Article
Biochemistry & Molecular Biology
Yuan-ru Zheng, Chun-lin Fan, Ye Chen, Jing-yu Quan, Ling-zhu Shi, Chun-yang Tian, Xiao Shang, Ni-shan Xu, Wen-cai Ye, Lin-zhong Yu, Jun-shan Liu
Summary: This study discovered that dammarane-type triterpenoid saponins from Panax notoginseng have anti-inflammatory, anti-angiogenetic, and anti-dengue virus effects. They may be developed as potential functional foods for treating inflammation, angiogenesis, and dengue-related diseases.
Article
Biochemistry & Molecular Biology
Qiaohong Xu, Fang Cui, Xiaodong Li, Nan Wang, Yingrui Gao, Shiping Yin, Fangdi Hu
Summary: Dangshen, a medicinal and edible plant, has been found to have protective effects on gastric mucosa. It can improve chronic non-atrophic gastritis by enhancing antioxidant capacity, suppressing inflammatory responses, and reducing cell apoptosis. This study reveals the potential value of Dangshen in the treatment of gastric diseases.
Article
Biochemical Research Methods
Zhiqiang Li, Shuli Wang, Jincheng Han, Chuanxin Shi, Guangli Yang, Yanyan Cui, Li Xi, Shuanghong Yin, Hui Zhang
Summary: GntR10 is a transcriptional regulator in Brucella that affects the growth and virulence of the bacteria and regulates the activation of NF-κB. This research provides new insights into the designing of Brucella vaccines and the screening of drug targets.
JOURNAL OF PROTEOMICS
(2023)
Review
Immunology
Cise Kizilirmak, Marco E. Bianchi, Samuel Zambrano
Summary: The transcription factor family NF-kappa B plays a crucial role in inflammation and immunity. Live cell imaging has revealed the dynamic nature of NF-kappa B activation, including oscillations in its nuclear localization. This interdisciplinary research has provided insights into the heterogeneous response of NF-kappa B in different cell types and its impact on gene expression. Future steps in this field should focus on filling existing knowledge gaps.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Catalina Pineda Molina, George S. Hussey, Alvin Liu, Jonas Eriksson, William A. D'Angelo, Stephen F. Badylak
Summary: The study suggests that surgical meshes composed of naturally occurring materials, such as 4HB, can increase resistance to surgical site infections by activating molecular pathways promoting antimicrobial peptide expression. The findings provide insights into the mechanisms behind the decreased incidence of infections associated with the use of these meshes.
Review
Dentistry, Oral Surgery & Medicine
E. C. Mooney, S. E. Sahingur
Summary: Inflammation is triggered by innate sensors, and immune cell activation is a strictly regulated process supported by negative feedback mechanisms. Ubiquitination plays a critical role in regulating the immune system, with A20 serving as an important ubiquitin-editing enzyme in inflammation.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Oncology
Paula Gonzalez-Lopez, Marta Alvarez-Villarreal, Ruben Ruiz-Simon, Andrea R. Lopez-Pastor, Melina Vega de Ceniga, Leticia Esparza, Jose L. Martin-Ventura, Oscar Escribano, Almudena Gomez-Hernandez
Summary: MicroRNAs miR-15a-5p and miR-199a-3p are significantly decreased in aortic and carotid samples from atherosclerosis patients and mice. Overexpression of these miRNAs can reduce inflammation and progression of atherosclerosis. MiR-15a-5p may serve as a novel diagnostic biomarker for advanced atherosclerosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Plant Sciences
Hong-Ying Yang, Weidong Yao, Pei-Zhi Huang, Hui Xu, Qian Ma, Xiaoming Chen, Jian-Jun Chen, Kun Gao
Summary: This study isolated three unreported ent-abietane-type norditerpene lactones, named euphohelides A-C (1-3), from the whole plants of Euphorbia helioscopia L. The structures of euphohelides A-C were established using spectroscopic methods, computational ECD, and X-ray crystallographic analyses. Euphohelide A (1) is a novel 2-nor-ent-abietane lactone with a unique 5/6/6/5 tetracyclic system.
JOURNAL OF NATURAL PRODUCTS
(2023)
Review
Chemistry, Medicinal
Saeed Mohammadian Haftcheshmeh, Maliheh Abedi, Kazem Mashayekhi, Mohammad Javad Mousavi, Jamshid Gholizadeh Navashenaq, Asadollah Mohammadi, Amir Abbas Momtazi-Borojeni
Summary: This review discusses the modulatory effects of berberine (BBR) on various inflammatory signaling pathways in the immune system and explores its therapeutic efficacy and anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2022)
Article
Cell Biology
Xuan Li, Wanlu Xie, Qiong Pan, Xiaoxun Zhang, Liangjun Zhang, Nan Zhao, Qiaoling Xie, Jingjing Ding, Jin Chai
Summary: This study found that both SEMA7A mutation and overexpression can activate the NF-κB p50/p65 pathway through integrin beta 1 and play a crucial role in inflammatory responses.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Na Li, Guanjie Zhao, Mingzhu Xu
Summary: This study investigated the effects of Kluyveromyces marxianus on high-fat diet-induced kidney injury. The results showed that K. marxianus can have a beneficial effect on kidney injury by improving gut microbiota and inhibiting the activation of TLR4/NF-kappa B pathway.
CELLULAR MICROBIOLOGY
(2023)
Review
Immunology
Zhending Gan, Meiyu Zhang, Donghui Xie, Xiaoyan Wu, Changming Hong, Jian Fu, Lijuan Fan, Shengyi Wang, Sufang Han
Summary: Glycine, acting as an inhibitory neurotransmitter, not only affects the functions of macrophages but also shapes their polarization through cellular signaling pathways and microRNAs. Additionally, glycine has beneficial effects in preventing and treating macrophage-associated diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Liang Wang, Hui Shi, Chun-chun Zhao, Jing-ya Li, Jian-fei Peng, An-lu Shen, Peng Zhou, Hui-min Bian
Summary: This study found that astragaloside IV can inhibit inflammatory response, reduce cardiac pathology, and have anti-apoptotic effects.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Microbiology
Hironori Nishitsuji, Satoko Iwahori, Mariko Ohmori, Kunitada Shimotohno, Takayuki Murata
Summary: This study reveals the molecular mechanisms behind the induction of proinflammatory cytokines by the SARS-CoV-2 virus. The NSP6 and ORF7a proteins activate the NF-kappa B pathway through interactions with TAK1. The polyubiquitination of NSP6 and ORF7a is essential for NF-kappa B activation, with TRIM13 and RNF121 playing key roles in this process. These findings provide novel insights into the pathogenesis of SARS-CoV-2 and the host immune response.
Article
Biochemistry & Molecular Biology
Eun-Young Heo, Kyoung-Hee Lee, Jisu Woo, Jiyeon Kim, Chang-Hoon Lee, Kyung-Jin Lee, Yun-Kyu Kim, Chul-Gyu Yoo
Summary: This article investigates the role of CRBN in chronic obstructive pulmonary disease (COPD) pathogenesis. The study found that lower levels of CRBN protein were observed in COPD patients compared to never smokers and smokers. CRBN deficiency was shown to aggravate elastase-induced emphysematous changes and increase neutrophil infiltration, lung cell injury, and protein leakage into the bronchoalveolar space. Furthermore, CRBN deficiency led to elevated release of neutrophilic chemokines and inflammatory cytokines. The findings suggest that targeting CRBN could be an effective therapeutic approach for COPD treatment.
Editorial Material
Biotechnology & Applied Microbiology
Phatcharida Jantaree, Liubov Bakhchova, Ulrike Steinmann, Michael Naumann
Summary: 2DMGOs-on-a-chip are consistent in structure and can survive for over a year in culture. This cell physiological system in a microfluidic device allows for investigation of stimuli dependent cellular responses in various differentiated 2DMGOs.
TRENDS IN BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Josephin Koschel, Gopala Nishanth, Sissy Just, Kunjan Harit, Andrea Kroeger, Martina Deckert, Michael Naumann, Dirk Schlueter
Summary: OTUB1 protein plays a role in preventing necroptosis in hepatocytes, protecting against liver damage and death, particularly in bacterial hepatitis and TNF challenge.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Biochemistry & Molecular Biology
Olga Sokolova, Michael Naumann
Summary: Infection with H. pylori triggers a robust cellular response in the host, potentially leading to gastric cancer. The regulation of cellular processes through ubiquitinylation mechanisms influences various pathologies including cancer, yet the exact impact of H. pylori on this process remains unclear.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Dirk Schluter, Eric Schulze-Niemand, Matthias Stein, Michael Naumann
Summary: Many bacterial and viral pathogens have evolved effective strategies to control the activity of ovarian tumor domain proteases (OTUs) to overcome host immune responses and maintain persistence in the host. Pathogen-encoded OTUs can mimic host OTUs and cause cellular dysregulation. Selective OTU inhibitors have the potential to become pharmacologic targets for treating harmful infections.
TRENDS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gunter Maubach, Michelle C. C. Lim, Olga Sokolova, Steffen Backert, Thomas F. Meyer, Michael Naumann
Summary: The study identifies a dual function of TIFA in activating both classical and alternative NF-kappa B signaling pathways in H. pylori-infected gastric epithelial cells, with TRAF6 and TRAF2 acting as the binding partners of TIFA to facilitate the process.
Review
Biochemistry & Molecular Biology
Supattra Chaithongyot, Phatcharida Jantaree, Olga Sokolova, Michael Naumann
Summary: Gastric cancer is a major cause of cancer-related deaths globally, with environmental factors and dysregulation of the transcription factor nuclear factor kappa B (NF-kappa B) playing crucial roles in its development. NF-kappa B actively participates in tumor microenvironment cell crosstalk, with diverse effects on tumor cell and immune cell populations.
Article
Biochemistry & Molecular Biology
Michelle C. C. Lim, Gunter Maubach, Anna M. Birkl-Toeglhofer, Johannes Haybaeck, Michael Vieth, Mchael Naumann
Summary: This study found that infection by Helicobacter pylori activates both classical and alternative NF-κB pathways in gastric epithelial cells, leading to inflammation and cell survival. The A20 protein negatively regulates the alternative NF-κB signaling by interfering with the association between TIFA and the NIK regulatory complex. The alternative NF-κB pathway is involved in the up-regulation of anti-apoptotic genes and the over-expression of RelB is associated with the suppression of apoptotic cell death.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Supattra Chaithongyot, Michael Naumann
Summary: STAMBPL1, a deubiquitinylase, plays an important role in cell survival and regulating cell death. This study found that chemotherapeutic agents and Helicobacter pylori can induce the degradation of STAMBPL1, and its interaction with CSN is crucial for its stability and function. Additionally, STAMBPL1 can deubiquitinylate the anti-apoptotic protein Survivin, enhancing cell survival.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Gunter Maubach, Michael Vieth, Francesco Boccellato, Michael Naumann
Summary: NF-03 signaling pathways are crucial for immune response and gastric pathophysiology, and their alterations induced by Helicobacter pylori infection have implications for gastric diseases.
TRENDS IN MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Phatcharida Jantaree, Supattra Chaithongyot, Olga Sokolova, Michael Naumann
Summary: Helicobacter pylori infection is associated with the development of gastric diseases, including cancer. NF-κB and DUB USP48 play important roles in this process. USP48 stabilizes NF-κB activity by deubiquitination, enhancing its transcriptional activity and reducing apoptotic cell death. This finding provides new insights into the cell survival mechanism in H. pylori infection.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Eric Schulze-Niemand, Michael Naumann
Summary: The COP9 signalosome (CSN) is a universal regulator of Cullin-RING ubiquitin ligases (CRLs) that control cellular processes by degrading signaling proteins. The CSN, with its eight-subunit architecture, inactivates CRLs by removing a small ubiquitin-like modifier called Nedd8. Recent findings on the versatile regulation of CSN-CRL complexes are presented in this review.
TRENDS IN BIOCHEMICAL SCIENCES
(2023)
Article
Chemistry, Medicinal
Kevin Boehm, Eric Schulze-Niemand, Thilo Kaehne, Elisa Siddiqui, Christian Taeger, Daniel Ramsbeck, Mirko Buchholz, Michael Naumann
Summary: Ubiquitin-specific proteases are enzymes that cleave ubiquitin from specific substrate proteins to regulate their activity. Recently, USP48 has been linked to inflammatory signaling. However, its crystal structure has not been resolved and its inhibitors are unknown. We screened 14 commercially available USP inhibitors and identified the USP2 inhibitor ML364 as a potential candidate. Through ligand-based approaches, we synthesized ML364 analogs and found that compound 17e showed inhibition activity against USP48.
ARCHIV DER PHARMAZIE
(2023)
