期刊
FOOD CHEMISTRY
卷 141, 期 3, 页码 2923-2933出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2013.05.033
关键词
Anthocyanins; Metabolites; Methylation; Antioxidant; Antiproliferative
资金
- FCT (Fundacao para a Ciencia e Tecnologia) (POCI, FEDER, Programa Comunitario de Apoio) [SFRH/BPD/86173/2012, PTDC/AGR-TEC/2227/2012]
Anthocyanins are major flavonoids in many plant foods and have been related to health promotion. In the human organism anthocyanins are metabolised to different metabolites. One of the most important phase II reactions of flavonoids is the methylation of the catechol group. This feature is expected to have an effect on the antioxidant and antiproliferative properties of flavonoids including anthocyanins. In this work, delphinidin-3-glucoside, cyanidin-3-glucoside and petunidin-3-glucoside methylated metabolites were obtained by enzymatic hemi-synthesis. The compounds were identified as monomethylated products by HPLC-MS and NMR. The methylated metabolites were found to still retain significant radical scavenging activity and reducing activity, suggesting that they could act as potential antioxidants in vivo. The antiproliferative activity of the metabolites in comparison with the parental anthocyanins was also evaluated in three cancer cell lines by sulforhodamine B assay. The conjugation with methyl groups decreased or did not alter the antiproliferative effect of the original anthocyanin. (C) 2013 Elsevier Ltd. All rights reserved.
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