Article
Fisheries
Zhaosheng Sun, Yuting Qin, Danjie Liu, Bangjie Wang, Zhao Jia, Junya Wang, Qian Gao, Jun Zou, Yue Pang
Summary: Chemokines are soluble peptides that guide cell migration in development and immune defense. The CXC chemokine system in lamprey has been found to have diversified, showing variations in gene organization and expression patterns in different tissues, indicating an evolutionary adaptation in jawless fish.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Environmental Sciences
Fuyu Jin, Yaqian Li, Xuemin Gao, Xinyu Yang, Tian Li, Shupeng Liu, Zhongqiu Wei, Shifeng Li, Na Mao, Heliang Liu, Wenchen Cai, Hong Xu, Haibo Zhang
Summary: Exercise training has the potential to mitigate the progression of silicosis by suppressing the SRB/NLRP3 and TLR4 pathways. Macrophage-derived IL-17A plays a key role in silica-induced pulmonary inflammation and fibrosis. Exercise training effectively inhibits the IL-17A-CXCL5-CXCR2 axis in silicotic mice, reducing collagen deposition and preserving elastic fibers, ultimately slowing down pulmonary fibrosis advancement and improving lung function post silica exposure.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Yuqing Li, Pei Zhang, Chengbin Gao, Min Cao, Ning Yang, Xingchun Li, Chao Li, Qiang Fu
Summary: The study identified chemokine ligands and receptors from Sebastes schlegelii genome, which showed widespread expression in healthy tissues and differential expression after infection, interacting with immune-related genes. These findings provide insights for further functional characterization and comparative immunological studies in teleost fish.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Immunology
Gertraud Orend, Richard P. Tucker
Summary: Tenascin-C plays important roles in immunity, interacting with Toll-like receptor 4, integrin alpha 9 beta 1, and chemokines. While tenascins predate the appearance of adaptive immunity, the first tenascin-C appears to have evolved in early chordate lineages. Adaptive immunity evolved independently in jawless and jawed vertebrates, with the former using variable lymphocyte receptors and the latter using immunoglobulins.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Sven H. Loosen, Tom F. Ulmer, Simon Labuhn, Jan Bednarsch, Sven A. Lang, Patrick H. Alizai, Anne T. Schneider, Mihael Vucur, Ulf P. Neumann, Tom Luedde, Christoph Roderburg
Summary: This study identified circulating levels of CXCL13 as a previously unrecognized marker for predicting outcomes following the resection of BTC, highlighting the potential role of the CXC chemokine family in BTC pathogenesis.
Article
Biology
Jennifer L. Vella, Aleksey Molodtsov, Christina Angeles, Bruce R. Branchini, Mary Jo Turk, Yina H. Huang
Summary: Dendritic cells play a crucial role in supporting T-RM responses to melanoma, with their close interaction being essential for maintaining immune protection. Chemotaxis and adhesion mediated by the CXCR6/CXCL16 axis are critical for T-RM migration and persistence in the skin, with the interaction between CXCR6-expressing T-RM cells and CXCL16-expressing APCs being pivotal for sustaining T-RM cell-mediated tumor protection.
LIFE SCIENCE ALLIANCE
(2021)
Article
Fisheries
Dan Qiao, Yanjing Zhao, Chao Pei, Xianliang Zhao, Xinyu Jiang, Lei Zhu, Jie Zhang, Li Li, Xianghui Kong
Summary: This study identified and characterized 61 CC chemokines from allotetraploid common carp, revealing their unique features in cell migration, gene arrangement, and chromosomal location. Additionally, the study predicted and verified the antimicrobial activity of certain CC chemokines, highlighting their important role in immune system evolution and pathogen infection.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yeonhee Lee, Jangwook Lee, Minkyoung Park, Areum Seo, Kyu Hyeon Kim, Seonmi Kim, Minjung Kang, Eunjeong Kang, Kyung Don Yoo, Sunhwa Lee, Dong Ki Kim, Kook-Hwan Oh, Yon Su Kim, Kwon Wook Joo, Seung Hee Yang
Summary: We investigated the levels of chemokine CCL8 in PD effluent and serum, as well as its tissue expression, and found an association with peritoneal fibrosis. We also found that CCL8 levels significantly increased with the duration of PD and were correlated with peritoneal transport parameters. In a mouse model, CCL8 blockade improved peritoneal inflammation and fibrosis.
Review
Oncology
Xianxian Wu, Hongdian Zhang, Zhilin Sui, Yang Wang, Zhentao Yu
Summary: Esophageal squamous cell carcinoma is the main type of esophageal cancer, where abnormal expression of CXCL12 and CXCR4 contributes to tumor proliferation, distant metastases, and worsening prognosis. Antagonists and imaging agents targeting CXCL12/CXCR4 have been developed to interfere with and monitor tumor metastasis.
CANCER BIOLOGY & MEDICINE
(2021)
Article
Immunology
Zeyu Sun, Wenhua Huang, Yuling Zheng, Peng Liu, Wenbo Yang, Zinan Guo, Decong Kong, Qingyu Lv, Xinyu Zhou, Zongmin Du, Hua Jiang, Yongqiang Jiang
Summary: The research discovered that mice without the Fpr2 receptor were highly susceptible to GBS infections, showing decreased chemotaxis of neutrophils, decreased bactericidal ability of neutrophils, and high mortality.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiumei Wei, Cheng Li, Yu Zhang, Kang Li, Jiaqi Li, Kete Ai, Kunming Li, Jiansong Zhang, Jialong Yang
Summary: The study identified a evolutionarily conserved NF-kappa B signaling pathway in Nile tilapia, which plays a critical role in adaptive immunity in fish.
Article
Cell Biology
Mariko Tsunoda, Mai Fukasawa, Anna Nishihara, Leo Takada, Masatake Asano
Summary: The study demonstrates that the proteasome inhibitor MG132 enhances IL-8 secretion, regulated by the transcription factor AP-1. The research investigates the combination of AP-1 family proteins contributing to MG132-driven IL-8 secretion.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Brianna L. L. Hill, Alyssa N. N. Calder, Joseph P. P. Flemming, Yiyang Guo, Sydney L. L. Gilmore, Melissa A. A. Trofa, Sean K. K. Daniels, Torbjoern N. N. Nielsen, Laura K. K. Gleason, Zoya Antysheva, Ksenia Demina, Nikita Kotlov, Christopher J. H. Davitt, David M. M. Cognetti, George C. C. Prendergast, Adam E. E. Snook, Jennifer M. M. Johnson, Gaurav Kumar, Alban J. J. Linnenbach, Ubaldo Martinez-Outschoorn, Andrew P. P. South, Joseph M. M. Curry, Larry A. A. Harshyne, Adam J. J. Luginbuhl, My G. Mahoney
Summary: Therapy using anti-PD-1 immune checkpoint inhibitors has revolutionized cancer treatment, but only a fraction of patients respond. The study identified Dsg2, miR-146a, and IL-8 as potential biomarkers for ICI response in HPVpos HNSCC patients, suggesting that targeting the Dsg2/miR-146a/IL-8 signaling axis could improve ICI responsiveness.
MOLECULAR CARCINOGENESIS
(2023)
Article
Fisheries
Daniel E. Saenz-Martinez, Paula A. Santana, Monica Arostica, Juan C. Forero, Fanny Guzman, Luis Mercado
Summary: The C-terminal end of IL-8 can be cleaved under acidic conditions, retaining its antibacterial properties and detectable in tissues of infected rainbow trout.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Immunology
Aaron F. Carlin, Suganya Viriyakosol, Sharon Okamoto, Lorraine Walls, Joshua Fierer
Summary: IL-8R2-deficient mice infected with Coccidioides immitis show decreased neutrophils in the lungs, lower organism count, higher expression of genes associated with lymphocyte activation, and increased levels of IL-17A and IFN-γ in bronchial alveolar lavage fluid, suggesting a potential role of neutrophils in interfering with the protective Th1/Th17 immune response to the infection.
INFECTION AND IMMUNITY
(2021)
Meeting Abstract
Immunology
Kazuki Yoshioka, Yoko Kato-Unoki, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao
Article
Biochemistry & Molecular Biology
Indriyani Nur, Nevien K. Abdelkhalek, Shiori Motobe, Ryota Nakamura, Masakazu Tsujikura, Tomonori Somamoto, Miki Nakao
MOLECULAR IMMUNOLOGY
(2016)
Article
Environmental Sciences
Nevien K. M. Abdelkhalek, Ismail A. M. Eissa, Eman Ahmed, Omnia E. Kilany, Mohamed El-Adl, Mahmoud A. O. Dawood, Ahmed M. Hassan, Mohamed M. Abdel-Daim
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2017)
Article
Pharmacology & Pharmacy
Yoko Kato-Unoki, Yuki Takai, Masato Kinoshita, Toshitaka Mochizuki, Ryohei Tatsuno, Yohei Shimasaki, Yuji Oshima
Article
Plant Sciences
Koki Mukai, Yohei Shimasaki, Xuchun Qiu, Yoko Kato-Unoki, Kun Chen, Mst Ruhina Margia Khanam, Yuji Oshima
EUROPEAN JOURNAL OF PHYCOLOGY
(2019)
Article
Fisheries
Nevien K. Abdelkhalek, Engy Risha, Mohamed A. El-Adl, Mohamed F. Salama, Mahmoud A. O. Dawood
FISH & SHELLFISH IMMUNOLOGY
(2020)
Article
Fisheries
Mahmoud A. O. Dawood, Ibrahim S. El-Shamaa, Nagwa Abdel-Razik, Azza H. Elkomy, Mahmoud S. Gewaily, Safaa E. Abdo, Ali A. Soliman, Bilal Ahamad Paray, Nevien Abdelkhalek
FISH & SHELLFISH IMMUNOLOGY
(2020)
Article
Environmental Sciences
Xuchun Qiu, Takumi Takamura, Shintaro Enoki, Yoko Kato-Unoki, Yuki Takai, Yosuke Nagano, Masato Kinoshita, Takeshi Kitano, Yohei Shimasaki, Yuji Oshima
MARINE POLLUTION BULLETIN
(2020)
Article
Fisheries
Mohammed F. El Basuini, Shimaa A. Shahin, Islam I. Teiba, Mohamed A. A. Zaki, Abdelaziz M. El-Hais, Hani Sewilam, Rafa Almeer, Nevien Abdelkhalek, Mahmoud A. O. Dawood
Summary: The study showed that dietary supplementation of different doses of Coenzyme Q10 and Vitamin C to Nile tilapia significantly influenced growth performance, digestive enzyme activity, blood indices, immune response, and antioxidative capacity, particularly enhancing the resistance of fish against Streptococcus agalactiae infection.
Article
Fisheries
Nevien Abdelkhalek, Mohamed El-Adl, Ahmed El-Ashram, Mayar Othman, Hossam Gadallah, Mohamed El-Diasty, Mahmoud A. O. Dawood, Rafa Almeer, Mohamed Abdel Daim
Summary: This study reveals that dietary curcumin can protect fish against the toxic effects of fipronil by improving antioxidant and immunological parameters in intoxicated fish.
AQUACULTURE RESEARCH
(2021)
Article
Fisheries
Norhan E. Saleh, Nevien Abdelkhalek, Samah Lashen, Eman Abbas
Summary: Supplementation of inosine (I) and uracil (U) in sea bream fingerlings' diet enhances growth, improves intestinal health, boosts immune response, increases resistance to stress exposure, and reduces oxidative stress levels.
AQUACULTURE RESEARCH
(2021)
Article
Fisheries
Zaki Z. Sharawy, Eman M. Abbas, Nevien K. Abdelkhalek, Ola A. Ashry, Lamis S. Abd El-Fattah, Mohamed A. El-Sawy, Mohamed F. Helal, Ehab El-Haroun
Summary: The study evaluated the effect of different stocking densities in a biofloc system with sugarcane bagasse as an organic carbon source on growth performance, immune response-related genes, and microbial biomass of shrimp larvae. The results showed that biofloc treatment significantly influenced the total number of heterotrophic bacteria and Vibrio spp. counts, positively impacting growth performance and disease resistance in shrimp larvae.
Article
Multidisciplinary Sciences
Yoko Kato-Unoki, Keitaro Umemura, Kosuke Tashiro
Article
Environmental Sciences
Yoko Kato-Unoki, Yuki Takai, Yosuke Nagano, Satoshi Matsunaga, Shintaro Enoki, Takumi Takamura, Sangwan Kim, Masato Kinoshita, Takeshi Kitano, Yohei Shimasaki, Yuji Oshima
MARINE POLLUTION BULLETIN
(2020)