Liraglutide protects against glucolipotoxicity-induced RIN-m5F β-cell apoptosis through restoration of PDX1 expression

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Liraglutide, a human glucagon-like peptide-1 analogue, stimulates AKT-dependent survival signalling and inhibits pancreatic β-cell apoptosis

(2018) Katerina Kapodistria et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity

(2018) Petr Ježek et al.   MOLECULES

Effects of Dietary Fatty Acids in Pancreatic Beta Cell Metabolism, Implications in Homeostasis

(2018) Paloma Acosta-Montaño et al.   Nutrients

Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy

(2018) Joselyn Rojas et al.   Journal of Diabetes Research

Guanabenz Sensitizes Pancreatic β Cells to Lipotoxic Endoplasmic Reticulum Stress and Apoptosis

(2017) Baroj Abdulkarim et al.   ENDOCRINOLOGY

Glucagon-like peptide 1 receptor agonist ameliorates the insulin resistance function of islet β cells via the activation of PDX-1/JAK signaling transduction in C57/BL6 mice with high-fat diet-induced diabetes

(2017) Tao Hao et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Insulin action and resistance in obesity and type 2 diabetes

(2017) Michael P Czech   NATURE MEDICINE

PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration

(2017) Yaxi Zhu et al.   Stem Cell Research & Therapy

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

(2017) Miriam Cnop et al.   Molecular Metabolism

Transcribing β-cell mitochondria in health and disease

(2017) Hindrik Mulder   Molecular Metabolism

Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis

(2017) Chunguang Chen et al.   Molecular Metabolism

Metabolic Stress and Compromised Identity of Pancreatic Beta Cells

(2017) Avital Swisa et al.   Frontiers in Genetics

Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells

(2016) Jing Wang et al.   CELLULAR SIGNALLING

Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Diabetes

(2016) Milagros Rocha et al.   CURRENT PHARMACEUTICAL DESIGN

MST1: a promising therapeutic target to restore functional beta cell mass in diabetes

(2016) Amin Ardestani et al.   DIABETOLOGIA

Endoplasmic Reticulum Stress and Associated ROS

(2016) Hafiz Zeeshan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease

(2016) Manoela Mota et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Transgenic Expression of a Single Transcription Factor Pdx1 Induces Transdifferentiation of Pancreatic Acinar Cells to Endocrine Cells in Adult Mice

(2016) Satsuki Miyazaki et al.   PLoS One

Glucolipotoxicity initiates pancreatic β-cell death through TNFR5/CD40-mediated STAT1 and NF-κB activation

(2016) Marta Bagnati et al.   Cell Death & Disease

Glucagon-like peptide-1 prevents methylglyoxal-induced apoptosis of beta cells through improving mitochondrial function and suppressing prolonged AMPK activation

(2016) Tien-Jyun Chang et al.   Scientific Reports

Mitochondrial degradation and energy metabolism

(2015) Su Melser et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Humic Acid Increases Amyloid β-Induced Cytotoxicity by Induction of ER Stress in Human SK-N-MC Neuronal Cells

(2015) Hsin-Hua Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes

(2015) Sumaira Z Hasnain et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes

(2014) Amin Ardestani et al.   NATURE MEDICINE

Variants of mitochondrial autophagy: Types 1 and 2 mitophagy and micromitophagy (Type 3)

(2014) John J. Lemasters   Redox Biology

Mechanisms of insulin resistance in obesity

(2013) Jianping Ye   Frontiers of Medicine

Increased DNA Methylation and Decreased Expression ofPDX-1in Pancreatic Islets from Patients with Type 2 Diabetes

(2012) Beatrice T. Yang et al.   MOLECULAR ENDOCRINOLOGY

Insulin Resistance in Obesity as the Underlying Cause for the Metabolic Syndrome

(2010) Emily J. Gallagher et al.   MOUNT SINAI JOURNAL OF MEDICINE

Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress

(2009) Mira M. Sachdeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA