Review
Endocrinology & Metabolism
Laurel Moar, Chloe Simela, Surabhi Nanda, Andreas Marnerides, Mudher Al-Adnani, Catherine Nelson-Piercy, Kypros H. Nicolaides, Panicos Shangaris
Summary: This systematic review and meta-analysis examines the perinatal outcomes of pregnancies affected by chronic histiocytic intervillositis (CHI) and investigates the relationship between CHI lesion severity and pregnancy loss. The results suggest that current evidence for the diagnosis and treatment of CHI is insufficient, with mixed results for the efficacy of different treatments. However, the study confirms previous hypotheses that more severe CHI lesions are associated with higher odds of pregnancy loss. Further prospective research is needed to obtain robust evidence regarding treatment safety, efficacy, and optimal drug regimens.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Health Care Sciences & Services
Alexandra Bouariu, Nicolae Gica, Anca Marina Ciobanu, Ana Maria Scutelnicu, Mihaela Roxana Popescu, Anca Maria Panaitescu
Summary: The placenta serves as the connection between maternal and fetal circulation, established early in pregnancy. Chronic placental inflammatory (CPI) lesions can lead to various pregnancy complications, and hydroxychloroquine (HCQ) shows potential in the treatment of CPI of unknown etiology.
Article
Obstetrics & Gynecology
Alexandra Benachi, Marion Rabant, Jelena Martinovic, Hanane Bouchghoul, Alexandre J. Vivanti, Juliette Leon, Anne Grunenwald, Lubka Roumenina, Jean-Louis Celton, Bettina Bessieres, Jean-Luc Taupin, Julien Zuber
Summary: This study demonstrates the role of anti-human leukocyte antigen alloantibodies in the pathogenesis of chronic histiocytic intervillositis, through thorough immunologic and pathologic investigations on two couples experiencing recurrent fetal losses. The findings suggest that fetus-specific antibodies targeting mismatched human leukocyte antigen alleles from paternal haplotypes induce complement activation in trophoblastic villi, leading to chronic intervillositis.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Developmental Biology
M. Bos, M. J. M. Koenders, K. L. Dijkstra, L. E. van der Meeren, P. G. J. Nikkels, K. W. M. Bloemenkamp, M. Eikmans, H. J. Baelde, M. L. P. van der Hoorn
Summary: Chronic histiocytic intervillositis (CHI) is a rare placental histopathological lesion associated with poor reproductive outcomes. The severity of intervillous infiltrate and clinical outcomes of CHI vary between cases. This study aims to determine the relationship between severity of intervillous infiltrate and clinical outcomes of CHI.
Review
Developmental Biology
Laura Linehan, Keelin O'Donoghue, Susan Dineen, Jessica White, John R. Higgins, Brendan Fitzgerald
Summary: SARS-CoV-2 infection during pregnancy can lead to placental infection, posing a threat to the fetus, though this situation is relatively rare.
Article
Medicine, General & Internal
Sophie Stenton, Jo McPartland, Rajeev Shukla, Kerry Turner, Tamas Marton, Beata Hargitai, Andrew Bamber, Jeremy Pryce, Cesar L. Peres, Nadia Burguess, Bart Wagner, Barbara Ciolka, William Simmons, Daniel Hurrell, Thivya Sekar, Corina Moldovan, Claire Trayers, Victoria Bryant, Liina Palm, Marta C. Cohen
Summary: Pregnant women with SARS-CoV-2 infection have higher rates of stillbirth and preterm birth. A unique pattern of chronic histiocytic intervillositis (CHI) and/or massive perivillous fibrin deposition (MPFD) called SARS-CoV-2 placentitis has emerged. This study describes a cohort of placentas diagnosed with SARS-CoV-2 placentitis and finds that it is associated with increased risk of pregnancy loss in the third trimester.
Article
Pathology
Raymond W. Redline, Sanjita Ravishankar, Christina Bagby, Shahrazad Saab, Shabnam Zarei
Summary: COVID-19 infection during pregnancy can lead to placental infection, preterm delivery, and preeclampsia. The study aimed to investigate the frequency, early pathogenesis, and associated lesions of placental infection in mothers with COVID-19. The results showed a higher prevalence of placental infection in preterm births and identified other placental lesions associated with COVID-19. Further investigation suggested that the infection may be caused by viral-infected maternal leukocytes.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Developmental Biology
Nora Hersoug Nedberg, Gitta Turowski, Katarzyna Guz, Ewa Przytula, Malgorzata Uhrynowska, Borghild Roald, Anne Husebekk, Vasilis Sitras, Mona Nystad, Marzena Debska, Ewa Brojer, Heidi Tiller
Summary: This study systematically examined placentas from pregnancies with maternal alloimmunization against HPA-1a, finding a significant association between chronic histiocytic intervillositis and maternal anti-HPA-1a antibodies. Maternal IVIg administration did not appear to protect against chronic inflammatory lesions.
Review
Obstetrics & Gynecology
M. Daumova, S. Hadravska, A. Strakova Peterikova, T. Vanecek, M. Matas, V. Korecko
Summary: Since 2020, there have been reported cases of pregnant women infected with SARS-CoV-2, leading to severe complications. Current studies suggest that the transmission of infection from mother to fetus through the placenta is rare, and the complications are more likely to be caused by placental tissue damage.
CESKA GYNEKOLOGIE-CZECH GYNAECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lotte E. van der Meeren, Juliette Krop, Kyra L. Dijkstra, Kitty W. M. Bloemenkamp, Emily F. Cornish, Peter G. J. Nikkels, Marie-Louise P. van der Hoorn, Manon Bos
Summary: Chronic intervillositis of unknown etiology (CIUE) is a rare histopathological diagnosis of the placenta that is thought to be immunologically driven and related to human leukocyte antigen mismatches between the mother and the fetus. In cases of dizygotic twins where CIUE is present in only one placenta, it can lead to selective growth restriction in the affected twin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Virology
David A. Schwartz
Summary: Stillbirth in pregnant women with COVID-19 may occur due to placental infection, resulting in placental dysfunction and subsequent fetal death. The pathological lesions include increased fibrin deposition, trophoblast necrosis, and chronic histiocytic intervillositis. This destructive placental process can lead to stillbirth and neonatal death, independent of fetal infection. Maternal vaccination may help prevent viremia and consequent placental infection.
Article
Developmental Biology
Jefferson Terry, Mohamed A. Bedaiwy
Summary: This study uses digital spatial profiling to assess the pathogenetic mechanism of CIUE and reveals a specific profile of inflammatory mediators dominated by IFN signaling.
Article
Biochemistry & Molecular Biology
Svitlana Skoroplyas, Ondrej Vasicek, Michaela Chorvatova, Petra Dad'ova, Katerina Lehka, Lukas Kubala
Summary: Pseurotin D has the potential to inhibit DTH reaction through inhibiting the activation and differentiation of both T cells and B cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Oncology
Ines Roger, Paula Montero, Martin Perez-Leal, Javier Milara, Julio Cortijo
Summary: The clinical practice faces the problem of delayed-type hypersensitivity (DTH) caused by various drugs, especially in antineoplastic treatments. DTH reactions can range from mild self-limiting maculopapular eruptions to severe Stevens-Johnson Syndrome, resulting in worsened patient quality of life. Apart from impacting patients, these reactions also lead to economic losses due to drug withdrawal and high hospitalization costs. However, there is currently no standard in vitro or in vivo method to evaluate the sensitizing potential of drugs in preclinical studies. This review aims to comprehensively evaluate in vitro and in vivo methods for detecting DTH and testing antineoplastic hypersensitivity reactions caused by different antineoplastic families.
Article
Respiratory System
Evans R. Fernandez Perez, Laura D. Harmacek, Brian P. O'Connor, Thomas Danhorn, Brian Vestal, Lisa A. Maier, Tilman L. Koelsch, Sonia M. Leach
Summary: PBMC expression profiles have prognostic value in patients with CHP, helping distinguish between those with disease progression and those without. Classification models based on gene expression and clinical factors outperform models based solely on clinical factors.
Article
Pathology
Mana Taweevisit, Boochit Theerasantipong, Kanlaya Taothong, Paul Scott Thorner
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
(2017)
Article
Dentistry, Oral Surgery & Medicine
Mana Taweevisit, Warisa Tantidolthanes, Somboon Keelawat, Paul Scott Thorner
INTERNATIONAL DENTAL JOURNAL
(2018)
Article
Pathology
Mana Taweevisit, Paul S. Thorner
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
(2019)
Article
Cell Biology
Mana Taweevisit, Paul Scott Thorner
Review
Pathology
Mana Taweevisit, Paul Thorner
FETAL AND PEDIATRIC PATHOLOGY
(2019)
Meeting Abstract
Developmental Biology
Mana Taweevisit, Paul Thorner
Review
Pathology
Mana Taweevisit, Paul Scott Thorner
Summary: This study examined the role of placental pathology in perinatal deaths at Chulalongkorn University Hospital in Bangkok. The results showed that placental causes of death were less common, but inflammatory-immune processes were more common. Further study is needed to understand the underlying factors.
FETAL AND PEDIATRIC PATHOLOGY
(2022)
Article
Pathology
Mana Taweevisit, Nutchanok Thawornwong, Paul Scott Thorner
Summary: The association between MPFD and placental syphilis expands the list of possible causes for this rare placental disorder. The syphilis infection in this case is believed to have led to a hypercoagulable state and resulted in MPFD. The recurrence risk of MPFD/MFI associated with infections, including syphilis, is thought to be lower compared to idiopathic cases.
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
(2021)
Article
Pathology
Mana Taweevisit, Montakarn Tansatit, Piriya Sutthiruangwong, Noppachai Siranart, Paul Scott Thorner
Summary: This article reports a case of massive perivillous fibrin deposition (MPFD) associated with cytomegalovirus (CMV) placentitis, showing features intermediate between CMV placentitis and villitis of unknown etiology (VUE). The study suggests that the viral infection in this case may have triggered a maternal immune response, leading to trophoblastic cell damage.
FETAL AND PEDIATRIC PATHOLOGY
(2022)
Article
Obstetrics & Gynecology
Mana Taweevisit, Panachai Nimitpanya, Paul S. Thorner
Summary: The aim of this study was to improve the accuracy of International Classification of Diseases for Perinatal Mortality (ICD-PM) by incorporating a wider spectrum of placental pathology as a separate parameter for classifying perinatal death.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Pathology
Mana Taweevisit, Panachai Nimitpanya, Paul S. Thorner
Summary: Maternal floor infarction (MFI) and massive perivillous fibrin deposition (MPFD) are placental disorders associated with adverse obstetric outcome and a risk of recurrence. We describe a case of a 31-year-old mother with asymptomatic thrombocytopenia and positive lupus anticoagulant, who delivered a normal neonate with a small-for-gestational-age placenta showing MPFD and excessive subchorionic fibrinoid deposition.
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
(2022)
Review
Pathology
Mana Taweevisit, Ariya Chindamporn, Kritsaporn Sujjavorakul, Rujipat Samransamruajkit, Paul Scott Thorner
Summary: Multisystem inflammatory syndrome in children (MIS-C) is a rare condition associated with SARS-COV-2 infection, characterized by hyper-inflammatory state and multi-organ failure. Autopsy examination plays an important role in understanding the pathogenesis of MIS-C. This report describes the first autopsy of an MIS-C patient from Asia, revealing the presence of SARS-COV-2 virus in multiple organs and highlighting the risks of immunosuppression in MIS-C.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Review
Biochemistry & Molecular Biology
Piya Chaemsaithong, Suchaya Luewan, Mana Taweevisit, Wararat Chiangjong, Pisut Pongchaikul, Paul Scott Thorner, Theera Tongsong, Somchai Chutipongtanate
Summary: Extracellular vesicles (EVs) are nano-scaled vesicles released from all cell types into extracellular fluids and specifically contain signature molecules of the original cells and tissues, including the placenta. Placenta-derived EVs can be detected in maternal circulation at as early as six weeks of gestation, and their release can be triggered by the oxygen level and glucose concentration. Placental-associated complications such as preeclampsia, fetal growth restriction, and gestational diabetes have alterations in placenta-derived EVs in maternal plasma, and this can be used as a liquid biopsy for the diagnosis, prediction, and monitoring of such pregnancy complications. Alpha-thalassemia major (homozygous alpha-thalassemia-1) or hemoglobin Bart's disease is the most severe form of thalassemia disease, and this condition is lethal for the fetus. Women with Bart's hydrops fetalis demonstrate signs of placental hypoxia and placentomegaly, thereby placenta-derived EVs provide an opportunity for a non-invasive liquid biopsy of this lethal condition. In this article, we introduced clinical features and current diagnostic markers of Bart's hydrops fetalis, extensively summarize the characteristics and biology of placenta-derived EVs, and discuss the challenges and opportunities of placenta-derived EVs as part of diagnostic tests for placental complications focusing on Bart's hydrop fetalis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Weerapat Anegkamol, Panumas Kamkang, Sittiphong Hunthai, Maroot Kaewwongse, Mana Taweevisit, Natthaya Chuaypen, Pakkapon Rattanachaisit, Thasinas Dissayabutra
Summary: Microbiota-dysbiosis-induced gut leakage is a pathophysiologic change in chronic kidney disease (CKD), leading to the production of uremic toxins and their absorption into the bloodstream. This study evaluates the benefits of resistant maltodextrin (RMD) and chitosan oligosaccharide (COS) supplements in cell culture and CKD-induced rats. The results show that RMD has a significant anti-inflammatory effect and improves gut barrier function in CKD rats compared to inulin and COS.
Meeting Abstract
Pediatrics
Mana Taweevisit, Paul Thorner
EUROPEAN JOURNAL OF PEDIATRICS
(2017)
