Article
Multidisciplinary Sciences
C. S. Sharanya, J. Abhithaj, K. G. Arun, Koti Reddy Eeda, Vignesh Bhat, E. J. Variyar, A. Sabu, M. Haridas
Summary: The study focused on designing methyl gallate derivatives and evaluating their anti-inflammatory effects through in silico, in vitro, and in vivo methods. One of the derivatives, MGSD 1, demonstrated anti-inflammatory activity in a rheumatoid arthritis animal model. The synthesized derivatives inhibited LOX enzyme and showed potential in reducing arthritis progression.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Lisard Iglesias-Carres, Lauren A. Essenmacher, Kathryn C. Racine, Andrew P. Neilson
Summary: The study aimed to develop a method to inhibit choline metabolism into TMA by gut microbiota using phenolic compounds. Results showed that DMB, gallic acid, and chlorogenic acid were effective TMA inhibitors that could significantly reduce TMA production, potentially through altering TMA-lyase activity or expression.
Article
Chemistry, Applied
Hui Wang, Shengping You, Wenhang Wang, Yan Zeng, Rongxin Su, Wei Qi, Kang Wang, Zhimin He
Summary: The study found that laccase can promote the cross-linking of gallic acid and soy protein isolate under neutral pH conditions. Gallic acid significantly enhanced the antioxidant activity of soy protein isolate, increasing DPPH free radical scavenging rate, ABTS free radical scavenging ability, and reducing power.
Article
Pharmacology & Pharmacy
Hirofumi Yamakawa, Shuichi Setoguchi, Shotaro Goto, Daisuke Watase, Kazuki Terada, Nami Nagata-Akaho, Erina Toki, Mitsuhisa Koga, Kazuhisa Matsunaga, Yoshiharu Karube, Jiro Takata
Summary: The study demonstrates that MKH derivatives show strong growth-inhibitory effects on ATRA-resistant APL cells and have the potential to overcome ATRA resistance.
Article
Chemistry, Physical
Shadi Molaei, Abbas Dadkhah Tehrani, Hamidreza Shamlouei
Summary: The biocompatibility, biodegradability, low-cost, and rich chemistry of carbohydrates make them promising materials for biomedical applications. Recent research has focused on exploring new polymeric antioxidants based on natural and synthetic carbohydrates. In this study, the antioxidant activity of two glucose conjugated derivatives of gallic acid was investigated using density functional theory (DFT) method. The results showed that the BDE mechanism is the best descriptor for evaluating antioxidant activities, and GG was found to be the most reactive antioxidant compound.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Medicinal
Gilles Degotte, Bernard Pirotte, Michel Frederich, Pierre Francotte
Summary: Malaria remains one of the deadliest infectious diseases of 2021, with an increasing number of infections attributed to drug resistance, highlighting the urgent need for new alternatives. Research has shown that derivatives of polyhydroxybenzoic acids, particularly gallic acid derivatives, have demonstrated potential for further development in antiplasmodial effects. This study identified methyl 4-benzoxy-3,5-dihydroxybenzoate as a potential lead compound for future antimalarial drug research due to its marked inhibitory activity against Plasmodium falciparum and significant water solubility.
ARCHIV DER PHARMAZIE
(2021)
Article
Biochemistry & Molecular Biology
Jie Feng, Fengming He, Yuhui Huang, Mi Zhou, Xiangzhong Liu, Xiansheng Ye, Renjing Yang, Wenjing Tian, Haifeng Chen
Summary: Two undescribed phenolic glycosides were isolated from the Trollius chinensis Bunge plant, showing different inhibitory effects on alpha-glucosidase. Spectroscopic analysis revealed the structural changes of the enzyme during binding with these compounds.
Article
Pharmacology & Pharmacy
Chao Chen, Yuyu Wu, Ziqin Su, Min Qiu, Tiantian Gao, Xinwen Liang, Qinkuai Wu, Kaijun Jiang, Weiwei Liu
Summary: Using Gallic acid as raw material, a two-step reaction was used for the synthesis of 1-(substituted aromatic acyl)-4-(3,4,5-trihydroxybenzoyl) thiosemicarbazone, and a series of new gallic acid amide derivatives containing 1,3,4-thiadiazole were synthesized through a cyclic reaction. The inhibitory activities of the newly prepared compounds against Vibrio harveyi were evaluated, and it was found that all compounds exhibited varying degrees of inhibitory activity, with compound 5b showing the best inhibition effect with a minimum inhibitory concentration (MIC) of 0.0313 mg/mL.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Chemistry, Medicinal
Liwei Ma, Jinling Zhang, Xuemei Wang, Jifang Yang, Lina Guo, Xiaoli Wang, Bo Song, Wei Dong, Wenbao Wang
Summary: DSG-amino acid ester derivatives showed cytotoxic activities against various human cancer cell lines, with compound 7g exhibiting the most significant cytotoxicity against the K562 cell line. Mechanistic studies revealed that compound 7g induced mitochondrial-related apoptosis in K562 cells, highlighting its potential as a promising scaffold for the development of more potent anticancer agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Meng-Yi Bai, Ting-Teng Wang, Xin-An Chen, Chia-Chun Wu
Summary: This study developed a nonwoven mat based on gallic acid, which inhibits pathogen growth and indicates pathogen levels in the air by color change.
Review
Chemistry, Medicinal
Renata Choi Ska, Katarzyna Dabrowska, Renata Swislocka, Wlodzimierz Lewandowski, Artur H. Swiergiel
Summary: This study discussed the biological properties of two popular AHAs, MA and GA, with focus on their antimicrobial properties. It was found that derivatives of these acids generally exhibit higher antimicrobial activity than the acids themselves, likely due to their increased lipophilicity for better cell membrane penetration. This suggests the potential for designing new compounds with improved health-promoting effects based on these AHAs and their derivatives.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Article
Food Science & Technology
Fardin Abdi, Zahra Golchinfar, Mahnaz Tabibiazar, Arezo Taghvimi, Marjan Ghorbani
Summary: The study showed that the addition of tannic acid and gallic acid in heat-treated food products can reduce the formation of Carboxyl methyllysine, decrease the rate of protein glycation, lower the level of intracellular reactive oxygen species, and exhibit high antibacterial activity.
Article
Biochemistry & Molecular Biology
Eon-Joo Roh
Summary: A series of coumarin derivatives were synthesized and evaluated for their inhibitory effects on mushroom tyrosinase activity. The geranyloxycoumarin derivatives were found to be more active than the hydroxycoumarin derivatives, with compound 3k showing double the activity of the positive control arbutin. This suggests that geranyloxycoumarin derivatives have potential as functional cosmetic ingredients with tyrosinase-inhibiting activity.
Article
Agriculture, Multidisciplinary
Wei Liu, Minglei Li, Guihua Wang, Hang Ma, Yu Mu, Dan Zheng, Xueshi Huang, Liya Li
Summary: This study investigated the phytochemical constituents of blue gum leaves and identified several compounds with potential anti-inflammatory effects. These findings support the further development of blue gum leaves as cosmeceutical and nutraceutical products.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Analytical
Huda M. Younis, A. O. Youssef, Said M. El-Sheikh, Sheta M. Sheta, Mohamed S. Attia
Summary: Fe-Gallic acid metal organic framework (MOF) was synthesized and characterized for use as a sensor to detect the antiviral drug Molnupiravir. The Fe-Gallic acid MOF sensor is highly sensitive and cost-effective, and does not require special equipment. It has potential applications in various settings, including clinical laboratories and point-of-care.
MICROCHEMICAL JOURNAL
(2023)
