Review
Biochemistry & Molecular Biology
Qi Liu, Lei Wang, Dongxia He, Yuewei Wu, Xian Liu, Yahan Yang, Zhizhi Chen, Zhan Dong, Ying Luo, Yuzhu Song
Summary: Antimicrobial peptides, as a potential treatment for gastrointestinal cancers, have unique anticancer mechanisms, including specific killing of tumor cells, low drug resistance, and high specificity. Modification and design of antimicrobial peptides can enhance their anticancer effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Xin Li, Siyao Zuo, Bin Wang, Kaiyu Zhang, Yang Wang
Summary: Antimicrobial peptides, widely present in nature, are a type of small-molecule peptide that serve as innate immune components in almost all living organisms. They exhibit broad-spectrum antibacterial activities against bacteria, fungi, viruses, and other microorganisms. Being effective against antibiotic-resistant strains and not easily inducing drug resistance, they have become a hot spot in medical research and hold potential as a new approach for combating microbial infections and drug-resistant bacteria.
Review
Medicine, General & Internal
Qi-Yu Zhang, Zhi-Bin Yan, Yue-Ming Meng, Xiang-Yu Hong, Gang Shao, Jun-Jie Ma, Xu-Rui Cheng, Jun Liu, Jian Kang, Cai-Yun Fu
Summary: Antimicrobial peptides (AMPs) are a promising candidate to combat antibiotic resistant bacteria, showing broad-spectrum antimicrobial activity with low toxicity and utilizing sophisticated mechanisms of action. This comprehensive review provides an overview of the origin, structural characteristics, mechanisms of action, biological activities, and clinical applications of AMPs. Strategies to optimize and develop AMP-based treatments for potential antimicrobial and anticancer therapeutics are also discussed.
MILITARY MEDICAL RESEARCH
(2021)
Article
Biophysics
Emanuelle D. Freitas, Rogerio A. Rataglioli, Josephine Oshodi, Marisa M. Beppu
Summary: The coronavirus pandemic has highlighted the importance of bioactive materials in mitigating viral infections. Bioinspired antimicrobial peptides (AMPs) have emerged as suitable building blocks for antimicrobial coatings due to their versatile design and environmentally friendly features. This review discusses the advances and opportunities in using AMPs to create virucidal coatings, including the fundamental characteristics of peptide structure, advances in coating medical devices, and the role of different materials in designing antiviral coatings.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Food Science & Technology
Laila N. Shwaiki, Kieran M. Lynch, Elke K. Arendt
Summary: Synthetic antimicrobial peptides based on plant AMPs are being developed as potential food preservatives, with a focus on enhancing their antimicrobial activity and stability. While the cost of synthesis may be a drawback, advancements in technology may fully exploit the potential role of these synthetic AMPs in combating food spoilage and waste in the long term.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Christian Anumudu, Abarasi Hart, Taghi Miri, Helen Onyeaka
Summary: Conventional thermal and chemical treatments in food preservation are being questioned by consumers who seek minimally processed and chemically-free foods. Antimicrobial peptides (AMPs) like bacteriocins and nisin offer a natural and effective alternative to prevent microbial growth in foods, especially spore-forming bacteria. When combined with other non-thermal treatments, such as high pressure or supercritical carbon dioxide, AMPs exhibit a synergistic effect in inactivating microbial spores, highlighting their potential for food safety and shelf-life extension.
Review
Biochemistry & Molecular Biology
Qian Chen, Jing Wu, Xiang Li, Ziyi Ye, Hailong Yang, Lixian Mu
Summary: This article reviews the properties, mechanisms, and potential applications of natural anticancer substances from amphibian skin, aiming to advance the identification and therapeutic use of these agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Thanh-Do Le, Itthanan Suttikhana, Tolulope Joshua Ashaolu
Summary: Food-derived peptides (FDPs) are gaining popularity due to their health benefits. Conventional techniques for studying FDPs are cumbersome, costly, and slow, leading to the development of unconventional or bioinformatic approaches. These methods help predict FDPs formation and analyze their structure-activity relationships. This review focuses on non-conventional production strategies, especially using in silico approaches, and explores the factors that affect the functions of FDPs.
FOOD HYDROCOLLOIDS
(2023)
Article
Food Science & Technology
Jose J. L. Silva, Maria R. A. de Miranda, Pedro F. N. Souza
Summary: Fungal contamination is a major cause of food spoilage, posing serious risks to human health and economic losses. This review discusses the recent advances in using synthetic peptides as agents to address foodborne fungal resistance and their applications in food preservation.
CURRENT OPINION IN FOOD SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Beatriz Lima, Maria Ricci, Adriana Garro, Tunde Juhasz, Imola Csilla Szigyarto, Zita Papp, Gabriela Feresin, Jose Garcia de la Torre, Javier Lopez Cascales, Livia Fulop, Tamas Beke-Somfai, Ricardo D. Enriz
Summary: A theoretical and experimental study was conducted on a new series of small-sized antibacterial peptides, showing that these peptides have a unique mechanism of action and pharmacophoric requirements. Evaluation of physiochemical parameters modulating antimicrobial activity and biophysical characterization of the peptides revealed important insights for designing new antibacterial peptides with specific structural characteristics.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2021)
Review
Chemistry, Medicinal
Jose Maria Garcia-Beltran, Marta Arizcun, Elena Chaves-Pozo
Summary: Aquaculture production is increasing, but infectious diseases pose a threat. Antimicrobial peptides (AMPs) from photosynthetic marine organisms have potential as alternatives to antibiotics in aquaculture due to their defense mechanisms and additional activities. This study reviews the knowledge about AMPs from photosynthetic marine organisms and evaluates their suitability for aquaculture.
Review
Food Science & Technology
Laila N. Shwaiki, Elke K. Arendt, Kieran M. Lynch
Summary: The modern approach to food preservation involves various hurdles for microbial pathogens to overcome, including thermal processes, chemical additives, irradiation, and modified atmosphere packaging. Plant compounds and peptides, particularly antimicrobial peptides, show promise as novel natural food preservatives. Further studies are needed to fully explore their potential in reducing food losses and waste.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Tiantian Tian, Wansheng Xie, Luxuan Liu, Siting Fan, Heqian Zhang, Zhiwei Qin, Chao Yang
Summary: In recent years, the emergence and development of antimicrobial peptides have been driven by the increasing drug resistance to traditional antibiotics. These peptides have gained considerable attention from scientists due to their high potency in combatting infectious pathogens. This review provides a summary of the mechanisms of action and structure-activity relationship of antimicrobial peptides, as well as their biological applications in various fields.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Rachita Dash, Surajit Bhattacharjya
Summary: Thanatin, an AMP with broad-spectrum activity, shows high potency in inhibiting the growth of bacteria and fungi at considerably low concentrations. Recent interest has been focused on understanding its modes of action, in vivo activity, and therapeutic potential against drug-resistant pathogens. Further research is needed to develop novel molecules for treating infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Mohsen Akbarian, Ali Khani, Sara Eghbalpour, Vladimir N. Uversky
Summary: This article reviews the various production methods and sources of bioactive peptides, explores their applications in antimicrobial, antioxidant, and blood-lipid-lowering effects, and discusses the future prospects of bioactive peptides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Ayesha Lone, Walid Mottawea, Youcef Mehdi, Riadh Hammami
Summary: The livestock industry is seeking alternatives to antibiotics to maintain productivity and health, with a particular focus on bacteriocinogenic probiotics that can produce bacteriocins to benefit the host. These probiotics have promising features in inhibiting pathogens, improving animal health, and being safe for consumption. Additional research is needed to further understand the safety and effectiveness of these probiotics in livestock.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biotechnology & Applied Microbiology
Camille Cavestri, Patricia Savard, Ismail Fliss, Jean-Guillaume Emond-Rheault, Jeremie Hamel, Irena Kukavica-Ibrulj, Brian Boyle, France Daigle, Danielle Malo, Sadjia Bekal, Linda J. Harris, Roger C. Levesque, Lawrence Goodridge, Gisele LaPointe
Summary: This study evaluated the survival capability of high and low virulence Salmonella strains in a simulated gastrointestinal environment. Results showed that high virulence strains had a significantly better survival rate, possibly due to their enhanced acid and bile resistance.
Article
Microbiology
Soufiane Telhig, Laila Ben Said, Carmen Torres, Sylvie Rebuffat, Severine Zirah, Ismail Fliss
Summary: Microcins have broad-spectrum antibacterial activities against Enterobacteriaceae resistant to antibiotics and show synergistic effects with antibiotics, especially colistin. They exhibit potent antibacterial activity against closely related bacteria, independent of antibiotic resistance profile and strain genus. Combining microcins with antibiotics can enhance therapeutic efficacy.
MICROBIOLOGY SPECTRUM
(2022)
Review
Infectious Diseases
Md Ramim Tanver Rahman, Ismail Fliss, Eric Biron
Summary: The overuse and misuse of antibiotics has led to the rise and spread of multidrug-resistant bacteria. Many countries have restricted the use of antibiotics and promoted the development of alternatives to address this global public health threat. In food-animal production, various alternatives to antibiotics have been identified and studied. However, there are still limitations in their use and concerns about resistance development.
Article
Biochemistry & Molecular Biology
Mira Abou-Diab, Jacinthe Thibodeau, Ismail Fliss, Pascal Dhulster, Laurent Bazinet, Naima Nedjar
Summary: This study successfully produced discolored and demineralized bovine hemoglobin hydrolysates without the addition of chemical agents using an optimized multi-step process of electrodialysis with bipolar membranes (EDBM). The hydrolysates showed significant antimicrobial and antioxidant activities, making them promising natural, low-salt food preservatives.
Article
Microbiology
Nissa Niboucha, Coralie Goetz, Laurie Sanschagrin, Juliette Fontenille, Ismail Fliss, Steve Labrie, Julie Jean
Summary: Biofilm formation in dairy processing plants can lead to reduced equipment efficiency, surface deterioration, and contamination of dairy products. This study developed an efficient technique for in-plant biofilm sampling by growing a specific strain of bacteria on a stainless-steel surface and comparing different sampling methods. The results suggest that sonicating synthetic sponge could be a promising method for biofilm recovery.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Sabrine Naimi, Severine Zirah, Anna Greppi, Christophe Lacroix, Sylvie Rebuffat, Ismail Fliss
Summary: This study evaluated the impact of MccJ25 on the composition and metabolic activity of the swine colonic microbiota in vitro. The results showed that MccJ25 only caused subtle changes in microbial diversity and metabolome, while rifampicin induced significant modification in amino acid levels. Although further validation is needed in vivo, this study provides a first proof of concept for considering MccJ25 as an alternative to antibiotics for veterinary and farming applications, considering its pathogen-selective and potent inhibitory activity.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Food Science & Technology
Liya Zhang, Laila Ben Said, Moussa Sory Diarra, Ismail Fliss
Summary: This study evaluated the effects of bacterial-derived antimicrobial agents on the microbiota and sensory attributes of raw chicken legs. The combinations of reuterin with lactic acid or microcin J25 were found to extend the shelf-life of chicken legs and affect the microbial community. The sensory property scores for chicken legs treated with these antimicrobial combinations remained higher than those treated with conventional peracetic acid.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Review
Microbiology
Saba Miri, JuDong Yeo, Sarah Abubaker, Riadh Hammami
Summary: The gut microbiome, influenced by diet, xenobiotics, genetics, and other environmental factors, acts as a metabolic interactome that affects the host's nutrient absorption, metabolism, and immune system. It also produces a variety of neuroactive metabolites that can impact brain function and cognition. The correlation between the gut microbiome and the central nervous system has sparked a new field of research called neuromicrobiology. Although microbiome-targeted interventions are seen as promising treatments, the mechanisms underlying host-microbiome interactions need further exploration to inform evidence-based therapeutic applications.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Food Science & Technology
Aurore Cournoyer, Jacinthe Thibodeau, Laila Ben Said, Zain Sanchez-Reinoso, Sergey Mikhaylin, Ismail Fliss, Laurent Bazinet
Summary: This study evaluated the effects of discoloration treatment on the antibacterial and antifungal activities of porcine cruor hydrolysate. The results showed that some peptides decreased in the hydrolysate after discoloration, and the raw hydrolysate exhibited higher antifungal activities. Eight new antifungal peptide sequences were identified and characterized.
Article
Infectious Diseases
Sara Garcia-Vela, Laila Ben Said, Samira Soltani, Ramzi Guerbaa, Rosa Fernandez-Fernandez, Houssem Ben Yahia, Karim Ben Slama, Carmen Torres, Ismail Fliss
Summary: This study aimed to screen and characterize potential inhibitory strains of Enterococcus against necrotic enteritis caused by Clostridium perfringens in poultry. Two potential strains, E. faecium X2893 and X2906, were found to have antimicrobial activity, no acquired resistance genes, no plasmids, and the acm gene implicated in host colonization, making them promising candidates for further research as protective cultures in poultry farming.
Article
Biochemistry & Molecular Biology
Yasmina Ait Chait, Walid Mottawea, Thomas A. Tompkins, Riadh Hammami
Summary: Growing evidence suggests that non-antibiotic therapeutics, such as psychotropic drugs, can significantly impact gut microbiome composition and metabolism. This study investigated the effects of two psychotropics, aripiprazole and (S)-citalopram, on the gut microbiome and the potential of probiotics to alleviate dysbiosis. The results showed that aripiprazole decreased the relative abundances of certain bacteria and lowered the levels of short-chain fatty acids, while (S)-citalopram increased microbial diversity. However, a probiotic combination was able to mitigate these effects and restore gut microbiome composition and function to a similar level as the control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Basit Yousuf, Walid Mottawea, Nour Elhouda Bouhlel, Riadh Hammami
Summary: The draft genome sequences of 12 Bacteroides, 4 Phocaeicola, and 2 Parabacteroides strains were announced, including a newly isolated species, Bacteroidaceae bacterium UO.H1004. These isolates produce health-benefiting short-chain fatty acids (SCFAs) and the neurotransmitter gamma-aminobutyric acid (GABA) in various concentrations.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Chemistry, Medicinal
Soheila Abachi Hokmabadinazhad, Jacinthe Thibodeau, Ismail Fliss, Andre Marette, Laurent Bazinet, Lucie Beaulieu
Summary: High blood pressure is recognized as a major risk factor of cardiometabolic syndrome. Synthetic drugs used to medicate hypertension often have adverse effects, leading to the search for natural alternatives. Our study focused on fractionating and identifying antihypertensive peptides, finding that the hydrophobic fraction was the most potent ACE inhibitor. The separation technique played an important role in the efficiency of isolation. The findings highlight the significance of polarity for the anti-ACE activity of Atlantic mackerel biopeptides.
JOURNAL OF MEDICINAL FOOD
(2022)
Review
Nutrition & Dietetics
Tristan St-Laurent, Riadh Hammami
Summary: This review compiles and discusses data on the application of ginseng berry in supporting mental health via the gut-brain axis, highlighting the potential of the berry to contain higher concentrations of neuroprotective and antidepressant compounds.
