Article
Biochemistry & Molecular Biology
Youngjae Ryu, Yong Jin Kim, Yoon Young Kim, Jungwoo Kim, Sung Woo Kim, Hoon Kim, Seung Yup Ku
Summary: This study successfully established a PCOS model in mice using STZ, with findings indicating that low doses of STZ can induce PCOS features without causing diabetes features. Different doses of STZ treatment had varying effects on body weight, blood glucose levels, and hormone levels in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Huamin Zeng, Ying Zhang, Sikai Huang, Jinghua Wu, Wenrui Ren, Lingru Zhou, Leneng Huang, Yuyin Ye
Summary: Metformin combined with spironolactone therapy may be more effective in reducing BMI and serum androgen levels in PCOS patients. However, it does not have a significant effect on hirsutism score or gonadotropin hormone levels, and is not associated with an elevation in side-effects. When the treatment course is greater than 6 months, combination therapy can effectively reduce FBG and improve insulin resistance.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Izabela Chudzicka-Strugala, Anna Kubiak, Beata Banaszewska, Barbara Zwozdziak, Martyna Siakowska, Leszek Pawelczyk, Antoni J. Duleba
Summary: The study demonstrated that in women with PCOS, lifestyle modifications combined with synbiotic supplementation can significantly decrease body weight, waist circumference, hip circumference, and thigh circumference, as well as lead to a significant reduction in serum testosterone levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Izabela Chudzicka-Strugala, Anna Kubiak, Beata Banaszewska, Barbara Zwozdziak, Martyna Siakowska, Leszek Pawelczyk, Antoni J. Duleba
Summary: The study found that synbiotic supplementation can enhance the effects of lifestyle modifications on weight and testosterone levels in patients with PCOS, leading to significant improvements.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Roshan Nazirudeen, Subbiah Sridhar, Raghavendran Priyanka, Baskaran Sumathi, Vasanthiy Natarajan, Eagappan Subbiah, Kasthuri Santharam Raghavan, Jayaraman Sangumani
Summary: This study compared the effects of metformin monotherapy with a combination of metformin, myoinositol, and d-chiro-inositol in patients with polycystic ovary syndrome (PCOS). The study found that the combination therapy showed significantly greater improvement in menstrual cycle regularity and quality of life, but there was no statistically significant difference in other hormonal and metabolic parameters.
CLINICAL ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Yanbo Liu, Yupei Shao, Jiping Xie, Linlin Chen, Guang Zhu
Summary: The combination of metformin and simvastatin is more effective in treating PCOS compared to metformin alone, with advantages in improving sex hormone levels, blood lipids, and blood sugar. However, the safety of this therapy still needs to be further explored in clinical studies with high-quality and large samples.
Article
Endocrinology & Metabolism
Qingjie Peng, Xiaojiang Chen, Xiaoxia Liang, Jiahui Ouyang, Qiangqiang Wang, Shuai Ren, Haibo Xie, Chunhong Wang, Yaqun Sun, Xin Wu, Hetao Liu, Changchun Hei, Miao Sun, Qing Chang, Xinrui Liu, Guangyong Li, Rui He
Summary: The study investigated the effect of metformin on PCOS using a PCOS mouse model and explored the mechanism of metformin in regulating PCOS mice through the ferroptosis pathway. The results showed that metformin not only improved body weight and metabolic disorders but also improved ovarian dysfunction in PCOS mice.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Jie Meng, Yingjun Zhu
Summary: The meta-analysis showed that combined treatment with simvastatin plus metformin was more effective in treating polycystic ovary syndrome (PCOS) compared to metformin monotherapy, resulting in significantly reduced total testosterone, LH:FSH ratio, and LDL cholesterol levels.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Natalia Wendland, Justyna Opydo-Szymaczek, Dorota Formanowicz, Anna Blacha, Grazyna Jarzabek-Bielecka, Malgorzata Mizgier
Summary: In adolescent girls with PCOS, hormonal and metabolic disturbances impact gingival health, leading to higher levels of proinflammatory cytokines in saliva. Despite similar periodontal parameters, PCOS patients exhibit significantly higher inflammatory markers, indicating a systemic low-grade inflammation associated with the condition.
Article
Endocrinology & Metabolism
Luigi Barrea, Ludovica Verde, Claudia Vetrani, Annamaria Docimo, Giulia de Alteriis, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: This study investigated the prevalence of different chronotype categories in women with PCOS and their impact on hormonal and metabolic aspects. The findings showed a higher prevalence of evening chronotype in women with PCOS, which was associated with worse hormonal and metabolic profiles.
JOURNAL OF PINEAL RESEARCH
(2023)
Review
Evolutionary Biology
Natalie L. Dinsdale, Bernard J. Crespi
Summary: Evolutionary and comparative approaches can provide new insights into human adaptation and disease. The study proposes the diametric disorder hypothesis between endometriosis and PCOS, with support from diverse fields of research. Findings suggest that PCOS and endometriosis represent maladaptive extremes of female life-history variation and expression of sexually dimorphic female reproductive traits.
EVOLUTIONARY APPLICATIONS
(2021)
Article
Endocrinology & Metabolism
Chuan Xing, Han Zhao, Jiaqi Zhang, Bing He
Summary: The study aimed to observe the effects of MET monotherapy and MET plus LIRA combination therapy on gonadal and metabolic profiles in overweight patients with PCOS. The results showed that both MET monotherapy and MET plus LIRA combination therapy improved glucose metabolism and relieved insulin resistance in overweight patients with PCOS. Furthermore, MET plus LIRA combination therapy was more effective in improving reproductive abnormalities and hyperandrogenemia compared to MET monotherapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Xiao Jiang, Jingyu Li, Bingqian Zhang, Jingmei Hu, Jinlong Ma, Linlin Cui, Zi-Jiang Chen
Summary: This study investigated the different expression profiles of plasma exosomal miRNAs in PCOS patients and controls, and their potential roles in PCOS pathogenesis. Through sequencing and analysis, differentially expressed miRNAs were identified, which may contribute to the understanding of PCOS pathophysiology. The expression of certain miRNAs correlated with clinical features of PCOS and could help distinguish PCOS patients from controls.
FERTILITY AND STERILITY
(2021)
Article
Medicine, General & Internal
Robert Krysiak, Karolina Kowalcze, Witold Szkrobka, Boguslaw Okopien
Summary: The aim of this study was to determine if the androgen status modulates the impact of metformin on plasma prolactin levels in women. The results showed that the drug decreased total and monomeric prolactin and increased luteinizing hormone (LH) in control subjects. In women with polycystic ovary syndrome (PCOS), metformin reduced LH, LH/FSH ratio, testosterone, and free androgen index (FAI).
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Si-wei Zhang, Jing Zhou, Hans-Jurgen Gober, Wing Ting Leung, Ling Wang
Summary: PCOS is a common disorder in women of reproductive age, affecting their physiology and metabolism, and often leading to metabolic syndrome and insulin resistance; Berberine can intervene in the development of PCOS in multiple ways, including alleviating insulin resistance, reducing androgen levels, regulating lipid metabolism, and reducing inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Obstetrics & Gynecology
Jon Hyett, Nasrin Asadi, Maryam Zare Khafri, Homeira Vafaei, Maryam Kasraeian, Alireza Salehi, Najmieh Saadati, Khadije Bazrafshan
Summary: This study found that daily administration of 400 mg vaginal progesterone after successful parenteral tocolysis can increase the latency period preceding delivery, improve cervical shortening, and improve neonatal outcomes.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Obstetrics & Gynecology
Maryam Kasraeian, Marjan Zare, Homeira Vafaei, Nasrin Asadi, Azam Faraji, Khadijeh Bazrafshan, Shohreh Roozmeh
Summary: This study conducted a meta-analysis on 87 SARS-CoV-2 positive pregnant women and found that almost 65% of the patients had a history of exposure to an infected person, 78% suffered from mild or moderate COVID-19 pneumonia, and 99.9% had successful termination. No evidence of vertical transmission was found. Despite the immunosuppressive state during pregnancy, most patients had mild or moderate COVID-19 pneumonia with no pregnancy loss.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Homeira Vafaei, Samaneh Karimi, Mojgan Akbarzadeh Jahromi, Nasrin Asadi, Maryam Kasraeian
Summary: This study compared the placental histology and neonatal outcomes among pregnant women with and without beta-thalassemia. The results showed that women with beta-thalassemia had a higher frequency of low birth weight and placental abnormalities.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Obstetrics & Gynecology
Kamran Hessami, Nahid Homayoon, Atefe Hashemi, Homeira Vafaei, Maryam Kasraeian, Nasrin Asadi
Summary: This comprehensive review examines the available evidence on maternal, fetal, and neonatal mortality associated with COVID-19 infection. The results suggest that maternal mortality is more common in women with pre-existing conditions, while fetal and neonatal mortality may be a result of maternal infection severity or prematurity. However, further research is needed to determine the exact magnitude of these mortality rates.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Azam Faraji, Mojgan Akbarzadeh-Jahromi, Shima Bahrami, Sayeh Gharamani, Hadi Raeisi Shahraki, Maryam Kasraeian, Homeira Vafaei, Marjan Zare, Nasrin Asadi
Summary: The study found significant differences in maternal age, gravidity, previous C/S, and PLGF serum levels between PAS and NP groups, with no significant difference in VEGF levels. A valid cut-off point for PLGF was reported at 63.55, presenting high predictive value for PAS. This study highlights the importance of early screening using maternal serum PLGF levels to reduce maternal-foetal morbidity and mortality for PAS patients.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
Nasrin Asadi, Homeira Vafaei, Kamaran Hessami, Mohammad Hasan Darabi, Maryam Kasraeian, Azam Faraji, Azin Alavi, Nazanin Abdi, Atena Gissuei, Shohre Roozmeh, Khadije Bazrafshan, Fereshteh Gharibpour
Summary: The study compared the success rate of vaginal misoprostol and intravenous oxytocin in terminating second trimester intrauterine fetal death. Results showed that as the first-line treatment, vaginal misoprostol had a significantly higher success rate compared to oxytocin, without any severe adverse events. As the second-line treatment, both methods had the same success rate.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Obstetrics & Gynecology
Maryam Kasraeian, Nasrin Asadi, Homeira Vafaei, Mahin Tazang, Azam Faraji, Neda Rahimirad, Sedighe Yousofi, Seyedeh Fatemeh Khaleghi, Marjan Zare
Summary: This study demonstrates that compared with 80 mg of aspirin, taking 150 mg of aspirin every night can reduce the rate of preterm birth and perinatal complications in high-risk pregnant women.
JOURNAL OF PERINATAL MEDICINE
(2022)
Letter
Clinical Neurology
Fariborz Ghaffarpasand, Sirus Sarhadi, Mohammad Hesam Alavi, Ali Rajabpour-Sanati, Maryam Dehghankhalili
WORLD NEUROSURGERY
(2022)
Article
Obstetrics & Gynecology
Azam Faraji, Lida Tahamtani, Najmeh Maharlouei, Nasrin Asadi
Summary: The study compared the efficacy and safety of oral glibenclamide and subcutaneous insulin in patients with gestational diabetes mellitus. The results showed that oral glibenclamide was as effective and safe as subcutaneous insulin in glycemic control and maternal and neonatal outcomes. Therefore, it could be used as a first-line treatment for gestational diabetes mellitus.
OBSTETRIC MEDICINE
(2023)
Article
Surgery
Alimohammad Bananzade, Maryam Dehghankhalili, Faranak Bahrami, Seyed Mohammad Kazem Tadayon, Fariborz Ghaffarpasand
Summary: This study compared the effects of early versus late closure of the stoma in patients with rectal cancer undergoing low anterior resection. The results showed that early closure was associated with shorter operation duration and lower intra-operative bleeding. There was no difference in complications between the two groups. Therefore, early closure of the stoma is a safe and feasible technique.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Clinical Neurology
Amin Niakan, Hosseinali Khalili, Mohammadhossein Vosoughi, Elnaz Azizi, Fariborz Ghaffarpasand
Summary: The effectiveness of correcting serum fibrinogen level in severe traumatic brain injury patients undergoing traumatic cranial surgery was evaluated in this study. Early delivery of fibrinogen concentrate (FC) was found to decrease intraoperative bleeding, but had no significant effect on other parameters. Further multicenter studies are recommended to investigate the role of early FC administration in the management of post traumatic coagulopathy.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Genetics & Heredity
Fariborz Ghaffarpasand, Sirous Sarhadi, Mohammad Hesam Alavi, Ali Rajabpour Sanati, Maryam Dehghankhalili
Summary: Intervertebral disc degeneration (IDD) is a major cause of low back pain and has significant social and economic impact. Current medical and surgical therapies are ineffective, but miRNA-based therapies show promise in regulating the pathogenesis of IDD. Overcoming obstacles associated with these therapies will allow for their translation from bench to bedside in the near future.
Review
Medicine, General & Internal
Keyvan Eghbal, Majid Reza Farrokhi, Seyed Reza Mousavi, Mohammadhadi Amir Shahpari Motlagh, Ali Kazeminezhad, Fariborz Ghaffarpasand
Summary: Patients with SAA should avoid rapid CSF drainage during durotomy by using cotton pads and keeping the head level low to prevent catastrophic complications.
CLINICAL CASE REPORTS
(2023)
Article
Clinical Neurology
Hosseinali Khalili, Amin Niakan, Ali Rajabpour-Sanati, Elaheh Shaghaghian, Mohammad Hesam Alavi, Maryam Dehghankhalili, Fariborz Ghaffarpasand
Summary: This study examined the effects of Dexmedotomdine hydrochloride (Percedex(R), DEX) on functional outcome of patients with moderate and severe traumatic brain injury (TBI). The results showed that DEX administration was associated with decreased hospital stay and improved functional outcome at 6-months.
JOURNAL OF CLINICAL NEUROSCIENCE
(2023)
Article
Obstetrics & Gynecology
Nasrin Asadi, Shohreh Roozmeh, Homeira Vafaei, Naeimehossadat Asmarian, Akram Jamshidzadeh, Khadije Bazrafshan, Maryam Kasraeian, Azam Faraji, Zahra Shiravani, Ali Mokhtar Pour, Shaghayegh Moradi Alamdarloo, Nazanin Abdi, Fereshte Gharibpour, Sedigheh Izze
Summary: This study evaluated the effects of Pentoxifylline on severe early-onset fetal growth restriction (FGR). It was found that Pentoxifylline improved fetal-placental perfusion, neonatal outcome, and increased fetal weight gain. Additionally, it reduced neonatal mortality by decreasing oxidative stress markers and inflammatory cascade.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2022)