Article
Genetics & Heredity
Itana Gomes Alves Andrade, Fabiola Isabel Suano-Souza, Fernando Luiz Affonso Fonseca, Carolina Sanchez Aranda Lago, Roseli Oselka Saccardo Sarni
Summary: The study revealed that nearly 40% of A-T patients have selenium levels below the reference value, and low GPx activity. There was a significant, inverse and independent association between selenium concentrations and oxidative stress biomarkers.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Eleni Tsiplakou, Christina Mitsiopoulou, Chrysoula Karaiskou, Marica Simoni, Athanasios C. Pappas, Federico Righi, Kyriaki Sotirakoglou, Nikolaos E. Labrou
Summary: The study showed that sesame meal improves the oxidative status of both the organism and the milk in mid-lactation goats, particularly in reducing protein carbonyls content.
Article
Medicine, Research & Experimental
Xiaojun Ma, Yujie Guo, Pengfei Li, Jingjing Xu, Yanyan Gao, Xiuwen Ren, Nicholas Van Halm-Lutterodt, Linhong Yuan
Summary: This study investigated the impact of ApoE status on circulating vitamin A (VA) and vitamin E (VE) in aging adults with dyslipidemia. The results showed that serum VE and VA concentrations were dependent on circulating lipids and ApoE status, with dyslipidemia subjects demonstrating higher levels compared to normal subjects. Additionally, ApoE genotype-dependent differences in serum lipid profile, VE, and VA levels were observed in both normal and dyslipidemia subjects.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Goutham Narayanan Subramanian, Abrey Jie Yeo, Magtouf Hnaidi Gatei, David John Coman, Martin Francis Lavin
Summary: The ATM protein kinase has diverse functions in the cell, including protecting DNA, maintaining cellular homeostasis, and safeguarding against external and internal damage.
Article
Nutrition & Dietetics
Sedda Amzali, Vinicius Dias Wilson, Sebastien Bommart, Marie-Christine Picot, Simon Galas, Jacques Mercier, Patrick Poucheret, Jean-Paul Cristol, Sandrine Arbogast, Dalila Laoudj-Chenivesse
Summary: In patients with FSHD, reduced physical performance is associated with lower blood levels of vitamin C, zinc, selenium, and increased oxidative stress markers. Supplementation of vitamin C, vitamin E, zinc, and selenium improves physical performance. Calorie intake is lower in women with FSHD than in men.
Article
Oncology
Yousra Ajouaou, Elena Magnani, Bhavani Madakashira, Eleanor Jenkins, Kirsten C. Sadler
Summary: Research on zebrafish demonstrates that overexpression of the UHRF1 gene causes a small liver, while mutation of the Atm gene exacerbates this phenomenon. It is also found that oxidative stress is one of the causes of the small liver, and the Atm gene can alleviate the effects of this stress.
Article
Immunology
Itana Gomes Alves Andrade, Fabiola Isabel Suano de Souza, Fernando Luiz Affonso Fonseca, Carolina Sanchez Aranda, Roseli Oselka Saccardo Sarni
Summary: The study revealed lower selenium levels, decreased plasma Se and GPX activity, higher LDLox concentrations, and lower Apo A-1 levels in CVID patients compared to controls, indicating oxidative stress and increased cardiovascular risk.
Article
Biochemistry & Molecular Biology
Francesco Violi, Cristina Nocella, Lorenzo Loffredo, Roberto Carnevale, Pasquale Pignatelli
Summary: Vitamin E possesses antioxidant and anti-inflammatory properties that have an impact on atherosclerosis and thrombus formation, but intervention trials have yielded negative results.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Agriculture, Dairy & Animal Science
Qihui Li, Siwang Yang, Fang Chen, Wutai Guan, Shihai Zhang
Summary: The performance of high-yielding sows directly affects pig farming productivity. The oxidative stress experienced by sows during late pregnancy and lactation has negative effects on their reproduction and lactation abilities. Understanding the nutritional strategies to alleviate oxidative stress is crucial for maintaining the performance of sows.
Review
Cell Biology
Julio Aguado, Cecilia Gomez-Inclan, Hannah C. Leeson, Martin F. Lavin, Yosef Shiloh, Ernst J. Wolvetang
Summary: Ataxia-telangiectasia (A-T) is a complex disorder characterized by progressive cerebellar degeneration, immunodeficiency, radiation sensitivity, genome instability, and predisposition to cancer. The premature aging component of A-T is of great importance in driving the disease.
AGEING RESEARCH REVIEWS
(2022)
Review
Medicine, Research & Experimental
Aman B. Upaganlawar, Nitu L. Wankhede, Mayur B. Kale, Mohit D. Umare, Aayush Sehgal, Sukhbir Singh, Saurabh Bhatia, Ahmed Al-Harrasi, Agnieszka Najda, Renata Nurzynska-Wierdak, Simona Bungau, Tapan Behl
Summary: Epilepsy, affecting nearly 50 million people worldwide, can be caused by genetic predisposition or acquired acute insult leading to alteration of cellular and molecular mechanisms. The imbalanced state of enhanced excitatory glutamatergic and reduced inhibitory GABAergic signaling is considered to be accountable for seizures associated damage. Neurodegeneration contributing to epileptogenesis has become increasingly appreciated, with potential intervention through vitamin E therapy in managing epilepsy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Nutrition & Dietetics
Virginia Boccardi, Giulia Poli, Roberta Cecchetti, Patrizia Bastiani, Michela Scamosci, Marta Febo, Emanuela Mazzon, Stefano Bruscoli, Stefano Brancorsini, Patrizia Mecocci
Summary: Alzheimer's disease (AD) is the leading cause of dementia globally and is a major contributor to disability in older individuals. Vitamin E levels are lower in AD patients, and inflammation and microRNAs also play significant roles in the development of AD. MiR-122 may be a modulating factor, correlating with alpha-tocopherol and inflammation molecules.
Article
Biochemistry & Molecular Biology
Jing Zhang, Yuecheng Sun, Wentao Song, Anshan Shan
Summary: This study found that exposure to phoxim at low levels can cause bioaccumulation with neurotoxicity, oxidative stress, tissue damage, and abnormal nutrient metabolism. Vitamin E was found to alleviate phoxim-induced nephrotoxicity by inhibiting mitochondrial apoptosis.
Article
Genetics & Heredity
Sara Biagiotti, Ambra Barone, Mattia Paolo Aliano, Giulia Federici, Marco Malatesta, Caterina Caputi, Silvia Soddu, Vincenzo Leuzzi, Luciana Chessa, Mauro Magnani
Summary: Most ATM variants associated with Ataxia Telangiectasia are classified as variants with uncertain significance. This study focused on a specific ATM variant found in Lebanese brothers, revealing it to be pathogenic even though it causes an atypical phenotype. Dexamethasone showed therapeutic potential on this and possibly other missense ATM variants.
FRONTIERS IN GENETICS
(2021)
Article
Allergy
Ismail Ogulur, Tugce Ertuzun, Burcu Kocamis, Yasemin Kendir Demirkol, Emel Uyar, Ayca Kiykim, Dilek Baser, Gozde Yesil, Hacer Akturk, Ayper Somer, Ahmet Ozen, Elif Karakoc-Aydiner, Meltem Muftuoglu, Safa Baris
Summary: Heterozygous relatives of ataxia-telangiectasia (AT) patients are at increased risk for certain AT-related manifestations, and parents of AT patients show an increase in infection frequency. It is hypothesized that parents may exhibit immune alterations similar to their affected children.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Review
Pediatrics
Roseli Oselka Saccardo Sarni, Cristiane Kochi, Fabiola Isabel Suano-Souza
Summary: Recent studies have shown that the environment plays a crucial role in the etiopathogenesis of obesity and its comorbidities. Factors such as air pollution, exposure to chemical substances, excessive consumption of ultra-processed foods, changes in gut microbiota, and sedentary lifestyle are associated with increased obesity, insulin resistance, type 2 diabetes, and changes in lipid metabolism.
JORNAL DE PEDIATRIA
(2022)
Article
Public, Environmental & Occupational Health
Talita Rodrigues Azevedo-Silva, Anna Caroline Pereira Vivi, Fernando Luiz Affonso Fonseca, Cibele Wolf Lebrao, Maria Wany Louzada Strufaldi, Roseli Oselka Saccardo Sarni, Fabiola Isabel Suano-Souza
Summary: This study compared serum and erythrocyte zinc levels between preterm and full-term infants and found that zinc levels were associated with breastfeeding and the timing of solid food introduction. The zinc levels were adequate in both groups and not significantly related to infant growth or dietary intake.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Medicine, General & Internal
Juliana Dias Goncalves dos Santos, Fabiola Isabel Suano de Souza, Joao Carlos Pina Faria, Luciana Satiko Sawamura, Anelise Del Vecchio Gessullo, Roseli Oselka Saccardo Sarni
Summary: The aim of this study was to investigate the relationship between homocysteine concentrations and various health parameters in overweight and obese children and adolescents. The results showed that there was no association between homocysteine levels and body mass index, blood pressure, renal function, and insulin resistance in this population.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2023)
Article
Genetics & Heredity
Talita Lemos Neves Barreto, Roberto Jose de Carvalho Filho, David Carlos Shigueoka, Fernando Luiz Affonso Fonseca, Ariel Cordeiro Ferreira, Cristiane Kochi, Carolina Sanchez Aranda, Roseli Oselka Saccardo Sarni
Summary: This study found that about 20% of A-T patients had significant hepatic fibrosis, which was associated with increased liver enzymes, ferritin, HOMA-AD, and severity of ataxia.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Review
Medicine, General & Internal
Aline Morais Venancio de Alencar, Roseli Oselka Saccardo Sarni
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2023)
Article
Surgery
Tatiana Souza Alvarez, Maria Carolina Batista Campos Von Atzingen, Roseli Oselka Saccardo Sarni
Summary: This study analyzed the acceptability of recipes containing whey-based protein supplements in individuals undergoing bariatric and metabolic surgery. The results showed that all recipes had food acceptance above 78% and the average protein content per serving was 13 grams. Therefore, recipes with whey proteins are good dietary alternatives for preventing sarcopenia and weight relapse in individuals undergoing bariatric and metabolic surgery.
Article
Endocrinology & Metabolism
Rodrigo dos Santos Lima, Roseli Oselka Saccardo Sarni
Summary: This study aimed to investigate the association between BMI and dyslipidemia in children and found that excess body weight and dyslipidemia were common among the evaluated children. The study results showed that elevated triglyceride levels were positively correlated with increased BMI, highlighting the importance of monitoring nutritional status in well-child visits and performing universal screening for dyslipidemia in children.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Narjara Pereira Leite, Tatiana Souza Alvarez, Fernando Luiz Affonso Fonseca, Sonia Hix, Roseli Oselka Saccardo Sarni
Summary: This study aimed to evaluate serum 25(OH)D concentrations in homebound elderly people and their relationship with dementia level, nutritional risk, and dietary administration. The study found high prevalence of vitamin D deficiency in bedridden elderly individuals, which was not associated with nutritional risk or dementia level, but was correlated with oral feeding.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2023)
Article
Nutrition & Dietetics
Juliana Davini Mori, Milene Saori Kassai, Cibele Wolf Lebra, Fernando Luiz Affonso-Fonseca, Roseli Oselka Saccardo Sarni, Fabiola Isabel Suano-Souza
Summary: This study aimed to evaluate the influence of serum 25-hydroxyvitamin D levels on postnatal growth in preterm infants at discharge and 12 months of corrected age. The results showed that there was a moderate correlation between umbilical cord and maternal serum 25-hydroxyvitamin D levels, but no significant impact on the postnatal growth of preterm infants.
Article
Medicine, General & Internal
Maria Vitoria Mareschi Barbosa, Joo Carlos Pina Faria, Stephanie Ramos Coelho, Fernando Luiz Affonso Fonseca, Andrea Paula Kafejian Haddad, Fabiola Isabel Suano de Souza, Roseli Oselka Saccardo Sarni
Summary: This study compared serum amyloid A concentrations between overweight and eutrophic children and adolescents, finding higher concentrations in the overweight group. Furthermore, it revealed an independent association between higher serum amyloid A concentrations and Z-score, body mass index, apolipoprotein B, and carotid intima-media thickness.
EINSTEIN-SAO PAULO
(2023)
Article
Medicine, General & Internal
Luennia Kerlly Alves Rocha de Araujo, Joao Carlos Pina Faria, Roseli Oselka Saccardo Sarni
Summary: This study aimed to describe the prevalence of anemia and iron deficiency anemia (IDA) in infants and examine the association between iron deficiency and nutritional status. The results showed that approximately 60% of infants had anemia or IDA, and iron deficiency was significantly associated with weight-for-height Z-score, indicating the vulnerability of infants during the introduction of complementary feeding.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2022)
Article
Medicine, General & Internal
Camila Augusta Victorino, Joao Carlos Pina Faria, Luciana Satiko Sawamura, Fabiola Isabel Suano de Souza, Roseli Oselka Saccardo Sarni
Summary: This study describes the prevalence of acanthosis nigricans and high blood pressure in children and adolescents from low-income families and verifies their association with nutritional status. The study found that overweight and the presence of acanthosis nigricans increased the risk of high blood pressure more than twofold.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2022)
