TWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression

Macrophage targeting in cancer

(2020) Martha Lopez‐Yrigoyen et al.   Annals of the New York Academy of Sciences

Cholangiocarcinoma 2020: the next horizon in mechanisms and management

(2020) Jesus M. Banales et al.   Nature Reviews Gastroenterology & Hepatology

Tumor-associated lymphangiogenesis predicts unfavorable prognosis of intrahepatic cholangiocarcinoma

(2019) Meng Sha et al.   BMC CANCER

Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer

(2019) Lichun Ma et al.   CANCER CELL

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

Platelet-Derived Growth Factor-D Enables Liver Myofibroblasts to Promote Tumor Lymphangiogenesis in Cholangiocarcinoma

(2018) Massimiliano Cadamuro et al.   JOURNAL OF HEPATOLOGY

Autocrine and Paracrine Mechanisms Promoting Chemoresistance in Cholangiocarcinoma

(2017) Massimiliano Cadamuro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cholangiocarcinoma stem-like subset shapes tumor-initiating niche by educating associated macrophages

(2017) Chiara Raggi et al.   JOURNAL OF HEPATOLOGY

Cholangiocarcinoma — evolving concepts and therapeutic strategies

(2017) Sumera Rizvi et al.   Nature Reviews Clinical Oncology

Interaction of TWEAK with Fn14 leads to the progression of fibrotic liver disease by directly modulating hepatic stellate cell proliferation

(2016) Annika Wilhelm et al.   JOURNAL OF PATHOLOGY

Blocking the CCL2–CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model

(2016) Kun-Yu Teng et al.   MOLECULAR CANCER THERAPEUTICS

Notch3 drives development and progression of cholangiocarcinoma

(2016) Rachel V. Guest et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumors

(2015) D. Meulendijks et al.   CLINICAL CANCER RESEARCH

Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma

(2015) Xiaoguang Li et al.   GUT

WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited

(2015) Luke Boulter et al.   JOURNAL OF CLINICAL INVESTIGATION

A Phase I Monotherapy Study of RG7212, a First-in-Class Monoclonal Antibody Targeting TWEAK Signaling in Patients with Advanced Cancers

(2014) U. N. Lassen et al.   CLINICAL CANCER RESEARCH

Roles for Chemokines in Liver Disease

(2014) Fabio Marra et al.   GASTROENTEROLOGY

Activated macrophages promote Wnt/β-catenin signaling in cholangiocarcinoma cells

(2014) Watcharin Loilome et al.   TUMOR BIOLOGY

Treatment and Prognosis for Patients With Intrahepatic Cholangiocarcinoma

(2014) Michael N. Mavros et al.   JAMA Surgery

Cell Lineage Tracing Reveals a Biliary Origin of Intrahepatic Cholangiocarcinoma

(2013) R. V. Guest et al.   CANCER RESEARCH

Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma

(2013) Massimiliano Cadamuro et al.   HEPATOLOGY

Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling

(2013) T. G. Bird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of CXCL5/ENA-78 as a factor involved in the interaction between cholangiocarcinoma cells and cancer-associated fibroblasts

(2012) Hirohisa Okabe et al.   INTERNATIONAL JOURNAL OF CANCER

Cholangiocarcinomas can originate from hepatocytes in mice

(2012) Biao Fan et al.   JOURNAL OF CLINICAL INVESTIGATION

Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes

(2012) Sayaka Sekiya et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of the stromal-derived factor-1 (SDF-1)–CXCR4 axis in the interaction between hepatic stellate cells and cholangiocarcinoma

(2012) Alessandra Gentilini et al.   JOURNAL OF HEPATOLOGY

Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors

(2011) Jesper B. Andersen et al.   GASTROENTEROLOGY

Myofibroblast-derived PDGF-BB promotes hedgehog survival signaling in cholangiocarcinoma cells

(2011) Christian D. Fingas et al.   HEPATOLOGY

TAK1 Suppresses a NEMO-Dependent but NF-κB-Independent Pathway to Liver Cancer

(2010) Kira Bettermann et al.   CANCER CELL

Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma

(2010) Horlad Hasita et al.   CANCER SCIENCE

Circulating CD14+CD16+ monocyte levels predict tissue invasive character of cholangiocarcinoma

(2010) C. Subimerb et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Tumor necrosis factor-like weak inducer of apoptosis is a mitogen for liver progenitor cells

(2010) Janina E. E. Tirnitz-Parker et al.   HEPATOLOGY

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY

Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis

(2009) S. Inokuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA