Article
Biotechnology & Applied Microbiology
Li An, Hong Gao, Yi Zhong, Yanqiu Liu, Ying Cao, Jing Yi, Xiang Huang, Chunlei Wen, Rui Tong, Zhijun Pan, Xu Yan, Meiyan Liu, Shengzhao Wang, Xue Bai, Hao Wu, Tingju Hu
Summary: This study investigated the role of stress-induced phosphoprotein 1 (STIP1), heat shock protein (HSP) 70, and HSP90 in the ubiquitination of connexin 43 (Cx43) in rat H9c2 cardiomyocytes. The results showed that STIP1 bound to HSP70 and HSP90, while Cx43 bound to HSP40, HSP70, and HSP90. Overexpression of STIP1 facilitated the transition of Cx43-HSP70 to Cx43-HSP90 and inhibited Cx43 ubiquitination, while knockdown of STIP1 had the opposite effects. Inhibition of HSP90 counteracted the inhibitory effect of STIP1 overexpression on Cx43 ubiquitination. STIP1 is found to suppress Cx43 ubiquitination in H9c2 cardiomyocytes by promoting the transition of Cx43-HSP70 to Cx43-HSP90.
Article
Multidisciplinary Sciences
Maksim Kitsak, Alexander Ganin, Ahmed Elmokashfi, Hongzhu Cui, Daniel A. Eisenberg, David L. Alderson, Dmitry Korkin, Igor Linkov
Summary: Obtaining shortest paths between nodes in complex networks is difficult when there is incomplete information on the network structure. However, the authors have discovered that these paths can be geometrically localized in hyperbolic representations of the networks, allowing them to be detected even in the presence of missing network links. The authors demonstrate the usefulness of this geometric pathfinding in Internet routing and reconstructing cellular pathways.
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Sihan Du, Ying Liu, Yuan Yuan, Yuran Wang, Yanfang Chen, Shuai Wang, Yuhua Chi
Summary: HSP70 is a highly conserved protein that plays a crucial role in maintaining protein homeostasis. It has been found that HSP70 is abundantly expressed in cancer and contributes to tumor resistance to radiotherapy through various mechanisms. Inhibiting HSP70 can enhance the effectiveness of radiotherapy and serve as an effective target for cancer treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Jianxiang Li, Gui Yang, Xiang-Qian Luo, Li-Hua Mo, Shu-Yao Qiu, Li-Tao Yang, Da-Bo Liu, Yun-Fang An, Ping-Chang Yang
Summary: This study investigated the role of Ras activation in down regulating IL-10 expression in tonsillar B cells, finding that B cells from tonsillar tissues with recurrent inflammation showed higher Ras activation, lower IL-10 expression, and higher Bcl2L12 expression than peripheral B cells. Bcl2L12 interacted with Ras activation to inhibit IL-10 expression in tonsillar B cells, which could be restored with inhibition of Bcl2L12.
CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Zixiang Wang, Shourong Wang, Junchao Qin, Xiyu Zhang, Gang Lu, Hongbin Liu, Haiyang Guo, Ligang Wu, Victoria O. Shender, Changshun Shao, Beihua Kong, Zhaojian Liu
Summary: This study reveals that altered expression of splicing factor BUD31 can enhance ovarian cancer progression by promoting exon inclusion in the anti-apoptotic BCL2 family member, BCL2L12. The findings highlight the critical role of BUD31-regulated exon inclusion in ovarian cancer cell survival and cancer progression.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Jing Gao, Bo Hou, Qiwen Zhu, Lei Yang, Xingyu Jiang, Zhifeng Zou, Xutong Li, Tianfeng Xu, Mingyue Zheng, Yi-Hung Chen, Zhiai Xu, Huixiong Xu, Haijun Yu
Summary: Researchers have developed a new polymeric PROTAC nanoparticle for targeted delivery and degradation of proteins in tumors, combined with photodynamic therapy. This study demonstrates the potential of POLY-PROTACs for precise protein degradation and PROTAC-based cancer therapy.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Myung-Sun Kim, Kyunggon Kim, Su Kyung Oh, Gidae Lee, Jin-Ock Kim, Lan Li, Jung-Hyun Park, Kwang-Hyun Baek
Summary: The study successfully prevented ubiquitination of growth hormone hGH by substituting lysine residues with arginine residues, particularly identifying K141R as the most effective substituent to create a long-lasting hGH named AUT-hGH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Li An, Hong Gao, Yi Zhong, Yanqiu Liu, Ying Cao, Jing Yi, Xiang Huang, Chunlei Wen, Rui Tong, Zhijun Pan, Xu Yan, Meiyan Liu, Shengzhao Wang, Hao Wu, Tingju Hu
Summary: This study investigates the expression of connexin 43 (Cx43) and stress-induced phosphoprotein 1 (STIP1) in reperfusion arrhythmia (RA). The results show that Cx43 and STIP1 are decreased in RA rat myocardial tissues and H/R-stimulated H9C2 cells. The study also reveals that STIP1 overexpression promotes Cx43 protein expression, intercellular communication, and cell viability, while reducing cell apoptosis and oxidative stress in H/R-stimulated H9C2 cells.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Taiga Maemoto, Yuichi Kitai, Runa Takahashi, Haruka Shoji, Shunsuke Yamada, Shiho Takei, Daiki Ito, Ryuta Muromoto, Jun-ichi Kashiwakura, Haruka Handa, Ari Hashimoto, Shigeru Hashimoto, Toyoyuki Ose, Kenji Oritani, Tadashi Matsuda
Summary: In this study, researchers found that 2D5 peptide can inhibit the binding of STAP-2 and EGFR, suppress tumor cell proliferation, and inhibit tumor growth in murine xenograft models of prostate and lung cancer. These findings suggest that 2D5 peptide is a novel anticancer peptide that inhibits STAP-2-mediated activation of EGFR signaling.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Plant Sciences
Jian-Ping An, Xiao-Fei Wang, Xiao-Wei Zhang, Chun-Xiang You, Yu-Jin Hao
Summary: This study revealed that MdBT2 plays an antagonistic role in JA-mediated leaf senescence by promoting the ubiquitination degradation of MdMYC2 and interacting with MdJAZ2 to inhibit JA-induced leaf senescence. Additionally, MdBT2 interacts with various JAZ proteins in apple, providing new insights into the molecular mechanisms of JA-modulated leaf senescence. The dynamic regulatory module consisting of JA-MdBT2-MdJAZ2-MdMYC2 plays a crucial role in JA-modulated leaf senescence.
PLANT CELL AND ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Yuluo Rong, Jin Fan, Chengyue Ji, Zhuanghui Wang, Xuhui Ge, Jiaxing Wang, Wu Ye, Guoyong Yin, Weihua Cai, Wei Liu
Summary: This study reveals the involvement of ferroptosis in spinal cord ischemia-reperfusion injury (SCIRI) and the key role of USP11 in regulating ferroptosis, as well as promoting autophagy activation. Targeting USP11-mediated autophagy-dependent ferroptosis could be a promising approach for the treatment of SCIRI.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Biochemistry & Molecular Biology
Jaeeun Jung, Jiseok Baek, Kun Tae, Donghyuk Shin, Seungsu Han, Wonjin Yang, Wookyung Yu, Su Myung Jung, Seok Hee Park, Cheol Yong Choi, Sangho Lee
Summary: The study reveals the molecular mechanisms underlying the regulation of Rab7 by site-specific monoubiquitination, where ubiquitination on K191 and K194 plays a crucial role in membrane localization and interaction with SARS-CoV-2. This highlights the common regulatory effects of Rab proteins through site-specific monoubiquitination while emphasizing the specific roles of different ubiquitination sites in each Rab protein.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Yuyin Li, Yaxin Zhang, Lu Li, Mei Zhang, Ning Song, Qing Zhao, Zhenxing Liu, Aipo Diao
Summary: The transmembrane prostate androgen-induced protein (TMEPAI) is highly expressed in various types of cancer and activates the NF-kappa B signaling pathway through the ubiquitination of I kappa B alpha. This results in the degradation of I kappa B alpha and the subsequent activation of NF-kappa B signaling. Further investigation revealed that TMEPAI-induced cell proliferation and tumor growth in immune deficient mice are mediated by the NF-kappa B signaling pathway. This study provides valuable insights into the role of TMEPAI in tumorigenesis and suggests it as a potential target for cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Cell Biology
Daniel S. Simpson, Anna Gabrielyan, Rebecca Feltham
Summary: Over the last two decades, research has focused on understanding the role of RIPK1 in cell survival and death pathways, particularly its involvement in NF-kappa B signaling and cell death processes. However, the specific impact of RIPK1 ubiquitination on signaling outcomes remains unclear due to the complexity of ubiquitin signaling.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Ziqian Wang, Ting Song, Zongwei Guo, Laura B. Uwituze, Yafei Guo, Hong Zhang, Hang Wang, Xiaodong Zhang, Hao Pan, Tong Ji, Fangkui Yin, Sheng Zhou, Jian Dai, Zhichao Zhang
Summary: The novel Hsp70 inhibitor S1g-6 disrupts Hsp70-Bim protein-protein interactions and selectively antagonizes Hsp70 ATPase activity, leading to selective apoptosis induction in certain cancer cell lines. This represents a new class of antitumor candidates targeting cancer-related Hsp70-Bim interactions.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Engineering, Chemical
Hongliang Zong, Cheng Fang, Zhongxiang Lin, Qiming Yan, Xing Lin
Summary: A novel UV/moisture dual-curable polyurethane resin has been synthesized via a two-step process, with its properties easily controlled by changing blocking agents and KH590 content. Using PETA as a blocking agent results in higher mechanical strength and better thermal properties, while HEMA leads to higher crosslink density in DPUA. Increasing KH590 content can enhance tensile strength and elongation at break.
JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY
(2021)
Review
Cell Biology
Zhen Wei, Xiaoyi Liu, Chunming Cheng, Wei Yu, Ping Yi
Summary: Metabolic reprogramming involving amino acid metabolism is a recognized hallmark of malignancy, with potential therapeutic implications in targeting this pathway for cancer treatment. Amino acids play a crucial role in supporting survival and proliferation of cancer cells under various stress conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Yi Wang, Yuya Wang, Yifei Ren, Qi Zhang, Ping Yi, Chunming Cheng
Summary: Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) or programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1)-based immune checkpoint inhibitors (ICIs) have shown significant improvements in overall survival of certain cancer patients, but resistance to immunotherapy remains a challenge. This article examines the metabolic modulation of tumor immunity and immune checkpoints in the tumor microenvironment (TME) and discusses potential metabolism-based therapeutic strategies. Understanding the link between tumor metabolism and immunotherapy is crucial for cancer treatment and research.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Qiao Zhou, Qi Zhang, Kaiwen Wang, Ting Huang, Shaoping Deng, Yi Wang, Chunming Cheng
Summary: This review summarizes the risk of HBV reactivation and medication management plan for HBV carriers, especially rheumatic patients, during rheumatoid therapy. It also provides preventive strategies for HBV reactivation-induced liver diseases, particularly cirrhosis and hepatocellular carcinoma (HCC). These findings are significant for developing treatments for rheumatic patients and preventing HBV-related liver diseases.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Mayumi Sugita, Roman Galetto, Hongliang Zong, Nathan Ewing-Crystal, Vicenta Trujillo-Alonso, Nuria Mencia-Trinchant, Winnie Yip, Stephanie Filipe, Celine Lebuhotel, Agnes Gouble, Duane C. Hassane, Julianne Smith, Gail J. Roboz, Monica L. Guzman
Summary: This study reports the design and characterization of allogeneic CD123-targeted CAR-T cells as a therapeutic approach for acute myeloid leukemia.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Erh-Hsuan Lin, Jhen-Wei Hsu, Ting-Fang Lee, Chiung-Fang Hsu, Tsung-Hsien Lin, Yi-Hua Jan, Hsiang-Yi Chang, Chun-Ming Cheng, Hui-Jan Hsu, Wei-Wei Chen, Bo-Hung Chen, Hsing-Fang Tsai, Jung-Jung Li, Chi-Ying Huang, Shih-Hsien Chuang, Jia-Ming Chang, Michael Hsiao, Cheng-Wen Wu
Summary: This study demonstrates the crucial roles of BMI1 and MCL1 in cancer stemness in non-small cell lung cancer (NSCLC), and the JNK signaling pathway as a link between oncogenic pathways or genotoxicity and cancer stemness. High levels of BMI1 are associated with poor survival in NSCLC patients, and BMI1 expression is positively correlated with MCL1. The development of the small molecule BI-44 effectively suppresses BMI1/MCL1 expressions and inhibits tumor formation and progression in preclinical models, providing a new therapeutic approach for NSCLC treatment.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Immunology
Qiao Zhou, Ting Li, Kaiwen Wang, Qi Zhang, Zhuowen Geng, Shaoping Deng, Chunming Cheng, Yi Wang
Summary: Transplantation is a last resort for end-stage organ failures, but the shortage of donor organs limits its success. Xenotransplantation of pig organs is an alternative, but immune rejection is a major challenge. This review comprehensively discusses the mechanisms of immune rejection and strategies to prevent it, such as gene knockout donors and immunosuppressive regimens.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jun Li, Chunming Cheng, Jinshu Xu, Ting Zhang, Bengu Tokat, Georgia Dolios, Aarthi Ramakrishnan, Li Shen, Rong Wang, Pin-Xian Xu
Summary: Eya1 is critical for the establishment and maintenance of nephron progenitor cells. By interacting with chromatin-remodeling factors and DNA-binding proteins, Eya1 regulates gene transcription to maintain cellular state.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Medicine, Research & Experimental
Zhen Geng, Qi Zhang, Ting Li, Ting Huang, Hailian Wang, Qiao Zhou, Shaoping Deng, Yanshuang Zhao, Yanjiao Li, Chunming Cheng, Carmen Gonelle-Gispert, Leo. H. H. Buhler, Yi Wang
Summary: This study tested a new polymer combination for islet encapsulation and transplantation, as well as explored a new site for xenogeneic islet transplantation. Transplanting encapsulated islets into the retroperitoneal space maintained normoglycemia, providing a valuable new implantation strategy for the treatment of type 1 diabetes.
XENOTRANSPLANTATION
(2023)
Article
Biochemistry & Molecular Biology
Qian Yuan, Kui Su, Shuyi Li, Xinyi Long, Lang Liu, Jianwu Sun, Xin Yuan, Minghui Yang, Rui Tian, Wanting Zhang, Zhujie Deng, Quanjiang Li, Changhong Ke, Yue He, Chunming Cheng, Jingna Yuan, Zhuohao Wen, Wei Zhou, Zhengqiang Yuan
Summary: The aberrantly up-regulated CDK9 can be targeted for cancer therapy. The CDK inhibitor dinaciclib (Dina) has limited selectivity, but CDK9-targeted siRNA (siCDK9) may be a good alternative. The encapsulation of siCDK9 molecules into EV-Ts to form siEV-T can efficiently suppress CDK9 expression and overcome TRAIL resistance, inducing enhanced apoptosis in lung cancer. It potentially constitutes a novel, highly effective and safe therapy for cancers.
Editorial Material
Cell Biology
Chunming Cheng, Si Zhang, Dongyin Guan, Yi Wang, Nidhi Jyotsana
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Chunming Cheng, Scott Kelsey, Deliang Guo
Review
Medicine, Research & Experimental
Yanjie Chen, Jie Xu, Xiaoyi Liu, Linlin Guo, Ping Yi, Chunming Cheng
Summary: The interplay between genetic alterations and metabolic dysregulation plays a crucial role in cancer pathogenesis. Recent findings have shown the translocation of metabolites and metabolic enzymes to the nucleus, which are closely associated with tumor cell proliferation. However, there is still a lack of understanding regarding their specific roles within the nuclear environment, their effects on gene transcription and cellular proliferation, and their coordination with the genomic landscape.
Article
Endocrinology & Metabolism
Chunming Cheng, Feng Geng, Zoe Li, Yaogang Zhong, Huabao Wang, Xiang Cheng, Yue Zhao, Xiaokui Mo, Craig Horbinski, Wenrui Duan, Arnab Chakravarti, Xiaolin Cheng, Deliang Guo
Summary: In this study, researchers found that ammonia released from glutaminolysis activates SREBP-1 and promotes lipogenesis, thus supporting tumor growth. The study reveals the role of ammonia as a key activator in promoting lipid synthesis through dissociation of SCAP-Insig and activation of SREBP-1. It also demonstrates the critical role of SCAP as a sensor for glutamine, glucose, and sterol levels in precise control of lipid synthesis.
Meeting Abstract
Oncology
Dongming Zhang, Frederic Vigant, Qun He, Anirban Kundu, Wei Zhang, Hongliang Zong, Ewa Jaruga-Killeen, Gregory Schreiber, Michelle Andraza, Alissa R. Kerner, Gregory I. Frost, Sid P. Kerkar
