Article
Biochemistry & Molecular Biology
Min Kim, Seung-Cheol Jee, Kyeong-Seok Kim, Hyung-Sik Kim, Kyoung-Nae Yu, Jung-Suk Sung
Summary: The Group 1 carcinogen, benzo[a]pyrene, can cause DNA mutations and cancer. Quercetin, a dietary flavonoid, and its metabolite isorhamnetin have been shown to reduce benzo[a]pyrene-induced cytotoxicity and BPDE-DNA adduct levels by promoting xenobiotic detoxification enzymes and regulating the expression levels of phase enzymes through the translocation of AhR and NRF2. This suggests that quercetin and isorhamnetin play a role in promoting metabolism, detoxification, and elimination of B[a]P to protect against genotoxic effects and cytotoxicity induced by B[a]P.
Article
Engineering, Environmental
Shanshan Feng, Yanwei Li, Ruiming Zhang, Qingzhu Zhang, Wenxing Wang
Summary: Polycyclic Aromatic Hydrocarbon (PAHs) is a common class of environmental pollutants. A recent study found that a lab-synthesized derivative of PAHs can selectively kill cancer cells. However, the metabolic process and selectivity of P450 catalyzed PAHs activation is not well understood. This study systematically investigated the activation mechanism of a representative PAHs, benzo[a] pyrene (BaP), by P450 enzymes, and identified the involvement of electrophilic addition and epoxidation steps. The selectivity was attributed to the structural and electrostatic parameters of both BaP and P450.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Soo Ji Woo
Summary: The study found that exposure to benzo[a]pyrene led to increased hepatic EROD activity and CYP1A protein levels in black rockfish, while adverse histological changes were observed in the gills and kidneys. Immunohistochemical analysis showed strong immunostaining of CYP1A against 200 mu g/g of B[a]P in the liver. These findings suggest that polycyclic aromatic hydrocarbons can induce metabolic changes in fish liver and that specific tissues may exhibit increased CYP1A induction for monitoring marine ecosystems.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Oscar Samuel Avila-Rosales, Mauricio Diaz-Munoz, Rafael Camacho-Carranza, Elvia Coballase-Urrutia, Jose Pedraza-Chaverri, Jorge Omar Garcia-Rebollar, Jesus Javier Espinosa-Aguirre
Summary: The study found that DRF can modify the expression of ARNT and CYP1A1 genes, and can protect the body from the toxicity of benzo[a]pyrene.
Article
Medicine, Research & Experimental
Bartosz Kazimierz Slowikowski, Maurycy Jankowski, Pawel Piotr Jagodzinski
Summary: Lung cancer is one of the most frequently diagnosed tumor types globally, with increasing mortality rates and incidences observed in recent years, especially among nonsmokers. The mechanisms of lung cancer formation and progression remain unclear due to their complexity involving environmental, genetic, and molecular factors. Besides the undeniable association with cigarette smoke exposure, the presence of estrogens and their interaction with tobacco smoke components can also affect lung cancer development.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Daniel Munoz-Reyes, Alfredo G. Casanova, Ana Maria Gonzalez-Paramas, Angel Martin, Celestino Santos-Buelga, Ana I. Morales, Francisco J. Lopez-Hernandez, Marta Prieto
Summary: Quercetin, a potential therapeutic substance, has shown protective effects against cisplatin nephrotoxicity in rats. However, its low bioavailability limits its clinical utility. A newly-developed P-quercetin formulation with enhanced solubility and bioavailability also showed no nephroprotection when administered orally. Further investigation revealed that the metabolite of quercetin may be responsible for the nephroprotective effects, and quercetin-3-O-glucuronide was the only metabolite partially preventing the cytotoxic effects of cisplatin in cultured tubule cells.
Article
Environmental Sciences
Isis Mayna Martins dos Reis, Jaco Joaquim Mattos, Marilia Nardelli Siebert, Flavia Lucena Zacchi, Camila Lisarb Velasquez Bastolla, Miguel Saldana-Serrano, Marcia Caruso Bicego, Satie Taniguchi, Carlos Henrique Araujo de Miranda Gomes, Claudio Manoel Rodrigues de Melo, Afonso Celso Dias Bainy
Summary: Oysters are commonly used as sentinel organisms to monitor the effects of contaminants. This study evaluated the molecular and histological responses in male and female oysters exposed to PYR. CYP2AU1 levels were found to be a good biomarker for PYR exposure, and the interpretation of biomarker responses should consider gender.
Article
Environmental Sciences
Ritwick Bhattacharya, Arnab Chatterjee, Soumendranath Chatterjee, Nimai Chandra Saha
Summary: This study evaluated the interaction between Cyprinus carpio cytochrome P450 and surfactants through homology modelling and molecular docking experiments. The in silico analysis revealed the prevalent hydrophobic interactions and potential oxidative stress induced by the binding of cytochrome P450 with the surfactants. In vivo analysis showed that exposure to sublethal concentrations of surfactants adversely affected the oxidative stress and antioxidant enzymes in the liver of Cyprinus carpio.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Ying Huang, Dan Jiang, Guangxi Ren, Yan Yin, Yifan Sun, Tengfei Liu, Chunsheng Liu
Summary: In this study, de novo biosynthesis of the rare compound Glycyrrhetic acid 3-O-mono-beta-D-glucuronide (GAMG) was achieved in engineered Saccharomyces cerevisiae strains using CRISPR/Cas9 genome editing technology. The engineered yeast strains provided a new approach for the production of glycosylated triterpenoids in pharmaceutical, cosmetic, and food industries, with significantly increased production yield through pathway optimization and environmental conditions enhancement.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Medicine, Research & Experimental
Miklos Poor, Hana Kaci, Slavka Bodnarova, Violetta Mohos, Eszter Fliszar-Nyul, Sandor Kunsagi-Mate, Csilla Ozvegy-Laczka, Beata Lemli
Summary: This study investigated the interactions between resveratrol and its metabolites with human proteins, enzymes, and transporters using in vitro models. The results showed that the metabolites of resveratrol played a significant role in its pharmacokinetic interactions.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Hana Kaci, Slavka Bodnarova, Eszter Fliszar-Nyul, Beata Lemli, Helena Pelantova, Katerina Valentova, Eva Bakos, Csilla Ozvegy-Laczka, Miklos Poor
Summary: This study aimed to investigate the interactions of sulfate and glucuronic acid conjugates of luteolin and naringenin with human serum albumin, cytochrome P450 enzymes, and organic anion transporting polypeptide transporters. The main findings indicate that sulfate conjugates formed more stable complexes with albumin than the parent flavonoids, while certain conjugates of luteolin and naringenin are potent inhibitors of OATP1B1 and/or OATP2B1 enzymes. These conjugated metabolites may play an important role in the pharmacokinetic interactions of these flavonoids.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Food Science & Technology
Zhenyu Wang, Chaoyi Xue, Xuan Wang, Maomao Zeng, Zhaojun Wang, Qiuming Chen, Jie Chen, Mark Christian, Zhiyong He
Summary: Lotus leaf, particularly its component Q3G, can stimulate thermogenesis by activating brown adipocytes through the AMPK and β3-AR signaling pathways. The ethanol extract from lotus leaf contains high levels of polyphenols and flavonoids, with Q3G being the most abundant. The extract promotes mitochondrial biogenesis and fatty acid beta-oxidation, leading to increased energy expenditure.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Environmental Sciences
Nan Zhao, Weiwei Wu, Shiwei Cui, Haibin Li, Yongliang Feng, Ling Guo, Yawei Zhang, Suping Wang
Summary: This study found a significant association between high levels of maternal PAHs exposure and increased risk of preterm birth. Additionally, the study suggests that dietary intake levels of vitamins, carotene, and folate during pre- and post-conception may modify this association.
ENVIRONMENTAL HEALTH
(2022)
Article
Clinical Neurology
Samah Eltalal, Mostafa El Ayouty, Afaf El-Said, Yahya Wahba
Summary: A study investigated the relationship between polymorphisms of CYP2C9 and CYP2C19 genes and the efficacy of antiepileptic drugs in children with nonlesional epilepsy, finding that mutations in CYP2C9*2 and CYP2C19 were more frequent among this population. The CYP2C9*2 (TT) genotype was associated with susceptibility to refractory epilepsy.
ACTA NEUROLOGICA BELGICA
(2021)
Article
Chemistry, Multidisciplinary
Mohammad A. Alzohairy, Amjad Ali Khan, Mohammad Azam Ansari, Ali Yousif Babiker, Mohammed A. Alsahli, Saleh A. Almatroodi, Arshad Husain Rahmani
Summary: This study demonstrates the therapeutic role of Quercetin in protecting against Benzo(a)pyrene-induced lung injury in rats, by regulating inflammatory factors, oxidative stress, and maintaining lung tissue architecture. The treatment with Qu significantly reversed the effects of B(a)P, leading to increased antioxidant enzymes and decreased proinflammatory cytokines level, suggesting a potential protective effect against lung injury.
APPLIED SCIENCES-BASEL
(2021)
Article
Medicine, General & Internal
Sung-Yuan Hu, Ming-Shun Hsieh, Meng-Yu Lin, Chiann-Yi Hsu, Tzu-Chieh Lin, Chorng-Kuang How, Chen-Yu Wang, Jeffrey Che-Hung Tsai, Yu-Hui Wu, Yan-Zin Chang
Article
Biochemistry & Molecular Biology
Jau-Tien Lin, Yi-Chen Chen, Yan-Zin Chang, Ting-Yu Chen, Deng-Jye Yang
Article
Biochemical Research Methods
Yuan-Jhe Chang, Mu-Rong Chao, Su-Chin Chen, Chih-Hong Chen, Yan-Zin Chang
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2014)
Article
Geriatrics & Gerontology
Nae-Cherng Yang, Tuzz-Ying Song, Yan-Zin Chang, Mei-Yau Chen, Miao-Lin Hu
Article
Agriculture, Multidisciplinary
Chia-Leng Liao, Chien-Min Chen, Yan-Zin Chang, Guang-Yaw Liu, Hui-Chih Hung, Tung-Ying Hsieh, Chih-Li Lin
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2014)
Article
Cell Biology
Edy Kornelius, Hsin-Hua Li, Chiung-Huei Peng, Yi-Sun Yang, Wei-Jen Chen, Yan-Zin Chang, Yi-Chiao Bai, Stanley Liu, Chien-Ning Huang, Chih-Li Lin
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Medicine, General & Internal
Sung-Yuan Hu, Ming-Shun Hsieh, Tzu-Chieh Lin, Shu-Hui Liao, Vivian Chia-Rong Hsieh, Jen-Huai Chiang, Yan-Zin Chang
Article
Environmental Sciences
Yih-Farng Liou, Pei-Ni Chen, Shu-Chen Chu, Shao-Hsuan Kao, Yan-Zin Chang, Yih-Shou Hsieh, Horng-Rong Chang
ENVIRONMENTAL TOXICOLOGY
(2019)
Article
Orthopedics
Sung-Yuan Hu, Ming-Shun Hsieh, Yao-Tien Chang, Chih-Che Huang, Che-An Tsai, Chung-Lin Tsai, Chiann-Yi Hsu, Chia-Hui Shen, Yan-Zin Chang
BMC MUSCULOSKELETAL DISORDERS
(2019)
Article
Gastroenterology & Hepatology
Hsin-Ju Tsai, Ya-Wen Chuang, Sheng-Shun Yang, Yan-Zin Chang, Horng-Rong Chang, Teng-Yu Lee
Summary: The study found that while TDF is generally safe for chronic hepatitis B patients without chronic kidney disease, it is best to be avoided in the elderly.
JOURNAL OF VIRAL HEPATITIS
(2021)
Article
Chemistry, Analytical
Hsiu-Chuan Chen, Pin-Duo Lee, Yan-Zin Chang
Summary: A high-throughput method using microwave-assisted extraction, chemical derivatization, and liquid chromatography-electrospray tandem mass spectrometry (LC-ESI-MS/MS) was developed for the simultaneous analysis of illicit drugs and their metabolites in a micro-segment of a single hair. The method showed high throughput, high sensitivity, and short analysis time.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Pediatrics
Chian-Chi Chen, Shan-Ming Chen, Yan-Zin Chang, Hai-Lun Sun, Min-Sho Ku
Summary: The study found that maternal exposure to high levels of certain air pollutants (such as carbon monoxide, nitric oxide, nitrogen dioxide, and methane) during pregnancy may increase the phototherapy rates for neonatal jaundice. Male newborns were more susceptible to the effects of this pollution. The clinical study showed that there was a positive correlation between serum bilirubin levels in male newborns and exposure to carbon monoxide, particles with a diameter <= 2.5 μm, particles with a diameter <= 10 μm, nitric oxide, nitrogen dioxide, nonmethane hydrocarbon, and methane during the three months prior to birth. Female newborns had a positive correlation with methane. There was also a positive correlation between exposure to carbon monoxide, particles with a diameter <= 2.5 μm, particles with a diameter <= 10 μm, nitrogen dioxide, nonmethane hydrocarbon, methane, and serum hemoglobin levels in male newborns.
JOURNAL OF PEDIATRICS
(2022)
Article
Chemistry, Analytical
Hsiu-Chuan Chen, Ya-Yi Chen, Mu-Rong Chao, Yan-Zin Chang
Summary: People who chew betel nuts and smoke have a much higher probability of developing oral cancer. This study developed a high-throughput method using MAE and LC-MS/MS to measure biomarkers of betel nuts and cigarettes in hair samples. The method showed good accuracy and precision and was successfully applied in the analysis of the samples. The results indicate lower concentrations of the substances in gray hair.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Nursing
Shu-Juan Liu, Wen-Jiuan Yen, Yan-Zin Chang, Min-Sho Ku
Summary: Adding educational digital video disc to routine education can reduce maternal anxiety and depression levels when their children undergo heart surgery, especially when surgical or post-surgical complications occur. This study highlights the positive impact of educational digital video disc in alleviating maternal anxiety.
NURSING IN CRITICAL CARE
(2023)
Article
Medicine, General & Internal
Yih-Farng Liou, Yih-Shou Hsieh, Tung-Wei Hung, Pei-Ni Chen, Yan-Zin Chang, Shao-Hsuan Kao, Shu-Wen Lin, Horng-Rong Chang
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2019)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
