Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Chemistry, Applied
Willmann Antonio Jimenez-Morales, Maria del Pilar Canizares-Macias, Jose Pedraza-Chaverri
Summary: A novel fluorescent ORAC-SIA method was developed to determine antioxidant capacity in food samples. The method showed improved efficiency and precision compared to the standard micmplate method.
Article
Biotechnology & Applied Microbiology
Chen Dong, Xuehua Ma, Yi Huang, Yujie Zhang, Xiang Gao
Summary: This study demonstrates the synthesis of carbon dots nanozyme with excellent scavenging activity of reactive oxygen species (ROS) for anti-inflammatory therapy, indicating its potential in the treatment of inflammation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Junzhi Liang, Yingzhuo Gao, Ziyi Feng, Bowen Zhang, Zhijing Na, Da Li
Summary: Reactive oxygen species (ROS) are produced in mitochondria and play a crucial role in regulating the ovarian cycle through signaling. However, an imbalance between ROS generation and the antioxidant defense system can lead to ovarian diseases. Understanding the mechanisms of ROS generation and homeostasis in the ovary, as well as the pathological effects and potential antioxidant strategies, is important for the development of effective treatments.
Review
Plant Sciences
Petr Dvorak, Yuliya Krasylenko, Adam Zeiner, Jozef Samaj, Tomas Takac
Summary: Reactive oxygen species (ROS) are essential signaling molecules in plant responses to environmental stimuli and development. Antioxidant enzymes play a critical role in scavenging ROS and their regulation is influenced by both environmental conditions and transcriptional activation.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Zhao Jinyuan, Zhang Qian, Wang Jian, Zhang Qi, Li Heng, Du Yaping
Summary: This paper briefly reviews the research progress on scavenging materials for ROS and proposes a three-level pyramidic structure for the design of related materials. The design of nano-hybrid free radical scavenger not only solves the toxicity problem, but also provides additional functions.
ACTA CHIMICA SINICA
(2022)
Review
Chemistry, Multidisciplinary
Jingnan Zhao, Fanfan Guo, Lin Hou, Yongxing Zhao, Pengchao Sun
Summary: Inflammatory diseases are associated with high levels of ROS. Excess ROS leads to the polarization of microphages into the proinflammatory M1 phenotype and causes damage to DNA, proteins, and lipids, worsening the inflammatory response. Scavenging ROS to alleviate oxidative stress has proven to be an effective strategy for reversing inflammation. Inspired by natural antioxidant enzymes, electron transfer-based artificial antioxidant nanozymes have emerged as therapeutic agents for treating inflammatory diseases.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Microbiology
Mingjuan Guo, Ping Tian, Qingqing Li, Bao Meng, Yuting Ding, Yanyan Liu, Yasheng Li, Liang Yu, Jiabin Li
Summary: This study found that combining gallium nitrate (GaNt) with the antibiotic colistin can significantly enhance the antimicrobial activity against multidrug-resistant Klebsiella pneumoniae. Mechanistically, GaNt suppressed bacterial antioxidant activity, leading to the accumulation of reactive oxygen species (ROS) in K. pneumoniae, which was further enhanced by colistin. Overall, GaNt has the potential to serve as a novel colistin adjuvant for improving the treatment outcomes of bacterial infections caused by multidrug-resistant K. pneumoniae.
MICROBIOLOGY SPECTRUM
(2023)
Review
Medicine, General & Internal
Chao Dong, Nai-Jin Zhang, Li-Jun Zhang
Summary: Oxidative stress is closely related to leukemia, affecting its treatment and prognosis. Research is exploring the use of antioxidants in leukemia treatment as an alternative to standard chemotherapy.
CHINESE MEDICAL JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Xin Deng, Peng Ouyang, Wei Xu, Erhua Yang, Zhen Bao, Yijing Wu, Jin Gong, Jinghua Pan
Summary: Hepatic ischemia-reperfusion injury (HIRI) is an additional injury to ischemic tissue after hepatic revascularization, and its pathological mechanism is complex. Recent studies have found that the antioxidant treatment of nano selenium can reduce the excessive production of reactive oxygen species (ROS) and play a potential protective role in reducing HIRI.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Fleur L. Meulmeester, Jiao Luo, Leon G. Martens, Kevin Mills, Diana van Heemst, Raymond Noordam
Summary: Oxidative stress is a major contributor to lifestyle- and age-related diseases. Antioxidant supplementation has been proposed as a method to delay and improve these diseases, but clinical trials have failed to provide evidence for its benefits. This review discusses recent developments and research techniques in clarifying the controversy surrounding antioxidant supplementation in health and disease.
Review
Biochemistry & Molecular Biology
Minyu Piao, Yan Tu, Naifeng Zhang, Qiyu Diao, Yanliang Bi
Summary: Under current breeding conditions, multiple stressors pose important challenges for animal husbandry in maintaining animal wellbeing. The use of antibiotics in the livestock industry has raised social concerns, necessitating the exploration of alternative technologies and products. Phytogenic extracts offer natural and extensive sources with low residue, pollution-free, and renewable characteristics. They can alleviate various stresses on animals, regulate proinflammatory cytokines, enhance animal immunity, and improve the gastrointestinal microorganism structure, making them a preferred choice for improving animal health.
Review
Biochemistry & Molecular Biology
Swati Sachdev, Shamim Akhtar Ansari, Mohammad Israil Ansari, Masayuki Fujita, Mirza Hasanuzzaman
Summary: Climate change has devastating effects on plants, leading to the production of reactive oxygen species (ROS) as byproducts of oxygen consumption. While excessive ROS can disrupt cellular homeostasis, moderate levels can activate growth and stress responses in plants, though the exact mechanisms are not fully understood. Advancements in modern techniques like molecular priming and crop modeling offer potential solutions for managing ROS levels in plants under stress.
Article
Food Science & Technology
Juan David Figueroa, Noreima Barroso-Torres, Marcela Morales, Barbara Herrera, Mario Aranda, Eva Dorta, Camilo Lopez-Alarcon
Summary: The ORAC assay does not differentiate between peptides based on their chemical structures and the contribution of oxidation products. Peptides showed similar ORAC values, but the bond dissociation energy (BDE) varied.
Article
Biochemistry & Molecular Biology
Praveen Kumar Issac, Manikandan Velayutham, Ajay Guru, Gokul Sudhakaran, Raman Pachaiappan, Jesu Arockiaraj
Summary: Morin reduces oxidative stress in MDCK cells by upregulating antioxidant enzymes, providing protection against diabetic nephropathy pathogenesis caused by oxidative stress.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemical Research Methods
Radim Knob, Robert L. Hanson, Olivia B. Tateoka, Ryan L. Wood, Israel Guerrero-Arguero, Richard A. Robison, William G. Pitt, Adam T. Woolley
JOURNAL OF CHROMATOGRAPHY A
(2018)
Review
Oncology
Michelle H. Townsend, Gajendra Shrestha, Richard A. Robison, Kim L. O'Neill
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2018)
Article
Oncology
Evita G. Weagel, Weston Burrup, Roman Kovtun, Edwin J. Velazquez, Abigail M. Felsted, Michelle H. Townsend, Zachary E. Ence, Erica Suh, Stephen R. Piccolo, K. Scott Weber, Richard A. Robison, Kim L. O'Neill
CANCER CELL INTERNATIONAL
(2018)
Article
Oncology
Michelle H. Townsend, Zac E. Ence, Abigail M. Felsted, Alyssa C. Parker, Stephen R. Piccolo, Richard A. Robison, Kim L. O'Neill
CANCER CELL INTERNATIONAL
(2019)
Correction
Oncology
Evita G. Weagel, Weston Burrup, Roman Kovtun, Edwin J. Velazquez, Abigail M. Felsted, Michelle H. Townsend, Zachary E. Ence, Erica Suh, Stephen R. Piccolo, K. Scott Weber, Richard A. Robison, Kim L. O'Neill
CANCER CELL INTERNATIONAL
(2019)
Article
Biotechnology & Applied Microbiology
William G. Pitt, Mahsa Alizadeh, Rae Blanco, Alex K. Hunter, Colin G. Bledsoe, Daniel S. McClellan, Madison E. Wood, Ryan L. Wood, Tanner Raysten, Caroline L. Hickey, William Cameron Beard, Jacob R. Stepan, Alexandra Carter, Ghaleb A. Husseini, Richard A. Robison, Evelyn Welling, Rebekah N. Torgesen, Clifton M. Anderson
BIOTECHNOLOGY PROGRESS
(2020)
Review
Immunology
Michelle H. Townsend, Kelsey Bennion, Richard A. Robison, Kim L. O'Neill
IMMUNOLOGIC RESEARCH
(2020)
Article
Virology
Craig Meyers, Janice Milici, Richard Robison
JOURNAL OF MEDICAL VIROLOGY
(2020)
Article
Oncology
Edwin J. Velazquez, Taylor D. Brindley, Gajendra Shrestha, Eliza E. Bitter, Jordan D. Cress, Michelle H. Townsend, Bradford K. Berges, Richard A. Robison, K. Scott Weber, Kim L. O'Neill
CANCER CELL INTERNATIONAL
(2020)
Article
Immunology
Michelle H. Townsend, Claudia M. Tellez Freitas, Dallas Larsen, Stephen R. Piccolo, K. Scott Weber, Richard A. Robison, Kim L. O'Neill
Article
Multidisciplinary Sciences
Israel Guerrero-Arguero, Taalin R. Hoj, E. Shannon Tass, Bradford K. Berges, Richard A. Robison
Article
Microbiology
Jacob Kent Player, Justen Thalmus Despain, Richard A. Robison
Article
Microbiology
Taalin R. Hoj, Bradley McNeely, Kylie Webber, Evelyn Welling, William G. Pitt, Larry C. Ford, Richard A. Robison
Summary: This study presents a pentaplex, real-time PCR-based assay to quickly identify common beta-lactamase genes in sepsis cases, aiming to improve patient outcomes by providing critical drug resistance information within 2 hours of septicemia onset. The assay successfully identified beta-lactamase genes from bacteria in blood samples at concentrations of 4-8 c.f.u. ml(-1), which can greatly impact the appropriate use of antimicrobials and prevent further antibiotic resistance evolution.
JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Colleen R. Newey, Abigail T. Olausson, Alyssa Applegate, Ann-Aubrey Reid, Richard A. Robison, Julianne H. Grose
Summary: SARS-CoV-2 shows low stability on banknotes and higher stability on money cards, but no viable virus was detected on either. Therefore, using money cards to slow the spread of the virus may not be advisable.
Review
Biotechnology & Applied Microbiology
Israel Guerrero-Arguero, Claudia M. Tellez-Freitas, K. Scott Weber, Bradford K. Berges, Richard A. Robison, Brett E. Pickett
Summary: Human pathogens belonging to the Alphavirus genus are primarily transmitted by mosquitoes, causing symptoms such as fever, polyarthralgia, and encephalitis. Recent outbreaks of CHIKV in Asia, Europe, and the Americas have increased our understanding of Alphavirus interactions with the human host, emphasizing the importance of developing effective treatments.
JOURNAL OF GENERAL VIROLOGY
(2021)
Article
Food Science & Technology
Yonghong Ye, Songyan Zheng, Yuanxing Wang
Summary: In this study, the changes of aroma components in Gannan navel orange during growth were systematically studied using HS-SPME-GC-MS. Key aroma components and markers were identified. These findings contribute to a better understanding of the dynamic variation of aroma compounds during navel orange growth and have potential for industrial applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Jia Xu, Yayuan Zhang, Mengke Zhang, Xinlin Wei, Yiming Zhou
Summary: This study evaluated the effects of glucosamine selenium on summer-autumn tea, showing that it can enhance nutritional quality, improve sensory characteristics, and increase plant adaptation to environmental changes and abiotic stresses.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yuanming Chu, Zhaoyang Ding, Jing Xie
Summary: This study investigated the use of ice glazing containing D-sodium erythorbate (DSE) and vacuum packaging to maintain the quality of large yellow croaker during frozen storage. The results showed that vacuum packaging effectively inhibited ice crystal growth and minimized water loss, while the combination of vacuum packaging and 0.3% DSE-infused ice glazing maintained freshness indicators at low levels throughout the 300-day storage period. This combination was considered the most effective in preserving the quality of the fish.
FOOD RESEARCH INTERNATIONAL
(2024)
Review
Food Science & Technology
Md. Ashikur Rahman, Shirin Akter, Md. Ashrafudoulla, Md. Anamul Hasan Chowdhury, A. G. M. Sofi Uddin Mahamud, Si Hong Park, Sang-Do Ha
Summary: This comprehensive review aims to provide insights into the mechanisms and key factors influencing biofilm formation by A. hydrophila in the food industry. It explores the molecular processes involved in various stages of biofilm formation and investigates the impact of intrinsic factors and environmental conditions on biofilm architecture and resilience. The article also highlights the potential of bibliometric analysis in conceptualizing the research landscape and identifying knowledge gaps in A. hydrophila biofilm research.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Chujing Wang, Wenni Tian, Zengliu Song, Qun Wang, Yong Cao, Jie Xiao
Summary: Solid lipid ratio in emulsions has significant effects on colloidal stability, mucus permeability, and bioavailability in vivo. Higher solid lipid ratio improves intestinal stability but reduces mucus permeability.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Dacai Zhong, Liping Kang, Juan Liu, Xiang Li, Li Zhou, Luqi Huang, Zidong Qiu
Summary: In this study, a novel online extraction electrospray ionization mass spectrometry method was developed to comprehensively characterize complex foods. Meanwhile, a characteristic marker screening method and chemometrics modeling were used for the accurate authentication of highly-similar foods. This research has significant implications for ensuring food quality and safety.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Qiannan Zhao, Jinyi Yang, Jiahui Li, Lei Zhang, Xiaohai Yan, Tianli Yue, Yahong Yuan
Summary: This study investigated the transport and hypoglycemic effects of phenolics in mulberry leaves using an in vitro digestion model. The results showed that digested phenolics had higher absorbability and could inhibit glucose digestion and absorption. Phenolics also regulated glucose metabolism. Luteoforol and p-coumaric acid were found to be the primary phenolics strongly correlated with the hypoglycemic ability of mulberry leaves.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yanyun Cao, Qingling Wang, Jinou Lin, Yin-Yi Ding, Jianzhong Han
Summary: This study investigated the effects of gallic acid (GA) and epigallocatechin gallate (EGCG) at different ratios on the gel properties of calcium induced-whey protein emulsion gel. It was found that GA and EGCG could promote gel formation, increase gel strength, and delay the release of emulsified oil droplets.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Monique Martins Strieder, Vitor Lacerda Sanches, Mauricio Ariel Rostagno
Summary: This study proposed an integrated and automated procedure for extracting, separating, and quantifying bioactive compounds from coffee co-products. By optimizing the extraction, separation, and analysis method, real-time analysis was achieved. The results suggest that coupling different techniques can efficiently extract, separate, and analyze phenolic compounds, providing an integrated method to produce high-added value ingredients for various applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Kyu Sang Sim, Hyoyoung Kim, Suel Hye Hur, Tae Woong Na, Ji Hye Lee, Ho Jin Kim
Summary: Geographical origin plays a crucial role in determining the quality and safety of agricultural products. In this study, ICP analysis was used to determine the inorganic elemental content of onions and identify their geographical origin. Chemometric methods were applied to analyze the ICP results, and the accuracy of distinguishing between Korean and Chinese onions was found to be excellent. The findings suggest that this method can be beneficial for identifying agricultural products.
FOOD RESEARCH INTERNATIONAL
(2024)
