Editorial Material
Microbiology
Agustina Taglialegna
Summary: In this study, Sharafutdinov et al. report the identification of a single nucleotide polymorphism in the gene encoding the HtrA protease of Helicobacter pylori that is linked to gastric cancer.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Cell Biology
Yuefan Guo, Guangxue Wang, Zhongrui Wang, Xin Ding, Lu Qian, Ya Li, Zhen Ren, Pengfei Liu, Wenjing Ma, Danni Li, Yuan Li, Qian Zhao, Jinhui Lu, Qinchuan Li, Qinhong Wang, Zuoren Yu
Summary: The miR-221/222 cluster plays a crucial role in regulating CSCs in NSCLC, affecting tumor initiation, metastasis, and drug resistance. Reck, identified as a key direct target gene of miR-221/222, plays a critical role in the activation of the Notch1 signaling pathway in NSCLC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Tomohiko Yasuda, Hyun Seok Lee, Su Youn Nam, Hiroto Katoh, Yuko Ishibashi, Somay Yamagata Murayama, Hidenori Matsui, Hiroki Masuda, Emiko Rimbara, Nobuyuki Sakurazawa, Hideyuki Suzuki, Hiroshi Yoshida, Yasuyuki Seto, Shumpei Ishikawa, Seong Woo Jeon, Masahiko Nakamura, Sachiyo Nomura
Summary: Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are advancing, with NHPH reported to accompany certain gastric conditions. A study on Korean gastric cancer patients found a low percentage positive for NHPH, suggesting it may play a role in gastric cancer development, albeit with lower pathogenicity compared to H. pylori.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Lusheng Song, Minkyo Song, Charles S. Rabkin, Stacy Williams, Yunro Chung, Jennifer Van Duine, Linda M. Liao, Kailash Karthikeyan, Weimin Gao, Jin G. Park, Yanyang Tang, Jolanta Lissowska, Ji Qiu, Joshua LaBaer, M. Constanza Camargo
Summary: This study evaluated humoral responses to a nearly complete H. pylori immunoproteome among GC cases and controls, finding higher prevalence of certain antibodies in controls and lower seroprevalence in GC cases, suggesting immune protection and potential changes in specific proteins.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Microbiology
Victor E. Reyes
Summary: Helicobacter pylori infection is a major risk factor for gastric cancer and is associated with chronic inflammation and DNA damage. Understanding the mechanisms of H. pylori-induced carcinogenesis and immune evasion is crucial for preventing gastric cancer and reducing the burden of this disease.
Review
Cell Biology
Beatrice Messina, Federica Lo Sardo, Stefano Scalera, Lorenzo Memeo, Cristina Colarossi, Marzia Mare, Giovanni Blandino, Gennaro Ciliberto, Marcello Maugeri-Sacca, Giulia Bon
Summary: The Hippo pathway is a critical regulator of tissue homeostasis, balancing cellular proliferation and differentiation. Dysregulation of this pathway is commonly observed in gastric cancer and Helicobacter pylori-induced infection, suggesting its important role in disease onset and progression. This review provides an overview of the architecture and regulation of the Hippo pathway, discusses its dysregulation in gastric cancer, and explores the crosstalk with other oncogenic signaling pathways. Furthermore, therapeutic approaches targeting aberrant YAP/TAZ activation are highlighted, along with their clinical perspectives and challenges.
CELL DEATH & DISEASE
(2023)
Review
Biotechnology & Applied Microbiology
Linqi Zhu, Yue Huang, Hong Li, Shihe Shao
Summary: Infection with Helicobacter pylori may promote the occurrence and progression of gastric cancer by influencing the tumor microenvironment (TME).
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Olga Sokolova, Michael Naumann
Summary: Gastric cancer is a major cause of cancer-related deaths globally, and its development is influenced by genetic predisposition, environmental factors, and Helicobacter pylori infection. Matrix metalloproteinases (MMPs) play an active role in the progression of gastric cancer, with bacterial dependence being less significant in later stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Surinder M. Soond, Andrey A. Zamyatnin
Summary: The relationship between pathogens and the increased risk of cancer has attracted significant attention, particularly the contribution of Helicobacter pylori infection to the risk of developing gastric cancer. Research is increasingly focusing on the mechanisms by which the microorganism affects host cells and the importance of the host immune system in disease progression.
Article
Biology
Yun Liu, Jia Cao, Qi Yang, Linqi Zhu, Wenjun Zhao, Xiuping Wang, Jun Yao, Yong Zhou, Shihe Shao
Summary: This study demonstrates the inhibitory role of circRNA_15430 in gastric cancer (GC) and its regulation in the progression of Helicobacter pylori (HP) infection-related GC. CircRNA_15430 is primarily located in the cytoplasm of GC cells, downregulated in GC cell lines and tissues, and negatively correlated with tumor size. The downregulation of circRNA_15430 promotes proliferation and migration while suppressing apoptosis and autophagy in GC cells.
Article
Oncology
Ken Namikawa, Norio Tanaka, Yuki Ota, Manabu Takamatsu, Mayuko Kosugi, Yoshitaka Tokai, Shoichi Yoshimizu, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Sayuri Amino, Rie Furuya, Osamu Gotoh, Tomoko Kaneyasu, Izuma Nakayama, Yu Imamura, Tetsuo Noda, Junko Fujisaki, Seiichi Mori
Summary: This study compared the genomic differences between HP-exposed and HP-naive diffuse-type gastric cancer (DGC) and found that they develop along different molecular pathways. This finding provides a basis for early detection strategies in high incidence settings.
JOURNAL OF PATHOLOGY
(2022)
Article
Oncology
Qun Zhang, Ying Ni, Xiaofei Zhi, Jiwei Wang, Zheng Li, Jie Tang, Linjun Wang, Weizhi Wang, Zekuan Xu
Summary: In patients with gastric cancer infected with H. pylori, the expression of APRIL was upregulated and promoted the proliferation, migration, invasion, viability, and metastasis of GC cells through miR-145. Furthermore, APRIL induced gastric tumorigenicity by activating the NF-kappa B pathway. These findings lay the groundwork for a more in-depth analysis of APRIL in gastric cancer risk and prognosis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Olga Sokolova, Michael Naumann
Summary: Infection with H. pylori triggers a robust cellular response in the host, potentially leading to gastric cancer. The regulation of cellular processes through ubiquitinylation mechanisms influences various pathologies including cancer, yet the exact impact of H. pylori on this process remains unclear.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Na Li, Biao Si, Ji-Feng Ju, Meng Zhu, Feng You, Dong Wang, Jie Ren, Yan-Song Ning, Feng-Quan Zhang, Kai Dong, Jing Huang, Wen-Qian Yu, Tong-Jian Wang, Bin Qiao
CANADIAN JOURNAL OF CARDIOLOGY
(2016)
Article
Microbiology
Haiguang Wang, Qian Li, Yao Fang, Shu Yu, Bin Tang, Li Na, Bo Yu, Quanming Zou, Xuhu Mao, Jiang Gu
MICROBIOLOGICAL RESEARCH
(2016)
Article
Multidisciplinary Sciences
Bin Tang, Kun Wang, Yin-ping Jia, Pan Zhu, Yao Fang, Zhu-jun Zhang, Xu-hu Mao, Qian Li, Dong-zhu Zeng
Article
Oncology
Chan Mao, Jiang Gu, Hai-Guang Wang, Yao Fang, Ping Yang, Bin Tang, Na Li, Ting-Ting Wang, Quan-Ming Zou, Qian Li
MOLECULAR MEDICINE REPORTS
(2017)
Article
Cell Biology
Pan Zhu, Jun Xue, Zhu-jun Zhang, Yin-ping Jia, Ya-nan Tong, Dan Han, Qian Li, Yang Xiang, Xu-hu Mao, Bin Tang
CELL DEATH & DISEASE
(2017)
Article
Immunology
Na Li, Bin Tang, Yin-ping Jia, Pan Zhu, Yuan Zhuang, Yao Fang, Qian Li, Kun Wang, Wei-jun Zhang, Gang Guo, Tong-jian Wang, You-jun Feng, Bin Qiao, Xu-hu Mao, Quan-ming Zou
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Biao Si, Bin Qiao, Guang Yang, Meng Zhu, Fengyu Zhao, Tongjian Wang, Na Li, Xiaopeng Ji, Guanghong Ding
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2018)
Article
Multidisciplinary Sciences
Yin-ping Jia, Kun Wang, Zhu-jun Zhang, Ya-nan Tong, Dan Han, Chun-yu Hu, Qian Li, Yang Xiang, Xu-hu Mao, Bin Tang
Article
Oncology
Na Li, Jianlong Wang, Wenqian Yu, Kai Dong, Feng You, Biao Si, Bin Tang, Yan Zhang, Tongjian Wang, Bin Qiao
MOLECULAR MEDICINE REPORTS
(2019)
Article
Immunology
Na Li, Shi-feng Liu, Kai Dong, Gui-chun Zhang, Jing Huang, Zhi-heng Wang, Tong-jian Wang
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2019)
Article
Immunology
Na Zhang, Yafeng Lyu, Jia Guo, Jiahui Liu, Yongdong Song, Zhaomin Fan, Xiaofei Li, Na Li, Daogong Zhang, Haibo Wang
Summary: This study found that IgE levels are elevated in Meniere's disease and positively correlated with clinical symptoms. Additionally, CD23-mediated IgE transcytosis plays a critical role in initiating inflammation in the inner ear. Therefore, reducing IgE levels may be a potentially effective approach for treating Meniere's disease.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Dao-Gong Zhang, Wen-Qian Yu, Jia-Hui Liu, Li-Gang Kong, Na Zhang, Yong-Dong Song, Xiao-Fei Li, Zhao-Min Fan, Ya-Feng Lyu, Na Li, Hai-Bo Wang
Summary: Meniere's disease is a multifactorial disorder of the inner ear characterized by severe vertigo episodes and hearing loss. This study reveals that downregulation of serum/glucocorticoid-inducible kinase 1 is associated with activation of NLRP3 inflammasome in Meniere's disease patients. Serum/glucocorticoid-inducible kinase 1 depletion enhances IL-1 beta production, leading to inner ear damage.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Yiming Hou, Wenqian Yu, Gaoyi Wu, Zhaoling Wang, Shuai Leng, Ming Dong, Na Li, Lei Chen
Summary: The correlation between LEF1 and KDM4A is crucial for the development of oral squamous cell carcinoma (OSCC). LEF1 promotes cell proliferation and inhibits apoptosis in OSCC by suppressing the expression of LATS2. The findings suggest that LEF1 has the potential to serve as a target for early diagnosis and treatment of OSCC.
CELL DEATH & DISEASE
(2023)
Article
Obstetrics & Gynecology
Wenqian Yu, Baowei Shao, Meng Li, Pengfei Zhang, Haijie Li, Xilong Teng, Honglu Wang, Guohai Su, Fengquan Zhang, Na Li
Summary: The study found a positive association between metabolic syndrome and coronary artery calcification prevalence, especially in female participants. In postmenopausal women, metabolic syndrome was associated with a higher prevalence of coronary artery disease compared to premenopausal women and men.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2021)
