Ribosome-independent biosynthesis of biologically active peptides: Application of synthetic biology to generate structural diversity

Chemical Logic and Enzymatic Machinery for Biological Assembly of Peptidyl Nucleoside Antibiotics

(2011) Christopher T. Walsh et al.   ACS Chemical Biology

Unraveling Terminal C-Domain-Mediated Condensation in Fungal Biosynthesis of Imidazoindolone Metabolites

(2011) Stuart W. Haynes et al.   BIOCHEMISTRY

The ATP-grasp enzymes

(2011) Maria V. Fawaz et al.   BIOORGANIC CHEMISTRY

Directed Evolution of a Gatekeeper Domain in Nonribosomal Peptide Synthesis

(2011) Benoit Villiers et al.   CHEMISTRY & BIOLOGY

Directed Evolution of the Nonribosomal Peptide Synthetase AdmK Generates New Andrimid Derivatives In Vivo

(2011) Bradley S. Evans et al.   CHEMISTRY & BIOLOGY

Nine Enzymes Are Required for Assembly of the Pacidamycin Group of Peptidyl Nucleoside Antibiotics

(2011) Wenjun Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of TioQ, a type II thioesterase from the thiocoraline biosynthetic cluster

(2011) Ahmed S. A. Mady et al.   Molecular BioSystems

Insights into the complex biosynthesis of the leupyrrins in Sorangium cellulosum So ce690

(2011) Maren Kopp et al.   Molecular BioSystems

Cyclodipeptide synthases, a family of class-I aminoacyl-tRNA synthetase-like enzymes involved in non-ribosomal peptide synthesis

(2011) Ludovic Sauguet et al.   NUCLEIC ACIDS RESEARCH

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

tRNA-dependent peptide bond formation by the transferase PacB in biosynthesis of the pacidamycin group of pentapeptidyl nucleoside antibiotics

(2011) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for nonribosomal peptide synthesis by an aminoacyl-tRNA synthetase paralog

(2011) L. Bonnefond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Engineering for the Production of Natural Products

(2011) Lauren B. Pickens et al.   Annual Review of Chemical and Biomolecular Engineering

Implementation of communication-mediating domains for non-ribosomal peptide production in Saccharomyces cerevisiae

(2010) Verena Siewers et al.   BIOTECHNOLOGY AND BIOENGINEERING

Nonribosomal peptide synthetases: structures and dynamics

(2010) Matthias Strieker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Nonribosomal Peptide Synthetase Enzyme DdaD TethersNβ-Fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-Ketoglutarate-Dependent Epoxidation by DdaC during Dapdiamide Antibiotic Biosynthesis

(2010) Marie A. Hollenhorst et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fungal cyclooligomerdepsipeptides: From classical biochemistry to combinatorial biosynthesis

(2010) Roderich Süssmuth et al.   NATURAL PRODUCT REPORTS

The structure and mechanism of the Mycobacterium tuberculosis cyclodityrosine synthetase

(2010) Matthew W Vetting et al.   Nature Chemical Biology

Synthetic biology: applications come of age

(2010) Ahmad S. Khalil et al.   NATURE REVIEWS GENETICS

Identification of the biosynthetic gene cluster for the pacidamycin group of peptidyl nucleoside antibiotics

(2010) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Click Chemistry and Bioorthogonal Reactions: Unprecedented Selectivity in the Labeling of Biological Molecules

(2009) Michael D. Best   BIOCHEMISTRY

The ATP-Dependent Amide Ligases DdaG and DdaF Assemble the Fumaramoyl-Dipeptide Scaffold of the Dapdiamide Antibiotics

(2009) Marie A. Hollenhorst et al.   BIOCHEMISTRY

Automated genome mining for natural products

(2009) Michael HT Li et al.   BMC BIOINFORMATICS

Mapping the Limits of Substrate Specificity of the Adenylation Domain of TycA

(2009) Benoit R. M. Villiers et al.   CHEMBIOCHEM

Strategies for the Discovery of New Natural Products by Genome Mining

(2009) Malek Zerikly et al.   CHEMBIOCHEM

Chemical synthesis using synthetic biology

(2009) James M Carothers et al.   CURRENT OPINION IN BIOTECHNOLOGY

Diversification of echinomycin molecular structure by way of chemoenzymatic synthesis and heterologous expression of the engineered echinomycin biosynthetic pathway

(2009) Kenji Watanabe et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

CLUSEAN: A computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters

(2009) T. Weber et al.   JOURNAL OF BIOTECHNOLOGY

Dapdiamides, Tripeptide Antibiotics Formed by Unconventional Amide Ligases†

(2009) Jessica Dawlaty et al.   JOURNAL OF NATURAL PRODUCTS

Heterologous production of non-ribosomal peptide LLD-ACV in Saccharomyces cerevisiae

(2009) Verena Siewers et al.   METABOLIC ENGINEERING

New natural product biosynthetic chemistry discovered by genome mining

(2009) Christophe Corre et al.   NATURAL PRODUCT REPORTS

Cyclodipeptide synthases are a family of tRNA-dependent peptide bond–forming enzymes

(2009) Muriel Gondry et al.   Nature Chemical Biology

The second wave of synthetic biology: from modules to systems

(2009) Priscilla E. M. Purnick et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functional Characterization ofttmMUnveils New Tautomycin Analogs and Insight into Tautomycin Biosynthesis and Activity

(2009) Jianhua Ju et al.   ORGANIC LETTERS

Computational structure-based redesign of enzyme activity

(2009) C.-Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural studies on minor enniatins from Fusarium sp. VI 03441: Novel N-methyl-threonine containing enniatins

(2009) Silvio Uhlig et al.   TOXICON

Synthetic Biology for Synthetic Chemistry

(2008) Jay D. Keasling   ACS Chemical Biology

Natural-Product Sugar Biosynthesis and Enzymatic Glycodiversification

(2008) Christopher J. Thibodeaux et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protein Design by Directed Evolution

(2008) Christian Jäckel et al.   Annual Review of Biophysics

Non-Heme Hydroxylase Engineering For Simple Enzymatic Synthesis ofL-threo-Hydroxyaspartic Acid

(2008) Matthias Strieker et al.   CHEMBIOCHEM

Module Extension of a Non-Ribosomal Peptide Synthetase of the Glycopeptide Antibiotic Balhimycin Produced byAmycolatopsis balhimycina

(2008) Diane Butz et al.   CHEMBIOCHEM

Combinatorial Mutasynthesis of Scrambled Beauvericins, Cyclooligomer Depsipeptide Cell Migration Inhibitors fromBeauveria bassiana

(2008) Yuquan Xu et al.   CHEMBIOCHEM

A survey of nonribosomal peptide synthetase (NRPS) genes in Aspergillus nidulans

(2008) Hans von Döhren   FUNGAL GENETICS AND BIOLOGY

Optimizing Natural Products by Biosynthetic Engineering: Discovery of Nonquinone Hsp90 Inhibitors†

(2008) Ming-Qiang Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of the Cryptophycin P450 Epoxidase Reveals Substrate Tolerance and Cooperativity

(2008) Yousong Ding et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ClustScan : an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures

(2008) Antonio Starcevic et al.   NUCLEIC ACIDS RESEARCH

The evolution of gene collectives: How natural selection drives chemical innovation

(2008) M. A. Fischbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Termination Module of a Nonribosomal Peptide Synthetase

(2008) A. Tanovic et al.   SCIENCE