Article
Medicine, General & Internal
Admire Matsika
Summary: Placental histopathological reports often contain diagnostic entities with contentious clinical significance, impacting maternal and neonatal outcomes. Evidence-based guidelines for management of these conditions are lacking, warranting further research and clinical trials for guidance.
AUSTRALIAN JOURNAL OF GENERAL PRACTICE
(2021)
Review
Immunology
Mekinian Arsene, Kamila Kolanska, Meryam Cheloufi, Aurore Coulomb, Jonathan Cohen, Noemie Abisror, Marie Bornes, Gilles Kayem, Jaume Alijotas-Reig, Olivier Fain
Summary: Villitis of unknown etiology (VUE) is characterized by lympho-histiocytic infiltrates in the villous stroma, which can have adverse effects on fetal growth and pregnancy outcomes. However, data on the management and treatment of VUE are extremely limited, with a need for prospective and well-designed studies to determine the real prevalence of adverse pregnancy events associated with VUE.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Pathology
Catherine K. Gestrich, Yi Yuan Zhou, Sanjita Ravishankar
Summary: This case report describes a rare congenital CMV infection associated with MPVFD, lacking classical placental findings. MPVFD is an uncommon placental lesion linked to adverse fetal outcomes and a high recurrence risk, but patients with an infectious cause may have a lower risk of recurrence compared to those with other associated clinical conditions.
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
(2021)
Article
Developmental Biology
Linda M. Ernst, Crystal Bockoven, Alexa Freedman, Vivien Wang, Matthew Pellerite, Todd N. Wylie, Kristine M. Wylie
Summary: Viruses, particularly herpesviruses, were more frequently detected in cases compared with controls. Antiviral pathways were upregulated in cases. VUE may have multiple inflammatory gene expression profiles.
Article
Obstetrics & Gynecology
Joao Figueira Scarini, Natalia de Magalhaes Rodrigues, Wellington Lima Sabino, Ciro Soares, Thayna Melo de Lima Morais, Reydson Alcides de Lima-Souza, Livia Ramalho Crescencio, Rogerio de Oliveira Gondak, Fernanda Viviane Mariano, Albina Altemani, Erika Said Abu Egal
Summary: The study identified the predominance of M1 macrophages in inflamed areas of villitis of unknown etiology (VUE), indicating their influence in the pathogenesis of VUE. The higher presence of M2 in both inflamed villi and normal areas suggests a potential immunoregulatory mechanism in the inflammatory process of VUE.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Pathology
Mana Taweevisit, Nutchanok Thawornwong, Paul Scott Thorner
Summary: The association between MPFD and placental syphilis expands the list of possible causes for this rare placental disorder. The syphilis infection in this case is believed to have led to a hypercoagulable state and resulted in MPFD. The recurrence risk of MPFD/MFI associated with infections, including syphilis, is thought to be lower compared to idiopathic cases.
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
(2021)
Article
Pathology
Mana Taweevisit, Panachai Nimitpanya, Paul S. Thorner
Summary: Maternal floor infarction (MFI) and massive perivillous fibrin deposition (MPFD) are placental disorders associated with adverse obstetric outcome and a risk of recurrence. We describe a case of a 31-year-old mother with asymptomatic thrombocytopenia and positive lupus anticoagulant, who delivered a normal neonate with a small-for-gestational-age placenta showing MPFD and excessive subchorionic fibrinoid deposition.
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
(2022)
Review
Developmental Biology
Lawrence de Koning, Susan Crawford, Erik Nohr, Rati Chadha, Christopher Horn, James R. Wright, Elaine S. Chan
Summary: In this study, the largest, most comprehensive, and methodologically robust to date, the recurrence risk of villitis of unknown etiology (VUE) was found to be similar to 30%.
Article
Developmental Biology
Jeffery A. Goldstein, Ramin Nateghi, Ismail Irmakci, Lee A. D. Cooper
Summary: In this study, a machine learning model was used to identify and classify placental parenchymal lesions. The overall balanced accuracy was 0.86, and the three lesions were successfully recognized. Attention maps were used to gain further insight into the model's function.
Article
Developmental Biology
Ingrid Iara Damas, Luccas Lavareze, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Carolina Emerick, Mayara Trevizol Goncalves, Tayna Figueiredo-Maciel, Gustavo de Souza Vieira, Talita de Carvalho Kimura, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, My N. Helms, Fernanda Viviane Mariano, Albina Altemani, Erika Said Abu Egal
Summary: Villitis of unknown etiology (VUE) is an inflammatory disease characterized by the infiltration of maternal CD8 + T cells into the placental villi. Dysregulation of the immune system appears to be an important factor in the development of VUE, and its pathogenesis may be similar to graft vs host disease (GVHD) and allographic rejection. Understanding the immunological characteristics of VUE in comparison to GVHD and allograft rejection can contribute to the development of therapeutic strategies for VUE in the future.
Article
Developmental Biology
Brenden Osborne, Sonia R. Dancey, Erika Mery, Irina Oltean, Vid Bijelic, Joseph de Nanassy, Sarah L. Lawrence, Felipe Moretti, Dina El Demellawy
Summary: This study aimed to investigate the relationship between the severity and distribution of villitis of unknown etiology (VUE) and adverse neonatal outcomes. The results showed a significant association between the severity and distribution of VUE and the need for newborn resuscitation, but no significant association with other neonatal outcomes of interest. Further studies with larger sample sizes are needed to confirm these associations for obstetric and neonatal case management.
Review
Immunology
Emily F. Cornish, Thomas McDonnell, David J. Williams
Summary: Chronic inflammatory placental disorders, including villitis of unknown etiology, chronic histiocytic intervillositis, and massive perivillous fibrin deposition, are rare but devastating gestational syndromes associated with adverse pregnancy outcome. These disorders are characterized by infiltration of maternal immune cells in the placenta, disrupting the gas exchange between the mother and fetus, and have a significant risk of recurrence in subsequent pregnancies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Developmental Biology
K. Lampi, N. Papadogiannakis, M. Sirotkina, K. Pettersson, G. Ajne
Summary: The study aimed to investigate the impact of massive perivillous fibrin deposition (MPVFD) in the placenta. The results showed a correlation between severe MPVFD and higher rates of preterm birth, fetal growth restriction, and intrauterine fetal death.
Article
Obstetrics & Gynecology
Hannah M. Scott, Ramila Mehta, Megan E. Branda, Jennifer Hughes, Sunanda V. Kane, Sylvie Girard, Andrew P. Norgan, Regan N. Theiler, Elizabeth Ann L. Enninga
Summary: This study investigated the effects of anti-TNF-alpha treatment in pregnant women with autoimmune diseases. The results showed that anti-TNF-alpha therapy did not significantly affect the occurrence of chronic villitis of unknown etiology or other obstetric complications. Therefore, this study supports the safety profile of biologic use in pregnancy.
REPRODUCTIVE SCIENCES
(2023)
Article
Obstetrics & Gynecology
Charlotte Krones, Mi Vu, Benjamin Popp, Laura Scardamaglia
Summary: We report the case of a 42-year-old woman with dermatomyositis in pregnancy, presenting with a rash and joint pain in the third trimester. She underwent an emergency Caesarean section due to fetal distress and her placenta showed massive perivillous fibrin deposition. This is the first reported case of MDA-5 positive dermatomyositis in pregnancy with a live delivery.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Article
Pathology
Mana Taweevisit, Boochit Theerasantipong, Kanlaya Taothong, Paul Scott Thorner
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
(2017)
Article
Dentistry, Oral Surgery & Medicine
Mana Taweevisit, Warisa Tantidolthanes, Somboon Keelawat, Paul Scott Thorner
INTERNATIONAL DENTAL JOURNAL
(2018)
Article
Pathology
Mana Taweevisit, Paul S. Thorner
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
(2019)
Article
Cell Biology
Mana Taweevisit, Paul Scott Thorner
Review
Pathology
Mana Taweevisit, Paul Thorner
FETAL AND PEDIATRIC PATHOLOGY
(2019)
Meeting Abstract
Developmental Biology
Mana Taweevisit, Paul Thorner
Review
Pathology
Mana Taweevisit, Paul Scott Thorner
Summary: This study examined the role of placental pathology in perinatal deaths at Chulalongkorn University Hospital in Bangkok. The results showed that placental causes of death were less common, but inflammatory-immune processes were more common. Further study is needed to understand the underlying factors.
FETAL AND PEDIATRIC PATHOLOGY
(2022)
Article
Pathology
Mana Taweevisit, Nutchanok Thawornwong, Paul Scott Thorner
Summary: The association between MPFD and placental syphilis expands the list of possible causes for this rare placental disorder. The syphilis infection in this case is believed to have led to a hypercoagulable state and resulted in MPFD. The recurrence risk of MPFD/MFI associated with infections, including syphilis, is thought to be lower compared to idiopathic cases.
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
(2021)
Article
Obstetrics & Gynecology
Mana Taweevisit, Panachai Nimitpanya, Paul S. Thorner
Summary: The aim of this study was to improve the accuracy of International Classification of Diseases for Perinatal Mortality (ICD-PM) by incorporating a wider spectrum of placental pathology as a separate parameter for classifying perinatal death.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Pathology
Mana Taweevisit, Panachai Nimitpanya, Paul S. Thorner
Summary: Maternal floor infarction (MFI) and massive perivillous fibrin deposition (MPFD) are placental disorders associated with adverse obstetric outcome and a risk of recurrence. We describe a case of a 31-year-old mother with asymptomatic thrombocytopenia and positive lupus anticoagulant, who delivered a normal neonate with a small-for-gestational-age placenta showing MPFD and excessive subchorionic fibrinoid deposition.
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
(2022)
Review
Pathology
Mana Taweevisit, Ariya Chindamporn, Kritsaporn Sujjavorakul, Rujipat Samransamruajkit, Paul Scott Thorner
Summary: Multisystem inflammatory syndrome in children (MIS-C) is a rare condition associated with SARS-COV-2 infection, characterized by hyper-inflammatory state and multi-organ failure. Autopsy examination plays an important role in understanding the pathogenesis of MIS-C. This report describes the first autopsy of an MIS-C patient from Asia, revealing the presence of SARS-COV-2 virus in multiple organs and highlighting the risks of immunosuppression in MIS-C.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Review
Biochemistry & Molecular Biology
Piya Chaemsaithong, Suchaya Luewan, Mana Taweevisit, Wararat Chiangjong, Pisut Pongchaikul, Paul Scott Thorner, Theera Tongsong, Somchai Chutipongtanate
Summary: Extracellular vesicles (EVs) are nano-scaled vesicles released from all cell types into extracellular fluids and specifically contain signature molecules of the original cells and tissues, including the placenta. Placenta-derived EVs can be detected in maternal circulation at as early as six weeks of gestation, and their release can be triggered by the oxygen level and glucose concentration. Placental-associated complications such as preeclampsia, fetal growth restriction, and gestational diabetes have alterations in placenta-derived EVs in maternal plasma, and this can be used as a liquid biopsy for the diagnosis, prediction, and monitoring of such pregnancy complications. Alpha-thalassemia major (homozygous alpha-thalassemia-1) or hemoglobin Bart's disease is the most severe form of thalassemia disease, and this condition is lethal for the fetus. Women with Bart's hydrops fetalis demonstrate signs of placental hypoxia and placentomegaly, thereby placenta-derived EVs provide an opportunity for a non-invasive liquid biopsy of this lethal condition. In this article, we introduced clinical features and current diagnostic markers of Bart's hydrops fetalis, extensively summarize the characteristics and biology of placenta-derived EVs, and discuss the challenges and opportunities of placenta-derived EVs as part of diagnostic tests for placental complications focusing on Bart's hydrop fetalis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Weerapat Anegkamol, Panumas Kamkang, Sittiphong Hunthai, Maroot Kaewwongse, Mana Taweevisit, Natthaya Chuaypen, Pakkapon Rattanachaisit, Thasinas Dissayabutra
Summary: Microbiota-dysbiosis-induced gut leakage is a pathophysiologic change in chronic kidney disease (CKD), leading to the production of uremic toxins and their absorption into the bloodstream. This study evaluates the benefits of resistant maltodextrin (RMD) and chitosan oligosaccharide (COS) supplements in cell culture and CKD-induced rats. The results show that RMD has a significant anti-inflammatory effect and improves gut barrier function in CKD rats compared to inulin and COS.
Meeting Abstract
Pediatrics
Mana Taweevisit, Paul Thorner
EUROPEAN JOURNAL OF PEDIATRICS
(2017)