Ryanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction

Cardiac ryanodine receptor phosphorylation by CaM Kinase II: keeping the balance right

(2010) Susan Currie   Frontiers in Bioscience-Landmark

Role of coupled gating between cardiac ryanodine receptors in the genesis of triggered arrhythmias

(2009) Wei Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease

(2009) Spyros Zissimopoulos et al.   BIOCHEMICAL JOURNAL

Search for cardiac calcium cycling gene mutations in familial ventricular arrhythmias resembling catecholaminergic polymorphic ventricular tachycardia

(2009) Annukka Marjamaa et al.   BMC Medical Genetics

A mechanism of ryanodine receptor modulation by FKBP12/12.6, protein kinase A, and K201

(2009) L. M. Blayney et al.   CARDIOVASCULAR RESEARCH

Requirement for Ca2+/calmodulin–dependent kinase II in the transition from pressure overload–induced cardiac hypertrophy to heart failure in mice

(2009) Haiyun Ling et al.   JOURNAL OF CLINICAL INVESTIGATION

β-Adrenergic receptor signaling in the heart: Role of CaMKII

(2009) Michael Grimm et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass

(2009) Fredrick A. Hilliard et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

New roles of calsequestrin and triadin in cardiac muscle

(2009) Björn C. Knollmann   JOURNAL OF PHYSIOLOGY-LONDON

Intra-sarcoplasmic reticulum Ca2+oscillations are driven by dynamic regulation of ryanodine receptor function by luminal Ca2+in cardiomyocytes

(2009) Sarah C.W. Stevens et al.   JOURNAL OF PHYSIOLOGY-LONDON

The RYR2-Encoded Ryanodine Receptor/Calcium Release Channel in Patients Diagnosed Previously With Either Catecholaminergic Polymorphic Ventricular Tachycardia or Genotype Negative, Exercise-Induced Long QT Syndrome

(2009) Argelia Medeiros-Domingo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Markedly Improves the Function of Failing Cardiomyocytes by Stabilizing Interdomain Interactions Within the Ryanodine Receptor

(2009) Shigeki Kobayashi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans

(2009) Hiroshi Watanabe et al.   NATURE MEDICINE

Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

(2009) Andrew M Bellinger et al.   NATURE MEDICINE

 -Adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel

(2009) P. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structures of the N-Terminal Domains of Cardiac and Skeletal Muscle Ryanodine Receptors: Insights into Disease Mutations

(2009) Paolo Antonio Lobo et al.   STRUCTURE

ARVC-Related Mutations in Divergent Region 3 Alter Functional Properties of the Cardiac Ryanodine Receptor

(2008) Andrea Koop et al.   BIOPHYSICAL JOURNAL

Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts

(2008) H. Tateishi et al.   CARDIOVASCULAR RESEARCH

Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy

(2008) Ali El-Armouche et al.   CARDIOVASCULAR RESEARCH

A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation

(2008) Jeffrey R. Erickson et al.   CELL

Identification of Target Domains of the Cardiac Ryanodine Receptor to Correct Channel Disorder in Failing Hearts

(2008) Takeshi Yamamoto et al.   CIRCULATION

Adrenergic Regulation of Cardiac Contractility Does Not Involve Phosphorylation of the Cardiac Ryanodine Receptor at Serine 2808

(2008) Scott M. MacDonnell et al.   CIRCULATION RESEARCH

Redox Modification of Ryanodine Receptors Contributes to Sarcoplasmic Reticulum Ca 2+ Leak in Chronic Heart Failure

(2008) Dmitry Terentyev et al.   CIRCULATION RESEARCH

Increased Ca 2+ Sensitivity of the Ryanodine Receptor Mutant RyR2 R4496C Underlies Catecholaminergic Polymorphic Ventricular Tachycardia

(2008) María Fernández-Velasco et al.   CIRCULATION RESEARCH

Therapeutic Strategies for Long-QT Syndrome

(2008) Yanfei Ruan et al.   Circulation-Arrhythmia and Electrophysiology

Sudden Death in a Young Man with Catecholaminergic Polymorphic Ventricular Tachycardia and Paroxysmal Atrial Fibrillation

(2008) STEPHEN PIZZALE et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Left Cardiac Sympathetic Denervation for Catecholaminergic Polymorphic Ventricular Tachycardia

(2008) Arthur A.M. Wilde et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart

(2008) Sandeep S. Hothi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY