期刊
FEBS JOURNAL
卷 280, 期 2, 页码 505-524出版社
WILEY
DOI: 10.1111/j.1742-4658.2012.08565.x
关键词
cancer; cell signalling; dual specificity phosphatases; metastasis; phosphatase of regenerating liver; protein phosphatases
资金
- German Science Foundation (Deutsche Forschungsgemeinschaft, DFG) within the Emmy-Noether program
- EMBL
- Marie Curie Action EMBL Interdisciplinary Postdoc fellowships
The phosphatases of regenerating liver (PRLs) are an intriguing family of dual specificity phosphatases due to their oncogenicity. The three members are small, single domain enzymes. We provide an overview of the phosphatases of regenerating liver, compare them to related phosphatases, and review recent reports about each phosphatase. Finally, we discuss similarities and differences between the phosphatases of regenerating liver, focusing on their molecular mechanisms and signalling pathways.
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