Article
Immunology
Yi Zhai, Yanli Pang
Summary: PCOS is a common disorder related to endocrine/reproductive/metabolic systems, and it is associated with low-grade chronic inflammation. Patients with PCOS have higher levels of inflammatory cells and factors, as well as lower levels of anti-inflammatory cytokines. This systemic inflammation is thought to interact with obesity, insulin resistance, and hyperandrogenism.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Kexin Wang, Yanhua Li
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. The etiologies of this syndrome are complex and involve prenatal factors, genetic variation, epigenetic mechanisms, unhealthy lifestyles, and environmental toxins. This review examines the molecular mechanisms underlying PCOS pathogenesis at the level of signaling pathways and discusses potential therapies including exosome therapy, gene therapy, and drugs based on traditional Chinese medicine and natural compounds.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, Research & Experimental
Si-wei Zhang, Jing Zhou, Hans-Jurgen Gober, Wing Ting Leung, Ling Wang
Summary: PCOS is a common disorder in women of reproductive age, affecting their physiology and metabolism, and often leading to metabolic syndrome and insulin resistance; Berberine can intervene in the development of PCOS in multiple ways, including alleviating insulin resistance, reducing androgen levels, regulating lipid metabolism, and reducing inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Congshun Ma, Qianru Xiang, Ge Song, Xuefei Wang
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease with no specific drug treatment. Quercetin (QUR), a flavonoid, has potential therapeutic effects for PCOS patients. However, the mechanisms of QUR in PCOS patients remain unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Necati Hancerliogullari, Aytekin Tokmak, Gurhan Guney, Meryem Kuru Pekcan, Esin Merve Koc, Tuba Candar, Yaprak Engin Ustun
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder, and inflammation is believed to play a crucial role in its pathogenesis. This study found that serum calprotectin levels were higher in women with PCOS, and were correlated with insulin resistance, hyperandrogenism, and chronic inflammation.
Review
Cell Biology
Waleed Hassan Almalki
Summary: The lack of certainty in identifying PCOS demonstrates confusion regarding the disorder's pathophysiology and therapeutic approaches. Systematic screening under NIH guidelines showed that about 4-10% of reproductive women aged 20-44 suffer from PCOS, with approximately 22% being asymptomatic.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Yuanyuan Peng, Hongyue Yang, Jiahui Song, Di Feng, Zhijing Na, Hongyu Jiang, Yaxin Meng, Bei Shi, Da Li
Summary: This study analyzed the association between leptin and polycystic ovary syndrome (PCOS). The results showed that serum leptin levels were significantly higher in patients with PCOS and were associated with multiple metabolic markers. Combined detection of leptin and anti-Mullerian hormone (AMH) had high accuracy in diagnosing PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hosna Mohammad Sadeghi, Ida Adeli, Daniela Calina, Anca Oana Docea, Taraneh Mousavi, Marzieh Daniali, Shekoufeh Nikfar, Aristidis Tsatsakis, Mohammad Abdollahi
Summary: PCOS is an endocrine-gynecology disorder affecting women of childbearing age, with incomplete understanding of its etiology and pathophysiology. Lifestyle modifications and alternative medicines are the preferred first-line therapy, and certain medications have shown potential for repurposing in PCOS. Further research and well-designed clinical trials are needed, as the current evidence is limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Jin Yu, Yulai Zhou, Jie Ding, Danying Zhang, Chaoqin Yu, Hefeng Huang
Summary: This study aimed to investigate the metabolic characteristics of overweight women with PCOS and analyze the possible mechanisms. The results showed that overweight PCOS patients were prone to hypertension, diabetes, low gonadal levels, and insulin resistance. Inflammatory cytokines CXCL12/SDF-1, Serpin E1/PAI-1, and MIF were predicted to play a crucial role in inducing insulin resistance in overweight PCOS through various biological functions and signal transductions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Hui He, Jiaxing Feng, Shike Zhang, Yu Wang, Jian Li, Jingshu Gao, Jing Cong, Yi Gong, Xiaoke Wu
Summary: The study found that there is a positive association between the ApoB/ApoA1 ratio and metabolic and endocrine parameters in women with PCOS. Higher ratios were also associated with increased risk of MetS and IR. The ratio could be a useful tool for screening MetS and IR in PCOS patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maryam Abolghasemi, Soleiman Mahjoub
Summary: PCOS is an endocrine disorder that affects 5-10% of reproductive-age women, characterized by chronic anovulation, polycystic ovaries, hyperandrogenism, hyperinsulinemia, and central obesity. Recent research has highlighted the potential involvement of long noncoding RNAs in the development of PCOS.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Chemistry, Analytical
Anna Rajska, Magdalena Buszewska-Forajta, Szymon Macioszek, Renata Wawrzyniak, Pawel Wityk, Andrzej Berg, Agnieszka Kowalewska, Dominik Rachon, Michal J. Markuszewski
Summary: Despite numerous studies, the cause of PCOS remains unknown. To confirm the reliability of proposed metabolomics biomarkers, we conducted a validation study on serum and urine samples from PCOS patients and healthy controls. Our analysis identified a comprehensive set of altered metabolites in PCOS patients, indicating disruptions in hormone synthesis, lipid metabolism, and energy production.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Endocrinology & Metabolism
Frank Gonzalez, Robert Considine, Ola A. Abdelhadi, Jiaping Xue, Anthony J. Acton
Summary: In PCOS, saturated fat intake triggers proatherogenic inflammation pathways, independent of obesity. This effect is more pronounced in PCOS combined with obesity compared to obesity alone. Abdominal adiposity and hyperandrogenism may contribute to perpetuating proatherogenic inflammation.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Reproductive Biology
Yan-Nan Liu, Yi Qin, Bin Wu, Hui Peng, Ming Li, Hai Luo, Lin-Lin Liu
Summary: Polycystic ovary syndrome (PCOS) is closely related to epigenetic factors, and changes in DNA methylation are associated with the pathogenesis of PCOS.
REPRODUCTIVE TOXICOLOGY
(2022)
Review
Endocrinology & Metabolism
Jiayue Liu, Ying Liu, Xiaoliang Li
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, characterized by ovulation disorders, high androgen levels, and insulin resistance. The pathogenesis of PCOS is still unclear. Intestinal flora, known as the second genome of human beings, is closely linked to metabolic diseases, immune diseases, and infectious diseases. There is increasing evidence that intestinal flora can regulate insulin synthesis and secretion, affect androgen metabolism and follicular development, and play a role in chronic inflammation and obesity. The imbalance of intestinal flora, related to changes in microbial diversity and interactions with host cells, is associated with the occurrence and development of PCOS. Modulating intestinal flora may offer a potential direction for PCOS treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Antonio Chahine, Tulay Koru-Sengul, Daniel J. Feaster, Samantha E. Dilworth, Michael H. Antoni, Nichole Klatt, Margaret E. Roach, Suresh Pallikkuth, Mark Sharkey, Jessica Salinas, Mario Stevenson, Savita Pahwa, Dietmar Fuchs, Adam W. Carrico
Summary: This study found that ongoing stimulant use and HIV persistence independently predicted dysregulated metabolism of amino acid precursors for catecholamines, but this did not explain amplified risk for depression.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2021)
Article
Endocrinology & Metabolism
Alain Diaz, Chloe J. Taub, Marc E. Lippman, Michael H. Antoni, Bonnie B. Blomberg
Summary: The study found that brief cognitive behavioral therapy (CBT) or relaxation training (RT) stress management interventions can mitigate increases in pro-inflammatory leukocyte NF-kappa B binding over 12 months of primary treatment in highly distressed breast cancer patients. These effects are likely brought about by improved stress management skills.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Integrative & Complementary Medicine
Carol Lynn Hecht, Arshati Amin, Jessica Miceli, Donna Olejniczak, Tristen Peyser, David A. Geller, Michael Antoni, Gauri Kiefer, Vincent Reyes, Dan P. Zandberg, Jonas T. Johnson, Marci L. Nilsen, Samer Tohme, Jennifer L. Steel
Summary: Trait mindfulness is associated with positive mental and physical health outcomes for caregivers of individuals diagnosed with cancer, showing lower levels of depression, perceived stress, and tobacco use, along with better caregiver quality of life and sleep quality. Further research on mindfulness-based interventions in the context of cancer caregiving is recommended.
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Article
Clinical Neurology
Adaixa Padron, Christina S. McCrae, Michael E. Robinson, Lori B. Waxenberg, Michael H. Antoni, Richard B. Berry, Jacqueline Castagno, Gregory Schultz, Elizabeth L. Kacel, Chantel Ulfig, Stephanie Garey, Seema Patidar, Timothy Sannes, Laura Trinastic, Shan Wong, Deidre B. Pereira
Summary: Cognitive Behavioral Therapy (CBT) shows significant improvement in the sleep outcomes of insomnia and pain patients, including subjective sleep efficiency, sleep quality, and sleep onset latency. Compared to psychoeducation, CBT has a more pronounced effect on sleep in patients with gynecologic cancers.
BEHAVIORAL SLEEP MEDICINE
(2022)
Article
Oncology
Molly E. Ream, Emily A. Walsh, Jamie M. Jacobs, Chloe Taub, Marc Lippman, Natasha Schaefer-Solle, Steven A. Safren, Michael H. Antoni
Summary: This study followed breast cancer patients for up to 8 years to examine adherence to AET, finding that women who received relaxation training showed better adherence compared to those who received health education or cognitive behavioral therapy. Specifically, they were less likely to forget to take their AET and intentionally miss doses of AET in the long term.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Laura B. Oswald, Brandy Arredondo, Mika Kadono, Dinorah Martinez-Tyson, Cathy D. Meade, Frank Penedo, Michael H. Antoni, Hatem Soliman, Ricardo L. B. Costa, Heather S. L. Jim
Summary: The study identified differences in perceptions of CDK4/6 inhibitor symptom burden between MBC patients and providers, with patients perceiving symptoms as more burdensome. Support resources not specific to MBC were reported to inadequately meet patient needs, and developing specific supportive interventions could potentially improve symptom management and treatment outcomes.
Article
Psychology, Clinical
Taghrid Asfar, Tulay Koru-Sengul, Michael A. Antoni, Asha Dorsey, Estefania C. Ruano Herreria, David J. Lee, Monica Webb Hooper
Summary: This study described lessons learned from recruiting a diverse sample of African American, White, and Hispanic/Latinx smokers in a smoking cessation trial. Word-of-mouth, flyers, newspaper, and online ads were more successful among racial/ethnic minorities. Flyers and newspaper ads were found to be the most economic methods for recruitment.
ADDICTIVE BEHAVIORS
(2022)
Article
Oncology
Jennifer L. Steel, Aarshati Amin, Tristen Peyser, Donna Olejniczak, Michael Antoni, Maureen Carney, Emily Tillman, Carol Lynn Hecht, Niva Pandya, Jessica Miceli, Vincent Reyes, Marci Nilsen, Jonas Johnson, Gauri Kiefer, Bhanu Pappu, Dan P. Zandberg, David A. Geller
Summary: This study examined the impact of the COVID-19 pandemic on patients diagnosed with cancer and their family caregivers. The results showed that while psychological functioning remained similar to pre-pandemic levels, there was a notable decrease in healthcare utilization due to fear of COVID-19. Additionally, a majority of participants reported some benefits from the pandemic, despite its negative effects.
Article
Oncology
Charmaine L. Blanchard, Keletso Mmoledi, Michael H. Antoni, Georgia Demetriou, Maureen Joffe, Gilberto Lopes, Paul Ruff, Daniel S. O'Neil
Summary: Questionnaires that allow patients to directly report chemotherapy side effects can improve their quality of life and clinical outcomes. This study aimed to design and validate a paper-based tool, the PRS-SA survey, for assessing patient-reported symptoms and chemotherapy-related symptoms in South African oncology clinics.
Article
Oncology
Patrick Bou-Samra, Paul Scott, Hannah Cheng, Cramer Kallem, Ritambhara Pathak, David A. Geller, Wallis Marsh, Yisi Wang, Michael Antoni, Frank Penedo, Allan Tsung, Jennifer L. Steel
Summary: The study found that older age and lower perceived social support were significantly associated with poorer survival in gastrointestinal cancer patients.
JOURNAL OF GASTROINTESTINAL CANCER
(2022)
Article
Oncology
Jamie M. Jacobs, Kathryn Post, Katina Massad, Nora K. Horick, Emily A. Walsh, Julia Cohn, Chelsea S. Rapoport, Amy J. Clara, Michael H. Antoni, Steven A. Safren, Ann H. Partridge, Jeffrey M. Peppercorn, Elyse R. Park, Jennifer S. Temel, Joseph A. Greer
Summary: The study found that the telehealth intervention STRIDE showed promising results in reducing symptom distress and improving self-management, coping, quality of life, and mood among patients taking AET after breast cancer. The intervention was well-received by patients and should be further tested in larger trials.
Article
Health Care Sciences & Services
Kate Loveys, Michael Antoni, Liesje Donkin, Mark Sagar, Elizabeth Broadbent
Summary: This study compared the feasibility and acceptability of virtual humans, teletherapy, and self-guided e-manuals in delivering stress management interventions. Results showed that all three technologies were feasible and acceptable for delivering one module of cognitive behavioral stress management to distressed adult women. The technologies had unique strengths and limitations that may depend on individual characteristics and specific circumstances.
JMIR FORMATIVE RESEARCH
(2023)
Article
Psychology, Clinical
Ruth G. St Fleur, Sara M. St George, Daniel J. Feaster, Tae Kyoung Lee, Michael H. Antoni
Summary: The study examined the effects of cognitive behavioral therapy (CBT)-based group interventions on the quality of life (QoL) in breast cancer patients. It found that the intervention improved emotional and functional QoL by increasing benefit finding. This effect was particularly significant among patients with low optimism levels before surgery.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Taghrid Asfar, Tulay Koru-Sengul, Debra Annane, Laura A. McClure, Amanda Perez, Michael A. Antoni, Judson Brewer, David J. Lee
Summary: Approximately 45% of young cancer survivors are smokers, and continued smoking after diagnosis leads to lower survival rates. Depression is a major predictor of smoking relapse in this population. Smartphone apps and mindfulness training show promise in improving smoking cessation outcomes, addressing issues of mobility and depression among cancer survivors. Validating a mindfulness-based smoking cessation intervention app in this population is a high priority.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2021)
Article
Psychology, Clinical
Jamie M. Jacobs, Emily A. Walsh, Chelsea S. Rapoport, Michael H. Antoni, Elyse R. Park, Kathryn Post, Amy Comander, Jeffrey Peppercorn, Steven A. Safren, Jennifer S. Temel, Joseph A. Greer
Summary: This study aims to develop a telehealth intervention to improve adherence, symptom management, and reduce distress for breast cancer patients taking AET. It utilizes patient feedback to refine the intervention and emphasizes theoretical and empirical rationales for each component.
JOURNAL OF CLINICAL PSYCHOLOGY IN MEDICAL SETTINGS
(2021)
