Article
Endocrinology & Metabolism
Sakib Hossain, Ankit Gilani, Jonathan Pascale, Elizabeth Villegas, Danielle Diegisser, Kevin Agostinucci, Melissa-Maria Kulaprathazhe, Ercument Dirice, Victor Garcia, Michal Laniado Schwartzman
Summary: GPR75 acts as the receptor for 20-HETE and overproduction of 20-HETE leads to insulin resistance in mice fed a high-fat diet. Loss-of-function variants of GPR75 have been associated with protection against obesity in a large-scale exome sequencing study.
Article
Biochemistry & Molecular Biology
Giulia Di Benedetto, Chiara Burgaletto, Maria Francesca Serapide, Rosario Caltabiano, Antonio Munafo, Carlo Maria Bellanca, Rosaria Di Mauro, Renato Bernardini, Giuseppina Cantarella
Summary: This study demonstrates the significant role of TRAIL-R2 in Aβ-related neurodegeneration and provides further evidence that the TRAIL system is a potential target for innovative AD therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Lele Jian, Xing Gao, Chao Wang, Xiao Sun, Yuqiao Xu, Ruili Han, Yuying Wang, Shenhui Xu, Lan Ding, Jingjun Zhou, Yu Gu, Yuanlin Zhao, Ying Yang, Yuan Yuan, Jing Ye, Lijun Zhang
Summary: Plin5 is critical for coordinating fatty acid and glucose oxidation in cardiomyocytes, and its deficiency leads to cardiac hypertrophy and insulin resistance, impairing glucose utilization and increasing lactate production.
Article
Physiology
Annett Juretzko, Antje Steinbach, Jeannine Witte, Anke Hannemann, Baerbel Miehe, Florian Siegerist, Carmen Wolke, Sylvia Stracke, Rainer Rettig
Summary: The renal renin-angiotensin system plays an important role in the development of chronic kidney disease. This study found that mice with reduced renal angiotensin I-converting enzyme (ACE) are protected against aristolochic acid nephropathy. The results suggest that in the absence of renal ACE, aristolochic acid can activate other components of the renin-angiotensin system and exert renal protective effects.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Andre Felipe Rodrigues, Mihail Todiras, Fatimunnisa Qadri, Natalia Alenina, Michael Bader
Summary: The study found that FVB/N mice without angiotensin peptides do not experience hypotension but regulate blood pressure through compensatory mechanisms. However, these mice also exhibit renal morphological and physiological changes, which may make them a model for drug-resistant hypertension.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yang Gong, Bin Kong, Wei Shuai, Tao Chen, Jingjing Zhang, He Huang
Summary: Chronic treatment with the dual SGLT-1 and 2 inhibitor sotagliflozin (Sto) improves left ventricular remodeling and reduces the incidence of ventricular arrhythmias (VAs) after myocardial infarction (MI) by modulating the TLR4/CaMKII signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Chao Song, Hanping Qi, Yongsheng Liu, Yunping Chen, Pilong Shi, Shu Zhang, Jing Ren, Lixin Wang, Yonggang Cao, Hongli Sun
Summary: The study identified a novel regulatory axis involving lncRNA Gm15834/miR-30b-3p/ULK1/autophagy in cardiac hypertrophy, providing a potential therapeutic target for the condition.
Article
Immunology
Gabriel Komla Adzika, Richard Mprah, Ruqayya Rizvi, Adebayo Oluwafemi Adekunle, Marie Louise Ndzie Noah, Prosperl Ivette Wowui, Seyram Yao Adzraku, Joseph Adu-Amankwaah, Fengli Wang, Yuwen Lin, Lu Fu, Xiaomei Liu, Jie Xiang, Hong Sun
Summary: The study found that occlusion preconditioning (OP) is an effective alternative therapeutic intervention for preventing hypoxia-induced myocarditis, cardiac remodeling, arrhythmias, and cardiometabolic disorders. By comparing the effects of OP and altitude preconditioning (AP) in mice and humans, it was demonstrated that OP can protect cardiac electric activity, mitigate maladaptive myocardial remodeling, induce adaptive immunomodulation and metabolic homeostasis, and enhance antioxidant defenses. Additionally, OP can improve respiratory and oxygen-carrying capacity, metabolic homeostasis, and endurance in humans.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Dinesh G. Goswami, Wendy E. Walker
Summary: The study found that IRF3 plays a detrimental role in sepsis in aged mice, providing protection. Male mice were more susceptible to sepsis compared to females, but females produced higher levels of serum cytokines and CK during sepsis onset.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Cell Biology
Matthew Amoni, Eef Dries, Sebastian Ingelaere, Dylan Vermoortele, H. Llewelyn Roderick, Piet Claus, Rik Willems, Karin R. Sipido
Summary: Ischemic heart disease is a common cause of lethal ventricular arrhythmias and sudden cardiac death, with implantable cardioverter defibrillators and ablation therapy being the most effective treatments. Advances in mechanistic insights and technological innovation have led to improved interventional approaches, while pharmacological management still needs improvement.
Article
Biochemistry & Molecular Biology
Shuaishuai Zhang, Jipeng Ma, Xiaowu Wang, Diancai Zhao, Jinglong Zhang, Liqing Jiang, Weixun Duan, Xiaoya Wang, Ziwei Hong, Zilin Li, Jincheng Liu
Summary: Post-menopausal women have a higher incidence of heart failure, which is mainly caused by cardiac hypertrophy and fibrosis, indicating a cardioprotective role of estrogen. The novel estrogen receptor G Protein Coupled Receptor 30 (GPR30) can attenuate myocardial fibrosis caused by ischemic heart disease, but its role in myocardial hypertrophy in ovariectomized mice has not been studied. This study found that G1, the specific agonist of GPR30, can attenuate myocardial hypertrophy and fibrosis in ovariectomized mice through AKT/mTOR mediated inhibition of autophagy, suggesting a potential drug treatment option for pressure overload-induced cardiac hypertrophy in postmenopausal women.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
G. Ryan Crislip, Hannah M. Costello, Alexandria Juffre, Kit-Yan Cheng, I. Jeanette Lynch, Jermaine G. Johnston, Charles B. Drucker, Phillip Bratanatawira, Annanya Agarwal, Victor M. Mendez, Ryanne S. Thelwell, Lauren G. Douma, Charles S. Wingo, Abdel A. Alli, Yogesh M. Scindia, Michelle L. Gumz
Summary: The BMAL1 protein has an impact on kidney function and blood pressure control. Male KS-BMAL1 KO mice showed lower blood pressure and attenuated immune response following a LKHS diet. These findings suggest that BMAL1 plays a role in the blood pressure increase and immune response caused by a LKHS diet.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Yining Liu, Jiamin Li, Ning Xu, Hang Yu, Liling Gong, Qingsui Li, Zhenyu Yang, Sijia Li, Jiming Yang, Di Huang, Yadong Xue, Genlong Xue, Jiali Liu, Haixin Chen, Ruijie Zhang, Anqi Li, Yiming Zhao, PengYu Li, Ming Li, Mingbin Liu, Ning Wang, Benzhi Cai
Summary: This study found that overexpression of Meis1 can improve the electrophysiological function of the heart after myocardial infarction and restore the expression level of Na(V)1.5. In addition, the study also found that E3 ubiquitin ligase CDC20 can mediate the ubiquitination and degradation of Meis1, leading to the remodeling of cardiac electrical conduction.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Biology
Thomas P. Burke, Patrik Engstrom, Cuong J. Tran, Ingeborg M. Langohr, Dustin R. Glasner, Diego A. Espinosa, Eva Harris, Matthew D. Welch
Summary: Mice lacking both interferon receptors provide a tractable model for investigating rickettsiosis, virulence factors, and immunity. The study shows that the actin-based motility factor Sca2 is required for dissemination from the skin to internal organs, and the outer membrane protein OmpB contributes to eschar formation, revealing potential live-attenuated vaccine candidates. Differences in interferon signaling may underlie the discrepancies in susceptibility to rickettsial pathogens between mice and humans.
Article
Biochemistry & Molecular Biology
Christophe Hedon, Karen Lambert, Nourdine Chakouri, Jerome Thireau, Franck Aimond, Cecile Cassan, Patrice Bideaux, Sylvain Richard, Adele Faucherre, Jean-Yves Le Guennec, Marie Demion
Summary: The TRPM4 channel plays a crucial role in the heart, participating in multiple physiological processes including cardiac conduction, hypertrophic adaptations, and potentially cardiac arrhythmias. Research has shown that TRPM4 is essential for survival and is required to activate the Akt and Calcineurin pathways, while also regulating transient calcium amplitudes that may lead to cellular arrhythmias. This channel has two functions: a role in adaptive hypertrophy, and an association with NCX that could trigger cellular arrhythmias.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Monika Gawalko, Arnela Saljic, Na Li, Issam Abu-Taha, Thomas Jespersen, Dominik Linz, Stanley Nattel, Jordi Heijman, Anke Fender, Dobromir Dobrev
Summary: Obesity is a significant contributing factor to atrial fibrillation (AF) by causing systemic changes and affecting different adipose tissue depots. Adipose tissue secretes various mediators that promote AF and cardiac remodeling. This review discusses the role of obesity-related factors, specific adipose tissue depots, and molecular mechanisms in AF, highlighting gaps in current knowledge and implications for clinical management.
CARDIOVASCULAR RESEARCH
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Jordi Heijman, Dobromir Dobrev
EUROPEAN HEART JOURNAL
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Anne M. Gillis, Dobromir Dobrev
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Neurosciences
Jordi Heijman, Dobromir Dobrev
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Cardiac & Cardiovascular Systems
Dobromir Dobrev, Jordi Heijman, Roddy Hiram, Na Li, Stanley Nattel
Summary: This Review discusses the role of cardiomyocyte inflammatory signaling in atrial fibrillation (AF), evaluates the therapeutic potential associated with these signaling pathways, and highlights crucial questions for future research. The authors summarize the evidence for the involvement of inflammation in AF and focus on the NLRP3 inflammasome in atrial cardiomyocytes as a potential key player. They also discuss the possibility of similar signaling in non-myocyte cardiac cells and the importance of active resolution of inflammation in suppressing AF-related inflammatory signaling. The review concludes by considering the therapeutic potential and broader implications of this knowledge.
NATURE REVIEWS CARDIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Peter Ferdinandy, Ioanna Andreadou, Gary F. Baxter, Hans Erik Botker, Sean M. Davidson, Dobromir Dobrev, Bernard J. Gersh, Gerd Heusch, Sandrine Lecour, Marisol Ruiz-Meana, Coert J. Zuurbier, Derek J. Hausenloy, Rainer Schulz
Summary: Preconditioning, postconditioning, and remote conditioning of the myocardium have the potential to provide novel therapeutic paradigms for cardioprotection. However, the lack of rigorous preclinical evaluation and consideration of cardiovascular risk factors and comorbidities may be a major reason for the failure to develop cardioprotective drugs.
PHARMACOLOGICAL REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Nefeli Grammatika Pavlidou, Shokoufeh Dobrev, Kira Beneke, Franziska Reinhardt, Simon Pecha, Eric Jacquet, Issam H. Abu-Taha, Constanze Schmidt, Niels Voigt, Markus Kamler, Renate B. Schnabel, Istvan Baczko, Anne Garnier, Hermann Reichenspurner, Viacheslav O. Nikolaev, Dobromir Dobrev, Cristina E. Molina
Summary: In this study, it was found that upregulation of PDE8B isoforms in cAF patients reduces I-Ca,I-L through direct interaction with the Cav1.2(alpha 1C) subunit. Thus, upregulated PDE8B2 may serve as a novel molecular mechanism for the proarrhythmic reduction of I-Ca,I-L in cAF.
EUROPEAN HEART JOURNAL
(2023)
Article
Neurosciences
Eleonora Grandi, Manuel F. Navedo, Jeffrey J. Saucerman, Donald M. Bers, Nipavan Chiamvimonvat, Rose E. Dixon, Dobromir Dobrev, Ana M. Gomez, Osama F. Harraz, Bence Hegyi, David K. Jones, Trine Krogh-Madsen, Walter Lee Murfee, Matthew A. Nystoriak, Nikki G. Posnack, Crystal M. Ripplinger, Rengasayee Veeraraghavan, Seth Weinberg
Summary: This white paper summarises the outcomes of the seventh UC Davis Cardiovascular Research Symposium on Systems Approach to Understanding Cardiovascular Disease and Arrhythmia. The Symposium aimed to bring together experts in cardiovascular biomedicine to focus on the diversity and signaling involved in cardiovascular function. The paper presents an overview of major cell types, explores the complexity of cardiovascular development and disease at various levels, and discusses technological innovations for advancing understanding of integrated cardiovascular function and dysfunction.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Neurosciences
Stefan Meier, Adaia Grundland, Dobromir Dobrev, Paul G. A. Volders, Jordi Heijman
Summary: Cardiac electrophysiology is regulated by continuous trafficking and internalization of ion channels occurring over minutes to hours. Computer models incorporating ion-channel trafficking are important in elucidating the effects of genetic and acquired modulators on channel gating. A novel computational model is presented here which reproduces the observed production, trafficking, and degradation of K(v)11.1 channels, and their modulation by temperature, pentamidine, dofetilide, and extracellular K+. The model reveals the complex temporal regulation of cardiac electrophysiology by these factors through competing effects on channel gating and trafficking.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Cardiac & Cardiovascular Systems
Heinz Drexel, Juan Tamargo, Juan Carlos Kaski, Basil S. Lewis, Christoph H. Saely, Peter Fraunberger, Dobromir Dobrev, Maki Komiyama, Thomas Plattner, Stefan Agewall, Koji Hasegawa
Summary: Despite the reduction in atherosclerotic cardiovascular disease (ASCVD) risk achieved by lowering low-density lipoprotein cholesterol (LDL-C) levels, residual ASCVD risk still remains. This review highlights the pathophysiology of hypertriglyceridemia, the mechanisms of therapeutic agents, the interpretation of conflicting results from recent clinical trials, and the current options for primary and secondary prevention. Fibrates-induced reduction in triglycerides and increase in high-density lipoprotein cholesterol may outweigh the disadvantages of increasing LDL-C levels in primary prevention, while using eicosapentaenoic acid along with statins in secondary CVD prevention can be beneficial. This comprehensive review may contribute to the development of novel approaches targeting hypertriglyceridemia in the future.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Arnela Saljic, Jordi Heijman, Dobromir Dobrev
Summary: Cardiac arrhythmias remain a common cause of death and disability, and current antiarrhythmic drugs have moderate efficacy and potential adverse effects. Although the development of new drugs has decreased, there are promising candidates and exciting developments in drug repurposing. This review discusses conceptual considerations, new compounds in clinical development, and future directions in antiarrhythmic drug development, providing an optimistic outlook for improved treatment opportunities.
News Item
Cardiac & Cardiovascular Systems
Juan Carlos Kaski, Alexander Niessner, Dobromir Dobrev, Bianca Rocca
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Arnela Saljic, Julie Norup Hertel, Caroline Leonhardt, Sarah Dalgas Nissen, Dobromir Dobrev, Thomas A. Jepps, Thomas Jespersen, Stefan Michael Sattler
IJC HEART & VASCULATURE
(2022)
Article
Cardiac & Cardiovascular Systems
Daniel Benjamin Fyenbo, Tanja Charlotte Frederiksen, Dominik Linz, Thomas Jespersen, Dobromir Dobrev, Gunnar Gislason, Konstanze Betz, Arnela Saljic, Emil Nielsen Holck
Summary: Social media, particularly Twitter, has become increasingly important for professional use and scientific impact. This paper describes and discusses the impact of Twitter on research dissemination, provides a guide to getting started, and presents a case example and survey demonstrating the positive effects of Twitter on promoting scientific events and increasing professional use of SoMe. The limitations of Twitter and SoMe for scientific use are also addressed, highlighting the need for more evidence-based approaches.
IJC HEART & VASCULATURE
(2022)
Review
Biochemistry & Molecular Biology
Arnela Saljic, Jordi Heijman, Dobromir Dobrev
Summary: Atrial fibrillation (AF) is the most common cardiac arrhythmia globally and its mechanisms differ among different patient subgroups. Our understanding of the mechanisms underlying AF has increased significantly in recent years, but current antiarrhythmic drugs have not been developed specifically for AF. The development of novel antiarrhythmic agents and targeting key players in AF mechanisms provides opportunities for more effective therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)