Article
Endocrinology & Metabolism
Jin Yu, Yulai Zhou, Jie Ding, Danying Zhang, Chaoqin Yu, Hefeng Huang
Summary: This study aimed to investigate the metabolic characteristics of overweight women with PCOS and analyze the possible mechanisms. The results showed that overweight PCOS patients were prone to hypertension, diabetes, low gonadal levels, and insulin resistance. Inflammatory cytokines CXCL12/SDF-1, Serpin E1/PAI-1, and MIF were predicted to play a crucial role in inducing insulin resistance in overweight PCOS through various biological functions and signal transductions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, Research & Experimental
Si-wei Zhang, Jing Zhou, Hans-Jurgen Gober, Wing Ting Leung, Ling Wang
Summary: PCOS is a common disorder in women of reproductive age, affecting their physiology and metabolism, and often leading to metabolic syndrome and insulin resistance; Berberine can intervene in the development of PCOS in multiple ways, including alleviating insulin resistance, reducing androgen levels, regulating lipid metabolism, and reducing inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Endocrinology & Metabolism
Hui He, Jiaxing Feng, Shike Zhang, Yu Wang, Jian Li, Jingshu Gao, Jing Cong, Yi Gong, Xiaoke Wu
Summary: The study found that there is a positive association between the ApoB/ApoA1 ratio and metabolic and endocrine parameters in women with PCOS. Higher ratios were also associated with increased risk of MetS and IR. The ratio could be a useful tool for screening MetS and IR in PCOS patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Ye Zhenhon, Chunmei Zhang, Siyu Wang, Yurong Zhang, Li Rong, Yue Zhou, Jie Qiao
Summary: This study found that women with PCOS have significant abnormality in amino acid metabolism. Specific amino acid markers can be used as powerful indicators for diagnosing PCOS and predicting metabolic disturbances.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Review
Obstetrics & Gynecology
Lijuan Zhang, Airong Chen, Jing Lu, Liuliu Ren, Zelin Hu
Summary: The meta-analysis results suggest that sitagliptin can improve insulin resistance, body mass index, total testosterone level, and high-density lipoprotein in patients with PCOS. However, larger, higher-quality studies are needed to evaluate the efficacy of sitagliptin in women with PCOS.
REPRODUCTIVE SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Congshun Ma, Qianru Xiang, Ge Song, Xuefei Wang
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease with no specific drug treatment. Quercetin (QUR), a flavonoid, has potential therapeutic effects for PCOS patients. However, the mechanisms of QUR in PCOS patients remain unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Zhengfang Xiong, Bing Li, Wenjuan Wang, Rui Wang, Ronghua Ma, Shengyan Jian
Summary: A study found that patients with polycystic ovary syndrome (PCOS) have higher levels of CTRP1, especially in PCOS-IR patients. CTRP1 may serve as a new marker for PCOS-IR patients and is associated with glucose/lipid metabolic disorder in PCOS patients.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Immunology
Ling-Xia Ha, Wei-Xia Li, Yu-Dong Du, Ying-Ying Yuan, Xiao-Xiao Qu
Summary: This study found that the level of tumor necrosis factor alpha (TNF-alpha) is elevated in the uterine fluid of patients with polycystic ovary syndrome (PCOS) and is correlated with clinical parameters. This suggests the presence of local inflammation in the uterine cavity of PCOS patients, and detection of cytokines in uterine secretions may be a simple and feasible method to understand the uterine microenvironment of PCOS patients.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Endocrinology & Metabolism
Kexin Wang, Yanhua Li
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. The etiologies of this syndrome are complex and involve prenatal factors, genetic variation, epigenetic mechanisms, unhealthy lifestyles, and environmental toxins. This review examines the molecular mechanisms underlying PCOS pathogenesis at the level of signaling pathways and discusses potential therapies including exosome therapy, gene therapy, and drugs based on traditional Chinese medicine and natural compounds.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Luigi Barrea, Ludovica Verde, Claudia Vetrani, Annamaria Docimo, Giulia de Alteriis, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: This study investigated the prevalence of different chronotype categories in women with PCOS and their impact on hormonal and metabolic aspects. The findings showed a higher prevalence of evening chronotype in women with PCOS, which was associated with worse hormonal and metabolic profiles.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Immunology
Hongyu Zhao, Rufeng Chen, Dongxue Zheng, Feng Xiong, Fan Jia, Jinyuan Liu, Lili Zhang, Nana Zhang, Shiqin Zhu, Yongmei Liu, Linhua Zhao, Xinmin Liu
Summary: This study analyzed the characteristics of the intestinal microbiota in patients with PCOS-IR and explored the mechanism of modified Banxia Xiexin Decoction in treating PCOS-IR. The results showed that PCOS-IR model had an imbalance of intestinal microbiota and Genus Clostridium_sensu_stricto_1 might be the pivotal pathogenic bacteria. Modified Banxia Xiexin Decoction can improve PCOS-IR by regulating the balance of intestinal microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Manuel R. Garcia-Saenz, Miry Lobaton-Ginsberg, Claudia Ramirez-Renteria, Nitzia Lopez-Juarez, Renata Saucedo, Jorge Valencia-Ortega, Aldo Ferreira-Hermosillo
Summary: This study evaluated the clinical and biochemical characteristics of patients with type 1 diabetes (T1D) with and without polycystic ovarian syndrome (PCOS). The results showed a prevalence of 39% for PCOS in T1D patients, and significant differences were found between patients with and without PCOS in terms of insulin usage, glucose levels, ovarian volume, and Ferriman-Gallwey scores. Additionally, PCOS women had a higher incidence of insulin resistance and metabolic syndrome.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Obstetrics & Gynecology
Ke Yang, Xiaoqing Zhang, Wenwu Gui, Qianna Zhen, Yanna Ban, Ying Chen, Li Ma, Shengnan Pan, Yutong Yan, Min Ding
Summary: This study reveals that PCOS patients have elevated plasma levels of indoles and highlights their correlation with glucose metabolism.
REPRODUCTIVE SCIENCES
(2023)
Review
Endocrinology & Metabolism
Lucas Bandeira Marchesan, Ramon Bossardi Ramos, Poli Mara Spritzer
Summary: The metabolic profiles of women with PCOS in Latin America are worse than those without PCOS in the same region, with higher anthropometric and metabolic parameters. Further studies evaluating metabolic comorbidities and distinct PCOS phenotypes in different Latin American countries are needed for primary and secondary prevention of PCOS in the region.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Jiayue Liu, Ying Liu, Xiaoliang Li
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, characterized by ovulation disorders, high androgen levels, and insulin resistance. The pathogenesis of PCOS is still unclear. Intestinal flora, known as the second genome of human beings, is closely linked to metabolic diseases, immune diseases, and infectious diseases. There is increasing evidence that intestinal flora can regulate insulin synthesis and secretion, affect androgen metabolism and follicular development, and play a role in chronic inflammation and obesity. The imbalance of intestinal flora, related to changes in microbial diversity and interactions with host cells, is associated with the occurrence and development of PCOS. Modulating intestinal flora may offer a potential direction for PCOS treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)