Article
Biochemistry & Molecular Biology
Xinchang Gao, Chaoying Zhang, Ning Wang, Jin-Ming Lin, Yali Dang, Yufen Zhao
Summary: This study predicts the potential activity of peptides derived from Zizyphus jujuba proteins and investigates their ACE-inhibitory activity and in vitro digestion stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Rounak Chourasia, Loreni Chiring Phukon, Md Minhajul Abedin, Dinabandhu Sahoo, Amit Kumar Rai
Summary: A novel soy chhurpi cheese was developed by fermenting soymilk using Lactobacillus delbrueckii strains, and bioactive peptides with antioxidant and ACE-inhibitory properties were identified in the cheese. The peptide SVIKPPTDE showed strong antihypertensive activity and remained stable during gastrointestinal digestion.
Article
Chemistry, Applied
An Du, Wei Jia
Summary: A customized workflow was designed to screen short-chain peptides (SCPs) in goat milk and 186 SCPs were preliminarily identified. Twenty-two SCPs with predicted IC50 values less than 10 μM were found to have potential antihypertensive properties. This study facilitated the discovery of unknown food-derived antihypertensive peptides and enhanced understanding of bioaccessible peptides during digestion.
Article
Chemistry, Applied
Yi Zhang, Shudong He, Xin Rui, Benjamin K. Simpson
Summary: The study demonstrates the molecular mechanisms of marine-derived peptides in inhibiting multiple enzymes involved in chronic diseases. In silico analyses showed that one peptide could inhibit multiple enzymes by forming specific interactions with their active sites. Peptides with different mechanisms were found to inhibit ACE and α-amylase, while another peptide inhibited ACE, α-amylase, and lipase through direct interactions with catalytic residues.
Article
Food Science & Technology
Laura Berenice Olvera-Rosales, Emmanuel Perez-Escalante, Araceli Castaneda-Ovando, Elizabeth Contreras-Lopez, Alma Elizabeth Cruz-Guerrero, Patricia Regal-Lopez, Alejandra Cardelle-Cobas, Luis Guillermo Gonzalez-Olivares
Summary: The goal of this study was to determine the proteolytic and ACE inhibition capacities during whey fermentation. The results showed that co-culturing Lacticaseibacillus rhamnosus GG, Streptococcus thermophilus SY-102, and both bacteria together resulted in increased production of protein hydrolysates and low molecular weight peptides, as well as higher ACE inhibition activity.
Article
Chemistry, Applied
Xiaojie Duan, Yifan Dong, Min Zhang, Zihui Li, Guanhao Bu, Fusheng Chen
Summary: Plant-derived bioactive peptides, particularly ACE inhibitory peptides, were evaluated in rapeseed protein. The study identified novel ACE inhibitory peptides FQW, FRW, and CPF using bioinformatics methods. In vitro experiments showed that these peptides exhibited strong inhibitory effects on ACE, indicating that rapeseed protein can be a good source for ACE inhibitory peptides.
Article
Food Science & Technology
Mingzhe Ma, Yinghui Feng, Yulu Miao, Qiang Shen, Shuting Tang, Juan Dong, John Z. H. Zhang, Lujia Zhang
Summary: Chronic diseases, such as hypertension, have detrimental effects on human health. Conventional drugs for treatment often come with significant side effects. Food-sourced ACE inhibitory peptides provide a safer alternative, with fewer side effects. However, the lack of a systematic and effective screening method and understanding of the sequence characteristics and molecular mechanisms hinder the development of ACE inhibitory peptides.
Article
Food Science & Technology
Mingyang Li, Wenlai Fan, Yan Xu
Summary: This study identified four novel bioactive peptides from Pixian broad bean paste (PBBP), with RGLSK showing the strongest ACE inhibitory activity and TPCPPQ exhibiting the highest antioxidant capacity. The results suggest that PBBP is a good source of bioactive peptides.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Junde Chen, Shanshan Sun, Yushuang Li, Rui Liu
Summary: The SAR and release behavior of ACEi peptides from collagen enzymolysis have an impact on large-scale production. Different proteases have varied effects on the release of peptides from collagen and the SAR of larger collagen peptides, which can guide food production processes for ensuring food safety and producing high-quality active peptide products.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Acoustics
Wenjuan Qu, Yiting Feng, Ting Xiong, Yuhan Li, Hafida Wahia, Haile Ma
Summary: This study used ultrasound treatment to improve the iron chelating ability of corn peptide and retain its activity. The results showed that the ultrasound-treated corn ACE inhibitory peptide-ferrous chelate exhibited high iron chelating ability, ACE inhibition activity, and stability.
ULTRASONICS SONOCHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Yongfu Li, Nan Yang, Feng Shi, Fei Ye, Jinrong Huang
Summary: Tartary buckwheat albumin provides a good source of ACE inhibitory peptides, with the albumin hydrolysate showing the strongest ACE inhibitory activity and highest peptide yield. After isolation and identification, a total of 42 ACE inhibitory peptides were discovered, including 14 novel peptides. These peptides exhibit potent ACE inhibitory effects and can potentially be used as supplements or drugs.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Food Science & Technology
Aprilia Fitriani, Retno Indrati, Yustinus Marsono, Supriyadi Supriyadi
Summary: This study evaluated the ACE-I peptide activity in sprouted lamtoro gung flour through GID simulation and identified the peptide responsible for the ACE-I activity. The 180 min GID simulation showed the highest ACE-I activity, and the <1 kDa peptide fraction had the highest inhibitory activity. The peptides obtained also had other biological activities and were predicted to be non-toxic and safe to consume.
Article
Chemistry, Medicinal
Yuya Kumagai, Keigo Toji, Satoshi Katsukura, Rie Morikawa, Toshiki Uji, Hajime Yasui, Takeshi Shimizu, Hideki Kishimura
Summary: The hydrolysates of red algal proteins are good candidates for ACE inhibition. 42 ACE inhibitory peptides were identified from Pyropia pseudolinearis, among which LRM showed high inhibitory activity and was highly conserved in red algae.
Article
Food Science & Technology
Kunlun Liu, Zeru Gao, Qingyun Li, Huiyan Zhang
Summary: This study identified four novel ACEIPs from maize germ protein hydrolysates, which showed high potency in suppressing ACE activity. The kinetics studies revealed that PW inhibited ACE in a non-competitive manner, while VTLL, LPGP, and SPGTAF were ACE substrate-competitive inhibitors. The findings suggest that maize by-products could serve as an alternative source for generating ACEIPs.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xin-Xin Han, Yun-Qin Jia, Chun-Yu Liu, Hao-Yu Wang, Zhen-Yuan Zhu
Summary: In this study, three novel ACE-inhibitory peptides were prepared from Small-Aroma Chicken breast and showed significant inhibitory activity. The mechanism of inhibition and binding free energies were also investigated.
PROCESS BIOCHEMISTRY
(2023)
Article
Agronomy
Liang Zhang, Zhiyu Zhu, Fangfang Chen, Yueqing Zhu, Xiaocan Guo, Minjie Fu, Jiahong Chen, Jianguo Wu, Zhujun Zhu
Summary: In this study, distant hybridization between radish and kohlrabi was successfully achieved using tissue culture and chromosome doubling technology, resulting in the production of xBrassicoraphanus allotetraploids. The allotetraploid hybrids exhibited normal morphology and fertility, providing a basis for the production of new radish germplasm and serving as a bridge for gene transfer between Brassica and Raphanus vegetable species.
NEW ZEALAND JOURNAL OF CROP AND HORTICULTURAL SCIENCE
(2023)
Article
Statistics & Probability
Ruiyu Xu, Jianguo Wu, Xiaowei Yue, Yongxiang Li
Summary: This article proposes an online structural change-point detection method for high-dimensional streaming data through dynamic sparse subspace learning and an efficient Pruned Exact Linear Time algorithm. The effectiveness of the method is demonstrated through simulation studies and a real case study.
Review
Chemistry, Multidisciplinary
Xiao-Fan Chen, Zhi-Cheng Lin, Zenghua Qi, Zongwei Cai, Zhi-Feng Chen
Summary: Exposure to pollutants can cause damage to the eyes of aquatic organisms. Zebrafish is a commonly used model to study ocular toxicity and has shown morphological changes, retinal damage, and abnormalities in visual signal processes. The underlying mechanisms involve thyroid hormone signaling, retinoic acid signaling, and retinal glucose metabolism. This review discusses the phenotypes and signaling pathways associated with ocular toxicity from contaminants, detection methods, and a predictive model for potential ocular toxicity.
ENVIRONMENTAL CHEMISTRY LETTERS
(2023)
Article
Environmental Sciences
Guangmei Wu, Guitao Shi, Chuanjin Li, Ye Hu, Hongmei Ma, Zhenlou Chen
Summary: During the 2015-2016 Chinese Antarctic Research Expedition, a study was conducted on Particulate-bound mercury (PBM) in the boundary layer. The study found a significant latitudinal gradient in PBM, with higher levels over the Northern Hemisphere influenced by both continental and oceanic sources. Over the Southern Ocean, PBM levels were extremely low, while elevated PBM was observed across the Antarctic Ice Sheet, particularly at Dome A. The study also revealed the role of inland Antarctic snow in influencing atmospheric PBM concentrations over the Antarctic coastal seas.
ATMOSPHERIC ENVIRONMENT
(2023)
Article
Geosciences, Multidisciplinary
Yongjie Wang, Guitao Shi, Danhe Wang, Qian Zhao, Su Jiang, Yangjie Li, Dongqi Wang, Chuanjin Li, Zhenlou Chen, Roberto Bargagli
Summary: This study investigated soil mercury levels in different areas of Antarctica and found a close relationship between mercury distribution and organic carbon content. The findings contribute to a better understanding of the biogeochemical cycle of mercury in Antarctic terrestrial ecosystems.
Article
Plant Sciences
Yan Wang, Wei Dong, Qin Zhang, Zhen-Peng Li, Yue-Xing Wang, Xiu-Fen Li, Long-Jiang Huang
Summary: An efficient and scalable process for the synthesis of 19-hydroxyprogesterone was developed, achieving a total yield of 34.5%, which is significantly higher than the previously reported process (11.0% total yield). The plausible ring-opening mechanism of the 6,19-epoxy bridge in compound 7 was proposed, and the structures of intermediates were confirmed by LC-MS analysis.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Environmental Sciences
Wei Huang, Guodong Cao, Chengliang Deng, Yanyan Chen, Tao Wang, Da Chen, Zongwei Cai
Summary: This study investigated the effects of TCS exposure on kidney function in mice. The results showed that TCS caused renal injury, oxidative stress, inflammation, and fibrosis in a dose-dependent manner. Metabolite analysis revealed lipid accumulation and defective fatty acid metabolism in TCS-exposed mouse kidney, which may contribute to renal function impairment.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Huiyan Li, Huilin Zhang, Xiaofang He, Peiran Zhao, Tong Wu, Jinxuan Xiahou, Yelin Wu, Yanyan Liu, Yang Chen, Xingwu Jiang, Guanglei Lv, Zhenwei Yao, Jian Wu, Wenbo Bu
Summary: A communication interception strategy is developed to block spatiotemporal crosstalk between lysosomes and endoplasmic reticulum (ER) using amorphous-core@crystalline-shell Fe@Fe3O4 nanoparticles (ACFeNPs). This strategy induces autophagy and ER stress, leading to a significant therapeutic effect for cancer treatment.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Pengfei Hou, Yumiao Tian, Yu Xie, Fei Du, Gang Chen, Aleksandra Vojvodic, Jianzhong Wu, Xing Meng
Summary: This study develops a neural network potential (NNP) for aqueous MXene systems using deep neural networks and an active learning scheme, providing ab initio precision at low cost. The oxidation behaviors of super large aqueous MXene systems are investigated at nanosecond timescales, revealing the atomic-level process of MXenes oxidation and the inhibitory effects of free protons and oxides on subsequent oxidation reactions. These findings contribute to the development of effective protection strategies for controlling the stability of MXenes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Polymer Science
Alejandro Gallegos, Jianzhong Wu
Summary: In this work, a hierarchical method that incorporates liquid-state theories with the site-binding model is proposed to quantify the charging behavior of weak polyelectrolytes over a broad range of solution conditions.
Article
Chemistry, Analytical
Yijing Wu, Wenjun Zheng, Canrong Chen, Linyan Yang, Ping Tong, Yanhui Zhong, Zian Lin, Zongwei Cai
Summary: In this study, a spherical covalent organic framework (COf) based on imine linkages was prepared and utilized as an adsorbent in dispersive solid-phase extraction. The dSPE-HPLC-MS/MS method based on the spherical COF demonstrated high efficiency and accuracy in the determination of aryl organophosphate esters in biological samples.
JOURNAL OF SEPARATION SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Hui Chen, Cheng Jin, Li Xie, Jian Wu
Summary: Succinate, an intermediate of the TCA cycle, is crucial in mitochondrial metabolism, energy production, and is also considered a signaling molecule in metabolism and hepatic diseases. Its downstream signaling pathway through GPR91 leads to various intracellular responses, including succinylation, ROS production, HIF-1 alpha stabilization, and significant impact in cellular metabolism due to its role in the TCA cycle. Understanding the signaling mechanisms of succinate in hepatic fibrosis, metabolic reprogramming, inflammatory or immune responses, and carcinogenesis is of great interest. This review aims to provide the current understanding of succinate in mediating metabolism, inflammatory and immune responses in liver diseases, with the aim of establishing a molecular basis for therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Mathematics, Applied
Marco Tosato, Xue Zhang, Jianhong Wu
Summary: We investigate the behavior of solutions to a scalar Delay Differential Equation (DDE) with periodic switching between two constant values. This equation naturally arises in structured vector populations involved in the spread of various vector-borne diseases in a periodically changing environment. We examine the influence of two different time lags and the switching time on the existence and patterns of periodic solutions, with a specific focus on multi-cycles within the prime period.
DIFFERENTIAL EQUATIONS AND DYNAMICAL SYSTEMS
(2023)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
