LKB1 loss of function studied in vivo

LKB1 deletion with the RIP2.Cre transgene modifies pancreatic β-cell morphology and enhances insulin secretion in vivo

(2010) Gao Sun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells

(2010) A. F. Santidrian et al.   BLOOD

Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors

(2010) Julian Carretero et al.   CANCER CELL

microRNA-451: A conditional switch controlling glioma cell proliferation and migration

(2010) Jakub Godlewski et al.   CELL CYCLE

Fyn-Dependent Regulation of Energy Expenditure and Body Weight Is Mediated by Tyrosine Phosphorylation of LKB1

(2010) Eijiro Yamada et al.   Cell Metabolism

LKB1 Haploinsufficiency Cooperates With Kras to Promote Pancreatic Cancer Through Suppression of p21-Dependent Growth Arrest

(2010) Jennifer P. Morton et al.   GASTROENTEROLOGY

LKB1 Deficiency in Tie2-Cre-expressing Cells Impairs Ischemia-induced Angiogenesis

(2010) Koji Ohashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LKB1 Suppresses p21-activated Kinase-1 (PAK1) by Phosphorylation of Thr109in the p21-binding Domain

(2010) Atsuko Deguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An energetic tale of AMPK-independent effects of metformin

(2010) Russell A. Miller et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

(2010) Denghong Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Hamartomatous polyposis syndromes

(2009) Amanda Gammon et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

LKB1/KRAS mutant lung cancers constitute a genetic subset of NSCLC with increased sensitivity to MAPK and mTOR signalling inhibition

(2009) C L Mahoney et al.   BRITISH JOURNAL OF CANCER

Somatic Alterations of the Serine/Threonine KinaseLKB1Gene in Squamous Cell (SCC) and Large Cell (LCC) Lung Carcinoma

(2009) Mojca Stražišar et al.   CANCER INVESTIGATION

LKB1 Regulates Pancreatic β Cell Size, Polarity, and Function

(2009) Zvi Granot et al.   Cell Metabolism

Loss of Lkb1 in Adult β Cells Increases β Cell Mass and Enhances Glucose Tolerance in Mice

(2009) Accalia Fu et al.   Cell Metabolism

The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression

(2009) Yonghao Cao et al.   CELL RESEARCH

Energy addiction and lymphocyte differentiation: A new role for the liver kinase B1 kinase

(2009) Iannis Aifantis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance

(2009) Nicolas Dzamko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac-specific Deletion of LKB1 Leads to Hypertrophy and Dysfunction

(2009) Yasumasa Ikeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine

(2009) Boris Y. Shorning et al.   PLoS One

Somatic LKB1 Mutations Promote Cervical Cancer Progression

(2009) Shana N. Wingo et al.   PLoS One

mTOR and HIF-1 -mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

(2009) D. B. Shackelford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye

(2009) N. Amin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation

(2009) E. Zeqiraj et al.   SCIENCE

Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

(2008) Xu Huang et al.   BIOCHEMICAL JOURNAL

Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients

(2008) J P Koivunen et al.   BRITISH JOURNAL OF CANCER

Anoikis resistance and tumor metastasis

(2008) Craig D. Simpson et al.   CANCER LETTERS

Loss of Lkb1 Provokes Highly Invasive Endometrial Adenocarcinomas

(2008) C. M. Contreras et al.   CANCER RESEARCH

Lkb1 Deficiency Causes Prostate Neoplasia in the Mouse

(2008) H. B. Pearson et al.   CANCER RESEARCH

LKB1 Deficiency Sensitizes Mice to Carcinogen-Induced Tumorigenesis

(2008) S. Gurumurthy et al.   CANCER RESEARCH

The Tumor Suppressor LKB1 Regulates Lung Cancer Cell Polarity by Mediating cdc42 Recruitment and Activity

(2008) S. Zhang et al.   CANCER RESEARCH

LKB1 in endothelial cells is required for angiogenesis and TGF -mediated vascular smooth muscle cell recruitment

(2008) A. Londesborough et al.   DEVELOPMENT

C. elegans dauer formation and the molecular basis of plasticity

(2008) N. Fielenbach et al.   GENES & DEVELOPMENT

Lkb1 is required for TGF -mediated myofibroblast differentiation

(2008) K. Vaahtomeri et al.   JOURNAL OF CELL SCIENCE

Pancreatic Lkb1 Deletion Leads to Acinar Polarity Defects and Cystic Neoplasms

(2008) A. F. Hezel et al.   MOLECULAR AND CELLULAR BIOLOGY

STRADα Regulates LKB1 Localization by Blocking Access to Importin-α, and by Association with Crm1 and Exportin-7

(2008) Julia Dorfman et al.   MOLECULAR BIOLOGY OF THE CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival

(2008) Patrick Narbonne et al.   NATURE

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE

LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis

(2008) Pekka Katajisto et al.   NATURE GENETICS

Cardiac Plasticity

(2008) Joseph A. Hill et al.   NEW ENGLAND JOURNAL OF MEDICINE