Article
Pharmacology & Pharmacy
Hamidreza Dorostkar, Bibi Fatemeh Haghiralsadat, Mahdie Hemati, Fatemeh Safari, Azam Hassanpour, Seyed Morteza Naghib, Mohammad Hossein Roozbahani, M. R. Mozafari, Ali Moradi
Summary: Liposomal doxorubicin with favorable characteristics was designed and synthesized, and its physicochemical properties were investigated. The co-administration of liposomal doxorubicin with free doxorubicin and quercetin showed promising results in reducing cardiac enzymes, oxidative stress, and apoptosis, as well as improving antioxidant capacity in heart tissue.
Review
Environmental Sciences
Kanika Khanna, Sukhmeen Kaur Kohli, Puja Ohri, Renu Bhardwaj, Parvaiz Ahmad
Summary: Cadmium is a toxic pollutant that persists in soil and has negative effects on plant growth and metabolism. Plants have developed antioxidative defense responses and specific mechanisms to combat cadmium stress. Additionally, plant hormones play a crucial role in signal transduction pathways and overall growth and development of plants under toxic conditions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Susanta Sadhukhan, Mahammed Moniruzzaman, Subhajit Maity, Sudakshina Ghosh, Arup Kumar Pattanayak, Suman Bhusan Chakraborty, Biswanath Maity, Madhusudan Das
Summary: Synthesized organometallic gold-based folate nanoparticles (FAuNPs) have been proven to protect against lipopolysaccharide-induced brain inflammation and can overcome folate deficiency in the brain. FAuNPs demonstrate high physical stability and effective uptake, suggesting their potential applications in alleviating brain inflammation and reducing brain injury and neurodegeneration.
Article
Biochemistry & Molecular Biology
Syed Nasir Abbas Bukhari
Summary: Dietary polyphenols, found in nature in various forms, have hidden health promoting characteristics and show potential in combating neuropathological diseases such as Alzheimer's disease. Their antioxidant properties and ability to modulate biogenesis pathways make them effective in providing neuroprotection.
Article
Nutrition & Dietetics
Vernieda B. Vergara, John F. Kalinich
Summary: The study found that plant-based nutraceuticals may have metal-binding properties, with some being able to bind metals such as uranium and cobalt. These nutraceuticals can act as chelators to protect cells from metal-induced cytotoxicity. Metal binding is pH dependent, with no binding observed at lower pH values.
Article
Food Science & Technology
Mariangela Marrelli, Maria Pia Argentieri, Ersilia Alexa, Daniela Meleleo, Giancarlo Statti, Pinarosa Avato, Filomena Conforti, Rosanna Mallamaci
Summary: The study investigated the bioactive metabolites and protective effects of Trapea red onion extract on human Caco-2 colon adenocarcinoma cells and its antioxidant effects. The extract showed high levels of bioactive compounds and strong antioxidant activity. It also inhibited the release of NO in a dose-dependent manner. The extract provided higher cytoprotection and significantly reduced cell damage caused by Cd exposure. MTT and LDH assays indicated that the extract could effectively prevent Cd-induced cytotoxicity after 24 hours.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Weiwei Wu, Yan Yang, Zhuoying Liang, Xiling Song, Yadong Huang, Lin Qiu, Xiaozhong Qiu, Siming Yu, Wei Xue
Summary: This study demonstrated the effective strategy of utilizing near-infrared laser-induced simultaneous release of NO and alkyl radicals to inhibit tumor growth, achieved through the elaborately fabricated biocompatible free radical nanogenerator. Under NIR II laser irradiation, the nanogenerator can precisely control the release profiles of NO and alkyl radicals, displaying synergistic anticancer effects on breast tumors.
Article
Environmental Sciences
Yuan Zhao, Zi-Fa Li, Dong Zhang, Zhen-Yong Wang, Lin Wang
Summary: Autophagy dysregulation is a key factor in cadmium-induced nephrotoxicity, and Quercetin has a protective effect by restoring lysosomal function, which is dependent on TFEB activity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Ghedeir M. Alshammari, Wahidah H. Al-Qahtani, Nora A. AlFaris, Nadiah S. Alzahrani, Mahmoud Abdo Alkhateeb, Mohammed Abdo Yahya
Summary: QUR prevents CdCl2-induced hepatic steatosis and fibrosis mainly through attenuating its ability to upregulate miR-21, at least, by upregulation of Nrf2.
Article
Biochemistry & Molecular Biology
Hernan Speisky, Maria Fernanda Arias-Sante, Jocelyn Fuentes
Summary: Recent research challenges the belief that the oxidation of flavonoids would result in a loss of their antioxidant properties. It has been found that the oxidation of quercetin and its analogue kaempferol leads to the formation of metabolites with significantly higher antioxidant potency than the precursors. The amplification of antioxidant properties is even greater for kaempferol, with a 100-fold increase compared to quercetin.
Article
Chemistry, Applied
Giulia Simonetti, Francesca Buiarelli, Flaminia Bernardini, Patrizia Di Filippo, Carmela Riccardi, Donatella Pomata
Summary: This study analyzed the content of quercetin and its derivatives in wines from different varieties in Italy using HPLC-ESIMS/MS. Wines produced from Sangiovese and Nero d'Avola grapes were found to be richest in quercetin compounds.
Article
Chemistry, Multidisciplinary
Abdessamie Kellil, Spyros Grigorakis, Sofia Loupassaki, Dimitris P. Makris
Summary: This study focused on investigating the thermal decomposition of Quercetin (Qt) and the impacts of antioxidants on its degradation. An empirical sigmoidal model was proposed to trace degradation kinetics, and degradation pathways were analyzed through liquid chromatography-tandem mass spectrometry. Antioxidants were found to retard Qt degradation in a manner dependent on Qt/antioxidant molar ratio, with consistent degradation products identified. The study demonstrated the detrimental effects of heating on Qt and proposed a model that could be useful for interpreting the degradation behavior of other polyphenols.
APPLIED SCIENCES-BASEL
(2021)
Article
Environmental Sciences
Jicang Wang, Lulu Ding, Ke Wang, Ruxue Huang, Wenjing Yu, Bingzhao Yan, Hongwei Wang, Cai Zhang, Zijun Yang, Zongping Liu
Summary: This study aimed to determine the protective effect of quercetin (Que) on cadmium (Cd)-induced hepatotoxicity. Through in vivo and in vitro experiments using rat models, the researchers found that Cd caused liver injury and cell apoptosis, and activated endoplasmic reticulum stress (ERS) signaling pathways. However, Que was able to improve hepatocyte vitality, reduce liver damage and oxidative stress caused by Cd.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Plant Sciences
Feng Gao, Xiaodan Zhang, Jing Zhang, Jing Li, Tianhang Niu, Chaonan Tang, Cheng Wang, Jianming Xie
Summary: The use of zinc oxide nanoparticles (ZnONPs) can reduce the toxicity of cadmium (Cd) stress on lettuce, promote growth, reduce Cd content and reactive oxygen species (ROS) accumulation, and enhance the uptake of ions associated with photosynthesis. ZnONPs also increase the amount of lignin in the roots, blocking or reducing the entry of Cd into plant tissues.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Giovanni Palomino-Vizcaino, Nils Schuth, Jose A. Dominguez-Calva, Oscar Rodriguez-Meza, Eduardo Martinez-Jurado, Eugene Serebryany, Jonathan A. King, Thomas Kroll, Miguel Costas, Liliana Quintanar
Summary: Cataracts are caused by the aggregation of high-molecular-weight proteins in the human eye lens, which scatter light and cause lens opacity. Metal ions play an important role in the development of cataract disease, as human lens gamma-crystallins are susceptible to metal-induced aggregation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Oncology
M. Rajendran
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2016)
Article
Pharmacology & Pharmacy
M. Rajendran, M. Mahalakshmi, R. Ramya, D. Devapiriam
AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY
(2011)
Article
Chemistry, Inorganic & Nuclear
R. Ravichandran, M. Rajendran, D. Devapiriam
JOURNAL OF COORDINATION CHEMISTRY
(2014)
Article
Chemistry, Physical
M. Rajendran, J. Johnson Inbaraj, R. Gandhidasan, R. Murugesan
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2006)
Article
Agriculture, Multidisciplinary
M Rajendran, P Manisankar, R Gandhidasan, R Murugesan
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2004)
Article
Chemistry, Physical
A Rajendran, R Gandhidasan, R Murugesan
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2004)
Article
Chemistry, Physical
M Rajendran, JJ Inbaraj, R Gandhidasan, R Murugesan
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2004)
Article
Biochemistry & Molecular Biology
M Rajendran, S Ramasamy, C Rajamanickam, R Gandhidasan, R Murugesan
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2003)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.