for Assessing the Activity of Superoxide Dismutase Mimics

(2013) Artak Tovmasyan et al.   ANTIOXIDANTS & REDOX SIGNALING

Differential Coordination Demands in Fe versus Mn Water-Soluble Cationic Metalloporphyrins Translate into Remarkably Different Aqueous Redox Chemistry and Biology

(2013) Artak Tovmasyan et al.   INORGANIC CHEMISTRY

A Combination of Two Antioxidants (An SOD Mimic and Ascorbate) Produces a Pro-Oxidative Effect Forcing Escherichia coli to Adapt Via Induction of oxyR Regulon

(2012) Ines Batinic-Haberle et al.   Anti-Cancer Agents in Medicinal Chemistry

Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(iii) N-methoxyalkylpyridylporphyrins

(2011) Artak G. Tovmasyan et al.   DALTON TRANSACTIONS

Structural analysis of heme proteins: implications for design and prediction

(2011) Ting Li et al.   BMC STRUCTURAL BIOLOGY

Overcoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens

(2010) L. L. Anzaldi et al.   INFECTION AND IMMUNITY

High Lipophilicity of meta Mn(III)N-Alkylpyridylporphyrin-Based Superoxide Dismutase Mimics Compensates for Their Lower Antioxidant Potency and Makes Them as Effective as Ortho Analogues in Protecting Superoxide Dismutase-DeficientEscherichia coli

(2009) Ivan Kos et al.   JOURNAL OF MEDICINAL CHEMISTRY

Direct evidence for an iron(iv)-oxo porphyrin π-cation radical as an active oxidant in catalytic oxygenation reactions

(2008) Ah-Rim Han et al.   CHEMICAL COMMUNICATIONS

Metalloporphyrins and Functional Analogues as MRI Contrast Agents

(2008) Yicheng Ni   Current Medical Imaging Reviews

Clinical and economic burden of antimicrobial resistance

(2008) Lisa L Maragakis et al.   Expert Review of Anti-Infective Therapy

The Epidemic of Antibiotic-Resistant Infections: A Call to Action for the Medical Community from the Infectious Diseases Society of America

(2007) B. Spellberg et al.   CLINICAL INFECTIOUS DISEASES