Article
Environmental Sciences
Ning Li, Liuding Wen, Fangyu Wang, Tianlin Wang, Tiange Li, Mingwu Qiao, Lianjun Song, Erkigul Bukyei, Xianqing Huang
Summary: This study demonstrated that wheat germ peptides (WGPs) can protect PC12 cells from lead-induced oxidative stress. WGPs were found to reverse the cell damage and oxidative stress caused by lead exposure. Furthermore, WGPs enhance the antioxidant capacity of PC12 cells by regulating the TXNIP/Keap1/Nrf2 pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biotechnology & Applied Microbiology
Wen-Zhen Shi, Wu Li, Ye Cheng, Meng Zhang, Xiao-Chen Niu, Qi-Wei Gao, Ying Lu, Tian Tian, Shan Du, Yan Mi, Ming-Ze Chang, Ye Tian
Summary: The study demonstrated that omentin can protect PC12 cells from H2O2-induced apoptosis, possibly by inhibiting Bax expression through upregulation of miR-128-3p. However, further research is needed before its clinical application for the treatment of neurodegenerative diseases.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Shuai Chen, Xin Wu, Jielin Duan, Pan Huang, Tiejun Li, Yulong Yin, Jie Yin
Summary: The study demonstrated that low-protein diets supplemented with glutamic acid or aspartic acid can improve oxidative stress-induced intestinal dysfunction in weaned piglets by reducing oxidative stress-related protein expression, lowering serum diamine oxidase levels, inhibiting intestinal epithelial cell apoptosis, alleviating abnormal energy metabolism, and maintaining intestinal barrier integrity.
Article
Chemistry, Medicinal
Ramona Meanti, Laura Rizzi, Elena Bresciani, Laura Molteni, Vittorio Locatelli, Silvia Coco, Robert John Omeljaniuk, Antonio Torsello
Summary: Hexarelin displays inhibitory effects on H2O2-induced apoptosis in Neuro-2A cells, improving cell viability, reducing NO2- release, restoring cell morphology, and modulating apoptotic gene expression and protein kinase phosphorylation levels.
Article
Biochemistry & Molecular Biology
Zhongyuan Tang, Zonghui Zhang, Jiaqi Wang, Zhengwu Sun, Eskandar Qaed, Xinming Chi, Jun Wang, Yazeed Jamalat, Zhaohong Geng, Zeyao Tang, Qiying Yao
Summary: Phosphocreatine (PCr) can suppress H2O2-induced apoptosis in endothelial cells and reduce hyperlipidemia by inhibiting ROS generation and modulating the dysfunctional mitochondrial system, which might be an effective new therapeutic strategy to prevent atherosclerosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Food Science & Technology
Shuangqi Tian, Bingxiu Yu, Ke Du, Yongheng Li
Summary: This study used membrane separation and gel chromatography to improve the antioxidant activity of wheat germ albumin hydrolysates. The results showed that wheat germ albumin polypeptides with molecular weight less than 3 kD had significantly higher antioxidant activity.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Neurosciences
Mostofa Jamal, Ikuko Tsukamoto, Takata Maki, Sella Takei, Ryoji Konishi, Hiroshi Kinoshita
Summary: COA-Cl demonstrates protective effects against H2O2 and 6-OHDA-induced toxicity in PC12 cells, suggesting its potential as a therapeutic agent for Parkinson's disease.
NEUROTOXICITY RESEARCH
(2022)
Article
Environmental Sciences
Kaniz Fatima Binte Hossain, Md Mostafizur Rahman, Md Tajuddin Sikder, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasaki
Summary: This study investigated the protective role of selenium (Se) against inorganic mercury (iHg) toxicity in PC12 cells. Results showed that Se co-treatment inhibited intrinsic apoptosis and oxidative stress induced by iHg through various mechanisms, suggesting that excessive ROS generation plays a critical role in iHg-induced oxidative stress and Se has potential in attenuating iHg cytotoxicity via its antioxidant properties.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cell Biology
Kevin Rychel, Justin Tan, Arjun Patel, Cameron Lamoureux, Ying Hefner, Richard Szubin, Josefin Johnsen, Elsayed Tharwat Tolba Mohamed, Patrick V. Phaneuf, Amitesh Anand, Connor A. Olson, Joon Ho Park, Anand V. Sastry, Laurence Yang, Adam M. Feist, Bernhard O. Palsson
Summary: The relationships between the genome, transcriptome, and metabolome play a crucial role in determining the characteristics of an organism. However, it has been challenging to study these relationships due to the complexity of the variables involved. A new data analytic method called iModulons has been developed to simplify the interpretation of the transcriptome by grouping genes into independently regulated sets. In this study, the researchers used iModulons along with resequencing and metabolic models to gain a deep understanding of the effects of causal mutations and metabolic rewiring in E. coli strains subjected to high levels of oxidative stress. The findings highlight the power of iModulon knowledge mapping in evolutionary analysis.
Article
Chemistry, Organic
Rui Chen, Rongchen Wang, Jie Sun, Xuemei Dong, Chengjun Dong, Lixin Sun, Xianfeng Gu, Chunchang Zhao
Summary: An H2O2-activated, endoplasmic reticulum-targeted theranostic probe was developed, which can be activated by H2O2, leading to increased NIR fluorescence and photothermal signals for specific recognition of H2O2 and further photothermal therapy in H2O2-overexpressing cancer cells in the endoplasmic reticulum.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Mercedes Taroncher, Yelko Rodriguez-Carrasco, Tone Aspevik, Katerina Kousoulaki, Francisco J. Barba, Maria-Jose Ruiz
Summary: This study evaluated the in vitro cytotoxicity and antioxidant capacity of protein hydrolysates from different fish species, showing similar effects on cell viability. Additionally, the different fish fraction protein hydrolysates contain variable nutrients and unique bioactive peptide composition, demonstrating diverse bioactivity and potential for developing dietary supplements with specific functional properties.
Article
Pharmacology & Pharmacy
Aijing Bi, Zhen Guo, Guocui Yang, Youfang Huang, Zhimin Yin, Lan Luo
Summary: The highly toxic environmental pollutant cadmium (Cd) can lead to the occurrence and development of multiple neurological diseases. Gamma-glutamylcysteine (gamma-GC) has been found to inhibit Cd-induced apoptosis in PC12 cells by reducing oxidative stress and inhibiting the activation of MAPK and PI3K/Akt signaling pathways. This suggests that gamma-GC could potentially be used as a protective agent against Cd neurotoxicity.
Article
Biochemistry & Molecular Biology
Tahereh Farkhondeh, Milad Ashrafizadeh, Mohsen Azimi-Nezhad, Fariborz Samini, Michael Aschner, Saeed Samarghandian
Summary: This study demonstrates that curcumin can improve cell viability, reduce apoptosis, alleviate oxidative stress, and decrease interleukin-6 secretion in PC12 cells under GSD-induced stress. Additionally, curcumin also regulates the expression of apoptosis-related genes.
CURRENT MOLECULAR PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Meng Li, Xiaoming Luo, Shan Lei, Yurong Liu, Huishan Guo, Yu Zhang, Yuantao Pan, Kaiwei Chen, Jing Lin, Peng Huang
Summary: A glycopolymer containing a caged H2S and H2O2 dual-donor is developed to wrap glucose oxidase, which can deplete tumorigenic energy sources and block glycolysis. This strategy induces defects in mitochondrial function and shows good anticancer performance.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Reyhaneh Taheri, Elham Hadipour, Zahra Tayarani-Najaran
Summary: The study showed that crocin has protective effects against Aβ and H2O2 induced neurotoxicity in PC12 cells, and is able to block the apoptosis initiated with Aβ.
CURRENT MOLECULAR PHARMACOLOGY
(2021)
Article
Food Science & Technology
Yonghong Ye, Songyan Zheng, Yuanxing Wang
Summary: In this study, the changes of aroma components in Gannan navel orange during growth were systematically studied using HS-SPME-GC-MS. Key aroma components and markers were identified. These findings contribute to a better understanding of the dynamic variation of aroma compounds during navel orange growth and have potential for industrial applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Jia Xu, Yayuan Zhang, Mengke Zhang, Xinlin Wei, Yiming Zhou
Summary: This study evaluated the effects of glucosamine selenium on summer-autumn tea, showing that it can enhance nutritional quality, improve sensory characteristics, and increase plant adaptation to environmental changes and abiotic stresses.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yuanming Chu, Zhaoyang Ding, Jing Xie
Summary: This study investigated the use of ice glazing containing D-sodium erythorbate (DSE) and vacuum packaging to maintain the quality of large yellow croaker during frozen storage. The results showed that vacuum packaging effectively inhibited ice crystal growth and minimized water loss, while the combination of vacuum packaging and 0.3% DSE-infused ice glazing maintained freshness indicators at low levels throughout the 300-day storage period. This combination was considered the most effective in preserving the quality of the fish.
FOOD RESEARCH INTERNATIONAL
(2024)
Review
Food Science & Technology
Md. Ashikur Rahman, Shirin Akter, Md. Ashrafudoulla, Md. Anamul Hasan Chowdhury, A. G. M. Sofi Uddin Mahamud, Si Hong Park, Sang-Do Ha
Summary: This comprehensive review aims to provide insights into the mechanisms and key factors influencing biofilm formation by A. hydrophila in the food industry. It explores the molecular processes involved in various stages of biofilm formation and investigates the impact of intrinsic factors and environmental conditions on biofilm architecture and resilience. The article also highlights the potential of bibliometric analysis in conceptualizing the research landscape and identifying knowledge gaps in A. hydrophila biofilm research.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Chujing Wang, Wenni Tian, Zengliu Song, Qun Wang, Yong Cao, Jie Xiao
Summary: Solid lipid ratio in emulsions has significant effects on colloidal stability, mucus permeability, and bioavailability in vivo. Higher solid lipid ratio improves intestinal stability but reduces mucus permeability.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Dacai Zhong, Liping Kang, Juan Liu, Xiang Li, Li Zhou, Luqi Huang, Zidong Qiu
Summary: In this study, a novel online extraction electrospray ionization mass spectrometry method was developed to comprehensively characterize complex foods. Meanwhile, a characteristic marker screening method and chemometrics modeling were used for the accurate authentication of highly-similar foods. This research has significant implications for ensuring food quality and safety.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Qiannan Zhao, Jinyi Yang, Jiahui Li, Lei Zhang, Xiaohai Yan, Tianli Yue, Yahong Yuan
Summary: This study investigated the transport and hypoglycemic effects of phenolics in mulberry leaves using an in vitro digestion model. The results showed that digested phenolics had higher absorbability and could inhibit glucose digestion and absorption. Phenolics also regulated glucose metabolism. Luteoforol and p-coumaric acid were found to be the primary phenolics strongly correlated with the hypoglycemic ability of mulberry leaves.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yanyun Cao, Qingling Wang, Jinou Lin, Yin-Yi Ding, Jianzhong Han
Summary: This study investigated the effects of gallic acid (GA) and epigallocatechin gallate (EGCG) at different ratios on the gel properties of calcium induced-whey protein emulsion gel. It was found that GA and EGCG could promote gel formation, increase gel strength, and delay the release of emulsified oil droplets.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Monique Martins Strieder, Vitor Lacerda Sanches, Mauricio Ariel Rostagno
Summary: This study proposed an integrated and automated procedure for extracting, separating, and quantifying bioactive compounds from coffee co-products. By optimizing the extraction, separation, and analysis method, real-time analysis was achieved. The results suggest that coupling different techniques can efficiently extract, separate, and analyze phenolic compounds, providing an integrated method to produce high-added value ingredients for various applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Kyu Sang Sim, Hyoyoung Kim, Suel Hye Hur, Tae Woong Na, Ji Hye Lee, Ho Jin Kim
Summary: Geographical origin plays a crucial role in determining the quality and safety of agricultural products. In this study, ICP analysis was used to determine the inorganic elemental content of onions and identify their geographical origin. Chemometric methods were applied to analyze the ICP results, and the accuracy of distinguishing between Korean and Chinese onions was found to be excellent. The findings suggest that this method can be beneficial for identifying agricultural products.
FOOD RESEARCH INTERNATIONAL
(2024)