Review
Biochemistry & Molecular Biology
Francisco Gutierrez-Santiago, Francisco Navarro
Summary: Ribosomes are vital for protein production, and their biogenesis is regulated by cellular energy status and stress signals. In eukaryotic cells, stress signals and newly-synthesized ribosomes require transcription by RNA polymerases. The Target of Rapamycin pathway in eukaryotes influences RNA polymerase transcription to ensure proper ribosome production. This review focuses on how TOR regulates transcription in Saccharomyces cerevisiae and the coordination of three RNA polymerases.
Article
Chemistry, Multidisciplinary
Jiachen Liu, Weili Li, Jianfeng Li, Eli Song, Hongwei Liang, Weiwei Rong, Xinli Jiang, Nuo Xu, Wei Wang, Shuang Qu, Shouyong Gu, Yujing Zhang, Chen-Yu Zhang, Ke Zen
Summary: Extracellular microRNAs (miRNAs) play a critical role in horizontal gene regulation. RNA phase separation is shown as a novel pathway of miRNA uptake. Synthetic miRNAs self-assemble into nanoparticles in the presence of serum, enabling their entry into recipient cells. These nanoparticles deliver miRNAs into mitochondria, enhancing mitochondrial function.
Article
Infectious Diseases
Tereza Kozelkova, David Dolezel, Lenka Grunclova, Matej Kucera, Jan Perner, Petr Kopacek
Summary: Ticks, as blood-feeding arachnids, have the unique ability to engorge and digest large amounts of host blood, facilitating high reproductive potential. They activate blood digestive processes and ovaries maturation upon blood meal uptake through mechanisms that are largely unknown. The evolutionarily conserved Insulin Signaling Pathway (ISP) and Target of Rapamycin (TOR) pathway play crucial roles in nutritional sensing in ticks, with the insulin receptor (IrInR), AKT (IrAKT), and TOR (IrTOR) identified in hard ticks. Knock-down of these components in ticks resulted in reduced blood-feeding and reproductive capacity, highlighting the importance of investigating the roles of insulin-like peptides in tick physiological processes.
TICKS AND TICK-BORNE DISEASES
(2021)
Article
Multidisciplinary Sciences
Yugang Zhang, Zhewang Lin, Julia Zhu, Miao Wang, Hening Lin
Summary: Diphthamide, a modification unique to translation elongation factor 2 (EF2), suppresses -1 frameshifting in translation and affects the TORC1/mTORC1 signaling pathway. In yeast, diphthamide deficiency inhibits the translation of TORC1-activating proteins.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Che Bian, Haibo Zhang, Jing Gao, Yuxia Wang, Jia Li, Dan Guo, Wei Wang, Yuling Song, Yang Weng, Huiwen Ren
Summary: This study demonstrates that SIRT6 regulates glycolipid metabolism through AMPK alpha-mTORC1 pathway, modulating SREBP1c expression in the liver and pancreas induced by overnutrition and starvation, independently of LXR.
LABORATORY INVESTIGATION
(2022)
Article
Biotechnology & Applied Microbiology
Yu-Han Hung, Meghan Capeling, Jonathan W. Villanueva, Matt Kanke, Michael T. Shanahan, Sha Huang, Rebecca Cubitt, Vera D. Rinaldi, John C. Schimenti, Jason R. Spence, Praveen Sethupathy
Summary: This study reveals a novel role of miRNAs in regulating prenatal SI development, using multi-omic, systems biology approaches to identify candidate miRNA regulators associated with early SI developmental events. The study highlights miRNA-mediated post-transcriptional regulation relevant to SI lineage specification.
Article
Microbiology
Kyung Moon, Minji Sim, Chin-Hsien Tai, Kyungyoon Yoo, Charlotte Merzbacher, Sung-Huan Yu, David D. Kim, Jaehyun Lee, Konrad U. Forstner, Qing Chen, Scott Stibitz, Leslie G. Knipling, Deborah M. Hinton
Summary: Through transcriptomic analyses using RNA-seq and ANNOgesic, possible B. pertussis sRNAs were identified and their dependence on BvgAS was determined.
MICROBIOLOGY SPECTRUM
(2021)
Review
Cell Biology
Vojo Deretic, Guido Kroemer
Summary: Autophagy is both a metabolic process and a quality control process, involving specific receptors that selectively remove various intracellular targets. It is regulated by master regulators of cellular metabolism such as MTOR and AMPK, making the system responsive to amino acid and glucose starvation.
Article
Biochemistry & Molecular Biology
Guilherme C. Baiao, Daniela I. Schneider, Wolfgang J. Miller, Lisa Klasson
Summary: Hybridization and introgression of genomic elements contribute to genetic diversity in biological lineages. The mitochondrial evolutionary history of Drosophila paulistorum and the willistoni subgoup was investigated using phylogenetic and comparative analyses. The results show that D. paulistorum has polyphyletic mitochondria, which form two non-sister clades named alpha and beta. It is suggested that both alpha and beta mitochondria were acquired through introgression from unknown fly lineages within the willistoni subgroup.
MOLECULAR PHYLOGENETICS AND EVOLUTION
(2023)
Article
Biochemistry & Molecular Biology
Yulia S. Vershinina, George S. Krasnov, David G. Garbuz, Mikhail V. Shaposhnikov, Maria S. Fedorova, Elena A. Pudova, Irina V. Katunina, Alexey B. Kornev, Nadezhda V. Zemskaya, Alexander A. Kudryavtsev, Elizaveta V. Bulavkina, Anna A. Matveeva, Natalia S. Ulyasheva, Zulfiya G. Guvatova, Artemiy A. Anurov, Alexey A. Moskalev, Anna V. Kudryavtseva
Summary: Torin-2 is a highly selective inhibitor of TORC1 and TORC2 complexes, which can be used as an alternative to rapamycin. It has lower concentrations and fewer side effects than rapamycin. Our study evaluated the transcriptomic changes induced by Torin-2 in the heads of fruit flies and suggested possible neuroprotective mechanisms. Torin-2 had a slight positive effect on the lifespan of male flies but no positive effect on females.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Abdallah Alhaj Sulaiman, Reem Ali, Mustapha Aouida, Balasubramanian Moovarkumudalvan, Dindial Ramotar
Summary: Rapamycin inhibits cell cycle arrest in G(1) phase by disrupting gene expression of the pheromone pathway, which provides a new insight into the mechanism of action for rapamycin via Torc1 kinase.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Aleksandr A. Arzamasov, Aruto Nakajima, Mikiyasu Sakanaka, Miriam N. Ojima, Takane Katayama, Dmitry A. Rodionov, Andrei L. Osterman
Summary: This study describes the NagR-mediated transcriptional regulation of WI and LNnT utilization in Bifidobacterium longum subsp. infantis. The elucidated regulatory network appears optimally adapted to simultaneous utilization of multiple HMOs, providing a rationale to add HMO mixtures (rather than individual components) to infant formulas. The study also provides insights into the evolutionary trajectories of complex regulatory networks controlling carbohydrate metabolism in bifidobacteria.
Article
Cell Biology
Yue Liu, Haixia Yu, Yanlin Guo, Dong Huang, Jiahuan Liu, Mingzhu Pan, Liu Wang, Wenbing Zhang, Kangsen Mai
Summary: The study demonstrated that arginine can regulate the TOR signaling pathway in abalone through SLC38A9, highlighting the significance of this pathway in abalone research.
Review
Plant Sciences
Manuel J. Mallen-Ponce, Maria Esther Perez-Perez, Jose L. Crespo
Summary: Microalgae are photosynthetic microorganisms widely distributed on Earth and they play an important role in oxygen production and food chains. Recent studies have identified a protein called TOR, which regulates cell growth and nutrient sensing in microalgae. Conservation of TOR signaling pathway has been found in diverse microalgae.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Plant Sciences
Cintia Pereyra, Rodrigo Parola, Ana Paula Lando, Marianela Rodriguez, Giselle Maria Astrid Martinez-Noel
Summary: Sugars are both energy sources and central molecular signals that regulate growth, development, and response to environmental stresses. Different types and concentrations of sugars have different effects on TOR signaling, with sucrose, glucose, and to a lesser extent fructose inducing root apical meristem reactivation and TOR activity. High concentration of glucose does not induce RAM or kinase activity, while sucrose-induced TOR activity requires auxin signaling.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Microbiology
Svetlana Khakhina, Soraya S. Johnson, Raman Manoharlal, Sarah B. Russo, Corinne Blugeon, Sophie Lemoine, Anna B. Sunshine, Maitreya J. Dunham, L. Ashley Cowart, Frederic Devaux, W. Scott Moye-Rowley
Article
Biochemistry & Molecular Biology
Jawad Merhej, Thierry Delaveau, Juliette Guitard, Benoit Palancade, Christophe Hennequin, Mathilde Garcia, Gaelle Lelandais, Frederic Devaux
MOLECULAR MICROBIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Thierry Delaveau, Dimitri Davoine, Ariane Jolly, Antoine Vallot, Jerome O. Rouviere, Athenais Gerber, Sandra Brochet, Marion Plessis, Roxane Roquigny, Jawad Merhej, Thibaut Leger, Camille Garcia, Gaelle Lelandais, Elodie Laine, Benoit Palancade, Frederic Devaux, Mathilde Garcia
NUCLEIC ACIDS RESEARCH
(2016)
Article
Microbiology
Jawad Merhej, Antonin Thiebaut, Corinne Blugeon, Juliette Pouch, Mohammed El Amine Ali Chaouche, Jean-Michel Camadro, Stephane Le Crom, Gaelle Lelandais, Frederic Devaux
FRONTIERS IN MICROBIOLOGY
(2016)
Article
Multidisciplinary Sciences
Jerome O. Rouviere, Manuel Bulfoni, Alex Tuck, Bertrand Cosson, Frederic Devaux, Benoit Palancade
NATURE COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Hugo Bretes, Jerome O. Rouviere, Thibaut Leger, Marlene Oeffinger, Frederic Devaux, Valerie Doye, Benoit Palancade
NUCLEIC ACIDS RESEARCH
(2014)
Article
Multidisciplinary Sciences
Sanjiveeni Dhamgaye, Frederic Devaux, Patrick Vandeputte, Nitesh Kumar Khandelwal, Dominique Sanglard, Gauranga Mukhopadhyay, Rajendra Prasad
Article
Multidisciplinary Sciences
Sandra Mota, Neide Vieira, Sonia Barbosa, Thierry Delaveau, Claire Torchet, Agnes Le Saux, Mathilde Garcia, Ana Pereira, Sophie Lemoine, Fanny Coulpier, Xavier Darzacq, Lionel Benard, Margarida Casal, Frederic Devaux, Sandra Paiva
Article
Biochemistry & Molecular Biology
Jawad Merhej, Amandine Frigo, Stephane Le Crom, Jean-Michel Camadro, Frederic Devaux, Gaelle Lelandais
Article
Multidisciplinary Sciences
Antonin Thiebaut, Thierry Delaveau, Medine Benchouaia, Julia Boeri, Mathilde Garcia, Gaelle Lelandais, Frederic Devaux
SCIENTIFIC REPORTS
(2017)
Article
Microbiology
Medine Benchouaia, Hugues Ripoche, Mariam Sissoko, Antonin Thiebaut, Jawad Merhej, Thierry Delaveau, Laure Fasseu, Sabrina Benaissa, Genevieve Lorieux, Laurent Jourdren, Stephane Le Crom, Gaelle Lelandais, Eduardo Corel, Frederic Devaux
FRONTIERS IN MICROBIOLOGY
(2018)
Review
Microbiology
Frederic Devaux, Antonin Thiebaut
Review
Cell Biology
Claudina Rodrigues-Pousada, Frederic Devaux, Soraia M. Caetano, Catarina Pimentel, Sofia da Silva, Ana Carolina Cordeiro, Catarina Amaral
Article
Biochemistry & Molecular Biology
Regina Andrade Menezes, Catarina Pimentel, Ana Rita Courelas Silva, Catarina Amaral, Jawad Merhej, Frederic Devaux, Claudina Rodrigues-Pousada
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2017)
Meeting Abstract
Biochemistry & Molecular Biology
Jawad Merhej, G. Lelandais, A. Frigo, S. Le Crom, J. -M. Camadro, F. Devaux