Article
Food Science & Technology
Linghong Shi, Wu Li, Mohammad Shafiur Rahman, Nasser Al-Habsi, Muthupandian Ashokkumar, Frank R. Dunshea, Hafiz A. R. Suleria
Summary: This study compared the efficacy of ultrasonic-assisted and conventional methods in extracting phenolic compounds from date flesh and seed, and found that ultrasonic-assisted extraction significantly increased the content of functional components in the extracts. A total of 47 different phenolic compounds were identified, including various beneficial components.
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2023)
Article
Plant Sciences
Noga Sikron-Persi, Gila Granot, Albert Batushansky, David Toubiana, Gideon Grafi, Aaron Fait
Summary: A study on the petioles of perennial desert shrub Zygophyllum dumosum Boiss revealed a consistent seasonal pattern in petiole metabolism, involving organic acids, polyols, phenylpropanoids, sulfate conjugates, and piperazines. The metabolic changes were primarily related to the plant's development stage and its interaction with the environment, rather than specific environmental conditions.
Article
Biochemistry & Molecular Biology
Mirtha Navarro-Hoyos, Elizabeth Arnaez-Serrano, Maria Isabel Quiros-Fallas, Felipe Vargas-Huertas, Krissia Wilhelm-Romero, Felipe Vasquez-Castro, Diego Alvarado-Corella, Andres Sanchez-Kopper
Summary: This study analyzed the compounds found in Physalis peruviana fruits and husks from Costa Rica using ultra-performance liquid chromatography coupled with high-resolution mass spectrometry. A total of 66 different compounds were identified. The results suggest that the husks and fruits of Physalis peruviana from Costa Rica may have potential health benefits.
Article
Horticulture
Omaima Adil Najm, Faizul Helmi Addnan, Nur Fariha Mohd-Manzor, Mohamed Adel Elkadi, Wan Omar Abdullah, Amin Ismail, Fadlul Azim Fauzi Mansur
Summary: This study aimed to investigate the phytochemical components of the Ajwa cultivar using different extraction solvents and durations, resulting in the tentative identification of 169 bioactive compounds, including 21 compounds never previously reported.
INTERNATIONAL JOURNAL OF FRUIT SCIENCE
(2021)
Article
Food Science & Technology
Zihong Yang, Linghong Shi, Yunyang Qi, Cundong Xie, Wanrong Zhao, Colin J. Barrow, Frank R. Dunshea, Hafiz A. R. Suleria
Summary: This study investigated the changes in polyphenol content during pumpkin processing and comprehensively characterized and quantified the phenolic compounds using LC-ESI-QTOF-MS/MS and HPLC-PDA. The results showed that pumpkin seeds and skins had the highest total phenolic content and total antioxidant capacity, while separated pumpkin puree had a higher total condensed tannins content. Epicatechin and catechin were found to be the most abundant phenolic compounds in pumpkin seeds and skins. This study highlights the potential of pumpkins as a source of antioxidant polyphenols.
Article
Chemistry, Applied
Shi Shen, Xi Chen, Qin Zhuo, Yan Ma, Jingbo Wang, Liyuan Wang, Zhaolong Gong, Junsheng Huo
Summary: By applying untargeted and targeted metabolite analysis, differences in metabolites and compound contents among kiwifruits from different cultivars were found, which can benefit scientific research and new cultivar breeding.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Agricultural Engineering
Shila Neel, Abhishek Mandal, Anirban Dutta, Supradip Saha, Amrita Das, Gautam Chawla, Aditi Kundu
Summary: Optimal extraction conditions for bioactive phytochemicals from black cumin seeds were determined by response surface methodology. The ethanolic concentrate exhibited excellent antifungal action against different strains of Aspergillus flavus, inhibiting fungal ergosterol content. Nigellamine A1, kaempferol-3-O-pentoside, and nigellidine-4-O-sulfite showed promising interactions with the target protein.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Food Science & Technology
Kun Dai, Yingying Wei, Shu Jiang, Feng Xu, Hongfei Wang, Xin Zhang, Xingfeng Shao
Summary: Thinned peach polyphenols (TPPs) were extracted and purified, and they exhibited high antioxidant, hypoglycemic, and hypolipidemic capacities. TPPs inhibited the activities of alpha-amylase and alpha-glucosidase, and showed a higher binding capacity for bile acids.
Article
Multidisciplinary Sciences
Lucia Pappalardo
Summary: Pomegranate is a valuable source of nutrition with medicinal benefits. As the demand for pomegranate fresh fruit juices increases, the issue of adulteration becomes a concern. This study utilized UV-visible spectroscopy and multivariate statistical analysis to detect adulteration of pomegranate juice with apple juice concentrate.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Applied
Mariana Rodrigues da Silva, Felipe Sanchez Bragagnolo, Renato Lajarim Carneiro, Isabela de Oliveira Carvalho Pereira, Jose Antonio Aquino Ribeiro, Clenilson Martins Rodrigues, Rebecca E. Jelley, Bruno Fedrizzi, Cristiano Soleo Funari
Summary: This study conducted a comprehensive chemical investigation of coffee by-products, identifying a variety of bioactive compounds. Some compounds in the by-products even showed higher content than coffee beans, indicating potential economic and environmental benefits that can be explored.
Article
Agriculture, Multidisciplinary
Jieyao Yuan, Vaidhyanathan Anantharamkrishnan, Thomas R. Hoye, Gary A. Reineccius
Summary: Thermal processing is a critical step for ensuring the microbial safety of our food. This study investigated the covalent reactions between beta-lactoglobulin (BLG) and 46 flavor compounds under pasteurization and sterilization conditions. The results showed that the reactions between flavor compounds and BLG were accelerated under higher thermal treatment conditions and some flavor compounds exhibited reactivity not previously observed at room temperature. These findings are important for understanding the interactions between flavor compounds and proteins during food processing.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Plant Sciences
Ndamulelo Nengovhela, Dakalo T. Mbedzi, Ashwell R. Ndhlala, Lutendo M. Mathomu, Msizi I. Mhlongo, Ntakadzeni E. Madala
Summary: A comparative study was conducted on the leaves of Coccinia grandis and Coccinia rehmannii using metabolite profiling, which revealed differences in the conjugation of hydroxycinnamic acids (HCAs). The findings suggest that conjugation and isomerization processes can serve as chemotaxonomic markers and provide insights for future research on the pharmacological potency of these plants.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Multidisciplinary Sciences
Yi Wang, Junsen Cheng, Wei Jiang, Shu Chen
Summary: This study analyzed the flavonoids in Coreopsis tinctoria and compared the differences in flavonoids among C. tinctoria of different origins. A total of 31 different flavonoid metabolites were identified, with seven of them showing high accumulation in samples from specific locations. The identified flavonoid metabolites were annotated using the KEGG database, and key pathways regulating the biosynthesis of these compounds were analyzed.
Article
Biochemistry & Molecular Biology
Yasir Iqbal, Eric N. Ponnampalam, Hafiz A. R. Suleria, Jeremy J. Cottrell, Frank R. Dunshea
Summary: The study qualitatively and quantitatively analyzed polyphenols in chicory and lucerne, finding that they possess high antioxidant potential mainly due to polyphenolic compounds. Both chicory and lucerne are rich in polyphenolic compounds, making them suitable natural antioxidants for use in animal feeds, human foods, and pharmaceutical formulations.
Article
Agriculture, Multidisciplinary
Jing Sun, Haoan Zhao, Fanhua Wu, Min Zhu, Ying Zhang, Ni Cheng, Xiaofeng Xue, Liming Wu, Wei Cao
Summary: This study analyzed the different metabolites of honey samples at different stages using a metabolomics approach, revealing a distinct metabolic profile in mature honey compared to immature honey. Specific fatty acids, such as decenedioic acid, were identified as potential markers for discriminating between immature and mature honey. Additionally, mature honey showed higher concentrations of fatty acids, particularly three fatty acids that were significantly richer in mature honey compared to immature honey.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Applied
Manzura A. Agzamova, Nilufar Z. Mamadalieva, Andrea Porzel, Hidayat Hussain, Mthandazo Dube, Katrin Franke, Abdulaziz Janibekov, Ludger A. Wessjohann
Summary: In this study, a new cycloartane triterpene glycoside, named lehmanniaside, was isolated and identified from the aerial parts of Astragalus lehmannianus Bunge. Its structure was determined through spectroscopic analysis, and it exhibited weak anthelmintic, antifungal, and cytotoxic activities.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Susann Herrmann, Martin Dippe, Pascal Pecher, Evelyn Funke, Markus Pietzsch, Ludger A. Wessjohann
Summary: 4-Hydroxyphenylacetate 3-hydroxylase (4HPA3H), a flavin-dependent monooxygenase, was modified to convert larger substrates, especially phenolic natural products. The modified enzyme showed improved conversion of spacious substrates and demonstrated selective transformation of specific compounds without generating byproducts.
Article
Cell Biology
Ibrahim Morgan, Ludger A. Wessjohann, Goran N. Kaluderovic
Summary: Anthraquinone derivatives are a class of compounds that exhibit various biological activities, including antifungal, antibacterial, antiviral, and anticancer activities. This study tested various synthetic anthraquinone derivatives against different cancer cell lines and found that most of them exhibit anticancer effects. One specific compound, 1,4-bis(benzyloxy)-2,3-bis(hydroxymethyl)anthracene-9,10-dione, exhibited the highest cytotoxicity against PC3 cells and was further investigated for its mechanism of action. The compound was found to induce apoptosis, disrupt cellular equilibrium, and cause cell cycle arrest.
Article
Food Science & Technology
Asmaa M. Otify, Ahmed Serag, Andrea Porzel, Ludger A. Wessjohann, Mohamed A. Farag
Summary: This study characterized the metabolite profiles of five Cymbopogon species using NMR-based metabolomics. The results showed that Cymbopogon citratus has high essential oil and phenolic content, indicating strong antioxidant activity. Additionally, compounds with antimicrobial, insecticidal, antidiabetic, and antioxidant properties were identified and can serve as biomarkers for species authentication.
FOOD ANALYTICAL METHODS
(2022)
Article
Food Science & Technology
Mohamed A. Farag, Ahmed Zayed, Ibrahim E. Sallam, Amr Abdelwareth, Ludger A. Wessjohann
Summary: Coffee is a popular global beverage with unique flavor and multiple health benefits. Its chemical composition is complex, with metabolites that are endogenous to coffee seeds and generated during processing. Metabolomics technologies can help analyze and understand the chemical composition of coffee, and they have important implications for quality control and research on coffee's effects.
Article
Chemistry, Organic
Aldrin V. Vasco, Leonardo G. Ceballos, Ludger A. Wessjohann, Daniel G. Rivera
Summary: The replacement of the disulfide bridge by other side chain linkages is a method for developing cyclic peptide drugs. This study describes a method on resin that enables the substitution of the disulfide bond with a tertiary lactam bridge and allows the addition of various exocyclic moieties. Conformational analysis in comparison with octreotide provides important information on the functionalization type for mimicking the bioactive peptide.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ismail Ware, Katrin Franke, Hidayat Hussain, Ibrahim Morgan, Robert Rennert, Ludger A. Wessjohann
Summary: Peperomia obtusifolia is an ornamental plant native to Middle America, known for its mild antimicrobial properties. Chemical investigation of its leaves led to the discovery of two new compounds and five known compounds. Peperoside showed promising activity against cancer cells and bacteria, but no anthelmintic activity.
Article
Chemistry, Physical
Tamara Krajnovic, Nebojsa D. Pantelic, Katharina Wolf, Thomas Eichhorn, Danijela Maksimovic-Ivanic, Sanja Mijatovic, Ludger A. Wessjohann, Goran N. Kaluderovic
Summary: Xanthohumol and isoxanthohumol, compounds derived from hops, have been shown to possess a range of anti-tumor and protective properties. This study demonstrates that loading these compounds into mesoporous silica enhances their anti-cancer potential.
Article
Biochemistry & Molecular Biology
Ismail Ware, Katrin Franke, Mthandazo Dube, Hesham Ali El Enshasy, Ludger A. Wessjohann
Summary: In this study, three new compounds and 31 known compounds were isolated from Piper sarmentosum leaves, including 21 compounds that were isolated for the first time from this plant. The compounds were evaluated for their anthelmintic, antifungal, antibacterial, and cytotoxic activities. Several compounds showed significant activities against various pathogens, while exhibiting only mild cytotoxic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Yen T. H. Lam, Jana Hoppe, Quang N. Dang, Andrea Porzel, Alena Soboleva, Wolfgang Brandt, Robert Rennert, Hidayat Hussain, Mehdi D. Davari, Ludger Wessjohann, Norbert Arnold
Summary: Three new azepino-indole alkaloids, named purpurascenines A-C (1-3), along with a new-to-nature 7-hydroxytryptophan (4) and two known compounds, adenosine (5) and riboflavin (6), were isolated from the fruiting bodies of Cortinarius purpurascens. The structures of 1-3 were determined using spectroscopic analysis and ECD calculations. The biosynthesis of purpurascenine A (1) was investigated, and a biosynthetic route involving a direct Pictet-Spengler reaction between alpha-keto acids and 7-hydroxytryptophan (4) was proposed. Compound 1 showed no antiproliferative or cytotoxic effects against human cancer cells and exhibited some antagonistic effects on the 5-HT-dependent 5-HT2A activation and putative constitutive activity of the 5-HT2A receptor.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Luay. J. J. Rashan, Nadire Oezenver, Joelle. C. C. Boulos, Mona Dawood, Wynand. P. P. Roos, Katrin Franke, Ioannis Papasotiriou, Ludger. A. A. Wessjohann, Heinz-Herbert Fiebig, Thomas Efferth
Summary: A study found that a cold-water leaf extract called Breastin from Nerium oleander L. has potential as an anticancer agent, inhibiting the growth of multiple cancer cell lines and bypassing some traditional drug resistance mechanisms. The study also showed that protein expression profiles can be used to predict the sensitivity of tumor cells to Breastin constituents.
Article
Biochemistry & Molecular Biology
Duncan Mutiso Chalo, Katrin Franke, Vaderament-A. Nchiozem-Ngnitedem, Esezah Kakudidi, Hannington Origa-Oryem, Jane Namukobe, Florian Kloss, Abiy Yenesew, Ludger A. Wessjohann
Summary: The study found that Dalbergia melanoxylon is effective against microbial infections and contains several new prenylated isoflavanones. Two of these compounds showed promising antibacterial activity, including against methicillin-resistant Staphylococcus aureus (MRSA) and Mycobacterium. These findings support the traditional use of Dalbergia melanoxylon and suggest further research into its potential as an antibacterial lead compound.
Article
Food Science & Technology
Nehal S. Ramadan, Nesrin M. Fayek, Magdy M. El-Sayed, Rasha S. Mohamed, Ludger A. Wessjohann, Mohamed A. Farag
Summary: This study investigated the metabolite profile of Averrhoa carambola L. grown in tropical and temperate regions, using UPLC/MS-based molecular networking and chemometrics. The study also compared the immunostimulatory effect of ripe fruit and stem, and identified differences in secondary metabolite profiles between different origins and organ types. The study revealed the potential immune enhancing effect of A. carambola L. and its mechanisms of action.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Plant Sciences
Carlos Henrique Correa dos Santos, Pauline Stark, Paride Rizzo, Katrin Franke, Ludger Wessjohann
Summary: Two previously unknown prenylated acylphloroglucinol derivatives (hypercorisins A-B) and their two peroxide derivatives (hypercorisins C-D), along with seven known compounds, were isolated from Hypericum coris. The structures were determined using NMR experiments and mass spectrometry. Hypercorisins A, B, and D showed complete inhibition against the gram-positive bacterium Bacillus subtilis at the highest concentration tested, but had no significant antibacterial effect on the gram-negative Aliivibrio fischeri or cytotoxic activity on PC-3 or HCT-116 cancer cell lines.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Mohamed A. A. Farag, Mostafa H. H. Baky, Ibrahim Morgan, Mohamed R. R. Khalifa, Robert Rennert, Osama G. G. Mohamed, Magdy M. M. El-Sayed, Andrea Porzel, Ludger A. A. Wessjohann, Nehal S. S. Ramadan
Summary: This study conducted a comprehensive metabolic profiling and fingerprinting analyses of different parts of Balanites aegyptiaca, and evaluated its nutritional and cytotoxic activities. The results revealed a wide range of primary and secondary metabolites, including alkaloids, saponins, flavonoids, sugars, and amino and fatty acids. Additionally, the study identified specific markers for different parts of the plant, such as α-glucose, sucrose, and isorhamnetin for fruits and stems, and unsaturated fatty acids for seeds. Furthermore, potential antidiabetic compounds were discovered, such as nicotinic acid, trigonelline, and d-pinitol. In vitro cytotoxicity assays demonstrated the efficacy of immature fruits and seeds against prostate and colorectal cancer cell lines.
Article
Food Science & Technology
Yonghong Ye, Songyan Zheng, Yuanxing Wang
Summary: In this study, the changes of aroma components in Gannan navel orange during growth were systematically studied using HS-SPME-GC-MS. Key aroma components and markers were identified. These findings contribute to a better understanding of the dynamic variation of aroma compounds during navel orange growth and have potential for industrial applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Jia Xu, Yayuan Zhang, Mengke Zhang, Xinlin Wei, Yiming Zhou
Summary: This study evaluated the effects of glucosamine selenium on summer-autumn tea, showing that it can enhance nutritional quality, improve sensory characteristics, and increase plant adaptation to environmental changes and abiotic stresses.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yuanming Chu, Zhaoyang Ding, Jing Xie
Summary: This study investigated the use of ice glazing containing D-sodium erythorbate (DSE) and vacuum packaging to maintain the quality of large yellow croaker during frozen storage. The results showed that vacuum packaging effectively inhibited ice crystal growth and minimized water loss, while the combination of vacuum packaging and 0.3% DSE-infused ice glazing maintained freshness indicators at low levels throughout the 300-day storage period. This combination was considered the most effective in preserving the quality of the fish.
FOOD RESEARCH INTERNATIONAL
(2024)
Review
Food Science & Technology
Md. Ashikur Rahman, Shirin Akter, Md. Ashrafudoulla, Md. Anamul Hasan Chowdhury, A. G. M. Sofi Uddin Mahamud, Si Hong Park, Sang-Do Ha
Summary: This comprehensive review aims to provide insights into the mechanisms and key factors influencing biofilm formation by A. hydrophila in the food industry. It explores the molecular processes involved in various stages of biofilm formation and investigates the impact of intrinsic factors and environmental conditions on biofilm architecture and resilience. The article also highlights the potential of bibliometric analysis in conceptualizing the research landscape and identifying knowledge gaps in A. hydrophila biofilm research.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Chujing Wang, Wenni Tian, Zengliu Song, Qun Wang, Yong Cao, Jie Xiao
Summary: Solid lipid ratio in emulsions has significant effects on colloidal stability, mucus permeability, and bioavailability in vivo. Higher solid lipid ratio improves intestinal stability but reduces mucus permeability.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Dacai Zhong, Liping Kang, Juan Liu, Xiang Li, Li Zhou, Luqi Huang, Zidong Qiu
Summary: In this study, a novel online extraction electrospray ionization mass spectrometry method was developed to comprehensively characterize complex foods. Meanwhile, a characteristic marker screening method and chemometrics modeling were used for the accurate authentication of highly-similar foods. This research has significant implications for ensuring food quality and safety.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Qiannan Zhao, Jinyi Yang, Jiahui Li, Lei Zhang, Xiaohai Yan, Tianli Yue, Yahong Yuan
Summary: This study investigated the transport and hypoglycemic effects of phenolics in mulberry leaves using an in vitro digestion model. The results showed that digested phenolics had higher absorbability and could inhibit glucose digestion and absorption. Phenolics also regulated glucose metabolism. Luteoforol and p-coumaric acid were found to be the primary phenolics strongly correlated with the hypoglycemic ability of mulberry leaves.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yanyun Cao, Qingling Wang, Jinou Lin, Yin-Yi Ding, Jianzhong Han
Summary: This study investigated the effects of gallic acid (GA) and epigallocatechin gallate (EGCG) at different ratios on the gel properties of calcium induced-whey protein emulsion gel. It was found that GA and EGCG could promote gel formation, increase gel strength, and delay the release of emulsified oil droplets.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Monique Martins Strieder, Vitor Lacerda Sanches, Mauricio Ariel Rostagno
Summary: This study proposed an integrated and automated procedure for extracting, separating, and quantifying bioactive compounds from coffee co-products. By optimizing the extraction, separation, and analysis method, real-time analysis was achieved. The results suggest that coupling different techniques can efficiently extract, separate, and analyze phenolic compounds, providing an integrated method to produce high-added value ingredients for various applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Kyu Sang Sim, Hyoyoung Kim, Suel Hye Hur, Tae Woong Na, Ji Hye Lee, Ho Jin Kim
Summary: Geographical origin plays a crucial role in determining the quality and safety of agricultural products. In this study, ICP analysis was used to determine the inorganic elemental content of onions and identify their geographical origin. Chemometric methods were applied to analyze the ICP results, and the accuracy of distinguishing between Korean and Chinese onions was found to be excellent. The findings suggest that this method can be beneficial for identifying agricultural products.
FOOD RESEARCH INTERNATIONAL
(2024)