AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells

Biologic and clinical significance of molecular profiling in Chronic Lymphocytic Leukemia

(2010) Tom Butler et al.   BLOOD REVIEWS

AICA-riboside (acadesine), an activator of AMP-activated protein kinase with potential for application in hematologic malignancies

(2010) Eric Van Den Neste et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells

(2010) M. Baou et al.   HAEMATOLOGICA

Aspirin induces apoptosis in human leukemia cells independently of NF-κB and MAPKs through alteration of the Mcl-1/Noxa balance

(2009) Daniel Iglesias-Serret et al.   APOPTOSIS

Bcl2 family proteins in carcinogenesis and the treatment of cancer

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Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer

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2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells

(2009) A. J. Steele et al.   BLOOD

Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM

(2009) R. Alonso et al.   BLOOD

TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells

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Molecular and cellular mechanisms of CLL: novel therapeutic approaches

(2009) Lisa Pleyer et al.   Nature Reviews Clinical Oncology

Bim and Bmf in tissue homeostasis and malignant disease

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Noxa: at the tip of the balance between life and death

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Bcl-2-family proteins and hematologic malignancies: history and future prospects

(2008) J. C. Reed   BLOOD

Multiplex ligation-dependent probe amplification for detection of genomic alterations in chronic lymphocytic leukaemia

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Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy?

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AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function

(2008) Alice Mayer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates γ irradiation–induced thymic lymphoma development

(2008) Verena Labi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chronic lymphocytic leukaemia

(2008) G Dighiero et al.   LANCET

The BCL-2 protein family: opposing activities that mediate cell death

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