期刊
FOOD RESEARCH INTERNATIONAL
卷 54, 期 2, 页码 1376-1382出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.foodres.2013.10.020
关键词
Phenylpropanoid glycoside; Inhibitor; Pepsin; Trypsin; alpha-Chymotrypsin; Interaction
资金
- Natural Science Funding of Shenzhen University [801-00035911]
- Natural Science Funding of Guangdong Province [S2012010008514, S2013010016791]
- Shenzhen Funding for Technology Development Project [CXZZ20130320165017541, SW201110010, JCYJ20130326110246234]
Phenylpropanoid glycosides (PPGs) are important ingredients in Kudingcha bitter tea from Ligustrum purpurascens, possessing many beneficial properties. Here, we investigated the effect of PPGs on the activity of the digestive enzymes pepsin, trypsin and alpha-chymotrypsin. Furthermore, we explored the interactions between PPGs and digestive enzymes by a multi-spectroscopic method and docking studies. PPGs could inhibit digestive enzyme activities with a non-competitive pattern of inhibition. PPGs may have a binding effect on these digestive enzymes, changing the polarity and the structure of enzymes, which results in decreased enzyme activity. This description of the effects of PPG inactivation of pepsin, trypsin and alpha-chymotrypsin helps reveal the potential anti-nutritional property of PPGs. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.
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